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雅鲁藏布江中游异齿裂腹鱼耳石日轮特征及繁殖期推算

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水生生物学报 2024年第6期48卷 910-919页

作者：赖柏霖顾正选李磊何智高阔蒲勇田琴瑶熊金鑫罗文杰黄俊杰文磷熊旭唐子婷张明旺杨德英严太明四川农业大学动物科技学院成都611130 武汉瑞华中科生态股份有限公司武汉430000 华电西藏能源有限公司大古水电站分公司山南856200 长江上游鱼类资源与环境四川省野外科学观测研究站成都611130

研究以人工孵化的异齿裂腹鱼(Schizothorax o’connori)仔稚鱼为材料,验证了异齿裂腹鱼耳石轮纹沉积规律和第一日轮形成时间,建立了耳石轮纹数与日龄的关系,基于此对采集自雅鲁藏布江干流中游桑日县-加查县段的野生异齿裂腹鱼仔稚鱼的... 详细信息

研究以人工孵化的异齿裂腹鱼(Schizothorax o’connori)仔稚鱼为材料,验证了异齿裂腹鱼耳石轮纹沉积规律和第一日轮形成时间,建立了耳石轮纹数与日龄的关系,基于此对采集自雅鲁藏布江干流中游桑日县-加查县段的野生异齿裂腹鱼仔稚鱼的出膜时间进行了推算,并结合胚胎发育积温推算了亲鱼产卵时间。结果表明:人工养殖实验确定了异齿裂腹鱼孵化有效积温为2062.67℃·h,生物学零度为6.31℃;在水温6.8—8.8℃条件下,50%样本耳石第一轮纹在出膜后第1天形成(理论值为出膜后8.94h,n=439);微耳石和矢耳石轮纹数均与日龄呈线性相关,方程斜率均与1差异不显著(P>0.05),表明两对耳石的轮纹沉积均为日周期性,即仔稚鱼的日轮数为日龄。对野生异齿裂腹鱼仔稚鱼生长过程中耳石形态发育观察发现,微耳石的形态稳定,轮纹清晰,更适宜作为日轮计数材料。依据野生仔稚鱼样本微耳石日轮数,结合采样时间及耳石轮纹沉积规律等,推算出2022年野生仔稚鱼样本的孵化时间为3月11日至5月2日,结合孵化积温与实测平均水温,推算出其产卵时间为2月8日至4月23日。文章为研究异齿裂腹鱼自然种群资源保护与流域水电站生态调度等提供了科学依据。

关键词：耳石日轮技术繁殖期仔稚鱼雅鲁藏布江中游异齿裂腹鱼

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Large area^(3)he tube array detector with modular design for multi‑physics instrument at CSNS

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Nuclear Science and Techniques 2023年第1期34卷 1-12页

作者： lin Zhu jian‑Rong Zhou Yuan‑Guang Xia Liang Xiao Hong Luo Xiao‑Juan Zhou wen‑Qin Yang Bei‑Ju Guan xing‑Fen jiang Yan‑Feng wang Hong xu Hai‑Yun Teng Li‑Xin Zeng jia‑Jie Li lei Hu Ke Zhou Yong‑Xiang Qiu Pei‑xun Shen jun xu Li‑jiang Liao Xiao‑Zhuang wang Gui‑An Yang Huai‑Chan Chen Ju‑Ping xu zhi‑Duo Li Song‑lin wang jian Zhuang Yu‑Bin Zhao jun‑Rong Zhang wen Yin zhi‑jia Sun Yuan‑Bo Chen Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China University of Chinese Academy of Sciences Beijing 100049China

