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Carbon nanotubes-reinforced polylactic acid/hydroxyapatite porous scaffolds for bone tissue engineering

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Frontiers of Materials Science 2024年第1期18卷 59-69页

作者： Weiwei Lan mingbo wang Zhenjun Lv Jun Li Fuying Chen Ziwei Liang Di Huang Xiaochun Wei Weiyi Chen Research Center for Nano-Biomaterials&Regenerative Medicine Department of Biomedical EngineeringCollege of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Guangdong Engineering Technology Research Center of Implantable Medical Polymer Shenzhen Lando Biomaterials Co.Ltd.Shenzhen 518107China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030060China Department of Orthopaedics The Second Hospital of Shanxi Medical UniversityTaiyuan 030001China

In the field of bone defect repair,critical requirements for favorable cytocompatibility and optimal mechanical properties have propelled research efforts towards the development of composite *** this study,carbon nanotubes/polylactic acid/hydroxyapatite(CNTs/PLA/HA)scaffolds with different contents(0.5,1,1.5 and 2 wt.%)of CNTs were prepared by the thermally induced phase separation(TIPS)*** results revealed that the composite scaffolds had uniform pores with high porosities over 68%and high through *** addition of CNTs significantly enhanced the mechanical properties of resulted PLA/HA,in which the 1.5 wt.%CNTs/PLA/HA composite scaffold demonstrated the optimum mechanical behaviors with the bending elastic modulus of(868.5±12.34)MPa,the tensile elastic modulus of(209.51±12.73)MPa,and the tensile strength of(3.26±0.61)***,L929 cells on the 1.5 wt.%CNTs/PLA/HA scaffold displayed good spreading performance and favorable ***,it is expected that the 1.5 wt.%CNTs/PLA/HA scaffold has potential applications in bone tissue engineering.

关键词： CNTs/PLA/HA scaffold TIPS method mechanical property bone tissue engineering

Tubing Dimension Optimization for the Development of an Offshore Gasfield

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Fluid Dynamics & Materials Processing 2023年第2期19卷 315-327页

作者： Donglei Jiang Heng wang Huan Diao Tan Xiao Yi Yu Chunmin Zeng Rui Zhang Qi Huang mingbo wang Zhanjiang Branch Company CNOOCZhanjiang524057China School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580China

L1 is one of the largest offshore gas fields currently under *** order to optimize the related design,nodal analysis is applied(including proper consideration of the plant productivity,sensitivity to the tubing size,erosion effects,liquid carrying performance,and tubing string).As a result of such approach,it is shown that 13Cr material should be chosen as the appropriate tubing ***,3-1/2 inches 9.3 lb/ft N80 tubing,4-1/2 inches 12.75 lb/ft N80 tubing,5-1/2 inches 17 lb/ft N80 tubing should be used for a gas production rate under 80×10^(4)m^(3)/d,between 80×10^(4)m^(3)/d and 120×10^(4)m^(3)/d and above 120×10^(4)m^(3)/d,respectively.

关键词： Offshore gas field tubing selection nodal analysis tubing erosion prediction

A case report of a patient with first phenotype of papillary thyroid carcinoma and heterochronous multiprimary tumor harboring germline MUTYH Arg19*/Gly286Glu mutations

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A case report of a patient with first phenotype of papillary...

Systematic analysis of DNA polymerases as therapeutic targets in pan-cancers

2022CCTB中国肿瘤标志物学术大会暨中国整合肿瘤学大会暨第十六届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者： mingbo wang Dong’e County People’s Hospital

MUTYH-associated polyposis(MAP) is an autosomal recessively inherited disease with multiple system tumors mainly in alimentary *** occurrence of MAP patients is highly heterogeneous in space and *** is associated with germline biallelic mutations in *** targeted next-generation sequencing technology and Sanger sequencing are the important methods to screen MUTYH mutations ***,we identified a patient with heterochronous multiprimary tumor carring MUYTH Arg19*/Gly286Glu compound heterozygous *** patient in this case had a first phenotype of thyroid cancer at age 44,which earlier 2 years than the alimentary system *** conclusion,our case report creases the in-depth understanding of the MAP heterogeneous phenotype and further reminds recommendations for improvement of health management and genetic counseling,special treatment plans.

