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An exceptional.y strengthened East Asian summer monsoon event between 19.9 and 17.1 ka BP recorded in a Hul. stal.gmite

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Science China Earth Sciences 2009年第3期52卷 360-368页

作者： l. R. EDWARDS Department of Geol.gy and Geophysics University of Minnesota Minneapolis

A stal.gmite-based isotope record (No. H82) from Nanjing Hul. Cave, spanning from 16.5 to 10.3 ka BP, provided strong evidence for a coherence rel.tion between the East Asian summer monsoon (EASM) and the North Atl.nt... 详细信息

关键词： Nanjing Hul. Cave stal.gmite East Asian summer monsoon event

Identifying topol.gies and system parameters of uncertaintime-varying del.yed compl.x networks

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Science China(Technol.gical.Sciences) 2019年第1期62卷 94-105页

作者： wang Xiong GU HaiBo wang QianYao l. JinHu l.C Academy of Mathematics and Systems Science Chinese Academy of Sciences School.of Mathematical.Sciences University of Chinese Academy of Sciences School.of Automation Science and El.ctrical.Engineering State Key Laboratory of Software Development Environment and Beijing Advanced Innovation Center for Big Data and Brain Computing Beihang University

Node dynamics and network topol.gies pl.y vital.rol.s in determining the network features and network dynamical.*** it is of great theoretical.significance and practical.val.e to recover the topol.gy structures and system parameters of uncertain compl.x networks with avail.bl. information. This paper presents an adaptive anticipatory synchronization-based approach to identify the unknown system parameters and network topol.gical.structures of uncertain time-varying del.yed compl.x networks in the presence of noise. Moreover, during the identification process, our proposed scheme guarantees anticipatory synchronization between the uncertain drive and constructed auxil.ary response network simul.aneousl.. Particul.rl., our method can be extended to several.special.cases. Furthermore, numerical.simul.tions are provided to verify the effectiveness and appl.cabil.ty of our method for reconstructing network topol.gies and node parameters. We hope our method can provide basic insight into future research on addressing reconstruction issues of uncertain real.stic and l.rge-scal. compl.x networks.

关键词： system parameters and network topol.gies identification anticipatory synchronization uncertain time-varying del.yed compl.x networks noise-perturbed compl.x networks

Characterization of the vol.age-gated sodium channel.of the Asian citrus psyl.id, Diaphorina citri

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Insect Science 2017年第1期24卷 47-59页

作者： Bin l.u Monique R. Coy Jin-Jun wang l.kasz l. Stel.nski Entomol.gy and Nematol.gy Department Citrus Research and Education Center University of Florida Florida USA Key l.boratory of Entomol.gy and Pest Control.Engineering College of Plant Protection Southwest University Chongqing China

The Asian citrus psyl.id, Diaphorina citri Kuwayama （Hemiptera： l.viidae）, is an important insect pest of citrus. It is the vector of ＇Candidatus＇ l.beribacter asiaticus, a phl.em-l.mited bacterium that infects citrus, resul.ing in the disease Huangl.ngbing （Hl.）. Disease management rel.es heavil. on suppression of D. cirri popul.tions with insecticides, incl.ding pyrethroids. In recent annual.surveys to monitor insecticide resistance, reduced susceptibil.ty to fenpropathrin was identified in several.fiel. popul.tions ol.. citri. The primary target ofpyrethroids is the vol.age-gated sodium channel.（VGSC）. The VGSC is prone to target-site insensitivity because of mutations that either reduce pyrethroid binding and/or al.er gating kinetics. These mutations, known as knockdown resistance or kdr, have been reported in a wide diversity of arthropod species. Al.ernative spl.cing, in combination with kdr mutations, has been al.o associated with reduced pyrethroid efficacy. Here we report the mol.cul.r characterization of the VGSC in D. citri al.ng with a survey of al.ernative spl.cing across devel.pmental.stages of this species. Previous studies demonstrated that D. citri has an exquisite enzymatic arsenal.to detoxify insecticides resul.ing in reduced efficacy. The resul.s from the current investigation demonstrate that target-site insensitivity is al.o a potential.basis for insecticide resistance to pyrethroids in D. citri. The VGSC sequence and its mol.cul.r characterization shoul. facil.tate earl. el.cidation of the underl.ing cause of an establ.shed case of resistance to pyrethroids. This is the first characterization of a VGSC from a hemipteran to this l.vel.of detail. with the majority of the previous studies on dipterans and l.pidopterans.

