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Prognostic and incremental value of computed tomography-based radiomics from tumor and nodal regions in esophageal squamous cell carcinoma

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Chinese Journal of Cancer Research 2022年第2期34卷 71-82页

作者： Bangrong Cao Kun Mi Wei Dai Tong Liu Tianpeng Xie Qiang Li Jinyi Lang Yongtao Han Lin Peng qifeng wang Radiation Oncology Key Laboratory of Sichuan Province Sichuan Cancer Hospital&InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610041China Department of Biobank Sichuan Cancer Hospital&InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610041China Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610041China Department of Medical Imaging Sichuan Cancer Hospital&InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610041China Department of Radiation Oncology Sichuan Cancer Hospital&InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610041China

Objective:This study aimed to evaluate the prognostic value of preoperative radiomics and establish an integrated model for esophageal squamous cell cancer(ESCC).Methods:A total of 931 patients were retrospectively enrolled in this study(training cohort,n=624;validation cohort,n=307).Radiomics features were obtained by contrast-enhanced computed tomography(CT)before esophagectomy.A radiomics index was set based on features of tumor and reginal lymph nodes by using the least absolute shrinkage and selection operator(LASSO)Cox *** nomogram was built based on radiomics index and other independent risk *** prognostic value was assessed by using Harrell’s concordance index,time-dependent receiver operating characteristics and Kaplan-Meier ***:Twelve radiomic features from tumor and lymph node regions were identified to build a radiomics index,which was significantly associated with overall survival(OS)in both training cohort and validation *** radiomics index was highly correlated with clinical tumor-node-metastasis(cTNM)and pathologic TNM(pTNM)stages,but it demonstrated a better prognostic value compared with cTNM stage and was almost comparable with pTNM *** Cox regression showed that the radiomics index was an independent prognostic *** integrated model was constructed based on gender,preoperative serum sodium concentration,pTNM and the radiomics index for clinical *** integrated model demonstrated discriminatory ability better compared with the traditional clinical-pathologic model and pTNM alone,indicating incremental value for ***:CT-based radiomics for primary tumor and reginal lymph nodes was sufficient in predicting OS for patients with *** integrated model demonstrated incremental value for prognosis and was robust for clinical applications.

关键词： Esophageal squamous cell cancer radiomics lymph node prognosis

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Two-Dimensional Materials for Highly Efficient and Stable Perovskite Solar Cells

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Nano-Micro Letters 2024年第10期16卷 176-212页

作者： Xiangqian Shen Xuesong Lin Yong Peng Yiqiang Zhang Fei Long qifeng Han Yanbo wang Liyuan Han State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People's Republic of China Xinjiang Key Laboratory of Solid State Physics and Devices School of Physical Science and TechnologyXinjiang UniversityUrumqi 830046People's Republic of China Special Division of Environmental and Energy Science College of Arts and SciencesKomaba Organization for Educational ExcellenceUniversity of TokyoTokyo 153-8902Japan State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People's Republic of China College of Chemistry Henan Institute of Advanced TechnologyZhengzhou UniversityZhengzhou 450001People's Republic of China Guangxi Key Laboratory of Optical and Electronic Materials and Devices Collaborative Innovation Center for Exploration of Nonferrous Metal Deposits and Efficient Utilization of ResourcesSchool of Materials Science and EngineeringGuilin University of TechnologyGuilin 541004People's Republic of China

Perovskite solar cells(PSCs)offer low costs and high power conversion ***,the lack of long-term stability,primarily stemming from the interfacial defects and the sus-ceptible metal electrodes,hinders their practical *** the past few years,two-dimensional(2D)materials(e.g.,graphene and its derivatives,transitional metal dichalcogenides,MXenes,and black phosphorus)have been identified as a promising solution to solving these problems because of their dangling bond-free surfaces,layer-dependent electronic band structures,tunable functional groups,and inherent ***,recent progress of 2D material toward efficient and stable PSCs is summarized,including its role as both interface materials and *** discuss their beneficial effects on perovskite growth,energy level alignment,defect passivation,as well as blocking external *** particular,the unique properties of 2D materials to form van der Waals heterojunction at the bottom interface are ***,perspectives on the further development of PSCs using 2D materials are provided,such as designing high-quality van der Waals heterojunction,enhancing the uniformity and coverage of 2D nanosheets,and developing new 2D materials-based electrodes.

