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Comparison of ESI–and APCI–LC–MS/MS methods:A case study of levonorgestrel in human plasma

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Journal of Pharmaceutical Analysis 2016年第6期6卷 356-362页

作者： rulin wang Lin Zhang Zunjian Zhang Yuan Tian Key Laboratory of Drug Quality Control and Pharmacovigilance Ministry of EducationChina Pharmaceutical University State Key Laboratory of Natural Medicine China Pharmaceutical University

Electrospray ionization(ESI) and atmospheric pressure chemical ionization(APCI) techniques for liquid chromatography–tandem mass spectrometry(LC–MS/MS) determination of levonorgestrel were *** consideration of difference in ionization mechanism,the two ionization sources were compared in terms of LC conditions,MS parameters and performance of *** sensitivity for detection of levonorgestrel with ESI was 0.25 ng/m L which was lower than 1 ng/m L with *** effects were evaluated for levonorgestrel and canrenone(internal standard,IS) in human plasma,and the results showed that APCI source appeared to be slightly less liable to matrix effect than ESI *** an overall consideration,ESI was chosen as a better ionization technique for rapid and sensitive quantification of *** optimized LC–ESI–MS/MS method was validated for a linear range of 0.25–50 ng/m L with a correlation coefficient ≥*** intra-and inter-batch precision and accuracy were within 11.72% and 6.58%,*** application of this method was demonstrated by a bioequivalence study following a single oral administration of 1.5 mg levonorgestrel tablets in 21 Chinese healthy female volunteers.

关键词： Levonorgestrel LC–MS/MS Pharmacokinetics Electrospray ionization Atmospheric pressure chemical ionization

Identification of impurities in nafamostat mesylate using HPLC-ITTOF/MS:A series of double-charged ions

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Journal of Pharmaceutical Analysis 2020年第4期10卷 346-350页

作者： Yuxin Zhang Lufan An Lin Zhang rulin wang Yuan Tian Zunjian Zhang Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical SchoolNanjing210008PR China Jiangsu D&R Pharmaceutical Corporation Taizhou225312PR China Department of Pharmacy General Hospital Tianjin Medical UniversityTianjin300052PR China Key Laboratory of Drug Quality Control and Pharmacovigilance(Ministry of Education) China Pharmaceutical UniversityNanjing210009PR China

Nafamostat mesylate is a serine protease inhibitor used in the treatment of acute *** impurities in nafamostat mesylate,the active pharmaceutical ingredient(API),were profiled via high performance liquid chromatography tandem ion trap coupled with time-of-flight mass spectrometer(HPLC-IT-TOF/MS).The chromatography was performed on an ACE-3 C18 column(200 mm4.6 mm,3 mm)using methanol and 0.1%formic acid in purified water as mobile phase at a flow rate of 1.0 mL/*** ions were detected by IT-TOF/MS with a full-scan mass analysis from m/z 100 to *** total,eleven impurities were detected in nafamostat mesylate *** impurity profile was estimated based on the HPLC-IT-TOF/MS data,including accurate masses,MSn fingerprints of fragmentation pathways and a series of double-charged ***,seven impurities were identified and reported for the first *** results will provide technical support for the quality control and clinical safety of nafamostat mesylate.

关键词： Nafamostat mesylate Impurity Structure identification Double-charged ion

Determination of torasemide in human plasma and its bioequivalence study by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry

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Journal of Pharmaceutical Analysis 2016年第2期6卷 95-102页

作者： Lin Zhang rulin wang Yuan Tian Zunjian Zhang Key Laboratory of Drug Quality Control and Pharmacovigilance(Ministry of Education) China Pharmaceutical University State Key Laboratory of Natural Medicine China Pharmaceutical University

A sensitive and selective method using high-performance liquid chromatography coupled with elec- trospray ionization tandem mass spectrometry （HPLC-ESI-MS） to determine the concentration of tor- asemide in human plasma samples was developed and validated. Tolbutamide was chosen as the internal standard （IS）. The chromatography was performed on a GI Sciences Inertsil ODS-3 column （100 mm× 2.1 mm i.d., 5.0 μm） within 5 min, using methanol with 10 mM ammonium formate （60：40, v/ v） as mobile phase at a flow rate of 0.2 mL/min. The targeted compound was detected in negative io- nization at m/z 347.00 for torasemide and 269.00 for IS. The linearity range of this method was found to be within the concentration range of 1-2500 ng/mL （r=0.9984） for torasemide in human plasma. The accuracy of this measurement was between 94.05% and 103.86%. The extracted recovery efficiency was from 84.20% to 86.47% at three concentration levels. This method was also successfully applied in pharmacokinetics and bioequivalence studies in Chinese volunteers.

关键词： Torasemide HPLC-ESI-MS Human plasma Bioequivalence Pharmacokinetics

坚持“人性关爱,人情关爱,人文关爱”理念,以科学发展观推进人口和计划生育事业

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人口学刊 2005年第4期27卷 47-49页

作者：王儒林中共长春市委吉林长春130041

把“人性关爱,人情关爱,人文关爱”理念作为人口和计划生育工作的灵魂,符合人民群众的切身利益,符合全面建设小康社会的目标,符合构建社会主义和谐社会的要求。“三关爱”理念的推进可以切实将“以人为本”的科学发展观落实到人口和计... 详细信息

把“人性关爱,人情关爱,人文关爱”理念作为人口和计划生育工作的灵魂,符合人民群众的切身利益,符合全面建设小康社会的目标,符合构建社会主义和谐社会的要求。“三关爱”理念的推进可以切实将“以人为本”的科学发展观落实到人口和计划生育工作的实践中去。

关键词：人性关爱人情关爱人文关爱

Using the shaping filter for removing the effcets of the bubble pulses of explosive charge

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Chinese Journal of Acoustics 1991年第3期10卷 264-273页

作者： LI Saimu, ZHOU Yinhui, WU Lixin and wang rulin(Ocean University of Qingdao, Qingdao 266003)

Using the shaping filter to remove the effects of the bubble pulses of explosive charge, we obtained the impulse response function of the sea bottom. The result is quite satisfactory.

