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Efficacy of quercetin, oleanolic acid, icariin on apoptosis and mitogen-activated protein kinases signaling pathways in hippocampal neurons of Sprague-Dawley rats cultured with high glucose medium

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Journal of Traditional Chinese Medicine 2021年第5期41卷 732-738页

作者： YAN Bin wang jingbo TIAN Guoqing Department of Traditional Chinese Medicine Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijing 100730China

OBJECTIVE:To investigate the effect of quercetin,oleanolic acid,icariin and their compatibility on the apoptosisofhippocampalneuronsof Sprague-Dawley(SD)rats cultured with high glucose medium and the possible ***:The extracts were purchased from China Food and Drug Control Institute and *** was obtained from newborn 24 h SD *** culturing the hippocampus in different medium for 72 h,flow cytometry was used to detect the apoptosis of hippocampal neurons,and Western blot was utilized to test the expressions of p-p38,p38,p-c-Jun N-terminal kinase(JNK)and ***:Compared with the control group(CG),the neuronal apoptosis rate and the ratios of p-p38/p38 and p-JNK/JNK were significantly increased in the high glucose group(GG)(P<0.01);Compared with the GG,the apoptosis rate and the ratios ofp-p38/p38 and p-JNK/JNK were significantly decreased in other drug groups(P<0.01);Compared with the monomer groups respectively,the apoptosis rate and the ratios of p-p38/p38 and p-JNK/JNK in the two-drug groups and the three-drug group all decreased(P<0.01);Compared with the two-drug groups,the neuronal apoptosis rate and the ratio of p-JNK/JNK of the three-drug group decreased(P<0.05).CONCLUSION:Under the condition of high glucose,the quercetin,oleanolic acid and icariin can alleviate the apoptosis of hippocampus neurons,reduce the phosphorylation of p38 and JNK in p38 mitogen-activated protein kinases and JNK signaling *** the efficacy of the three drugs in combination with each other can be strengthened.

关键词： glucose hippocampus quercetin oleanolic acid icariin mitogen-activated protein kinases

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Analysis on First-stage Ignition of n-Heptane at Low Temperatures with a Lumped Skeletal Mechanism

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Chemical Research in Chinese Universities 2022年第6期38卷 1482-1491页

作者： XIAO Jiayu wang jingbo wang Fan LI Xiangyuan College of Chemical Engineering Sichuan UniversityChengdu610065P.R.China Engineering Research Center of Combustion and Cooling for Aerospace Power Ministry of EducationSichuan UniversityChengdu610065P.R.China Institute of Atomic and Molecular Physics Sichuan UniversityChengdu610065P.R.China

Two-stage ignition exists in the low-temperature combustion process of n-heptane and the first-stage ignition also shows a negative temperature coefficient(NTC) phenomenon. To study key reactions and understand chemical principles affecting the first-stage ignition of n-heptane, a lumped skeletal mechanism with 62 species is obtained based on the detailed NUIGMech1.0 mechanism using the directed relation graph method assisted by sensitivity analysis and isomer lumping. The lumped mechanism shows good performance on ignition delay time under wide conditions. The study revealed that the temperature after the first-stage ignition is higher and a larger amount of fuel is consumed at lower initial temperatures. The temperature at the first-stage ignition is relatively insensitive to the initial temperature. Further sensitivity analysis and reaction path analysis carried out based on the lumped mechanism show that the decomposition of RO_(2) to produce alkene and HO_(2) is the most important reaction to inhibit the first-stage ignitions. The chain branching explosion closely related to the first-stage ignition will be terminated when the rate constant for the RO_(2) decomposition is larger than that of the isomerization of RO_(2) to produce QOOH. The NTC behavior as well as other characteristics of the first-stage ignition can be rationalized from the competition between these two reactions.

关键词： Reduced mechanism Lumping of isomer Low-temperature reaction First-stage ignition Negative temperature coefficient(NTC) phenomenon

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Pulsar Survey With the QiTai 110 m Radio Telescope

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Research in Astronomy and Astrophysics 2022年第7期22卷 151-160页

作者： Xie Jintao wang jingbo wang Na Hu Yue Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Radio Astronomy Chinese Academy of SciencesUrumqi 830011China Xinjiang Key Laboratory of Radio Astrophysics Urumqi 830011China

With a collecting area of 9400 m^(2),the Xinjiang QiTai 110 m radio Telescope(QTT) will allow for a significant advance in the search and observation of *** have updated the galactic electron density model,scattering model,spectral distribution,and radial distribution of PSRPOPPY to generate the population of isolate radio pulsars in the *** spiral arm,including the local spiral arm,is considered when generating pulsar *** simulation,we estimate the number of previously undetected radio pulsars that QTT will discover with its possible receivers for different *** the PAF receiver,2200 previously unknown pulsars could be discovered in43 *** 96-beam PAF receiver can produce~10.56 GB of data per second.