关键词： Perovskite solar cells Two-dimensional materials Interface engineering Van der Waals heterojunction Electrodes

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RNF43 is a novel tumor-suppressor and prognostic indicator in clear cell renal cell carcinoma

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Oncology Research 2021年第3期29卷 159-174页

作者： DAWEI ZHU LEI ZHANG XIAOKAI SHI SHENGLIN GAO CHUANG YUE LIFENG ZHANG YU BAI qifeng wang ATSUSHI OKADA TAKAHIRO YASUI CHAO wang XINGANG CUI LI ZUO Department of Urology The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical UniversityChangzhouChina Department of Pathology Fudan University Shanghai Cancer CenterShanghaiChina Department of Nephro-Urology Nagoya City University Graduate School of Medical SciencesAichiJapan Department of Urinary Surgery Gongli HospitalSecond Military Medical University(Naval Medical University)ShanghaiChina Department of Urinary Surgery The Third Affiliated Hospital of Naval Medical University(Eastern Hepatobiliary Surgery Hospital)ShanghaiChina

Identifying prognostic indicators of clear cell renal cell carcinoma(ccRCC)and elucidating the mechanisms underlying ccRCC progression are crucial for improving ccRCC patient *** study investigated the clinical significance and biological role of Ring finger protein 43(RNF43)in *** independent cohorts of patients with ccRCC were employed to determine the prognostic significance of RNF43 by immunohistochemistry and statistical *** vitro and in vivo experiments,RNA-seq,and other techniques were used to determine the biological role of RNF43 in ccRCC and related molecular ***43 expression was commonly decreased in ccRCC specimens,and low expression of RNF43 indicated a higher TNM stage,SSIGN score,and WHO/ISUP grade and short survival in patients with ***,RNF43 overexpression suppressed the proliferation,migration,and targeted drug resistance of ccRCC cells,while the knockdown of RNF43 enhanced these characteristics of ***43 knockdown activated YAP signaling by decreasing YAP phosphorylation by p-LATS1/2 and increasing the transcription and nuclear distribution of *** contrast,RNF43 overexpression showed the opposite *** YAP abolished the effect of RNF43 knockdown in promoting the malignant features of ***,restoring RNF43 expression suppressed the resistance of the targeted drug pazopanib in in vivo orthotopic ***,combining the expression of RNF43 and YAP with TNM stage or the SSIGN score exhibited greater accuracy than any of these indicators alone in assessing the postoperative prognosis of ccRCC *** summary,our study identified a novel tumor suppressor,RNF43,which is also a prognostic indicator and potential target for ccRCC.

关键词： Clear cell renal cell carcinoma RNF43 Prognosis YAP Tumor progression

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MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1

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Protein & Cell 2014年第11期5卷 851-861页

作者： Mingxu Song Yuan Yin Jiwei Zhang Binbin Zhang Zehua Bian Chao Quan Leyuan Zhou Yaling Hu qifeng wang Shujuan Ni Bojian Fei Weili wang Xiang Du Dong Hua Zhaohui Huang Wuxi Oncology Institute the Affiliated Hospital of Jiangnan University Wuxi 214062 China Department of Surgical Oncology the Affiliated Hospital of Jiangnan University Wuxi 214062 China Department of Radiation Oncology the Affiliated Hospital of Jiangnan University Wuxi 214062 China Department of Pathology Fudan University Shanghai Cancer Center Shanghai 200032 China

