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Calcium-fortified fresh milk ameliorates postmenopausal osteoporosis via regulation of bone metabolism and gut microbiota in ovariectomized rats

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Food Science and Human Wellness 2024年第3期13卷 1258-1270页

作者： qishan wang Bin Liu Xianping Li Junying Zhao Zongshen Zhang Weicang Qiao Xinyue Wei Lijun Chen School of Bioengineering Dalian Polytechnic UniversityDalian 116034China National Engineering Research Center of Dairy Health for Maternal and Child Beijing Sanyuan Foods Co.Ltd.Beijing 100163China Beijing Engineering Research Center of Dairy Beijing Sanyuan Foods Co.Ltd.Beijing 100163China

The aging of the global population has made postmenopausal osteoporosis prevention essential;however,pharmacological treatments are ***,we evaluate the effect of calcium-fortified fresh milk(FM)in ameliorating postmenopausal osteoporosis in a rat model established using bilateral *** 3 months of FM(containing vitamin D,and casein phosphopeptides,1000 mg Ca/100 g)or control milk(110 mg Ca/100 g milk)supplementation,bone changes were assessed using dual-energy X-ray absorptiometry,microcomputed tomography,and bone biomechanical *** results revealed that FM can regulate bone metabolism and gut microbiota composition,which act on bone metabolism through pathways associated with steroid hormone biosynthesis,relaxin signaling,serotonergic synapse,and unsaturated fatty acid ***,FM administration significantly increased bone mineral content and density in the lumbar spine and femur,as well as femoral compressive strength,while improving femoral trabecular bone parameters and ***,we found that the effects may be due to increased levels of estrogen,bone formation marker osteocalcin,and procollagen typeⅠN-propeptide,and decreased expression of the bone resorption marker C-telopiptide and tartrate-resistant acid phosphatase ***,the findings suggest that FM is a potential alternative therapeutic option for ameliorating postmenopausal osteoporosis.

关键词： Dairy products Calcium Vitamin D Bone turnover markers Gut microbiota Postmenopausal osteoporosis

Chinese Vice President wang qishan Meets Members of InterAction Council

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International Understanding 2018年第4期 3-3页

作者： wang Bo 不详

Chinese Vice President wang qishan met with members of the Inter Action Council in Beijing on September *** said that every country should follow the path consistent with its own characteristics.

关键词： InterAction Council wang qishan

The novel generating algorithm and properties of hybrid-P-ary generalized bridge functions

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Science in China(Series F) 2006年第2期49卷 228-234页

作者： wang Gang ZHANG qishan Department of Electronic Engineering Beihang University Beijing 100083 China

In this paper, we develop novel non-sine functions, named hybrid-P-ary generalized bridge functions, based on the copy and shift methods. The generating algorithm of hybrid-P-ary generalized bridge functions is introduced based on the hybrid-P-ary generalized Walsh function＇s copy algorithm. The main property, product property, is also discussed. This function may be viewed as the generalization of the theory of bridge functions. And a lot of non-sine orthogonal functions are the special subset of these novel functions, The hybrid-P-ary generalized bridge functions can be used to search many unknown non-sine functions by defining different parameters.

关键词： hybrid-P-ary generalized Waish functions hybrid-P.ary generalized shift copy hybrid-P-ary generalized bridge functions.

Pig pangenome graph reveals functional features of non-reference sequences.

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Comparative study of the promotion of porcine fetal fibroblast proliferation by overexpression of two transcriptional variants of SIRT6

畜牧与生物技术杂志(英文版) 2024年第3期 956页

作者： Jian Miao Xingyu Wei Caiyun Cao Jiabao Sun Yuejin Xu Zhe Zhang qishan wang Yuchun Pan Zhen wang

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Chinese Science Bulletin 2013年第10期58卷 1169-1174页

作者： XIE XiaoXian HE Kan ZHANG AiLing ZHANG Hao wang qishan LI JiaQi MA YuFang School of Agriculture and Biology Department of Animal SciencesShanghai Jiao Tong UniversityShanghai Key Laboratory of Veterinary Biotechnology Department of Animal Genetics Breeding and ReproductionCollege of Animal SciencesSouth China Agricultural University Guangdong Provincial Key Laboratory of Agroanimal Genomics and Molecular Breeding College of Animal SciencesSouth China Agricultural University