关键词： (stars:)pulsars:general Galaxy:structure telescopes

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A Programmable Pre-emphasis Technique with Combined RLC Source Degeneration for High-Speed Serial Link Transmitters

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Chinese Journal of Electronics 2022年第1期31卷 52-58页

作者： wang Tonghui ZOU Jiaxuan QI Huanhuan wang Xi wang jingbo ZHANG Hong School of Microelectronics Xi'an Jiaotong University No.58 Research Institute China Electronic Technology Group Corporation

This paper presents a clock-less programmable pre-emphasis technique realized by a driver with combined resistive-inductive-capacitive source degeneration for high-speed serial link transmitters. The addition of a series inductive-capacitive resonance network expands the bandwidth of the driver without lowering down the pre-emphasis gain. The driver with the proposed preemphasis technique provides adjustable gain from mid-frequency to high-frequency which is controlled by a tunable tail current, offering the capability for the transmitter to adapt to different cable loss from 0 to 6 d B. The driver has been employed in a 2:4 multiplexing and cable driving integrated circuit for 1.65 Gbps high-definitionmultimedia-interface and digital-visual-interface application to drive up to 7 m 24-American-wire-gauge *** in 180 nm Si Ge Bi CMOS technology, the transmitter consumes 68.6 m W for 6 d B pre-emphasis under 3.3 V power supply.

关键词： RLC circuits high-speed serial link transmitters SiGe BiCMOS technology multiplexing equipment BiCMOS integrated circuits driver circuits pre-emphasis gain Ge-Si alloys high-definition-multimedia-interface combined RLC source degeneration series inductive-capacitive resonance network transmitter resistive-inductive-capacitive source degeneration programmable pre-emphasis technique transmitters digital-visual-interface application

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Charging-rate-based Battery Energy Storage System in Wind Farm and Battery Storage Cooperation Bidding Problem

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CSEE Journal of Power and Energy Systems 2022年第3期8卷 659-668页

作者： Zihang Qiu wang Zhang Shuai Lu Chaojie Li jingbo wang Ke Meng Zhaoyang Dong School of Electrical Engineering and Telecommunications UNSWSydneyNew South Wales2032Australia School of Electrical Engineering Southeast UniversityNanjing210096China School of Automation Nanjing University of Science and TechnologyNanjing210000China UNSW Digital Grid Futures Institute SydneyNew South Wales1466Australia

Wind power has been proven to have the ability to participate in the frequency modulation(FM)*** batteries to improve wind power stability can better aid wind farms participating in the FM *** energy storage system(BESS)has a promising future in applying regulation and load management in the power *** regulation services,normally,the regulation power prediction is estimated based on the required maximum regulation capacity;the power needed for the specific regulation service is unknown to the BESS ***,this information is needed in the regulation model when formulating the linearised BESS model with a constraint on the state of charge(SoC).This compromises the accuracy of the model greatly when it is applied for regulation ***,different control strategies can be employed by ***,the current depth of discharge(DoD)based models have difficulties in being used in a linearization *** to the consideration of the control strategy,the model becomes highly nonlinear and cannot be *** this paper,a charging rate(C-rate)based model is introduced,which can consider different control strategies of a BESS for cooperation with wind farms to participate in wind farm estimation error compensation,load management,energy bid,and regulation ***,the limitation of conventional BESS models are listed,and a new C-rate-based model is *** the C-rate-based BESS model is adopted in a wind farm and BESS cooperation ***,experimental studies are carried out,and the DoD model and C-rate model optimization results are compared to prove the rationality of the C-rate model.

