Polycomb chromobox 4 enhances migration and pulmonary metastasis of hepatocellular carcinoma cell line MHCC97L

作     者：MEI Zhu JIAO HuiKe WANG Wei LI Jie CHEN GuoQiang XU Ying 

作者机构：Department of PathophysiologyKey Laboratory of Cell Differentiation and Apoptosis of Ministry of Education Ruijin HospitalShanghai Jiao Tong University School of Medicine Institute of Health SciencesShanghai Institutes for Biological Sciences of Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2014年第57卷第6期

页      面：610-617页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (91213304,31101044) Shanghai Science and Technology Committee (11JC1406800) Shanghai Committee of Education 

主　　题：polycomb chromobox 4 hepatocellular carcinoma vascular endothelial growth factor metastasis 

摘      要：We recently report that the expression of polycomb chromobox 4(Cbx4)is significantly correlated with the overall survival of a great cohort of hepatocellular carcinoma(HCC)patients and it enhances hypoxia-induced vascular endothelial growth factor(VEGF)expression and angiogenesis in HCC cells through enhancing sumoylation of hypoxia inducible factor-1alpha(HIF-1α).Here we continue to investigate the potential effects of Cbx4 on the migration and metastasis of the metastatic HCC cell line *** results show that Cbx4 overexpression in the cell line increases the in vitro vessel formation of vascular endothelial cells in its SUMO interaction motifs-dependent manner,and promotes the in vitro migration of the cancer cell,which can be effectively abrogated by anti-VEGF *** Cbx4 expression does not impact the in vitro growth of MHCC97L cells,it still promotes the progression and metastasis of orthotopically transplanted tumors in nude *** results further support the role of Cbx4 as a SUMO E3 ligase in the progression and metastasis of HCC.