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Melatonin Augments the Effects of Fluoxetine on Depression-Like Behavior and Hippocampal BDNF–TrkB Signaling

Neuroscience Bulletin 2018年第2期34卷 303-311页

作者： Kun Li Si Shen Yu-Tian Ji Xu-Yun Li Li-san Zhang Xiao-Dong wang Department of Neurobiology Key Laboratory of Medical Neurobiology of the Ministry of Health of China Zhejiang Province Key Laboratory of Neurobiology Zhejiang University School of Medicine Hangzhou 310058 China Zhejiang University School of Medicine Hangzhou 310058China Experimental Teaching Center of Basic Medicine Zhejiang University School of Medicine Hangzhou 310058 China Department of Neurology Sir Run Run Shaw HospitalZhejiang University School of Medicine Hangzhou 310016China

Depression is a debilitating psychiatric disorder with a huge socioeconomic burden, and its treatment relies on antidepressants including selective serotonin reuptake inhibitors(SSRIs). Recently, the melatonergic system that is closely associated with the serotonergic system has been implicated in the pathophysiology and treatment of depression. However, it remains unknown whether combined treatment with SSRI and melatonin has synergistic antidepressant effects. In this study, we applied a sub-chronic restraint stress paradigm, and evaluated the potential antidepressant effects of combined fluoxetine and melatonin in adult male mice. Sub-chronic restraint stress(6 h/day for 10 days) induced depression-like behavior as shown by deteriorated fur state, increased latency to groom in the splash test, and increased immobility time in the forced-swim test. Repeated administration of either fluoxetine or melatonin at 10 mg/kg during stress exposure failed to prevent depression-like phenotypes. However,combined treatment with fluoxetine and melatonin at theselected dose attenuated stress-induced behavioral abnormalities. Moreover, we found that the antidepressant effects of combined treatment were associated with the normalization of brain-derived neurotrophic factor(BDNF)–tropomyosin receptor kinase B(Trk B) signaling in the hippocampus, but not in the prefrontal cortex. Our findings suggest that combined fluoxetine and melatonin treatment exerts synergistic antidepressant effects possibly by restoring hippocampal BDNF–Trk B signaling.

关键词： Melatonin Fluoxetine Depression BDNF TrkB

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Predictive Analysis of Susceptibility of Different Species to SARS-CoV-2 based on ACE2 Receptors

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Biomedical and Environmental Sciences 2020年第11期33卷 877-881页

作者： XU Xiao Gang wang Huan wang san Ying ZHANG Jing SUN Chuan WEI Ming Xiang YAN Jing MAO Gen Xiang Zhejiang Provincial Key Lab of Geriatrics&Geriatrics Institute of Zhejiang Province Department of GeriatricsZhejiang HospitalHangzhou 310013ZhejiangChina The George Washington University Department of BiostatisticsWashington DC 20052USA

Coronavirus Disease 2019(COVID-19)is a pulmonary inflammatory disease caused by infection with the highly pathogenic new coronavirus(SARSCo V-2)[1].To date,COVID-19 has spread to at least210 countries and territories,infected more than10.94 million people,and killed more than 519,000 people,according to Johns Hopkins *** April 15,2020,the COVID-19 outbreak was declared a global health emergency[2].

关键词： ACE2 Hopkins Receptor

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QUANTUM CHEMICAL STUDY ON THE THERMOLYSES OF 1，5－CYCLOOCTADIENE AND 4－VINYLCYCLOHEXENE

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Chinese Chemical Letters 1995年第6期6卷 487-490页

作者： san Guo HONG Shen wang(Department of Chemistry,Jiangxi Normal University.Nanchang 830027) Jiangxi Normal Univ Dept Chem Nanchang 330027 Peoples R China

MINDO/3 method *** used to study the thermolyses of 1,5-cyclooctadiene and *** results obtained show that the activation energies of the reta-determining ateps are 197.936and 225.534 ***.