The multi-physics instrument(MPI)is the first user cooperative instrument at the China Spallation Neutron Source(CSNS).It was designed to explore the structures of complex materials at multiple scales based on the neutron total scattering *** imposes the requirements for the detector,including a high detection efficiency to reduce the measurement time and a large solid angle coverage to cover a wide range of momentum *** satisfy these demands,a large-area array of 3he-filled linear position-sensitive detectors(LPSDs)was constructed,each with a diameter of 1 inch and pressure of 20 *** uses an orbicular layout of the detector and an eight-pack module design for the arrangement of 3he LPSDs,covering a range of scattering angles from 3°to 170°with a total detector area of approximately 7 *** detector works in air,which is separated from the vacuum environment to facilitate installation and *** characteristics of the MPI detector were investigated through Monte Carlo(MC)simulations using Geant4 and experimental *** results suggest that the detectors are highly efficient in the wavelength range of the MPI,and an efficiency over 25%is achievable for above 0.1 A neutrons.A minimal position resolution of 6.4 mm full width at half maximum(FWHM)along the tube length was achieved at a working voltage of 2200 V,and a deviation below 2 mm between the real and measured positions was attained in the beam *** detector module exhibited good consistency and an excellent counting rate capacity of up to 80 kHz,which satisfied the requirements of experiments with a high event *** of its operation over the past year have shown that the detector works steadily in sample experiments,which allows the MPI to serve the user program successfully.

关键词： Neutron detector LPSD Position resolution Counting rate capacity

Identification of a delayed leaf greening gene from a mutation of pummelo

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Science China(Life Sciences) 2021年第7期64卷 1165-1173页

作者： Hui-wen Yu zhi-Hao Lu Xia wang Dan Liu jia-Xian he Xiao-lin jiang ling-jun Ke wen-Wu Guo Xiu-Xin Deng qiang xu Key Laboratory of Horticultural Plant Biology(Ministry of Education) Huazhong Agricultural UniversityWuhan 430070China Key Laboratory of Landscape Plants with Fujian and Taiwan Characteristics ofFujian Colleges and Universities Minnan Normal UniversityZhangzhou 363000China

Delayed greening of young leaves is an unusual phenomenon of plants in *** are mostly evergreen tree ***,a natural mutant of“Guanxi”pummelo(Citrus maxima),which shows yellow leaves at the young stage,was characterized to identify the genes underlying the trait of delayed leaf greening in plants.A segregating population with this mutant as the seed parent and a normal genotype as the pollen parent was *** DNA pools respectively from the leaves of segregating seedlings with extreme phenotypes of normal leaf greening and delayed leaf greening were collected for *** segregant analysis(BSA)and In Del marker analysis demonstrated that the delayed leaf greening trait is governed by a 0.3 Mb candidate region on chromosome *** expression analysis further identified a key candidate gene(Citrus Delayed Greening gene 1,CDG1)in the 0.3 Mb region,which showed significantly differential expression between the genotypes with delayed and normal leaf greening *** was a 67 bp In Del region difference in the CDG1 promoter and the In Del region contains a TATA-box *** laser-scanning microscopy revealed that the CDG1-GFP fusion protein signals were co-localized with the chloroplast signals in the *** of CDG1 in tobacco and Arabidopsis led to the phenotype of delayed leaf *** results suggest that the CDG1 gene is involved in controlling the delayed leaf greening phenotype with important functions in chloroplast development.

关键词： citrus pummelo delayed leaf greening chlorophyll

基于白光中子源的^(197)Au中子辐射俘获截面测量及共振参数分析

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物理学报 2024年第7期73卷 104-113页

作者：罗淏天张奇玮栾广源王晓宇邹翀任杰阮锡超贺国珠鲍杰孙琪黄翰雄王朝辉吴鸿毅顾旻皓余滔解立坤陈永浩安琪白怀勇鲍煜曹平陈昊磊陈琪萍陈裕凯陈朕崔增琪樊瑞睿封常青高可庆韩长材韩子杰何泳成洪杨黄蔚玲黄锡汝季筱璐吉旭阳蒋伟江浩雨姜智杰敬罕涛康玲康明涛李波李超李嘉雯李论李强李晓李样刘荣刘树彬刘星言穆奇丽宁常军齐斌斌任智洲宋英鹏宋朝晖孙虹孙康孙晓阳孙志嘉谭志新唐洪庆唐靖宇唐新懿田斌斌王丽娇王鹏程王琦王涛峰文杰温中伟吴青彪吴晓光吴煊羊奕伟易晗于莉于永积张国辉张林浩张显鹏张玉亮张志永赵豫斌周路平周祖英朱丹阳朱科军朱鹏朱兴华中国原子能科学研究院核数据重点实验室北京102413 中国科学院高能物理研究所北京100049 散裂中子源科学中心东莞523803 核探测与核电子学国家重点实验室北京100049 中国科学技术大学近代物理系核探测与核电子学国家重点实验室合肥230026 北京大学物理学院核物理与核技术国家重点实验室北京100871 中国工程物理研究院核物理与化学研究所绵阳621900 西北核技术研究院西安710024 中国科学院大学北京100049 中国科学技术大学工程与应用物理系合肥230026 北京航空航天大学物理学院北京100083 华能山东石岛湾核电有限公司荣成264312