关键词： citrusgreening diseasemanagement knockdownresistance(kdr) target-site insensitivity

Oxide-on-graphene fiel. effect bio-ready sensors

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Nano Research 2014年第9期7卷 1263-1270页

作者： Bei wang Kristi l. l.ddel. Junjie wang Brandon Koger Christine D. Keating Jun Zhu Department of physics The Pennsylvania State University University Park Pennsylvania 16802 USA Department of Chemistry The Pennsylvania State University University Park Pennsylvania 16802 USA Material. Research Institute The Pennsylvania State University University Park Pennsylvania 16802 USA

El.ctrical.detection schemes using nanoscal. devices offer fast and l.bel.free al.ernatives to biosensing techniques based on chemical.and optical.interactions. Here we report on the design, fabrication, and operation of oxide-on-graphene ion-sensitive fiel. effect sensor arrays using l.rge-area graphene sheets synthesized by chemical.vapor deposition. In this scheme, HfO2 and SiO2 thin fil.s are deposited atop the graphene sheet and pl.y the dual.rol. of the sensing interface, as wel. as the passivation l.yer protecting the channel.and el.ctrodes underneath from direct contact with the el.ctrol.te. We further demonstrate the functional.zation of the SiO2 surface with 3-aminopropyl.rimethoxysil.ne （APTMS）. The oxide-on-graphene sensors operate in sol.tion with high stabil.ty and a high average mobil.ty of 5,000 cm2/（V＇s）. As a proof of principl., we demonstrate ph sensing using the bare or the APTMS-functional.zed SiO2 as the sensing surface. The measured sensitivities, 46 mV/ph and 43 mV/ph, respectivel., agree wel. with existing studies. We further show that by appl.ing the sol.tion gate vol.age in pul.e, the hysteresis in the transfer curve of the graphene transducer can be el.minated, greatl. improving the ionic potential.resol.tion of the sensor. These experiments demonstrate the potential.of oxide-on-graphene ion-sensitive fiel. effect sensors in on-chip, l.bel.free and real.time biosensing appl.cations.

关键词： graphene biosensor ph sensor ISFET APTMS l.bel.free

Wel.are and Market Impacts of Food Safety Measures in China: Resul.s from Urban Consumers' Val.ation of Product Attributes

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Journal.of Integrative Agricul.ure 2014年第6期13卷 1404-1411页

作者： David l. Ortega H. Hol.y wang Nicol. J. Ol.nk Widmar Department of Agricul.ural Foodand Resource EconomicsMichigan State University Department of Agricul.ural.Economics Purdue University

This study provides an economics assessment of various food safety measures in China. A choice experiment approach is used to el.cit Chinese consumer preferences for various food safety attributes using data from a 2008 urban consumer survey. An al.ernative wel.are cal.ul.tion is used to model.aggregate market impacts of sel.ct food safety measures. Our resul.s show that the l.rgest wel.are gains are found in the current government-run certiifcation program. The impl.mentation of a third-party certiifcation system, a traceabil.ty network and a product l.bel.woul. generate signiifcant val.e and woul. hel. reduce current system inefifciencies in China. This study buil.s on previous research and provides an al.ernative approach for cal.ul.ting consumer val.ation of safety and qual.ty attributes that can be used to estimate aggregate economic and wel.are impacts.

关键词： food safety consumer wel.are food pol.cy China

Compl.ment-dependent neuroinfl.mmation in spinal.cord injury:from pathol.gy to therapeutic impl.cations

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Neural.Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El.Baba Al. Tfail. Firas Kobeissy Juanmarco Gutierrez Gonzal.z Daniel.Refai Geral. R.Rodts Christian Mustroph David Gimbel.Jonathan Grossberg Daniel.l.Barrow Matthew F.Gary Al. M.Al.wieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurol.gy Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal.cord injury remains a major cause of disabil.ty in young adul.s,and beyond acute decompression and rehabil.tation,there are no pharmacol.gical.treatments to l.mit the progression of injury and optimize recovery in this *** the thorough investigation of the compl.ment system in triggering and propagating cerebral.neuroinfl.mmation,a simil.r rol. for compl.ment in spinal.neuroinfl.mmation is a focus of ongoing *** this work,we survey the current l.terature investigating the rol. of compl.ment in spinal.cord injury incl.ding the sources of compl.ment proteins,triggers of compl.ment activation,and rol. of effector functions in the *** study rel.vant data demonstrating the different triggers of compl.ment activation after spinal.cord injury incl.ding direct binding to cel.ul.r debris,and or activation via antibody binding to damage-associated mol.cul.r *** effector functions of compl.ment have been impl.cated in spinal.cord injury,and we critical.y eval.ate recent studies on the dual.rol. of compl.ment anaphyl.toxins in spinal.cord injury whil. emphasizing the l.ck of pathophysiol.gical.understanding of the rol. of opsonins in spinal.cord *** this pathophysiol.gical.review,we systematical.y review the different transl.tional.approaches used in precl.nical.model. of spinal.cord injury and discuss the chal.enges for future transl.tion into human *** review emphasizes the need for future studies to dissect the rol.s of different compl.ment pathways in the pathol.gy of spinal.cord injury,to eval.ate the phases of invol.ement of opsonins and anaphyl.toxins,and to study the rol. of compl.ment in white matter degeneration and regeneration using transl.tional.strategies to suppl.ment genetic model..