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The largest aluminum molecular rings:Phenol-thermal synthesis,photoluminescence,and optical limiting

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Aggregate 2023年第2期4卷 206-215页

作者： san-Tai wang Ya-Jie Liu Cheng-Cheng Feng Wei-Hui Fang Jian Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouP.R.China

It is of great interest to modulate the photophysical properties by atomically precise chemical *** incorporation of conjugated ligands into crystalline materials provides a platform for molecular-level interpretation of the structure-activity ***,we reported the phenol-thermal and scale-up synthesis of a new family of remarkably stable aluminum molecular *** are assembled by twenty Al^(Ⅲ) ions with large conjugated ligands and phenols,representing the currently largest sizes(up to 4 nm in diameter)in the field of main group metal oxo *** are not only reaction medium but also auxiliary bridging ligands on the surface of macrocyclic *** addition,they are either parallel to the center of the molecular ring or inserted into the molecular ring,or form dimers/tetramers that bind macrocyclic molecules to form supramolecular *** macrocyclic rings are hydrophobic and ultra-stable,evidenced by retaining their morphology and crystalline when exposed to air for more than a *** with the pristine conjugated ligands,they exhibit coordination-enhanced *** dispersing them into a polydimethylsiloxane(PDMS)matrix,we prepared transparent and flexible PDMS thin films for coupling flexible display and nonlinear optical *** discovery of such atomically precise rings provides a platform for the fine-tuning of photo-related performances.

关键词： aluminum macrocycles optical limiting

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Efficacy of Yiqiyangxin Chinese medicine compound combined with cognitive therapy in the treatment of generalized anxiety disorders

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Asian Pacific Journal of Tropical Medicine 2012年第10期5卷 818-822页

作者： Ting wang Jing-Yuan Ding Guang-Xing Xu Yu Zeng san-Rong Xiao School of Psychology and Cognitive Science East China Normal University East China sanatorium Department of Management Hainan Medical University

Objective:To observe the clinical efficacy of Yiqiyangxin Chinese medicine compound combined with cognitive therapy on generalized anxiety ***:A total of 202 generalized anxiety disorders patients were randomly allocated to a control condition(Paroxetine combined with cognitive therapy) or a treatment condition(Yiqiyangxin Chinese medicine compound combined with cognitive therapy).Subsequently,scores of Hamilton Anxiety Scale(HAMA), Zung Self-rating Anxiety Scale(SAS) and blood routine,urine routine,liver function,renal function,electrocardiogram were detected before treatment,3 months,6 months after treatment and 6 months after medicine withdrawal,***:HAMA and SAS scores were significantly reduced in two groups(P0.05).HAMA and SAS scores were significantly increased in two groups(P<0.05) after medicine withdrawal,and there were significant differences in HAMA and SAS scores,recurrent disease and adverse reaction(P<0.001). The incidence of recurrent disease and adverse reaction in treatment group was *** two groups showed no apparent abnormality in blood routine,urine routine,liver and renal function, and ***:Yiqiyangxin Chinese medicine compound combined with cognitive therapy can significantly reduce the recurrence after medicine withdrawal and is effective on generalized anxiety ***,the incidence of adverse reactions is low. The treatment program is worthy clinic application in the further.

关键词： Yiqiyangxin Chinese medicine Compound Cognitive therapy Generalized anxiety disorder

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Influence of inaccurate wavelet phase estimation on seismic inversion

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Applied Geophysics 2011年第1期8卷 48-59,95页

作者： Yuan san-Yi wang Shang-Xu State Key Laboratory of Petroleum Resource and Prospecting China University of Petroleum （Beijing） Beijing 102249 China CNPC Key Lab of Geophysical Exploration China University of Petroleum （Beijing） Beijing 102249 China

On the assumption that the seismic wavelet amplitude spectrum is estimated accurately, a group of wavelets with different phase spectra, regarded as estimated wavelets, are used to implement linear least-squares inversion. During inversion, except for the wavelet phase, all other factors affecting inversion results are not taken into account. The inversion results of a sparse reflectivity model （or blocky impedance model） show that：（1） although the synthetic data using inversion results matches well with the original seismic data, the inverted reflectivity and acoustic impedance are different from that of the real model. （2） the inversion result reliability is dependent on the estimated wavelet Z transform root distribution. When the estimated wavelet Z transform roots only differ from that of the real wavelet near the unit circle, the inverted reflectivity and impedance are usually consistent with the real model; （3） although the synthetic data matches well with the original data and the Cauchy norm （or modified Cauchy norm） with a constant damping parameter has been optimized, the inverted results are still greatly different from the real model. Finally, we suggest using the L1 norm, Kurtosis, variation, Cauchy norm with adaptive damping parameter or/and modified Cauchy norm with adaptive damping parameter as evaluation criteria to reduce the bad influence of inaccurate wavelet phase estimation and obtain good results in theory.

