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Shenqi Fuzheng injection alleviates chemotherapy-induced cachexia by restoring glucocorticoid signaling in hypothalamus

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Journal of Pharmaceutical Analysis 2024年第3期14卷 431-434页

作者： Entezar Berik Zijia zhang Wei Li Yawen Liu Sihan Chen Wenyong Wu Zhaojun wang Xinqin Kong Wenqiang Pei Huiqing Dong Huali {2. Min Lei Jennifer Yiyang wang Liangfeng Liu Jinjun Hou Jing Feng Zhaoxia Li wanying Wu De-an Guo beijing Key Lab of TCM Collateral Disease Theory Research School of Traditional Chinese MedicineCapital Medical UniversityBeijing100069China National Engineering Research Center of TCM Standardization Technology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China University of Chinese Academy of Sciences Beijing100049China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing210029China Limin Pharmaceutical Factory Livzon Group LimitedShaoguanGuangdong512028China Guangdong Corporate Key Laboratory of High-End Liquid Medicine R&D IndustrilizationShaoguanGuangdong512028China Center for Neurological and Psychiatric Research and Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of ScienceShanghai201203China

Chemotherapy-induced cachexia(CIC)is a debilitating condition characterized by weight loss,muscle atrophy,and anorexia[1].While peripheral mechanisms of cachexia have been extensively studied,the involvement of the central nervous system(CNS)in CIC is often *** drugs cause stress responses and inflammation,which may impact the hypothalamus and disrupt systemic energy and neuroendocrine *** hypothalamic roles in regulating these processes can provide insights into CIC's mechanisms and aid in developing novel therapies.

关键词： injection drugs glucocorticoid chemotherapy

Experimental realization of quantum cryptography communication in free space

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Science china(physics,Mechanics & Astronomy) 2005年第2期48卷 237-246页

作者： wang chuan1, {2. Jingfu1, wang Pingxiao1, DENG Fuguo1, AI Qing1 & long guilu1,2.1. Department of physics, Key Laboratory for Quantum Information and Measurements, tsinghua Univer- sity, beijing 100084, china 2. Center for Atomic and Molecular NanoSciences, tsinghua University, beijing 100084, china Department of physics Key Laboratory for Quantum Information and Measurements Tsinghua University Beijing 100084 China Atomic and Molecular NanoSciences Tsinghua University Beijing 100084 China

Utilizing linear optical devices, the principle of B92.quantum key distribution (QKD) protocol is demonstrated in free space with a distance of transmission of 2.2.meters. The faint laser pulses with 650 nm wavelength are used as the single photon sources. The experimental results show that the eavesdropping behavior in the signal transmission can be detected. We also discuss the problems and solutions in using the quantum cryptography communication practically. It is pointed out that one of the approaches to increasing the distance of the quantum communication is to overcome the attenuation of the single photon in transmission. This could not be solved by the use of single photon source, and new quantum communication protocols are needed to solve these problems.

关键词： quantum key distribution, free space, linear optics, faint pulses.

Implementation of a multiple round quantum dense coding using nuclear magnetic resonance

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Science china(physics,Mechanics & Astronomy) 2005年第6期48卷 706-715页

作者： zhang Jingfu1, XIE Jingyi2. wang {2., DENG Zhiwei3. LU Zhiheng4, & {3. guilu1,5 1. Key Laboratory For Quantum Information and Measurements of MOE, Department of physics, tsinghua University, beijing 100084,china 2. Department of Materials Science and Engineering, beijing Normal University, beijing 100875, china 3. Testing and Analytical Center, beijing Normal University, beijing 100875,china 4. Department of physics, beijing Normal University, beijing 100875, china 5. Key Laboratory For atomic and Molecular Nanosciences, tsinghua University, beijing 100084,china 1. Key Laboratory For Quantum Information and Measurements of MOE Department of Physics Tsinghua University 100084 Beijing China 2. Department of Materials science and Engineering Beijing Normal University 100875 Beijing China 3. Testing and Analytical Center Beijing Normal University 100875 Beijing China 4. Department of physics Beijing Normal University 100875 Beijing China 5. Key Laboratory For Atomic and Molecular Nanosciences Tsinghua University 100084 Beijing China

A multiple round quantum dense coding scheme based on the quantum phase estimation algorithm is proposed and implemented in a three qubit nuclear magnetic resonance (NMR) quantum computer. Using an m + 1 qubit system, Bob can transmit one of 2.+1 messages to Alice, through manipulating only one qubit and exchanging it between Alice and Bob for m rounds. The information capacity is enhanced to m + 1 bits as compared to m bits in a classical scheme. The scheme has been demonstrated in NMR system, and the experimental results show a good agreement between theory and experiment.

