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卵巢妊娠破裂三例诊疗体会

国际生殖健康／计划生育杂志 2024年第4期43卷 309-312页

作者：徐晓燕王笑璇山东中医药大学附属医院生殖与遗传科济南250011

卵巢妊娠临床发病率低,一旦破裂患者预后较差。卵巢妊娠大多数在妊娠早期发生破裂,导致腹腔内大量出血,甚至休克。卵巢妊娠破裂术前往往误诊为输卵管妊娠破裂或卵巢黄体破裂,术中经仔细探查方可明确诊断,因此卵巢妊娠的早期诊断和治疗... 详细信息

卵巢妊娠临床发病率低,一旦破裂患者预后较差。卵巢妊娠大多数在妊娠早期发生破裂,导致腹腔内大量出血,甚至休克。卵巢妊娠破裂术前往往误诊为输卵管妊娠破裂或卵巢黄体破裂,术中经仔细探查方可明确诊断,因此卵巢妊娠的早期诊断和治疗至关重要。本文报道3例卵巢妊娠,其中2例术前出现失血性休克表现,1例表现为腹痛加剧,均行急症手术治疗,术中探查均确诊为卵巢妊娠破裂。卵巢妊娠的治疗包括药物杀胚治疗和手术治疗,一旦发生破裂需行急症手术治疗。临床上对于异位妊娠患者均应考虑到卵巢妊娠可能,做到早诊断、早治疗,避免严重并发症的发生。

关键词：破裂妊娠,输卵管诊断治疗病例报告卵巢妊娠黄体破裂

抗N-甲基-D-天冬氨酸受体脑炎的神经影像学研究进展

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影像技术 2024年第1期36卷 74-80页

作者：王晓旋田军章暨南大学附属广东省第二人民医院广东510317

抗N-甲基-D-天冬氨酸受体(NMDAR)脑炎是一种严重的神经精神综合征,抗NMDAR脑炎具有发病率高、病程长、病情重、特异性较差、早期诊断困难等特点。目前,抗NMDAR脑炎的诊断主要依赖于抗体检测和神经影像技术。常规CT成像对该疾病的诊断具... 详细信息

抗N-甲基-D-天冬氨酸受体(NMDAR)脑炎是一种严重的神经精神综合征,抗NMDAR脑炎具有发病率高、病程长、病情重、特异性较差、早期诊断困难等特点。目前,抗NMDAR脑炎的诊断主要依赖于抗体检测和神经影像技术。常规CT成像对该疾病的诊断具有局限性,而磁共振成像和PET成像技术为疾病的诊断与疗效评估提供了科学的研究方法。本研究主要对近几年抗NMDAR脑炎的磁共振成像和PET成像研究进展进行综述,以期提高临床医生对该疾病的认识及早期诊断。

关键词：抗N-甲基-D-天冬氨酸受体脑炎磁共振成像正电子发射型计算机断层显像

Dynamic manipulation of multimodal emission in Er^(3+)-activated non-core-shell structure for optical thermometry and information security

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Rare Metals 2024年第4期43卷 1702-1712页

作者： xuan Liu Zi-Xia Lin Yin-Biao Shi xiao-Yan wang Ming-Ye Ding xiao-Fei Yang College of Science Nanjing Forestry UniversityNanjing210037China Testing Center Yangzhou UniversityYangzhou225009China

Regulating luminescent dynamics of lanthanide-based luminescent materials via external stimuli is of great significance in the fields of optical thermometry and high-level ***,it is still a huge challenge to realize multimodal emissions with tunable color outputs from a single activator in simple structures via smart dynamic control of photon transition ***,we present a mechanistic strategy to achieve multimodal luminescence of Er^(3+)activators with color-switchable outputs in a non-core-shell *** the control of excitation dynamics(λ_(ex)=980,808,1532,377 nm),the population among the intermediate en ergy levels of Er^(3+)and the interaction between Er^(3+)and Yb^(3+)could be precisely modulated through energy transfer and migration processes,leading to the generation of colortunable multimodal luminescence upon diverse excitation modes(non-steady-state,single-/dual-wavelength steady,thermal activation).Inspired by its special luminescent performance,the as-obtained material exhibits great potential in noncontact thermometry,multimodal anticounterfeiting,and high-capacity information encryption by performing a series of proof-of-concept *** findings might provide a conceptual model to modulate the luminescent dynamics in a simple-structured system for the generation of color-adjustable multimodal emissions,which is convenient for the development of advanced luminescent materials toward versatile cuttingedge applications.