关键词： Phase seismic wavelet inversion evaluation criterion root

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Current Status of Forest Medicine Research in China

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Biomedical and Environmental Sciences 2018年第7期31卷 551-554页

作者： HUANG Qing Dong WU Qing MAO Gen Xiang wang san Ying JIA Bing Bing wang Guo Fu Department of Geriatrics Zhejiang Hospital Zhejiang Provincial Key Lab of Geriatrics

In recent years,due to regional pollution and deteriorating environment,combined with intense social competition and heavier life pressure,an increasing number of people are affected by lifestyle-related diseases and ... 详细信息

关键词： Current Status of Forest Medicine Research in China

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直升机旋翼自转着陆过程的支持向量机模型

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系统仿真学报 2009年第3期21卷 707-710页

作者：王书舟伞冶王书文哈尔滨工业大学哈尔滨150001 苏州科技学院土木工程学院苏州215011

把支持向量机方法引入到直升机智能化建模领域,用支持向量机建立了直升机自转着陆过程的旋翼转速模型,并采用序列最小优化算法求解。与神经网络模型相比,直升机的支持向量机模型具有结构简单、运算速度快、泛化能力高等特点。理论分析... 详细信息

把支持向量机方法引入到直升机智能化建模领域,用支持向量机建立了直升机自转着陆过程的旋翼转速模型,并采用序列最小优化算法求解。与神经网络模型相比,直升机的支持向量机模型具有结构简单、运算速度快、泛化能力高等特点。理论分析和仿真结果表明,应用支持向量机建立直升机的仿真模型是切实可行的。

关键词：支持向量机直升机仿真模型泛化能力

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AN EXTENSION OF TOPSIS FOR FUZZY MCDM BASED ON VAGUE SET THEORY

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Journal of Systems Science and Systems Engineering 2005年第1期14卷 73-84页

作者： Juewang san-YangLIU JieZHANG DepartmentofMathematics XidianUniversiy

This paper extends the TOPSIS to fuzzy MCDM based on vague set theory, where the characteristics of the alternatives are represented by vague sets. A novel score function is proposed in order to determine the vague positive-ideal solution (VPIS) and vague negative-ideal solution (VNIS). We present a weighted difference index to calculate the distance between vague values, by means of which the distance of alternatives to VPIS and VNIS can be calculated. Finally, the relative closeness values of various alternatives to the positive-ideal solution are ranked to determine the best alternative. An example is shown to illustrate the procedure of the proposed method at the end of this paper. Keywords TOPSIS - fuzzy set - vague set - score function - fuzzy MCDM Jue wang received the B. Sc degree in mathematics from Qingdao University, 2000. From August 2000, she has been pursuing his Doctor degree in Xidian University, Xi’an, China. Her research interests include optimization theory and applications, intelligent information processing, rough sets theory and application in data mining, signal processing, etc. She has published over ten journal and conference papers.san-Yang Liu was born in Xi’an, China, in 1959. From 1985 to 1989, he was with the department of mathematics of Xi’an Jiaotong University, where he received the Ph. D. degree in Mathematics. He is currently a professor and Doctor advisor at the Xidian University. His interests include optimization theory and applications.Jie Zhang was born in Huaibei, Anhui province, P.R. China., in 1975. He received his B. Sc. in Applied Mathematics, in 1999 from Anhui Normal University and M. Sc. in Operation Research, in 2002 from Xidian University. From 2002, he has been pursuing his Doctor Degree in the National Key laboratory for Radar Signal Processing, Xidian Univ. His research interests lie in the area of signal and information processing with application to wireless communications.

关键词： TOPSIS fuzzy set vague set score function fuzzy MCDM

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Effective improvement of beam lifetime based on radiofrequency phase modulation at the HLS-II storage ring

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Nuclear Science and Techniques 2021年第1期32卷 1-9页

作者： Yun-Kun Zhao Bao-Gen Sun Ji-Gang wang Fang-Fang Wu Ping Lu Tian-Yu Zhou san-shuang Jin National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China

A radiofrequency(RF)phase modulation method is applied to the Hefei Light Source II storage ring to deeply investigate its longitudinal beam characteristics and improve the beam lifetime.A theoretical analytical model and corresponding experimental measurements of single bunch length and island phenomena are *** a series of online machine experiments,we demonstrate that the suitable phase modulation amplitude is 0.02 rad,corresponding to an optimum modulation frequency ranging from 19.6 to 20.7 kHz of the RF ***,the overall beam lifetime can be increased by a factor of 2.38 as a result of the beam dilution effect.

关键词： Phase modulation Amplitude Beam lifetime Longitudinal beam characteristics Beam dilution Island

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