关键词： Using the shaping filter for removing the effcets of the bubble pulses of explosive charge length

Mechanism of MPA drugs induced GI side effects in rats

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Mechanism of MPA drugs induced GI side effects in rats

坚持“三关爱”理念以科学发展观推进人口和计划生育事业

2013中国器官移植大会

作者： Yichen Jia rulin wang Ming Xu Ruiming Rong Tongyu Zhu Shanghai Key laboratory of Organ Transplantation Department of UrologyZhongshan HospitalFudan University

Gastrointestinal(GI)disorders are one of the main adverse events by mycophenolic acid(MPA).The aim of this preliminary study was to evaluate the GI side-effects of mycophenolate mofetil(MMF)and enteric-coated mycophenolate sodium(EC-MPS)in rat,discover the mechanism of MPA drugs inducing GI side *** male Sprague Dawley rats were randomized into Five groups:control,MMF (100 mg/Kg.d),N-(2-Hydroxyethyl)morpholine(30mg/kg.d),EC-MPS(72 mg/Kg.d),N-(2-Hydroxyethyl)morpholine+*** group was intragastric administration with MMF or EC-MPS once a day for seven *** grade and weight loss were significantly increased in MMF *** the last visit,the rats were sacrificed and GI tissue including stomach,duodenum,jejunum,ileum,colon and rectum were prepared for pathological *** group were significantly pathological injury especially in *** the last

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来源： cnki会议评论

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中国计划生育学杂志 2006年第1期14卷 5-6页

作者：王儒林中共吉林省委

以科学发展观指导和推进人口和计划生育工作,是实现全面建设小康社会目标,构建社会主义和谐社会,加快老工业基地振兴的题中应有之义.面对人口和计划生育工作新形势、新任务、新要求,必须不断创新工作方式、方法,从人民群众的切身利益和... 详细信息

以科学发展观指导和推进人口和计划生育工作,是实现全面建设小康社会目标,构建社会主义和谐社会,加快老工业基地振兴的题中应有之义.面对人口和计划生育工作新形势、新任务、新要求,必须不断创新工作方式、方法,从人民群众的切身利益和需要出发,将人性关爱、人情关爱、人文关爱的'三关爱'理念作为人口和计划生育工作的'灵魂',从而将以人为本的科学发展观落实到人口和计划生育工作的实践中去.

关键词：科学发展观人性关爱计划生育事业人口全面建设小康社会计划生育工作社会主义切身利益人民群众人文关爱

现场流线型网StreamLineNet研究与实现

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计算机工程与应用 2006年第9期42卷 205-207页

作者：张守祥王汝琳中国矿业大学信息与电气工程系

设计和分析了一种非常适合于工业现场总线通信的网络拓扑结构—流线型网络StreamLineNet。分析了StreamLineNet的基本原理、结构及应用特点,比较了传统的总线型网络、星型交换网络和新型的StreamLineNet网络技术,结论是StreamLineNet在... 详细信息

设计和分析了一种非常适合于工业现场总线通信的网络拓扑结构—流线型网络StreamLineNet。分析了StreamLineNet的基本原理、结构及应用特点,比较了传统的总线型网络、星型交换网络和新型的StreamLineNet网络技术,结论是StreamLineNet在很多工业监控领域更具优势。作者设计了StreamLineNet的应用结构模型,实验结果表明StreamLineNet技术适合在某些工业监控通信系统中应用。

关键词：流线型网现场总线 StreamLineNet 星型

基于MaxEnt的西藏飞蝗在中国的适生区预测

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生态学报 2017年第24期37卷 8556-8566页

作者：王茹琳李庆封传红石朝鹏四川农业大学农学院成都611130 四川省农村经济综合信息中心成都610072 四川省农业厅植物保护站成都610041 山东省植物保护总站济南250000

西藏飞蝗是青藏高原本地特有物种,为青稞和牧草的重要害虫,近年来危害范围有扩大蔓延趋势。研究并明确西藏飞蝗在中国的适生区域,对制定该虫的早期监测、预警及控制措施意义重大。近年来最大熵理论在物种适生研究领域得到广泛应用,基于... 详细信息

西藏飞蝗是青藏高原本地特有物种,为青稞和牧草的重要害虫,近年来危害范围有扩大蔓延趋势。研究并明确西藏飞蝗在中国的适生区域,对制定该虫的早期监测、预警及控制措施意义重大。近年来最大熵理论在物种适生研究领域得到广泛应用,基于西藏飞蝗的分布信息和环境变量,采用MaxEnt生态位模型和ArcGIS对其在中国的潜在分布区进行预测,用ROC曲线检测模型精度、刀切法(jackknife test)筛选主导环境变量及其适宜值。两次模拟的AUC值分别为0.996和0.993,预测结果与实际拟合度很高。西藏飞蝗在中国的高适生区主要位于四川的甘孜州,西藏的昌都地区、林芝地区、山南地区及拉萨市,中适生区则以高适生区为中心向外扩散,集中在青藏高原东部地区。海拔、8月份平均雨量、1月份平均雨量、等温性、12-2月份的平均温度是影响西藏飞蝗潜在分布的主要环境变量。

关键词：西藏飞蝗 MaxEnt模型适生分析影响因子