MicroRNAs （miRNAs） that exert function by posttran- scriptional suppression have recently brought insight in our understanding of the role of ***-coding RNAs in carcinogenesis and metastasis. In this study, we described the function and molecular mechanism of miR-139-5p in colorectal cancer （CRC） and its potential clinical application in CRC. We found that miR-139-5p was significantly downregulated in 73.8% CRC samples compared with adjacent noncancerous tissues （NCTs）, and decreased miR-139-5p was associated with poor prognosis. Functional analyses demonstrated that ectopic expression of miR-139-5p suppressed CRC cell migration and invasion in vitro and metastasis in vivo. Mechanistic investigations revealed that miR-139-5p suppress CRC cell invasion and metastasis by targeting AMFR and NOTCH1. Knockdown of the two genes phe- nocopied the inhibitory effect of miR-139-5p on CRC metastasis. Furthermore, the protein levels of the two genes were upregulated in CRC samples compared with NCTs, and inversely correlated with the miR-139-5p expression. Increased NOTCH1 protein expression was correlated with poor prognosis of CRC patients. Together, our data indicate that miR-139-5p is a potentialtumor suppressor and prognostic factor for CRC, and targeting miR-139-5p may repress the metastasis of CRC and improve survival.

关键词： miR-139-5p AMFR NOTCH1 colorectalcancer metastasis prognosis

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鲁氏结合酵母与酿酒酵母顺序发酵对米酒发酵性能及关键香气物质的影响

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天津科技大学学报 2024年第4期39卷 15-25页

作者：崔荣荣刘学礼乔赫梁王其峰姚云平赵国忠食品营养与安全国家重点实验室天津科技大学食品科学与工程学院天津300457

以鲁氏结合酵母(Zygosaccharomyces rouxii)SC01和酿酒酵母(Saccharomyces cerevisiae)GJM、VIC为研究对象,采用不同顺序接种方式进行米酒发酵,监测发酵过程中菌落数、理化指标的变化和发酵结束时挥发性化合物的差异。结果表明:与单菌... 详细信息

以鲁氏结合酵母(Zygosaccharomyces rouxii)SC01和酿酒酵母(Saccharomyces cerevisiae)GJM、VIC为研究对象,采用不同顺序接种方式进行米酒发酵,监测发酵过程中菌落数、理化指标的变化和发酵结束时挥发性化合物的差异。结果表明:与单菌发酵相比,鲁氏结合酵母的菌落数在顺序接种中有不同程度的减少,在SC01+48hGJM和SC01+24hVIC发酵组表现更为明显。在发酵过程中,随着酿酒酵母的添加,还原糖和糖度迅速降低,酒精度迅速升高。此外,米酒的香气特征也有显著增强。实验组的关键醇、酯和醛含量较商业米酒有明显提高,尤其是SC01+48hVIC发酵组。因此,鲁氏结合酵母与酿酒酵母顺序接种策略可以提高米酒的发酵性能并改善风味,为米酒的新产品开发提供新思路。

关键词：米酒鲁氏结合酵母酿酒酵母顺序发酵理化指标香气化合物

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面向服务的制造执行系统建模方法研究

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中国机械工程 2008年第13期19卷 1569-1573页

作者：王琦峰刘飞重庆大学

在分析现有建模方法和工具的基础上,提出了一种以体系结构为中心,以制造业务进行驱动,综合应用集成化计算机辅助制造系统功能建模方法、业务流程管理分析方法和基于统一建模语言分析与设计方法的集成化面向服务的制造执行系统建模方法,... 详细信息

在分析现有建模方法和工具的基础上,提出了一种以体系结构为中心,以制造业务进行驱动,综合应用集成化计算机辅助制造系统功能建模方法、业务流程管理分析方法和基于统一建模语言分析与设计方法的集成化面向服务的制造执行系统建模方法,通过建立系统的业务对象模型、功能模型、过程模型、组件模型、服务模型和服务交互模型实现了面向服务的制造执行系统的分析和设计。最后,通过实际系统的建模实现,验证了该方法的可行性。

关键词：面向服务架构制造执行系统体系结构系统建模

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Correction to:MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1

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Protein & Cell 2021年第8期12卷 667-669页