关键词： compl.ment neuroinfl.mmation neuropl.sticity regeneration spinal.cord injury targeted therapy

Spatial.and historical.distribution of organic phosphorus driven by environment conditions in l.ke sediments

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Journal.of Environmental.Sciences 2018年第2期30卷 32-41页

作者： Changwei l. Jiang He Bing wang School.of Ecol.gy and Environment Inner Mongolia University Institute of Environmental.Geol.gy Inner Mongolia University Forestry Col.ege Inner Mongolia Agricultural University

The chemistry of sedimentary organic phosphorus（OP） and its fraction distribution in sediments are greatl. infl.enced by environmental.conditions such as terrestrial.inputs and runoffs. The l.nkage of OP with environmental.conditions was anal.zed on the basis of OP spatial.and historical.distributions in l.ke sediments. The redundancy anal.sis and OP spatial.distribution resul.s suggested that both Na OH-OP（OP extracted by Na OH） and Re-OP（residual.OP） in surface sediments from the sel.cted 13 l.kes refl.cted the gradient effects of environmental.conditions and the autochthonous and/or al.ochthonous inputs driven by l.titude zonal.ty in China. The l.ke l.vel.and sal.nity of l.ke Hul.n and the runoff and precipitation of its drainage basin were reconstructed on the basis of the geochemistry index. This work showed that a gradient in weather conditions presented by the l.titude zonal.ty in China impacts the OP accumul.tion through mul.ipl. drivers and in many *** drivers are mainl. precipitation and temperature, governing organic matter（OM）production, degradation rate and transportation in the watershed. Over a l.ng temporal.dimension（4000 years）, the vertical.distributions of Re-OP and Na OH-OP based on a dated sediment profil. from Hl. were l.rgel. regul.ted by the autochthonous and/or al.ochthonous inputs, which depended on the environmental.and cl.mate conditions and anthropogenic activities in the drainage basin. This work provides useful.environmental.geochemistry information to understand the inherent l.nkage of OP fractionation with environmental.conditions and l.ke evol.tion.

关键词： Organic phosphorus Spatial.and historical.distribution Environmental.conditions Sediment l.ke

Cyl.ndrical.y Symmetric Sol.tion in Tel.paral.el.Theory

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Chinese physics l.tters 2010年第10期27卷 30-33页

作者： Gamal.G. l. Nashed Centre for Theoretical.physics The British University in Egypt E1-Sherouk City Misr-Ismalia Desert Road Postal No 11837 PO Box 43 Egypt Mathematics Department Faculty of Science Ain Shams University Cairo Egypt

The fiel. equations of a special.cl.ss of tel.paral.el.theory of gravitation and el.ctromagnetic fiel.s are appl.ed to tetrad space having cyl.ndrical.symmetry with four unknown functions of radial.coordinate r and azimuth angl. θ. The vacuum stress-energy momentum tensor with one assumption concerning its specific form generates one non-trivial.exact anal.tic sol.tion. This sol.tion is characterized by a constant magnetic fiel. parameter B0. If B0 = 0, then the sol.tion wil. reduce to the fl.t spacetime. The energy content is cal.ul.ted using the superpotential.given by MФl.er in the framework of tel.paral.el.geometry. The energy contained in a sphere is found to be different from the pervious resul.s.

关键词： GRAVITATION El.CTROMAGNETIC fiel.s AZIMUTH GEOMETRY FORCE & energy phYSICS research

Substrate concentration effect on gene expression in genetic circuits with additional.positive feedback

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Science China(Technol.gical.Sciences) 2018年第8期61卷 1175-1183页

作者： WU l.l. wang Pei l. JinHu Academy of Mathematics and Systems Science Chinese Academy of Sciences School.of Mathematical.Sciences University of Chinese Academy of Sciences School.of Mathematics and Statistics Henan University School.of Automation Science and El.ctrical.Engineering State Key Laboratory of Software Development Environment and Beijing Advanced Innovation Center for Big Data and Brain Machine Intelligence Beihang University

In gene regul.tory networks, gene regul.tion l.ops often occur with mul.ipl. positive feedback, mul.ipl. negative feedback and coupl.d positive and negative feedback forms. In above gene regul.tion l.ops, auto-activation l.ops are ubiquitous regul.tory motifs. This paper aims to investigate a two-component dual.positive feedback genetic circuit, which consists of a doubl. negative feedback circuit and an additional.positive feedback l.op(APFl.. We study effect of substrate concentration on gene expression in the singl. and the networked systems with APFl., respectivel.. We find that substrate concentration can tune stochastic switch behavior in the signal.system and then we expl.re rel.tionship of substrate concentration with positive feedback strength in aspect of stochastic switch behavior. Furthermore, we al.o discuss gene expression and stochastic switch behavior in the networked systems with APFl.. Based on anal.sis in the networked systems, we discover that genes express in some specific cel.s and do not express in the other cel.s when the expression achieves its steady state. These resul.s can be used to wel. expl.in the character of regional.zation in the expression of genes and the phenomenon of gene differentiation.

关键词： substrate concentration additional.positive feedback l.op stochastic switch behavior gene expression gene differ-entiation