关键词： Lanthanide ions Multimodal emission Upconversion Downshifting Anti-counterfeiting Luminescent thermometry

Exploring the Pathogenesis of Autoimmune Liver Diseases from the Heterogeneity of Target Cells

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Journal of Clinical and Translational Hepatology 2024年第7期12卷 659-666页

作者： Zi-xuan Qiu Lin-Xiang Huang xiao-xiao wang Zi-Long wang xiao-He Li Bo Feng Peking University People’s Hospital Peking University Hepatology InstituteBeijing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseasesBeijing International Cooperation Base for Science and Technology on NAFLD DiagnosisBeijingChina

The incidence of autoimmune liver diseases(ALDs)and research on their pathogenesis are increasing ***,except for autoimmune hepatitis,which responds well to immunosuppression,primary biliary cholangitis and primary sclerosing cholangitis are insensitive to immunosuppressive *** the known effects of the environment,genetics,and immunity on ALDs,the heterogeneity of target cells provides new insights into their *** review started by exploring the heterogeneity in the development,structures,and functions of hepatocytes and epithelial cells of the small and large bile *** example,cytokeratin(CK)8 and CK18 are primarily expressed in hepatocytes,while CK7 and CK19 are primarily expressed in intrahepatic ***,emerging technologies of single-cell RNA sequencing and spatial transcriptomic are being applied to study *** review offered a new perspective on understanding the pathogenic mechanisms and potential treatment strategies for ALDs.

关键词： Autoimmune hepatitis Primary biliary cholangitis Primary sclerosing cholangitis Disease heterogeneity Single-cell RNA sequencing Pathogenesis

Haploid Induction via In vitro Gynogenesis in Tomato(Solanum lycopersicum L.)

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Journal of Integrative Agriculture 2014年第10期13卷 2122-2131页

作者： ZHAO He wang xiao-xuan DU Yong-chen ZHU De-wei GUO Yan-mei GAO Jian-chang LI Fei John C Snyder Institute of Vegetables and Flowers Chinese Academy of Agricultural Sciences Department of Horticulture University of Kentucky

In order to determine the potential for haploid induction via in vitro gynogenesis in tomato, the ovules and protoplasts of embryo sacs from the hybrids Zhongza 101 and Zhongza 105 were cultured. An efficient method of ovule isolation was established in this study. Using this method, 100-150 ovules could be isolated from one ovary. Isolated ovules were cultured on three induction media to induce gynogenesis in vitro. During culture, ovules were enlarged markedly, with opaque white color. When observed microscopically, there were cell divisions and cell clumps in embryo sacs. Subsequently, the cell clumps in embryo sacs ceased growth, likely because the integument grew faster than embryo sacs did and hindered the fiarther development of embryo sacs. Therefore, subsequent callus morphogenesis might be originated from the integument. Thousands ofcalli from the two tomato varieties were obtained. Five diploid plants were regenerated after 15 months of subculturing. To eliminate the hindering effect of integument on embryo sac cells, the protoplasts of embryo sacs were prepared and cultured. After 48 hours of culture, the protoplasts of embryo sacs doubled in size and gradually formed clusters of cells. These results suggested that gynogenesis might be a potential way for haploid induction in tomato.

关键词： Solanum lycopersicum ovule protoplast of embryo sac macrospore in vitro gynogenesis haploid

The landscape of epigenetic regulation and therapeutic application of N^(6)-methyladenosine modifications in non-coding RNAs

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Genes & Diseases 2024年第5期11卷 236-251页

作者： Gui-e Xu xuan Zhao Guoping Li Priyanka Gokulnath Lijun wang Junjie xiao Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)and School of Life SciencesShanghai UniversityNantongJiangsu 226011China Cardiac Regeneration and Ageing Lab Institute of Cardiovascular SciencesShanghai Engineering Research Center of Organ RepairSchool of Life ScienceShanghai UniversityShanghai 200444China Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School BostonMA 02114USA

RNA N^(6)-methyladenosine(m^(6)A)methylation is the most abundant and conserved RNA modification in *** participates in the regulation of RNA metabolism and various pathophysiological ***-coding RNAs(ncRNAs)are defined as small or long transcripts which do not encode proteins and display numerous biological regulatory *** to mRNAs,m^(6)A deposition is observed in *** RNA m^(6)A modifications on ncRNAs is of great importance specifically to deepen our understanding of their biological roles and clinical *** this review,we summarized the recent research findings regarding the mutual regulation between RNA m^(6)A modification and ncRNAs(with a specific focus on microRNAs,long non-coding RNAs,and circular RNAs)and their *** also discussed the challenges of m^(6)A-containing ncRNAs and RNA m^(6)A as therapeutic targets in human diseases and their future perspective in translational roles.