关键词： C-rate based battery energy storage system model wind farm estimation error compensation

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Thermodynamics for nonequilibrium solvation and numerical evaluation of solvent reorganization energy

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Science China Chemistry 2008年第12期51卷 1246-1256页

作者： LI XiangYuan wang jingbo MA JianYi FU KeXiang HE FuCheng College of Chemical Engineering Sichuan UniversityChengdu 610065China

This work presents a thermodynamic method for treating nonequilibrium solvation. By imposing an extra electric field onto the nonequilibrium solvation system, a virtual constrained equilibrium state is prepared. In this way, the free energy difference between the real nonequilibrium state and the con-strained equilibrium one is simply the potential energy of the nonequilibrium polarization in the extra electronic field, according to thermodynamics. Further, new expressions of nonequilibrium solvation energy and solvent reorganization energy have been formulated. Analysis shows that the present formulations will give a value of reorganization energy about one half of the traditional Marcus theory in polar solvents, thus the explanation on why the traditional theory tends to overestimate this quantity has been found out. For the purpose of numerical determination of solvent reorganization energy, we have modified Gamess program on the basis of dielectric polarizable continuum model. Applying the procedure to the well-investigated intramolecular electron transfer in biphenyl-androstane-naphthyl and biphenyl-androstane-phenanthryl systems, the numerical results of solvent reorganization energy have been found to be in good agreement with the experimental fittings.

关键词： nonequilibrium solvation constrained equilibrium solvent reorganization energy numerical evaluation

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Puerarin reduces apoptosis in rat hippocampal neurons cultured in high glucose medium by modulating the p38 mitogen activated protein kinase and c-Jun N-terminal kinase signaling pathways

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Journal of Traditional Chinese Medicine 2016年第1期36卷 78-84页

作者： Xu Xiaohan wang jingbo Zhang Hong Tian Guoqing Liu Yuqin Department of Traditional Chinese Medicine Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences Institute of Basic Medical Sciences Chinese Academy of Medical Sciences

OBJECTIVE: To investigate the neuroprotective effect of puerarin on rat hippocampal neurons cultured in high glucose medium, and to examine the role of the p38 mitogen activated protein kinase(p38 MAPK) and c-Jun N-terminal kinase(JNK) signaling pathways in this ***: Primary cultures of hippocampal neurons were prepared from newborn Sprague Dawley rats. Neuron-specific enolase immunocytochemistry was used to identify neurons. The neurons were cultured with normal medium(control group) or with high-glucose medium(high-glucose group),and puerarin(puerarin group), a p38 MAPK inhibitor(SB239063; p38 MAPK inhibitor group) or a JNK inhibitor(SP600125; JNK inhibitor group) were added. After 72 h of treatment, terminal deoxynucleotidyl transferase-mediated d UTP nick end labeling assay was performed to detect apoptosis, and western blotting was used to assess protein levels of p-p38, p38, p-JNK and ***: In the high-glucose group, the neuronal apoptosis rate and the p-p38/p38 and p-JNK/JNK ratios were higher than in the control group. The p38 MAPK and JNK inhibitors prevented this increase in the apoptosis rate. The apoptosis rates in the puerarin group, the p38 MAPK inhibitor group and the JNK inhibitor group were significantly decreased compared with the high-glucose ***, protein levels of p-p38 and p-JNK were significantly reduced, and the p-p38/p38 and p-JNK/JNK ratios were decreased in the puerarin group compared with the high-glucose group. In addition, compared with the high-glucose group,p-p38 levels and the p-p38/p38 ratio were reduced in the p38 MAPK inhibitor group, and p-JNK levels and the p-JNK/JNK ratio were decreased in the JNK inhibitor ***: Puerarin attenuates neuronal apoptosis induced by high glucose by reducing the phosphorylation of p38 and JNK.

关键词： Glucose Hippocampus Puerarin p38mitogen-activated protein kinases JNK mitogen-activated protein kinases

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The Quantum Approximate Algorithm for Solving Traveling Salesman Problem

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Computers, Materials & Continua 2020年第6期63卷 1237-1247页

作者： Yue Ruan Samuel Marsh Xilin Xue Zhihao Liu jingbo wang School of Computer Science and Technology Anhui University of TechnologyMaanshanChina School of Physics University of Western AustraliaPerthAustralia School of Computer Science and Engineering Southeast UniversityNanjingChina

The Quantum Approximate Optimization Algorithm(QAOA)is an algorithmic framework for finding approximate solutions to combinatorial optimization *** consists of interleaved unitary transformations induced by two operators labelled the mixing and problem *** fit this framework,one needs to transform the original problem into a suitable form and embed it into these two *** this paper,for the well-known NP-hard Traveling Salesman Problem(TSP),we encode its constraints into the mixing Hamiltonian rather than the conventional approach of adding penalty terms to the problem ***,we map edges(routes)connecting each pair of cities to qubits,which decreases the search space significantly in comparison to other *** a result,our method can achieve a higher probability for the shortest round-trip route with only half the number of qubits consumed compared to IBM Q’s *** argue the formalization approach presented in this paper would lead to a generalized framework for finding,in the context of QAOA,high-quality approximate solutions to NP optimization problems.