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BIOCELL 2024年第1期48卷 123-138页

作者： ZHENHUA LI HUILAI LV FAN ZHANG ZIMING ZHU QIANG GUO mingbo wang CHAO HUANG LIJUAN CHEN WENPAN ZHANG YUN LI ZIQIANG TIAN Department of Thoracic Surgery Fourth Hospital of Hebei Medical UniversityShijiazhuang050011China Department of Thoracic Surgery The First Hospital of XingtaiXingtai054001China Department of Thoracic Surgery Affiliated Hospital of Hebei UniversityBaoding050017China Shanghai OrigiMed Co. Ltd.Shanghai200000China Department of Thoracic Surgery The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China

Introduction:DNA polymerases are crucial for maintaining genome stability and influencing ***,the clinical implications of DNA polymerases in tumorigenesis and their potential as anti-cancer therapy targets are not well ***:We conducted a systematic analysis using TCGA Pan-Cancer Atlas data and Gene Set Cancer Analysis results to examine the expression profiles of 15 DNA polymerases(POLYs)and their clinical *** also evaluated the prognostic value of POLYs by analyzing their expression levels in relation to overall survival time(OS)using Kaplan-Meier survival ***,we investigated the correlations between POLY expression and immune cells,DNA damage repair(DDR)pathways,and *** sensitivity analysis was performed to assess the relationship between POLY expression and drug ***:Our analysis revealed that 14 out of 15 POLYs exhibited significantly distinct expression patterns between tumor and normal samples across most cancer types,except for DNA nucleotidylexotransferase(DNTT).Specifically,POLD1 and POLE showed elevated expression in almost all cancers,while POLQ exhibited high expression levels in all cancer *** POLYs showed heightened expression in specific cancer subtypes,while others exhibited low ***-Meier survival curves demonstrated significant prognostic value of POLYs in multiple cancers,including PAAD,KIRC,and *** analysis further validated these *** patterns of POLYs varied significantly among different cancer types and were associated with poorer survival *** correlations were observed between the expression of POLY members and immune cells,DDR pathways,and *** sensitivity analysis indicated an inverse relationship between POLY expression and drug ***:Our comprehensive study highlights the significant role of POLYs in cancer development and identifies them as promising prognostic and

关键词： DNA polymerases(POLYs) Prognostic biomarker The Cancer Genome Atlas(TCGA) Ubiquitination network

Prediction of candidate small non-coding RNAs inAgrobacterium by computational analysis

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The Journal of Biomedical Research 2010年第1期24卷 33-42页

作者： Tingting Zhao Ren Zhang mingbo wang The Laboratory Center for Basic Medical Sciences Nanjing Medical University Nanjing 210029 Jiangsu Province China Department of Btologtcal Sciences University of Wollongong Wollongong NSW 2522 Australia CSIRO Plant Industry Canberra ACT2602 Australia

Small non-coding RNAs with important regulatory roles are not confined to eukaryotes. Recent work has uncovered a growing number of bacterial small RNAs （sRNAs）, some of which have been shown to regulate critical cellular processes. Computational approaches, in combination with molecular experiments, have played an important role in the identification of these sRNAs. At present, there is no information on the presence of small non-coding RNAs and their genes in the Agrobacterium tumefaciens genome. To identify potential sRNAs in this important bacterium, deep sequencing of the short RNA populations isolated from Agrobacterium tumefaciens C58 was carried out. From a data set of more than 10,000 short sequences, 16 candidate sRNAs have been tentatively identified based on computational analysis. All of these candidates can form stem-loop structures by RNA folding predictions and the majority of the secondary structures are rich in GC base-pairs：：Some are followed by a short stretch of U residues, indicative of a rho-independent transcription terminator, whereas some of the short RNAs are found in the stem region of the hairpin, indicative of eukaryotic-like sRNAs. Experimental strategies will need to be used to verify these candidates. The study of an expanded list of candidate sRNAs in Agrobacterium will allow a more complete understanding of the range of roles played by regulatory RNAs in prokaryotes.

