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Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects

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Journal of Nutritional Oncology 2021年第1期6卷 16-32页

作者： Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang wang zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li zeng Ning Li Kun Hua wang jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group department of Nutrition Daping Hospital&Research Institute of SurgeryThird Military Medical UniversityChongqing 400042China department of Epidemiology College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina Cancer Center Renmin Hospital of Wuhan UniversityWuhan 430060HubeiChina Cancer Center of the First Hospital of Jilin university Changchun 130021JilinChina department of Medical Oncology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhou 350014FujianChina department of Gastrointestinal Surgery Cancer Hospital Affiliated to Guangxi Medical UniversityNanning 530021GuangxiChina department of Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080GuangdongChina department of Clinical Nutrition West China Hospital of Sichuan UniversityChengdu 610041SichuanChina department of Gastrointestinal Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin Key Laboratory of Cancer Prevention and TherapyTianjin 300060China department of Nutrition and Metabolism of Oncology Affiliated Provincial Hospital of Anhui Medical UniversityHefei 230031AnhuiChina department of Clinical Nutrition the First Hospital of Hebei Medical UniversityShijiazhuang 050031HebeiChina department of Gastrointestinal Surgery Institute of Gastroenterologythe First Affiliated Hospital of Kunming Medical University 650032KunmingYunnanChina department of Clinical Nutrition the First People's Hospital of KashiKashi 844000XinjiangChina department of Clinical Nutrition Chongqing General HospitalChongqing 400014China department of Colorectal and Anal Surgery Huizhou Municipal Central HospitalHuizhou 516001GuangdongChina department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan 430071HubeiChina department of Oncology Xingtai People’s HospitalHebei Medical UniversityXingtai 054031HebeiChina Harbin Medical university Cancer Hospital Harbin 150085HeilongjiangChina

Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even ***,there is currently no large data available on the prevalence of malnutrition in Chinese cancer *** study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic *** We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)*** of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal *** patients were enrolled from 72 hospitals located in different regions of *** patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)*** cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,*** From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the *** patients included 12,494(52.9%)males and 11,124(47.1%)*** mean age was 55.8±13.7 *** proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,*** the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2

关键词： Nutritional status Nutritional assessment Malnutrition Patient generated subjective global assessment Body mass index Body weight loss Karnofsky Performance Status score Quality of life

采用有区分力的溶出曲线筛选利奥西呱片制备工艺

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国际药学研究杂志 2018年第12期45卷 954-958页

作者：张雨胡齐东李江王增明李蒙苏玉怀张慧胡连栋高静郑爱萍河北大学药学院河北省药物质量分析控制重点实验室保定071002 军事科学院军事医学研究院毒物药物研究所药物制剂研究室抗毒药物与毒理学国家重点实验室北京100850

目的通过比较利奥西呱片在4种介质中的溶出行为,获得具有区分力的溶出曲线,并以此为依据,筛选与原研片性质最为相近的仿制片制备工艺。方法以摇瓶法考察系列缓冲液中利奥西呱的溶解度,用于确定溶出介质的组成;按照国家药品监督管理局药... 详细信息

目的通过比较利奥西呱片在4种介质中的溶出行为,获得具有区分力的溶出曲线,并以此为依据,筛选与原研片性质最为相近的仿制片制备工艺。方法以摇瓶法考察系列缓冲液中利奥西呱的溶解度,用于确定溶出介质的组成;按照国家药品监督管理局药品审评中心颁布的'口服固体制剂溶出指导原则'和美国食品药品监督管理局公布的利奥西呱片溶出条件,测定原研片在不同介质中的溶出行为,获得具有区分力的溶出曲线;以该溶出条件考察不同制备工艺仿制片溶出行为,通过f2因子确定与原研片最相近的制备工艺。结果利奥西呱片在0.05%十二烷基硫酸钠的pH6.8磷酸盐缓冲液、75 r/min条件下的溶出曲线(USP溶出度测试仪Ⅱ)有较好的区分度,3种不同制备工艺A、B、C对应的f2因子分别为25、16、63,表明工艺C与原研片制备工艺最为相似。结论具有区分力的溶出曲线可用于利奥西呱仿制片的制备工艺筛选;3种制备工艺所得片剂溶出行为具有显著差异;流化床一步制粒法所得片剂与原研片体外溶出行为最相似。