中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2)探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室... 详细信息

中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2)探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室建立了伽马全吸收装置(Gamma total absorption facility,GTAF),该装置用28块六棱BaF_(2)晶体和12块五棱BaF_(2)晶体构成了外径25 cm,内径10 cm的球壳,覆盖了95.2%的立体角.利用GTAF在中国散裂中子源Back-n束线上,测量了197Au(n,γ)的反应截面数据.测量数据通过能量筛选、PSD方法、晶体多重性筛选进行了初步本底扣除,随后结合对^(nat)C及空样品的测量数据对本底进行了分析及扣除,获得了197Au俘获反应的产额,利用SAMMY程序拟合得到了^(197)Au在1—100 e V的共振能量、中子共振宽度和伽马共振宽度参数.实验测量结果与ENDF/B-VIII.0数据库符合良好,其共振参数存在一定差异,分析原因可能与GTAF能量分辨率、Back-n的中子能谱测量精度、以及实验本底扣除方法相关,这也是下一步工作的重点.

关键词：中子辐射俘获截面共振参数白光中子源伽马全吸收装置

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Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

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hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-Yi Su Sun-Bin ling Qiao-Nan Shan xu-Yong Wei rui wang Chang-Ku jia Li Zhuang Tian Shen Li-Min Ding zhi-Dan xu Lai-Bang Luo Li-Bo Sun Guang-Ming Li Tai-Shi Fang Nan jiang kun Zhang Zhao-Jie Su zhi-Hai Peng Ren Lang Tao jiang qiang he lin-Sen Ye Yang Yang Yu-Ting he wen-zhi Guo Liu-Gen Lan xu-Yong Sun Dong Chen zhi-Shui Chen Da-Wei Zhou Shao-jun Ye Qi-Fa Ye Min Tian jian-Hua Shi Bo wang jiang Liu Qian Lu Wei Rao Jin-Zhen Cai Tao Lv jia-Yin Yang Pu-Sen wang lin Zhong Jing-Sheng Ma Qi-Gen Li Sheng-Dong Wu Chang-jiang Lu Cai-De Lu Dong-Hua Zhang xuan wang Zi-qiang Li Mu-jian Teng jun-Jie Li wen-Tao jiang jian-Hua Li Quan-Bao Zhang Ning-Qi Zhu Zheng-Xin wang Kang he qiang Xia Shao-Hua Song zhi-Ren Fu Wei Qiu Guo-Yue Lv rui-Peng Song Ji-Zhou wang Zheng wang jian Zhou Gang Chen Ying-Peng Zhao Li Li Ze-Min Hu Qi-Jie Luo Zhong-Zhou Si Bin Xie Xiao-Shun he zhi-Yong Guo Shu-Sen Zheng Xiao xu Department of hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China Liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of hepatic Surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of General Surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of hepatic Surgery and Liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of hepatobiliary Surgery The First Affiliated Hos

Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents hepatocellular carcinoma Liver transplantation Conversion

Overproduction of OsRACK1A,an effector-targeted scaffold protein promoting OsRBOHB-mediated ROS production,confers rice floral resistance to false smut disease without yield penalty

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Molecular Plant 2022年第11期15卷 1790-1806页