关键词： small non-coding RNAs small RNAs Agrobacterium turnefaciens genome solexa sequencing technology

Study on Emergency Management Mechanism of Public Health Emergencies

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Meteorological and Environmental Research 2021年第2期12卷 34-37页

作者： Jinping GONG Haolin WAN Kaitai GENG mingbo wang Institute of NBC Defence Beijing 102205China

The outbreak of SARS in 2003 opened the way of public health emergency management in ***-19 which suddenly outbroke in 2019 is still raging all over the world,and emergency management mechanism of China is being *** to improve the emergency management mechanism can provide effective institutional guarantee for the overall victory of anti epidemic and the prevention and control of public health emergencies.

关键词： Public health emergencies Emergency management mechanism Voluntary reporting mechanism

不同离散格式在湍流旋流流动数值模拟中的应用

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中国机械工程 2007年第5期18卷 600-603页

作者：王明波王瑞和中国石油大学(华东) 东营257061

针对石油工业中径向水平井钻进技术的需要,采用RNGk-ε模型,应用二阶上风格式、QUICK格式和MUSCL格式对带有螺旋导叶的径向水平井锥形喷嘴外湍流旋流流动进行了模拟研究,以此来评价离散格式对湍流旋流流动数值模拟结果的影响。结果表明... 详细信息

针对石油工业中径向水平井钻进技术的需要,采用RNGk-ε模型,应用二阶上风格式、QUICK格式和MUSCL格式对带有螺旋导叶的径向水平井锥形喷嘴外湍流旋流流动进行了模拟研究,以此来评价离散格式对湍流旋流流动数值模拟结果的影响。结果表明:当计算结果满足网格无关性时,离散格式对时均速度场模拟结果的影响很小;采用二阶上风格式可以在保持计算绝对稳定的情况下获得QUICK格式和MUSCL格式的计算精度。要进一步改善模拟结果与实验数据间吻合的程度,需要采用基于各向异性假设基础上的湍流模型,如代数应力模型、雷诺应力模型等。

关键词：离散格式湍流旋流流动数值模拟 RNGk-ε湍流模型

学习马克思主义理论的原则和方法——读新中国成立前后刘少奇在马列学院的几篇讲话

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党的文献 2019年第6期 84-90页

作者：王明波中共广西壮族自治区委党校

在担任马列学院院长期间,刘少奇亲临马列学院几期班次的开学和毕业活动并作出一系列讲话。这些讲话集中阐述了学习马克思主义理论的原则和方法。他主张,学习马克思主义理论,要坚持既反对教条主义,又反对经验主义,用马克思主义去指导实践... 详细信息

在担任马列学院院长期间,刘少奇亲临马列学院几期班次的开学和毕业活动并作出一系列讲话。这些讲话集中阐述了学习马克思主义理论的原则和方法。他主张,学习马克思主义理论,要坚持既反对教条主义,又反对经验主义,用马克思主义去指导实践;坚持学习马克思主义理论"精"与"博"相统一,要"博"也要"精";坚持理论联系实际,学以致用、知行合一;坚持学习与宣传教育工作相结合,重点培养党员领导干部写文章的能力;坚持理论学习与改造思想作风相兼顾,整顿思想,加强修养。

关键词：刘少奇马克思主义理论学习马列学院宣传教育思想作风

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刍议建设项目全咨管理中的总控管理

建筑经济 2023年第3期44卷 18-23页

作者：王明波恒泰智晟项目管理咨询有限公司山东潍坊261041

相较于传统工程咨询,全过程工程咨询最突出的特点之一就是它具有整体性、综合性、一体化特点,而上述特点在很大程度上有赖于总控管理发挥作用。在分析总控管理应有功能的基础上,就总控管理的作用,工作职责和重点,总控管理如何有效落实... 详细信息

相较于传统工程咨询,全过程工程咨询最突出的特点之一就是它具有整体性、综合性、一体化特点,而上述特点在很大程度上有赖于总控管理发挥作用。在分析总控管理应有功能的基础上,就总控管理的作用,工作职责和重点,总控管理如何有效落实等展开讨论,以期为相关同业开展全过程工程咨询和进行全咨项目的总控管理提供参考。

关键词：全过程工程咨询总控管理综合性一体化