关键词：利奥西呱仿制片溶出曲线制备工艺流化床一步制粒

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住院医师岗位胜任力自评结果分析

中华医学教育杂志 2021年第8期41卷 744-748页

作者：曾庆奇王建六刘婧高书春崔月高杰北京大学人民医院继续教育处 100044 北京大学人民医院 100044 北京大学人民医院教育处 100044

目的了解某住院医师规范化培训基地的住院医师对其岗位胜任力的自评情况,为提高培训质量提供参考。方法采用问卷调查方法。2020年10月,以某住院医师规范化培训基地335名住院医师为研究对象,组织其对医师职业素养、教学与科研、团队合作... 详细信息

目的了解某住院医师规范化培训基地的住院医师对其岗位胜任力的自评情况,为提高培训质量提供参考。方法采用问卷调查方法。2020年10月,以某住院医师规范化培训基地335名住院医师为研究对象,组织其对医师职业素养、教学与科研、团队合作、人际沟通、医学知识与终身学习、信息与管理、疾病控制与健康促进、临床技能和医疗服务8个维度的岗位胜任力进行自评。采用Kruskal-Wallis非参数检验比较多组之间总评分和各维度评分的差异,采用Bonferroni秩和检验进行多组间评分的两两比较。结果住院医师岗位胜任力总评分是141.0(28.0)分,其中,医师职业素养和团队合作能力评分(满分15分)相对最高,均为15.0(2.0)分,教学与科研(满分20分)、疾病控制与健康促进能力(满分15分)评分相对较低,分别是17(4.0)分和13(3.0)分。第三年住院医师的岗位胜任力总评分和除医师职业素养之外的7个维度的评分均比第一年住院医师高[总评分:145.5(21.8)分比133.5(31.0)分;如教学与科研能力维度:19.0(4.0)分比16.0(5.0)分],其差异均具有统计学意义(均P<0.05)。在读专业学位硕士研究生、学术学位研究生和专业学位研究生学历的住院医师岗位胜任力总评分[142.0(27.0)分、143.5(24.5)分、136.0(26.5)分]均高于本科学历的住院医师[总评分130.0(37.5)分,其差异均具有统计学意义(均P<0.05)。结论规范化培训能够多方位提升住院医师岗位胜任力,具有研究生培养经历的住院医师岗位胜任力自评分数更高,但各维度的岗位胜任力发展不够均衡,要重视住院医师的教学与科研、疾病控制与健康促进能力的培养。

关键词：住院医师规范化培训岗位胜任力自我评估

坚持人与自然和谐共生，推动生态文明建设——“美丽秦巴”专家笔谈

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自然资源学报 2020年第2期35卷 493-500页

作者：洪增林张洪涛张国伟康绍忠成升魁谷树忠李景源沈镭王艳芬黄锡生杨霜林陕西省地质调查院西安710054 国务皖参事室北京100006 西北大学地质学系西安710069 中国农业大学水利与土木工程学院北京100083 中国科学院地理科学与资源研究所北京100101 国务院发展研究中心资源与环境政策研究所北京100010 中国社会科学院哲学研究所北京100732 中国科学院大学北京100049 重庆大学法学院重庆400044 西安市美术家协会西安710065

建设生态文明是中华民族永续发展的千年大计。为维护全球生态安全,建设美丽中国,为人民创造良好生产生活环境,达到坚持人与自然和谐共生的目标,就必须正确认识自然规律、尊重地球、敬畏地球、规范人类行为;必须树立和践行绿水青山就是... 详细信息

建设生态文明是中华民族永续发展的千年大计。为维护全球生态安全,建设美丽中国,为人民创造良好生产生活环境,达到坚持人与自然和谐共生的目标,就必须正确认识自然规律、尊重地球、敬畏地球、规范人类行为;必须树立和践行绿水青山就是金山银山的理念,坚持节约资源和保护环境的基本国策,像对待生命一样对待生态环境;必须坚持节约优先、保护优先、自然恢复为主的方针,形成节约资源和保护环境的空间格局、产业结构、生产方式和生活方式,还自然以宁静、和谐与美丽。

关键词：生态文明秦巴地区人与自然和谐共生

新型冠状病毒肺炎病区环境及医务人员防护设备表面SARS-CoV-2核酸污染的检测与评价

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北京大学学报（医学版） 2020年第5期52卷 803-808页

