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Arm motion control model based on central pattern generator

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Applied Mathematics and Mechanics(English Edition) 2017年第9期38卷 1247-1256页

作者： Zhigang ZHENG rubin wang Institute for Cognitive Neurodynamics East China University of Science and TechnologyShanghai 200237China

According to the theory of Matsuoka neural oscillators and with the con- sideration of the fact that the human upper arm mainly consists of six muscles, a new kind of central pattern generator （CPG） neural network consisting of six neurons is pro- posed to regulate the contraction of the upper arm muscles. To verify effectiveness of the proposed CPG network, an arm motion control model based on the CPG is established. By adjusting the CPG parameters, we obtain the neural responses of the network, the angles of joint and hand of the model with MATLAB. The simulation results agree with the results of crank rotation experiments designed by Ohta et al., showing that the arm motion control model based on a CPG network is reasonable and effective.

关键词： central pattern generator (CPG) arm motion joint angle hand angle,crank rotation experiment

Impact of θ-burst stimulation on memory mechanism:modeling study

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Applied Mathematics and Mechanics(English Edition) 2016年第3期37卷 395-402页

作者： Yating ZHU rubin wang Yihong wang Institute for Cognitive Neurodynamics East China University of Science and Technology Shanghai 200237 China

The information stored in working memory can be transformed into the system of long-term memory due to the long-term potential （LTP） mechanism. The 8- burst stimulation （TBS） can be used as an LTP induction protocol in some experiments, but it has not been used in the models related to memory. In this work, an improved Camperi-wang （C-W） model with the Ca2＋ subsystem-induced bistability is adopted, and the TBS is simulated to be the initial stimuli of this model. With the evolution of the effects of the stimuli properties such as the cycle, the amplitude, and the duty ration on the memory mechanism of this model, the TBS can be adopted to activate working memory models and produce long-term memory. The study helps to propose the relationship between working memory and long-term memory, which lays a theoretical basis for the study of the neural mechanism of long-term memory.

关键词： θ-burst stimulation (TBS) long-term potential (LTP) working memory,long-term memory

Dynamic multivariate multiscale entropy based analysis on brain death diagnosis

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Science China(Technological Sciences) 2015年第3期58卷 425-433页

作者： NI Li CAO JianTing wang rubin Institute for Cognitive Neurodynamics East China University of Science and Technology Department Electronic Engineering Saitama Institute of Technology Brain Science Institute RIKEN 2-1 HirosawaSaitama 351-0198 Japan

The recently introduced multivariate multiscale sample entropy(MMSE)well evaluates the long correlations in multiple channels,so that it can reveal the complexity of multivariate biological *** existing MMSE algorithm deals with short time series statically whereas long time series are common for real-time computation in practical *** a solution,we novelly proposed our dynamic MMSE(DMMSE)as an extension of *** helps us gain greater insight into the complexity of each section of time series,producing multifaceted and more robust estimates than the standard *** simulation results illustrated the feasibility and well performance in the brain death diagnosis.

关键词： EEG signals approximate entropy sample entropy brain death diagnosis

Measuring effects of different noises in a model using ISI-distance methods

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International Journal of Biomathematics 2015年第4期8卷 17-36页

作者： Jingyi Qu rubin wang Ying Du Tianjin Key Laboratory for Advanced Signal Processing College of Electronic Information EngineeringCivil Aviation University Tianjin 300300 P. R. China Institute for Cognitive Neurodynamics School of Science East China University of Science and Technology Shanghai 200237 P. R. China

This paper examines the effects of current and conductance noises in a minimal Hodgkin- Huxley type model of a cold receptor neuron. Current noise enters the membrane equation directly while conductance noise is propagated through the activation variables. Compared with common used interspike interval method, ISI-distance is a simple complementary approach to measure the different effects of current and conductance noises. ISI-distance extracts information from the interspike intervals by evaluating the ratio of instantaneous firing rates, which is parameter-free, time scale-independent and easy to visualize. Simulation results show that the most significant differences between different noise implementations in a pacemaker-like tonic firing regime at the transition to chaotic burst discharges.

关键词： Neural spike train current and conductance noise ISI-distance cold receptormodel impulse pattern.

The molecular dynamics of neural metabolism during the action potential

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Science China(Technological Sciences) 2014年第5期57卷 857-863页

作者： ZHENG HongWen wang rubin QIAO LinKun DU Ying The Institute for Cognitive Neurodynamics East China University of Science and Technology The Institute of Biological Engineering East China University of Science and Technology

Neural information processing is tightly coupled to both energy consumption and derivation from *** this study,the energy function of the neuron during the action potential(AP)is described and *** has been observed that energy consumption during the AP does not match predictions of the conventional theory of neural energy *** short time scales,neural energy expenditure shifts between positive and negative *** the AP,the energy source switches from neuronal stores(positive expenditure or net consumption)to exploitation of external substrates,specifically the glucose and oxygen carried in cerebral blood(the negative consumption phase).Based on the idea of reductionism,this paper demonstrates how ion channels,membrane pumps and transporters,ionotropic and metabotropic receptor signaling pathways,astrocyte glycolysis and the production lactate,and the glutamate-glutamine cycle all serve to relate cerebral blood flow and neuronal metabolism to neuronal activity and so maintain neuronal energy charge during the AP.