作者： Guo-Bang Li jia-xue he Jin-Long Wu he wang Xin Zhang Jie Liu Xiao-Hong Hu Yong Zhu Shuai Shen Yi-Fei Bai Zong-lin Yao Xin-Xian Liu Jing-Hao Zhao De-qiang Li Yan Li Fu Huang Yan-Yan Huang zhi-xue Zhao Ji-Wei Zhang Shi-Xin Zhou Yun-Peng Ji Mei Pu Peng Qin Shigui Li xuewei Chen Jing wang Min he Weitao Li Xian-jun Wu Zheng-jun xu wen-Ming wang Jing Fan State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural UniversityChengdu 611130China Rice Research Institute Sichuan Agricultural UniversityChengdu 611130China

Grain formation is fundamental for crop yield but is vulnerable to abiotic and biotic *** grain production is threatened by the false smut fungus Ustilaginoidea virens,which specifically infects rice floral organs,disrupting fertilization and seed ***,little is known about the molecular mechanisms of the ***-rice interaction and the genetic basis of floral ***,we report that *** secretes a cytoplasmic effector,UvCBP1,to facilitate infection of rice ***,UvCBP1 interacts with the rice scaffold protein OsRACK1A and competes its interaction with the reduced nicotinamide adenine dinucleotide phosphate oxidase OsRBOHB,leading to inhibition of reactive oxygen species(ROS)*** the analysis of natural variation revealed no OsRACK1A variants that could avoid being targeted by UvCBP1,expression levels of OsRACK1A are correlated with field resistance against *** in rice *** of OsRACK1A restores the OsRACK1A-OsRBOHB association and promotes OsRBOHB phosphorylation to enhance ROS production,conferring rice floral resistance to *** without yield *** together,our findings reveal a new pathogenic mechanism mediated by an essential effector from a flower-specific pathogen and provide a valuable genetic resource for balancing disease resistance and crop yield.

关键词： rice flower false smut fungal effector scaffold protein reactive oxygen species disease resistance

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu Yang Guo-wen Yin Bin-Yan Zhong jun-Hui Sun zhi-Cheng Jin jian-jian Chen Nai-jian Ge wen-Bin Ding wen-Hui Li Jin-Hua Huang Wei Mu Shan-zhi Gu jia-Ping Li Hui Zhao Shu-Wei wen Yan-Ming lei Yu-Sheng Song Chun-wang Yuan Wei-Dong wang Ming Huang Wei Zhao jian-Bing Wu Song wang xu Zhu jian-jun Han Wei-Xin Ren Zai-Ming Lu wen-Ge xing Yong Fan Hai-Lan lin Zi-Shu Zhang Guo-Hui xu wen-Hao Hu qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen xu-Ya Zhao Zhu-Ting Fang Qi wang Jin-Wei Zhao Ai-Bing xu jian xu Qing-Hua Wu Huan-Zhang Niu jian wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi jia-rui Li Guang Yang Hai-Bin Shi jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China Department of Minimally invasive Intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China Department of Interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China Department of Interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China Department of Interventional Radiology Nantong First People’s HospitalNantong 226001China Department of Interventional Radiology Yancheng Third People’s HospitalYancheng 224008China Department of Minimally Invasive Interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China Department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. Department of Interventional Radiology Hunan Cancer HospitalChangsha 410031China Department of Interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Interventional Radiology The Hospital of Nantong UniversityNantong 226001China Department of Interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China Department of Interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world *** this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May *** primary endpoint was progression-free survival(PFS)according to modified *** secondary outcomes included overall survival(OS),objective response rate(ORR),and *** performed propensity score matching approaches to reduce bias between two *** matching,228 pairs were included with a predominantly advanced disease *** PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;Pherapy groups,*** results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching

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深圳市新生儿脑卒中多中心现况调查

中国当代儿科杂志 2024年第5期26卷 450-455页

作者：时莉秀冯晋兴韦艳芳路欣茹张雨茜杨林颖何胜男陈佩娟韩静陈诚涂惠英余章斌黄进洁曾淑娟陈晚铃刘颖郭燕平毛姣玉李晓东张谦慎谢治利黄梅英晏昆山应尔雅陈俊王艳荣刘亚萍宋波刘华艳肖晓冬唐红王宇娜蔡茵莎龙琦许汉强王会战孙倩韩芳张瑞彪杨传忠窦蕾时会菊王瑞蒋萍无深圳市儿童医院新生儿科广东深圳518034 深圳市宝安区妇幼保健院新生儿科广东深圳518101 深圳市龙岗区妇幼保健院/汕头大学医学院龙岗妇幼临床学院新生儿科广东深圳518172 深圳市人民医院/暨南大学第二临床医学院/南方科技大学第一附属医院新生儿科广东深圳518020 深圳市龙岗中心医院/广州中医药大学深圳临床医学院新生儿科广东深圳518116 北京大学深圳医院新生儿科广东深圳518036 华中科技大学协和深圳医院新生儿科广东深圳518052 香港大学深圳医院新生儿科广东深圳518053 深圳市龙岗区人民医院新生儿科广东深圳518172 深圳市南山区妇幼保健院新生儿科广东深圳518067 深圳市第三人民医院新生儿科广东深圳518112 深圳市龙华区中心医院新生儿科广东深圳518110 深圳市盐田区人民医院新生儿科广东深圳518081 深圳远东妇产医院新生儿科广东深圳518002 深圳市第二人民医院新生儿科广东深圳518025 陆丰市人民医院新生儿科广东陆丰516500 惠阳三和医院新生儿科广东惠州518200 惠州市第三人民医院新生儿科广东惠州516100 深圳市妇幼保健院新生儿科广东深圳518028 南方科技大学医院新生儿科广东深圳518055 深圳市罗湖区人民医院新生儿科广东深圳518005 深圳新生儿数据协作网

目的总结深圳市新生儿脑卒中发病率、临床特征及预后等情况,提高脑卒中新生儿的早期诊治能力。方法由深圳市儿童医院牵头,收集2020年1月—2022年12月深圳新生儿数据协作网组织21家单位收治的新生儿脑卒中36例,分析深圳市新生儿脑卒中发... 详细信息

目的总结深圳市新生儿脑卒中发病率、临床特征及预后等情况,提高脑卒中新生儿的早期诊治能力。方法由深圳市儿童医院牵头,收集2020年1月—2022年12月深圳新生儿数据协作网组织21家单位收治的新生儿脑卒中36例,分析深圳市新生儿脑卒中发病率、临床特征、治疗、预后等情况。结果深圳市21家医院2020、2021、2022年新生儿脑卒中的发病率分别为1/15137、1/6060、1/7704。缺血性脑卒中占75%(27/36),男性患儿占64%(23/36)。86%(31/36)的患儿在生后3d内起病,53%(19/36)以惊厥起病。颅脑影像学结果显示,22例(61%)大脑左侧发生梗死,13例(36%)基底节梗死;12例完成磁共振血管成像检查,9例(75%)累及大脑中动脉。29例患儿完成脑电图检查,21例(72%)出现尖波,10例(34%)出现电发作。不同医院对症支持治疗不同。12例(33%)完善新生儿行为神经测定评分,平均得分(32±4)分。共随访27例患儿12月龄左右的预后情况,44%(12/27)的患儿预后良好。结论新生儿脑卒中主要为缺血性脑卒中,多以惊厥为首发症状,多累及大脑中动脉,脑电图多出现尖波,神经发育评分较低,以对症支持治疗为主,部分患儿预后不良。

关键词：脑卒中多中心研究新生儿

AIWW:a new nutrition-screening tool for the oncologic population

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Science China(Life Sciences) 2023年第8期66卷 1831-1840页