作者：袁晓宁孟庆阳沈宁李宇轩梁超崔曼葛庆岗李晓光谭昆陈茜王晶曾晓勇北京大学第三医院医院感染管理科北京100191 北京大学第三医院运动医学研究所北京100191 北京大学第三医院呼吸与危重症医学科北京100191 北京大学第三医院危重医学科北京100191 北京大学第三医院急诊科北京100191 北京大学第三医院感染疾病科北京100191 华中科技大学同济医学院附属同济医院医院感染管理科武汉430030 华中科技大学同济医学院附属同济医院普通外科武汉430030 华中科技大学同济医学院附属同济医院泌尿外科武汉430030

目的:对武汉某定点医院新型冠状病毒肺炎(corona virus disease 2019,COVID-19)病区内的空气、污染区高频接触物体表面及医务人员防护服表面采样,并检测新型冠状病毒(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)核酸... 详细信息

目的:对武汉某定点医院新型冠状病毒肺炎(corona virus disease 2019,COVID-19)病区内的空气、污染区高频接触物体表面及医务人员防护服表面采样,并检测新型冠状病毒(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)核酸,以明确病区内SARS-CoV-2污染程度,指导感染控制,保证医务人员安全。方法:于2020年3月11—19日,使用便携式生物气溶胶采样器WA-15采集病区内清洁区、缓冲区及污染区的空气样本,应用预湿无菌棉签涂抹法采集污染区高频接触物体表面样本和医务人员防护服表面样本(最外层手套表面以及气管切开操作者正压呼吸防护头套和隔离衣表面),采用实时荧光定量PCR方法检测样本中的SARS-CoV-2核酸。隔离医学观察期间对病区内工作过的医务人员行咽拭子SARS-CoV-2核酸检测,血清SARS-CoV-2 IgM、IgG抗体检测及胸部CT扫描明确医务人员COVID-19感染情况。结果:病区内90个清洁区、缓冲区及污染区空气样本,38个污染区高频接触物体表面样本和16个医务人员防护服表面样本,均未检出SARS-CoV-2核酸。137位在病区参与COVID-19救治工作的医务人员咽拭子SARS-CoV-2核酸检查结果均阴性,血清SARS-CoV-2 IgM、IgG抗体均阴性,胸部CT检查均无COVID-19肺部影像学表现。结论:良好的通风条件、严格环境设施消毒、正确的患者生活习惯指导以及医务人员严格手卫生,是减少隔离病房内病毒气溶胶形成、降低气溶胶含量、避免交叉感染的重要保证。面对未完全掌握的按甲类管理的传染病,医务人员按高级别防护是安全的。

关键词：冠状病毒感染肺炎,病毒性疾病传播,传染性卫生人员病人隔离

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门诊和居家患者药物相关问题分类系统的研制

药物不良反应杂志 2021年第3期23卷 120-127页

作者：刘清扬白向荣王可苏甦褚燕琦曾艳唐静沈江华张青霞刘洋杨军王海莲姜德春闫素英首都医科大学宣武医院药学部国家老年疾病临床医学研究中心北京100053

目的建立门诊和居家患者药物相关问题(DRP)分类系统,为医务人员提供对DRP进行标准化记录的工具。方法检索国外数据库,收集现有DRP分类系统并进行遴选。对入选DRP分类系统进行比较分析,并结合我国门诊和居家患者药学服务工作特点进行整合... 详细信息

目的建立门诊和居家患者药物相关问题(DRP)分类系统,为医务人员提供对DRP进行标准化记录的工具。方法检索国外数据库,收集现有DRP分类系统并进行遴选。对入选DRP分类系统进行比较分析,并结合我国门诊和居家患者药学服务工作特点进行整合,形成初始DRP分类系统。制作DRP分类系统专家咨询表,采用德尔菲法进行2轮专家咨询,根据专家意见进行修改和调整,形成终版DRP分类系统。结果经检索获得25个DRP分类系统,遴选出16个DRP分类系统进行整合,形成初始DRP分类系统。初始DRP分类系统的一级结构包含问题状态、问题类型、问题原因、问题干预和干预结果5个部分,每个部分有数量不等的条目,其中问题原因、问题干预和干预结果有数量不等的二级结构条目。第1轮咨询邀请32名专家,回收咨询表30份,回收率94%;第2轮咨询邀请30名专家,回收咨询表30份,回收率100%。经2轮咨询后,专家对一级结构中问题状态、问题类型、问题原因、问题干预和干预结果的认同率分别为100%、90%、83%、83%和97%。对于DRP分类系统中药物治疗适应证、有效性、安全性、经济性和依从性5类问题的评价,除经济性问题专家权威系数为0.79外,其他4类问题的专家权威系数均>0.8。第1、2轮咨询中专家意见协调系数分别为0.386(χ^(2)=995.258,P<0.001)和0.364(χ^(2)=971.232,P<0.001)。结合专家意见进行修改,形成包含一级结构条目5类共38个、二级结构条目3类共90个的终版DRP分类系统。结论初步建立了适合我国国情的门诊和居家患者DRP分类系统,可用作DRP的标准化记录工具。