关键词： neural energy action potential ion channels astrocytes hyperaemia

Contributions of distinct prefrontal neuron classes in reward processing

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Science China(Technological Sciences) 2014年第6期57卷 1257-1268页

作者： PAN XiaoChuan FAN HongWei wang rubin SAKAGAMI Masamichi Institute for Cognitive Neurodynamics East China University of Science and Technology Brain Science Institute Tamagawa UniversityTamagawagakuen 6-1-1MachidaTokyo 194-8610Japan

The prefrontal cortex(PFC)is thought to be involved in higher order cognitive functions,such as in working memory,abstract categorization,and reward *** has been reported that two distinct neuron classes(putative pyramidal cells and interneurons)in the PFC played different functional roles in neural circuits involved in forming working memory and abstract ***,it remains elusive how the two types of neurons process reward information in the *** investigate this issue,the activity of single neurons was extracellularly recorded in the PFC of the monkey performing a reward predicting *** neurons were classified into putative pyramidal cells and interneurons,respectively,based on the waveforms of action *** the two types of neurons encoded reward information and discriminated two reward conditions(the preferred reward condition *** nonpreferred reward condition).However,the putative pyramidal neurons had better and more reliable discriminability than the putative ***,the pyramidal cells represented reward information in the preferred reward condition,but not in the nonpreferred reward condition by raising their firing rates relative to the baseline *** contrast,the interneurons encoded reward information in the nonpreferred reward condition,but not in the preferred reward condition by inhibiting their discharge rates relative to the baseline *** results suggested that the putative pyramidal cells and interneurons had complementary functions in reward *** findings may help to clarify individual functions of each type of neurons in PFC neuronal circuits involved in reward processing.

关键词： prefrontal cortex reward pyramidal neuron interneuron monkey single-unit activity

Neurodynamics analysis of cochlear hair cell activity

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Theoretical & Applied Mechanics Letters 2020年第1期10卷 8-15页

作者： Weifeng Rong rubin wang Jianhai Zhang Wanzeng Konga School of Computer Science Hangzhou Dianzi UniversityHangzhou 310018China Institute for Cognitive Neurodynamics East China University of Science and TechnologyShanghai 200237China

There have been many studies on the effect of cochlea basal membrane movement on the resolution of different frequencies and ***,these studies did not take into account the influence of power and energy consumption of the hair cells in the process of the electromotility movement,as well as the neurodynamic mechanism that produced this *** makes previous studies unable to fully clarify the function of outer hair cells(OHCs)and the mechanism of sound *** this end,we introduce the gate conductance characteristics of the hair cells in the mechanical process of increasing frequency *** research finds that the low attenuation of OHCs membrane potential and the high gain in OHC power and energy consumption caused that OHC amplification is driven by *** research results show that the amplification of the OHCs is driven by low attenuation of membrane potential and high gain of power and energy *** conclusion profoundly reveals the physiological mechanism of the electromotility movement.

关键词： Hair cells Sound frequencies Membrane potential Power Outer hair cell amplification

Phytochemical Analysis of Medicinal Plants with Kidney Protective Activities

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Chinese Journal of Integrative Medicine 2012年第10期18卷 790-800页

作者： Eric Jung-chi Lien Linda Lin-min Lien rubin wang Jeffrey wang Department of Pharmacology and Pharmaceutical Sciences School of PharmacyUniversity of Southern California Department of Chemistry & Biochemistry University of California Department of Pharmaceutical Sciences College of PharmacyWestern University of Health Sciences

In view of the increasing number of patients undergoing kidney dialysis or transplant every year, a survey of the literature on renal protective medicinal plants was undertaken. Most of them are from traditional Chinese medicine （TCM）. Although many of the medicinal herbs reported have not been investigated in terms of active chemical ingredients, some do have compounds well characterized. They fall into a wide range of structures. Several groups of compounds with well established activities are discussed. These include： antioxidant phenolic compounds like tannins, flavonoids, isoflavonoids, unsaturated organic acids and lignans; circulation enhancing compounds like saponins, and basic alkaloids with multiple targets （G-protein coupled receptors）. Also presented are proinflammatory and antiinflammatory fatty acids like linoleic （n-6） and α-Iinolenic （n-3） acids, respectively. Attention is also drawn to the plants containing nephrotoxic aristolochic acid. Different directions of future research are also presented. We hope that this review may provide some leads for new drug discovery and development, and more rational application of TCM.

关键词： kidney protective herbs kidney protection natural products antioxidants free radical scavengers immunomodulating agents antiinflammatory agents structure-activity relationship physicochemical parameters

Study on the mechanical properties of outwash deposits with random structure method

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Transportation Safety and Environment 2021年第3期3卷 316-330页

作者： Chaojun Jia Qiang Zhang Mingfeng Lei Jun Yu rubin wang Jingyan Liu School of Civil Engineering Central South UniversityChangsha410075China State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin China Institute of Water ResourcesBeijing100048China China Institute of Water Resources and Hydropower Research Beijing100048China School of Transportation and Civil Engineering Nantong UniversityNantong226019China Research Institute of Geotechnical Engineering Hohai UniversityNanjing210098China College of Water Resources Science and Engineering Taiyuan University of TechnologyTaiyuan030024China

Outwash deposit is one of the major threats to the safety and stability of railway transit engineering in the Sichuan–Tibet *** this paper,different samples of outwash deposits were prepared based on the random structure method,and a series of large-scale direct shear tests were carried out under different normal *** influence of stone content and the spatial distribution of stone blocks on the physical and mechanical properties of outwash deposits were *** results show that with the increase of stone content,the shear stress-displacement curve changs from strain softening to strain *** shear zone is larger,and its shape is more tortuous due to the movement and rotation of stone *** internal frictional angle increases linearly while the cohesion diseases with the increase of stone *** main influence of the spatial distribution of stone blocks on the mechanical properties of outwash deposits is the peak *** shear zone is mainly determined by the distribution of the stone blocks near the shear zone.

关键词： outwash deposit mechanical property random mesostructure discrete-element method direct shear test