关键词： Quantum approximate optimization algorithm traveling salesman problem NP optimization problems

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Effect of icariin on apoptosis in hippocampal neurons cultured in high glucose

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Journal of Traditional Chinese Medicine 2018年第4期38卷 556-561页

作者： Yan Bin wang jingbo Zhang Hong Tian Guoqing Liu Yuqin Department of Traditional Chinese Medicine Peking Union Medical College HospitalChinese Academy of Medical Sciences Institute of Basic Medical Sciences Chinese Academy of Medical Sciences

OBJECTIVE:To investigate effect of icariin on apoptosis in hippocampal neurons cultured in high glucose,and the possible mechanism behind the ***:Hippocampus was obtained from newborn 24 h Sprague-Dawley rats and then primarily *** hippocampal neurons were divided into normal control group,high glucose group,icariin group,icariin + protein kinase B(Akt) inhibitor group and Akt agonist *** each group was cultured in different conditioned medium for 72 h,we detected the apoptosis of neurons with flow cytometry,and the expression of Akt,p-Akt,B-cell lymphoma-2(Bcl-2) and Bcl-2 associated X protein(Bax) with western ***:Compared with the normal control group,the apoptosis rate of hippocampal neurons increased significantly(P < 0.01),and p-Akt/Aktand Bcl-2/Bax decreased significantly(P < 0.01) in high glucose *** with the high glucose group,the apoptosis rate of hippocampal neurons decreased significantly(P < 0.01),and p-Akt/Akt and Bcl-2/Bax increased significantly(P < 0.05)in icariin group and Akt agonist *** with the icariin + Akt inhibitor group,the apoptosis rate of hippocampal neurons decreased significantly(P < 0.01),and p-Akt/Akt and Bcl-2/Bax increased significantly(P < 0.01) in icariin ***:Icariin could reduce the apoptosis of neurons cultured in high glucose,which may be achieved by increasing the phosphorylation of Akt protein in Akt signal pathway,then increasing the expression of Bcl-2 and inhibiting the expression of Bax.

关键词： Icariin Protein kinase B High glucose Hippocampal neurons Apoptosis

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A Study of 10 Rotating Radio Transients Using Parkes Radio Telescope

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Research in Astronomy and Astrophysics 2024年第4期24卷 114-123页

作者： Xinhui Ren jingbo wang Wenming Yan Jintao Xie Shuangqiang wang Yirong Wen Yong Xia Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Institute of Optoelectronic Technology Lishui UniversityLishui 323000China Xinjiang Key Laboratory of Radio Astrophysics Urumqi 830011China Research Center for Intelligent Computing Platforms Zhejiang LaboratoryHangzhou 311100China

Rotating Radio Transients(RRATs)are a relatively new subclass of pulsars that emit detectable radio bursts *** analyzed 10 RRATs observed using the Parkes telescope,with eight of these observed via the ultra-wide-bandwidth low-frequency(UWL)*** measured the burst rate and produced integrated profiles spanning multiple frequency bands for three *** also conducted a spectral analysis on both integrated pulses and individual pulses of three *** of their integrated pulses follow a simple power law,consistent with the known range of pulsar spectral *** average spectral indices of single pulses are-0.9,-1.2,and-1.0 respectively,which are within the known range of pulsar spectral ***,we find that the spreads of single-pulse spectral indices for these RRATs(ranging from-3.5 to+0.5)are narrower compared to what has been observed in other ***,the average spectral index and scatter of single pulses are both relatively *** the remaining five RRATs observed at the UWL receiver,we also provide the upper limits on fluence and flux *** addition,we obtain the timing solution of PSR *** analysis shows that PSRs J1919+1745,J1709-43,and J1649-4653 are potentially nulling pulsars or weak pulsars with sparse strong pulses.

关键词： (stars:)pulsars:general stars:neutron stars:individual(PSRs J1919+1745.1909+0641,0628+0909)

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