关键词： quantum dense coding, multiple round, nuclear magnetic resorance

New HⅠObservations Toward the NGC 5055 Galaxy Group with FAST

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Research in Astronomy and Astrophysics 2024年第7期24卷 249-256页

作者： Xiao-Lan Liu Ming Zhu Jin-long Xu Peng Jiang chuan-Peng {2. Nai-Ping Yu Jun-Jie {3. Yan-Bin Yang National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Guizhou Radio Astronomical Observatory Guizhou UniversityGuiyang 550000China CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China GEPI Observatoire de ParisUniversite PSLCNRSPlace Jules Janssen92195 MeudonFrance

We report a new high-sensitivity HⅠmapping observation of the NGC 5055 galaxy group over an area of 1°.5×0°.75 with the Five-hundred-meter Aperture Spherical radio Telescope(FAST).Our observation reveals that the warped HⅠdisk of NGC 5055 is more extended than what was previously observed by WSRT,out to2.0}(61.7 kpc).The total HⅠmass of NGC 5055 is determined to be~1.1×10^(10)M_Θ.We identified three HⅠclouds with HⅠmasses of the order of~10^(7)M_Θat the southeastern edge of the HⅠdisk,as well as a candidate high-velocity cloud with an HⅠmass of(1.2.0.5)×10^(6)M_Θto the north of NGC *** HⅠcontent of UGCA3.7 is robustly detected for the first time by the FAST *** has a narrow HⅠlinewidth of W_(50)=17.4±3.8 km s^(-1)with a total HⅠmass of(3.5±0.3.×10^(6)M_Θ.Comparing the gas content and g-r color of UGCA 3.7 with typical low-mass dwarf galaxies,UGCA 3.7 appears relatively gas-poor despite its blue *** suggests that UGCA 3.7 may have undergone gas stripping in the *** also analyzed the possible origin of the diffuse HⅠclouds located at the outskirts of NGC 5055,and speculate that they might be the remnant features of a merger event in the past.

关键词： galaxies evolution-galaxies structure-galaxies individual(NGC 5055)-galaxies kinematics and dynamics-galaxies interactions

Stable photocurrent-voltage characteristics of perovskite single crystal detectors obtained by pulsed bias

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Chinese physics B 2024年第4期33卷 209-214页

作者：刘新陈之龙王虎张雯清董昊王鹏祥邵宇川 Laboratory of Thin Film Optics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Materials for High-Power Laser Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China Key Laboratory for Ultrafine Materials of Ministry of Education Shanghai Engineering Research Center of Hierarchical NanomaterialsSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China School of Microelectronics Shanghai UniversityShanghai 201899China Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou 310024China

Photocurrent-voltage characterization is a crucial method for assessing key parameters in x-ray or y-ray semiconductor detectors,especially the carrier mobility lifetime ***,the high biases during photocurrent measurements tend to cause severe ion migration,which can lead to the instability and inaccuracy of the test *** the mixed electronic-ionic charac teristics,it is imperative to devise novel methods capable of precisely measuring photocurrentvoltage characteristics under high bias conditions,free from interference caused by ion *** this paper,pulsed bias is employed to explore the photocurrent-voltage characteristics of MAPbBr_(3. single *** method yields stable photocurrent-voltage characteristics at a pulsed bias of up to 3. V,proving to be effective in mitigating ion *** fitting the modified Hecht equation,we determined the mobility lifetime products of 1.0×10^(2. cm^(2.·V^(-1)for hole and 2.78×10~(-3.cm^(2.·V^(-1)for *** approach offers a promising solution for accurately measuring the transport properties of carriers in perovskite.

关键词： perovskites ion migration pulsed bias mobility lifetime product

The Nano Research Young Innovators Awards in bio-inspired nanomaterials

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Nano Research 2024年第2期17卷 417-425页

作者： Jun Chen Shuotao wang Department of Bioengineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China

Nano Research Young Innovators(NR45)Awards are designed to acknowledge and celebrate the achievements of young researchers under 45 years of *** individuals have made significant contributions to the field of nanoscience and *** the inaugural NR45 Awards in 2.18,the journal's editorial board has recognized over a hundred innovators specializing in nanobiotechnology,nano energy,two-dimensional materials,and *** focus of the 2.2.1}NR45 Awards is on bioinspired nanomaterials,acknowledging thirty-three outstanding young innovators for their extraordinary contributions in developing these materials with applications spanning clean energy,human healthcare,monitoring,and disease treatments,as shown in *** extend our heartfelt congratulations to all the 3. NR45 Awardees in 2.2.1}

关键词： journal materials contributions

Efficient production of omega-3.fatty acid desaturase (sFat-1)-transgenic pigs by somatic cell nuclear transfer

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Science china(Life Sciences) 2010年第4期53卷 517-523页

作者： PAN DengKe1, zhang Li1, ZHOU YanRong2. FENG Chong1, long {2., LIU Xiao1, WAN Rong3. zhang Jian3. LIN AiXing3. DONG EnQiu4, wang ShuChen4, XU HouGang4 & CHEN HongXing2.1 Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, beijing 100193. china 2.beijing Institute of Biotechnology, beijing 100071, china 3.china Agricultural University, beijing 100193. china 4 Yutian Breeding Swine Farms, Yutian 064104, china 1. Institute of Animal Sciences Chinese Academy of Agricultural Sciences Beijing 100193 China2. Beijing Institute of Biotechnology Beijing 100071 China3. China Agricultural University Beijing 100193 China4. Yutian Breeding Swine Farms Yutian 064104 China

