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Reduction of drosopterin content caused by a 45-nt insertion in Henna pre-mRNA of Drosophila melanogaster

science china(Life sciences) 2008年第8期51卷 702-710页

作者： wang qin, zhao chunjiang, bai lihua, deng xuemei & wu changxin state key laboratory of agrobiotechnology & key laboratory of animal genetics and breeding of the ministry of agriculture, college of animal science and technology, china agricultural university, beijing 100193, china 1. state key laboratory of agrobiotechnology & key laboratory of animal genetics and breeding of the ministry of agriculture College of Animal Science and Technology China Agricultural University Beijing 100193 China

Phenylalanine hydroxylase is assumed to be a key enzyme in drosopterin metabolism, but direct in vivo evidence to support this hypothesis is still *** the present study, we found a new natural reces-sive purple eye mutant of Drosophila melanogaster, Hnbp, which was a 45-nt insertion mutant in the second exon of *** insertion resulted in a predicted protein with 15 additional amino acids as compared to the wild-type *** analysis of protein structure showed that the predicted mutant protein probably had two more β-sheets, which may cause instability of two α-helices near the catalytic centre of the enzyme in the Biopterin-Hydroxyl binding *** mutant showed eye color defect with decrease of mRNA level, as well as drosopterin content *** drosopterin defect could be fully rescued by expression of wild type Henna in the Hnbp background by GMR-GAL4 UAS-Henna/UAS-Henna:Hnbp/Hnbp transgenic *** taken together, it can be concluded that the mu-tation in Henna is responsible for drosopterin reduction in mutant Hnbp, which provides key in vivo evidence to support the hypothesis that Henna is involved in drosopterin synthesis.

关键词： Drosophila melanogaster Henna gene drosopterin phenylalanine hydroxylase Hnbp

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