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Current advances in the application of proteomics in apoptosis research

Science china(Life Sciences) 2011年第3期54卷 209-219页

作者： wang lishun & chen guoqiang department of pathophysiology,key laboratory of cell differentiation and apoptosis of ministry of education of china E-Institutes of Shanghai Municipal education Commission Chemical Biology Division,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,china department of pathophysiology Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China E-Institutes of Shanghai Municipal education Commission Chemical Biology Division Shanghai Jiao Tong University School of Medicine Shanghai China

apoptosis,or programmed cell death,is a complex,genetically-determined process involved in the development and maintenance of homeostasis in multicellular *** of apoptosis has been implicated in a number of diseases,including cancer and autoimmune ***,the investigation of apoptotic regulation has evoked considerable *** apoptotic proteins have been shown to be post-translationally modulated,such as by protein cleavage,translocation,protein-protein interaction,and various post-translational modifications,which fall precisely within the range of proteomic ***,contemporary proteomic technologies have achieved significant advances and have accelerated research in functional and chemical proteomics,which have been applied to the field of apoptosis research and have the potential to be a driving force for the *** review highlights some of the major achievements in the application of proteomics in apoptosis research and discusses new directions and challenges for the near future.

关键词： apoptosis proteomics small compound oncogene tumor suppressor

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Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B),a novel caspase-3 substrate,exerts anti-apoptotic effects on acute myeloid leukemic cells

Acidic leucine-rich nuclear phosphoprotein 32 family member ...

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2008年中国病理生理学会第十一届肿瘤和第十二届免疫专业委员会学术会议

作者： Yun Yu Shaoming Shen lishun wang guoqiang chen~(1*) 1 department of pathophysiology,key laboratory of cell differentiation and apoptosis of National ministry of education,Rui-Jin Hospital,Shanghai Jiao-Tong University School of Medicine,Shanghai 200025,china,

The acidic leucine-rich nuclear phosphoprotein 32B (ANP32B,also called APRIL) is a member of a conserved superfamily of nuclear proteins that includes ANP32A/pp32,a factor that binds histones and inhibits their acetyl... 详细信息

关键词： ANP32B apoptosis caspase-3

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Acidic Leucine-rich Nuclear Phosphoprotein 32 Family Member B(ANP32B),Contributes to Retinoic Acid-induced differentiation of Leukemic cells

Acidic Leucine-rich Nuclear Phosphoprotein 32 Family Member ...

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中国病理生理学会受体、肿瘤和免疫专业委员会联合学术会议

作者： Yun Yu,~1 Shaoming Shen,~2 lishun wang,~1 guoqiang chen~(1*) department of pathophysiology,key laboratory of cell differentiation and apoptosis of National ministry of education,Rui-Jin Hospital,Shanghai Jiao-Tong University School of Medicine

The acidic leucine-rich nuclear phosphoprotein 32B(ANP32B) is a member of a conserved superfamily of nuclear proteins that includes ANP32A/pp32,a factor that binds histones and inhibits their acetylation and regulates cell growth and differentiation in a tissue-specific *** this work,we provide the first demonstration that ANP32B expression is down-regulated during differentiation induction of leukemic cells by all-trans retinoic acid(ATRA).The ectopic expression of ANP32B partially inhibits ATRA-induced leukemic U937 cells differentiation,while knock-down of ANP32B expression by specific small interfering RNA enhances ATRA-induced differentiation to a degree,proposing the role of ANP32B in leukemic cell ***,ANP32B partially inhibits the transcriptional activity of retinoic acid receptor(RARα).Although the exact mechanism how ANP32B regulates the cellular event remains unresolved,our results suggest that ANP32B plays the antagonistic role regarding leukemic cells *** data will shed new insights into understanding the biological functions of ANP32B protein.

关键词： ANP32B differentiation leukemic cells

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Sumoylation of hypoxia inducible factor-1α and its significance in cancer

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Science china(Life Sciences) 2014年第7期57卷 657-664页

作者： LI Jie XU Ying JIAO HuiKe wang Wei MEI Zhu chen guoqiang department of pathophysiology Chemical Biology Division of Shanghai Universities E-InstitutesKey Laboratory of Cell Differentiation and Apoptosis of Ministry of EducationShanghai Jiao Tong University School of Medicine Institute of Health Sciences Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine

Hypoxia-inducible factor-1(HIF-1)is a key heterodimeric transcription factor for the cellular adaptive response to hypoxia,a common feature of the microenvironment in solid *** transcriptional activity,protein stabilization,protein-protein interactions and cellular localization of HIF-1α,an oxygen-sensitive subunit of HIF-1,are mainly modulated by various post-translational ***,we reported that polycomb chromobox 4(Cbx4)governs the transcriptional activity of HIF-1αby enhancing its sumoylation at K391 and K477,through which Cbx4 potentiates angiogenesis of hepatocellular *** review summarizes the current knowledge of HIF-1α sumoylation and its roles in the pathogenesis of cancer.

关键词： HIF-1α sumoylation cancer

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Polycomb chromobox 4 enhances migration and pulmonary metastasis of hepatocellular carcinoma cell line MHCC97L

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Science china(Life Sciences) 2014年第6期57卷 610-617页

作者： MEI Zhu JIAO HuiKe wang Wei LI Jie chen guoqiang XU Ying department of pathophysiology Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education Ruijin Hospital Shanghai Jiao Tong University School of Medicine Institute of Health Sciences Shanghai Institutes for Biological Sciences of Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine

We recently report that the expression of polycomb chromobox 4(Cbx4)is significantly correlated with the overall survival of a great cohort of hepatocellular carcinoma(HCC)patients and it enhances hypoxia-induced vascular endothelial growth factor(VEGF)expression and angiogenesis in HCC cells through enhancing sumoylation of hypoxia inducible factor-1alpha(HIF-1α).Here we continue to investigate the potential effects of Cbx4 on the migration and metastasis of the metastatic HCC cell line *** results show that Cbx4 overexpression in the cell line increases the in vitro vessel formation of vascular endothelial cells in its SUMO interaction motifs-dependent manner,and promotes the in vitro migration of the cancer cell,which can be effectively abrogated by anti-VEGF *** Cbx4 expression does not impact the in vitro growth of MHCC97L cells,it still promotes the progression and metastasis of orthotopically transplanted tumors in nude *** results further support the role of Cbx4 as a SUMO E3 ligase in the progression and metastasis of HCC.

关键词： polycomb chromobox 4 hepatocellular carcinoma vascular endothelial growth factor metastasis

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