关键词： Circular RNA Epigenetic regulation Long non-coding RNA MicroRNA Non-coding RNA RNA m^(6)A modification

Pharmacological Effects of Botanical Drugs on Myocardial Metabolism in Chronic Heart Failure

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Chinese Journal of Integrative Medicine 2024年第5期30卷 458-467页

作者： HU Yu-xuan QIU Sheng-lei SHANG Ju-ju wang Zi LAI xiao-lei Beijing Hospital of Traditional Chinese Medicine Capital Medical UniversityBeijing 100010China

Although there have been significant advances in the treatment of heart failure in recent years,chronic heart failure remains a leading cause of cardiovascular disease-related *** studies have found that targeted cardiac metabolic remodeling has good potential for the treatment of heart ***,most of the drugs that increase cardiac energy are still in the theoretical or testing *** research has found that botanical drugs not only increase myocardial energy metabolism through multiple targets but also have the potential to restore the balance of myocardial substrate *** this review,we summarized the mechanisms by which botanical drugs(the active ingredients/formulas/Chinese patent medicines)improve substrate utilization and promote myocardial energy metabolism by activating AMP-activated protein kinase(AMPK),peroxisome proliferator-activated receptors(PPARs)and other related *** the same time,some potential protective effects of botanical drugs on myocardium,such as alleviating oxidative stress and dysbiosis signaling,caused by metabolic disorders,were briefly discussed.

关键词： botanical drugs chronic heart failure myocardial metabolism pharmacological effects review

Holographic Polymer Nanocomposites with High Refractive Index Modulation by Doping Liquid Crystal E6M

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Chinese Journal of Polymer Science 2024年第7期42卷 926-935,I0006页

作者： Meng-Yun wang Yue Zhang Dan wang Ming Yao Yi-xuan wang Xing-Ping Zhou Hai-Yan Peng xiao-Lin Xie Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of EducationSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan430074China State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan430074China National Anti-counterfeit Engineering Research Center Huazhong University of Science and TechnologyWuhan430074China

Holographic optical elements(HOEs)based on polymer composites have become a research hot spot in recent years for augmented reality(AR)due to the significant improvement of optical performance,dynamic range,ease of processing and high yield ***,it remains a formidable challenge to obtain a large field of view(FOV)and brightness due to the limited refractive index ***,we report an effective method to tackle the challenge by doping an epoxy liquid crystal termed E6M,which enables a large refractive index modulation of 0.050@633 nm and low haze of 5.0%at a doping concentration of 5 wt%.This achievement may be ascribed to the improved molecular ordering of liquid crystals within the holographic polymer *** high refractive index modulation can endow transmission-type holographic polymer composites with a high diffraction efficiency of 96.2%at a small thickness of 5μm,which would promise the design of thin and lightweight AR devices.

关键词： Polymer nanocomposites Holography AR/VR Refractive index modulation Liquid crystal

Automatic velocity picking based on optimal key points tracking algorithm

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Petroleum Science 2024年第2期21卷 903-917页

作者： Yong-Hao wang Wen-Kai Lu Song-Bai Jin Yang Li Yu-xuan Li xiao-Feng Gu The Institute for Artificial Intelligence(THUAI) Tsinghua UniversityBeijing100084China State Key Laboratory of Intelligent Technology and Systems Tsinghua UniversityBeijing100084China Beijing National Research Center for Information Science and Technology(BNRist) Beijing100084China The Department of Automation Tsinghua UniversityBeijing100084China

Picking velocities from semblances manually is laborious and necessitates experience. Although various methods for automatic velocity picking have been developed, there remains a challenge in efficiently incorporating information from nearby gathers to ensure picked velocity aligns with seismic horizons while also improving picking accuracy. The conventional method of velocity picking from a semblance volume is computationally demanding, highlighting a need for a more efficient strategy. In this study, we introduce a novel method for automatic velocity picking based on multi-object tracking. This dynamic tracking process across different semblance panels can integrate information from nearby gathers effectively while maintaining computational efficiency. First, we employ accelerated density clustering on the velocity spectrum to discern cluster centers without the requirement for prior knowledge regarding the number of clusters. These cluster centers embody the maximum likelihood velocities of the main subsurface structures. Second, our proposed method tracks key points within the semblance volume. Kalman filter is adopted to adjust the tracking process, followed by interpolation on these tracked points to construct the final velocity model. Our synthetic data example demonstrates that our proposed algorithm can effectively rectify the picking errors of the clustering algorithm. We further compare the performances of the clustering method(CM), the proposed tracking method(TM), and the variational method(VM) on a field dataset from the Gulf of Mexico. The results attest that our method offers superior accuracy than CM, achieves comparable accuracy with VM, and benefits from a reduced computational cost.

关键词： Velocity picking Multi-object tracking Density clustering Kalman filter