作者： Mingxu Song Yuan Yin Jiwei Zhang Binbin Zhang Zehua Bian Chao Quan Leyuan Zhou Yaiing Hu qifeng wang Shujuan Ni Bojian Fei Weiii wang Xiang Du Dong Hua Zhaohui Huang Wuxi Oncology Institute the Affiliated Hospital of Jiangnan UniversityWuxi 214062China Department of Surgical Oncology the Affiliated Hospital of Jiangnan UniversityWuxi 214062China Department of Radiation Oncology the Affiliated Hospital of Jiangnan UniversityWuxi 214062China Department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China

CORRECTION TO:PROTEIN CELL(2014)5(11):851-861 HTTPS://***/10.1007/S13238-014-0093-5 In the original publication the display of Fig.1 is in *** correct Fig.1 is available in this correction.

关键词： invasion colorectal cancer

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基于语义的协同制造执行平台集成框架研究

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中国机械工程 2008年第17期19卷 2050-2054,2112页

作者：雷琦刘飞王琦峰重庆大学重庆400044

针对协同制造执行平台集成内容与集成对象的多样性和复杂性,分析了协同制造执行平台对动态快速集成、统一的集成模式、支持相关的集成标准、支持语义和松散耦合的集成方式等的需求,建立了一种基于语义的协同制造执行平台集成框架,以实... 详细信息

针对协同制造执行平台集成内容与集成对象的多样性和复杂性,分析了协同制造执行平台对动态快速集成、统一的集成模式、支持相关的集成标准、支持语义和松散耦合的集成方式等的需求,建立了一种基于语义的协同制造执行平台集成框架,以实现集成对象松散耦合的按需集成;在此基础上,建立了集成对象的语义描述模型,采用语义Web服务描述本体OWL-S对集成对象进行了语义建模,并对制造企业内部语义集成及跨企业制造过程语义集成的相关技术进行了研究。研究成果在某柴油机部套产品生产企业协同制造执行平台上得到了应用,取得了较好的应用效果。

关键词：协同制造集成框架集成对象语义

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LM_BP神经网络在总辐射日曝辐量计算中的应用研究

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太阳能学报 2013年第7期34卷 1202-1205页

作者：朱良山林婵王起峰山东电力工程咨询院有限公司济南250013

提出基于LM_BP神经网络的总辐射日曝辐量计算模型,模型以地外日射日曝辐量、日照百分率、日最高温度和日相对湿度等4个气象因子作为输入向量,以日曝辐量作为输出向量,利用气象站实测的气象数据进行模型实验,结果表明:该模型计算结果较... 详细信息

提出基于LM_BP神经网络的总辐射日曝辐量计算模型,模型以地外日射日曝辐量、日照百分率、日最高温度和日相对湿度等4个气象因子作为输入向量,以日曝辐量作为输出向量,利用气象站实测的气象数据进行模型实验,结果表明:该模型计算结果较为精确,且泛化性能好,可以推广应用。

关键词： BP神经网络 LM算法总辐射日曝辐量模型

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金属杂六元环的合成方法研究进展

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有机化学 2010年第2期30卷 157-166页

作者：王奇峰林辰席振峰中国科学院化学研究所北京分子科学国家实验室北京100190 北京大学化学与分子工程学院北京分子科学国家实验室生物有机与分子工程教育部重点实验室北京100871

研究发现许多重要的金属促进的合成反应都是经过金属杂环进行的,因此金属杂环的合成方法学以及反应化学研究受到了学术界及工业界的极大关注.关于金属杂五元环的研究报道数量很多,而金属杂六元环的文献报道非常之少.考虑到金属杂六元环... 详细信息

研究发现许多重要的金属促进的合成反应都是经过金属杂环进行的,因此金属杂环的合成方法学以及反应化学研究受到了学术界及工业界的极大关注.关于金属杂五元环的研究报道数量很多,而金属杂六元环的文献报道非常之少.考虑到金属杂六元环在有机合成化学中潜在的重要用途,结合作者近年的一些研究工作,对目前已经报道的金属杂六元环的合成方法进行回顾与展望.

关键词：金属杂六元环金属杂环己烷金属杂环己烯金属杂环己二烯金属苯

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