Omega-3.ω-3. fatty acid desaturase transgenic pigs may improve carcass fatty acid composition. The use of transgenic pigs is also an excellent large animal model for studying the role of ω-3.fatty acids in the prevention and treatment of coronary heart disease and cancer. Transgenic pigs carrying synthesized fatty acid desaturase-1 gene (sFat-1) from Caenorhabditis briggsae by somatic cell nuclear transfer (SCNT) were produced for the first time in china. Porcine fetal fibroblast cells were transfected with a sFat-1 expression cassette by the liposome-mediated method. Transgenic embryos were reconstructed by nuclear transfer of positive cells into enucleated in vitro matured oocytes. A total of 1889 reconstructed embryos were transferred into 10 naturally cycling gilts. Nine early pregnancies were established, 7 of which went to term. Twenty-one piglets were born. The cloning efficiency was 1.1% (born piglets/transferred embryos). The integration of the sFat-1 gene was confirmed in 15 live cloned piglets by PCR and Southern blot except for 2.piglets. Expression of the sFat-1 gene in 12.of 13.piglets was detected with RT-PCR. The data demonstrates that an efficient system for sFat-1 transgenic cloned pigs was developed, which led to the successful production of piglets expressing the sFat-1 gene.

关键词： sFat-1 nuclear transfer ovulation status transgenic pig

Efficient entanglement purification for doubly entangled photon state

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Science china(Technological Sciences) 2009年第12期52卷 3464-3467页

作者： wang chuan SHENG YuBo LI XiHan DENG FuGuo {2. Wei {3. guilu School of Science Beijing University of Posts and TelecommunicationsBeijing 100876China Institute of Low Energy Nuclear Physicsand Department of Material Science and EngineeringBeijing Normal UniversityBeijing 100875China Department of Electronic Engineering Tsinghua UniversityBeijing 100084China Department of physics Tsinghua UniversityBeijing 100084China tsinghua National Laboratory for Information Science and Technology Tsinghua UniversityBeijing 100084China

In this paper,we present an efficient purification scheme that improves the efficiency of entanglement purification of the recently proposed entanglement purification scheme for doubly entangled photon states (***.A,2.08,77:042.15).This modified scheme contains the bit-flip error correction where all the photon pairs can be kept while all the bit-flip errors are corrected and the entanglement purification of phase-flip errors where a wavelength conversion process is *** scheme has the advantage of high efficiency and a much lower minimum fidelity of the original *** works under existing technology.

关键词： entanglement purification doubly entangled photon state quantum communication

The FAST all sky HI survey(FASHI):The first release of catalog

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Science china(physics,Mechanics & Astronomy) 2024年第1期67卷 112-133页

作者： chuan-Peng zhang Ming Zhu Peng Jiang Cheng Cheng Jing {2. Jie {2. Jin-long Xu Xiao-Lan Liu Nai-Ping Yu Lei Qian Haiyang Yu Mei Ai Yingjie Jing Chen Xu Ziming Liu Xin Guan Chun Sun Qingliang Yang Menglin Huang Qiaoli Hao FAST Collaboration Guizhou Radio Astronomical Observatory Guizhou UniversityGuiyang 550000China National Astronomical Observatories Chinese Academy of Sciences(CAS)Beijing 100101China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China

The FAST All Sky HI survey(FASHI)was designed to cover the entire sky observable by the Five-hundred-meter Aperture Spherical radio Telescope(FAST),spanning approximately 2.000 square degrees of declination between-14°and+66°,and in the frequency range of 1050-1450 MHz,with the expectation of eventually detecting more than 100000 HI *** August 2.2. and June 2.2.0}FASHI had covered more than 7600 square degrees,which is approximately 3.%of the total sky observable by *** has a median detection sensitivity of around 0.76 m Jy beam-1and a spectral line velocity resolution of~6.4 km s-1at a frequency of~1.4 *** of now,a total of 41741 extragalactic HI sources have been detected in the frequency range 13.5.5-1419.5 MHz,corresponding to a redshift limit of z■*** cross-matching FASHI sources with the Siena Galaxy Atlas(SGA)and the Sloan Digital Sky Survey(SDSS)catalogs,we found that 16972.40.7%)sources have spectroscopic redshifts and 10975(2..3.)sources have only photometric *** of the remaining 13.94(3..0%)HI sources are located in the direction of the Galactic plane,making their optical counterparts difficult to identify due to high extinction or high contamination of Galactic stellar *** on current survey results,the FASHI survey is an unprecedented blind extragalactic H I *** has higher spectral and spatial resolution and broader coverage than the Arecibo Legacy Fast ALFA Survey(ALFALFA).When completed,FASHI will provide the largest extragalactic HI catalog and an objective view of HI content and large-scale structure in the local universe.

关键词： surveys redshifts galaxies telescope radio lines HI line