作者： Yi-Zhong Ge Zhen-Ming Fu Qi Zhang Meng-Meng Song Guo-Tian ruan Xi Zhang Xiao-Wei Zhang Xiang-rui Li Kang-Ping Zhang Meng Tang Xiao-Yue Liu Ming Yang Tong Liu Hai-Lun Xie he-Yang Zhang Zi-wen wang Chun-lei Hu Shi-Qi lin rui Zhang Hong-Xia xu Wei Li Chun-Hua Song Ming Liu jun-qiang Chen kun-Hua wang Li Bo Ming-Hua Cong Zeng-Ning Li Zeng-Qin Guo Xiao-Bin wang Bin-Yan wang Benjamin xu Xian-Hui Qin Xi-Ping xu Rocco Barazzoni Qing-Hua Yao Min weng Xian Shen Han-Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group Department of Gastrointestinal Surgery/Department of Clinical Nutrition Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China The Second Affiliated Hospital and Yuying Children’s Hospital of wenzhou Medical University Wenzhou 325000China National Clinical Research Center for Geriatric Diseases Xuanwu HospitalCapital Medical UniversityBeijing 100053China Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing 100038China Key Laboratory of Cancer FSMP for State Market Regulation Beijing 100038China Cancer Center Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Colorectal Surgery Cancer Hospital of University of Chinese Academy of SciencesZhejiang Cancer HospitalHangzhou 310022China Department of Clinical Nutrition Daping HospitalArmy Medical University(Third Military Medical University)Chongqing 400042China Cancer Center of the First Hospital of Jilin University Changchun 130021China Department of Epidemiology College of Public HealthZhengzhou UniversityZhengzhou450001China Department of Colorectal Surgery the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150081China Department of Gastrointestinal Surgery First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Yunnan University Kunming 650091China General Surgery Clinical Medical Center of Yunnan Province Kunming 650032China Affiliated Hospital of Yunnan University Kunming 650091China Comprehensive Oncology Department Cancer HospitalChinese Academy of Medical SciencesBeijing 100021China Department of Clinical Nutrition The First Hospital of Hebei Medical UniversityShijiazhuang 050031China Department of Medical Oncology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhou 350014China Department of Population Family and Reproductive HealthJohns Hopkins University Bloomberg School of Public HealthBaltimore MD 21228USA Shenzhen Evergreen Medical Institute Shenzhen 518052China Department of Epid

Malnutrition is a common comorbidity among patients with ***,no nutrition-screening tool has been recognized in this population.A quick and easy screening tool for nutrition with high sensitivity and easy-to-use is *** on the previous 25 nutrition-screening tools,the Delphi method was made by the members of the Chinese Society of Nutritional Oncology to choose the most useful item from each *** to these results,we built a nutrition-screening tool named age,intake,weight,and walking(AIWW).Malnutrition was defined based on the scored patient-generated subjective global assessment(PG-SGA).Concurrent validity was evaluated using the Kendall tau coefficient and kappa consistency between the malnutrition risks of AIWW,nutritional risk screening 2002(NRS-2002),and malnutrition screening tool(MST).Clinical benefit was calculated by the decision curve analysis(DCA),integrated discrimination improvement(IDI),and continuous net reclassification improvement(c NRI).A total of 11,360 patients(male,n=6,024(53.0%)were included in the final study cohort,and 6,363 patients had malnutrition based on *** on AIWW,NRS-2002,and MST,7,545,3,469,and1,840 patients were at risk of malnutrition,*** sensitivities of AIWW,NRS-2002,and MST risks were 0.910,0.531,and 0.285,and the specificities were 0.768,0.946,and *** Kendall tau coefficients of AIWW,NRS-2002,and MST risks were 0.588,0.501,and 0.326,*** area under the curve of AIWW,NRS-2002,and MST risks were0.785,0.739,and 0.630,*** IDI,c NRI,and DCA showed that AIWW is non-inferior to NRS-2002(IDI:0.002(-0.009,0.013),c NRI:-0.015(-0.049,0.020)).AIWW scores can also predict the survival of patients with *** missed diagnosis rates of AIWW,NRS-2002,and MST were 0.09%,49.0%,and 73.2%,*** showed a better nutritionscreening effect than NRS-2002 and MST for patients with cancer and could be recommended as an alternative nutritionscreening tool

关键词： nutrition-screening AIWW NRS-2002 MST cancer