Phytochemical Analysis of Medicinal Plants with Kidney Protective Activities

作     者：Eric Jung-chi Lien Linda Lin-min Lien Rubin Wang Jeffrey Wang 

作者机构：Department of Pharmacology and Pharmaceutical SciencesSchool of PharmacyUniversity of Southern California Department of Chemistry & BiochemistryUniversity of California Department of Pharmaceutical SciencesCollege of PharmacyWestern University of Health Sciences 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2012年第18卷第10期

页      面：790-800页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：kidney protective herbs kidney protection natural products antioxidants free radical scavengers immunomodulating agents antiinflammatory agents structure-activity relationship physicochemical parameters 

摘      要：In view of the increasing number of patients undergoing kidney dialysis or transplant every year, a survey of the literature on renal protective medicinal plants was undertaken. Most of them are from traditional Chinese medicine （TCM）. Although many of the medicinal herbs reported have not been investigated in terms of active chemical ingredients, some do have compounds well characterized. They fall into a wide range of structures. Several groups of compounds with well established activities are discussed. These include： antioxidant phenolic compounds like tannins, flavonoids, isoflavonoids, unsaturated organic acids and lignans; circulation enhancing compounds like saponins, and basic alkaloids with multiple targets （G-protein coupled receptors）. Also presented are proinflammatory and antiinflammatory fatty acids like linoleic （n-6） and α-Iinolenic （n-3） acids, respectively. Attention is also drawn to the plants containing nephrotoxic aristolochic acid. Different directions of future research are also presented. We hope that this review may provide some leads for new drug discovery and development, and more rational application of TCM.