Mammalian Sirtuin 6(SIRT6) plays an important role in the transcriptional silencing of silent mating-type loci,telomeres,and ***,the roles of porcine SIRT6 in cell proliferation are poorly understood,and a better knowledge of these will help improve our understanding of the biological mechanisms of cell growth and *** this study,a novel variant of porcine SIRT6(SIRT6 V2) identified by reverse transcription-polymerase chain reaction and BLAST analysis showed a 124-bp deletion compared to wild-type SIRT6 mRNA(SIRT6 V1).Two recombinant plasmids overexpressing SIRT6 V1 and SIRT6 V2 were produced and their roles in the proliferation of porcine fetal fibroblasts(PFFs) were *** transfected with SIRT6 V1 proliferated significantly faster than those transfected with SIRT6 V2(P<0.01),though both proliferated significantly faster than cells expressing an empty vector(P<0.01).These results might be caused by altered proportions of α helices and β sheets in the SIRT6 V2 structure relative to SIRT6 *** results indicate that overexpression of SIRT6 V1/V2 was involved in promoting PFF *** of a 124-bp sequence attenuated the effects of SIRT6 on cell proliferation,possibly as a result of changes in the proportions of α helices and β sheets in the protein secondary structure.

关键词：成纤维细胞增殖胎儿成纤维细胞 DNA转录过度表达猪变体聚合酶链反应 BLAST

Maximizing the Role of Inspection Tours to Boost Strict Governance of the CPC （Extract）

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Qiu Shi 2016年第2期8卷 37-45页

作者： wang qishan Standing Committee of the Political Bureau of the Communist Party of China and Secretary of the CPC's Central Commission for Discipline Inspection

Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis

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Bone Research 2022年第3期10卷 509-523页

作者： Yiqi Yang Yixuan Lin Minqi wang Kai Yuan qishan wang Pei Mu Jingke Du Zhifeng Yu Shengbing Yang Kai Huang Yugang wang Hanjun Li Tingting Tang Shanghai Key Laboratory of Orthopaedic Implants Department of Orthopaedic SurgeryShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Bone and Joint Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Orthopaedics Shanghai Jiangong HospitalShanghaiChina Department of Trauma Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Clinical Stem Cell Research Center Renji HospitalShanghai Jiao Tong University School of MedicineShanghaiChin

Diabetic osteoporosis(DOP) is the leading complication continuously threatening the bone health of patients with diabetes. A key pathogenic factor in DOP is loss of osteocyte viability. However, the mechanism of osteocyte death remains unclear. Here, we identified ferroptosis, which is iron-dependent programmed cell death, as a critical mechanism of osteocyte death in murine models of DOP. The diabetic microenvironment significantly enhanced osteocyte ferroptosis in vitro, as shown by the substantial lipid peroxidation, iron overload, and aberrant activation of the ferroptosis pathway. RNA sequencing showed that heme oxygenase-1(HO-1) expression was notably upregulated in ferroptotic osteocytes. Further findings revealed that HO-1 was essential for osteocyte ferroptosis in DOP and that its promoter activity was controlled by the interaction between the upstream NRF2 and c-JUN transcription factors. Targeting ferroptosis or HO-1 efficiently rescued osteocyte death in DOP by disrupting the vicious cycle between lipid peroxidation and HO-1 activation, eventually ameliorating trabecular deterioration. Our study provides insight into DOP pathogenesis, and our results provide a mechanism-based strategy for clinical DOP treatment.

关键词： peroxidation osteoporosis diabetic

Address at the Opening Session of the 5th China-Africa People’s Forum

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International Understanding 2018年第3期 4-6页

作者： wang qishan the people's republic of china

Your Excellency Vincent Meriton,President of the People's Party of Seychelles and Vice President of Seychelles, Your Excellency Clement Mouamba ,Prime Minister of the Republic of the Congo, Ladies and Gentlemen, Dear friends,I feel greatly delighted to have you with us here in Chengdu,the city of Hibiscus,at the 5th China-Africa People's *** forum is especially honoured with the message of congratulations from President Xi *** adequately reflects the importance the Communist Party of China and the Chinese goyemment have placed on the people-to-people exchanges and cooperation between China and Africa,and points out the way to follow in the proceedings of the Forum.

关键词： Your Excellency Vincent Meriton 5th China-Africa People's

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Stay Confident and Work Together fo A Shared Future--Speech at the 2019 World Economic Forum Annual Meeting

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Beijing Review 2019年第6期62卷 I0001-I0007页

作者： wang qishan the People's Republic of China

Dear *** Schwab, Ladies and gentlemen, Friends, It gives me great pleasure to attend the 2019 World Economic Forum (WEF)Annual Meeting.

关键词：世界经济论坛年会致辞信心施瓦布