关键词：药物治疗管理德尔菲技术药物相关副作用和不良反应药学服务分类法

基于PI3K/Akt/mTOR自噬信号通路研究雷公藤多苷片对糖尿病肾病大鼠肾脏损伤的保护作用

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中南药学 2020年第6期18卷 905-909页

作者：何康婧高增平王晓雪李朋梅柳芳北京中医药大学中药学院北京102488 中日友好医院药学部北京100029

目的考察不同剂量雷公藤多苷片对糖尿病肾病大鼠肾脏损伤的保护作用及其作用机制。方法构建糖尿病肾病大鼠模型,给药第8周时,检测比较各组单侧肾指数,肾功能指标(血尿素氮、血肌酐和肌酐清除率),肾脏自噬相关蛋白(LC3B、PI3K、Akt和mTOR... 详细信息

目的考察不同剂量雷公藤多苷片对糖尿病肾病大鼠肾脏损伤的保护作用及其作用机制。方法构建糖尿病肾病大鼠模型,给药第8周时,检测比较各组单侧肾指数,肾功能指标(血尿素氮、血肌酐和肌酐清除率),肾脏自噬相关蛋白(LC3B、PI3K、Akt和mTOR)的表达水平,LAMP1和LC3蛋白的荧光表达,观察肾脏病理切片。结果6.25 mg·kg^-1雷公藤多苷片组可显著降低BUN,提高LC3B蛋白表达,抑制PI3K、Akt和mTOR蛋白表达,增强LAMP1和LC3蛋白荧光表达,促进自噬,发挥肾脏保护作用;当剂量增加到25、50 mg·kg^-1时,Ccr显著降低,PI3K、Akt和mTOR蛋白表达升高,LC3B蛋白表达水平降低,LAMP1和LC3表达减少,表明肾脏功能下降,自噬呈抑制状态。结论6.25 mg·kg^-1雷公藤多苷对糖尿病肾病大鼠肾脏损伤具有保护作用,可能与PI3K/Akt/mTOR自噬信号通路有关。

关键词：雷公藤多苷片糖尿病肾病自噬 PI3K/Akt/mTOR信号通路

Sex differences in the scored Patient-Generated Subjective Global Assessment in 19,528 cancer patients

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Journal of Nutritional Oncology 2023年第1期8卷 38-46页

作者： wang Yan-Li Wu Tian-Tian Fu Zhen-Ming Guo zeng-Qing Lin Yuan Shi Ying-Ying Hu Wen Ba Yi Li Su-Yi Li zeng-Ning wang Kun-Hua Wu jing He Ying Yang Jia-Jun Xie Cong-Hua Zhou Fu-Xiang Song Xin-Xia Chen Gong-Yan Ma Wen-Jun Luo Su-Xia Chen Zi-Hua Cong Ming-Hua Ma Hu Zhou Chun-Ling wang Wei Luo Qi Shi Yong-Mei Qi Yu-Mei Jiang Hai-Ping Guan Wen-Xian Chen Jun-Qiang Chen Jia-Xin Fang Yu Zhou Lan Feng Yong-Dong Tan Rong-Shao Li Tao Ou Jun-Wen Zhao Qing-Chuan Wu Jian-Xiong Lin Xin Yang Liu-Qing Zhang Qi Jia Ping-Ping Li Wei Xu Hong-Xia Shi Han-Ping Song Chun-Hua The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group Chinese Society of Nutritional Oncology department of Epidemiology and Statistics College of Public HealthZhengzhou UniversityZhengzhouHenanChina Cancer Center Renmin Hospital of Wuhan UniversityWuhanHubeiChina department of Medical Oncology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhouFujianChina department of Gastrointestinal Surgery Affiliated Tumor Hospital of Guangxi Medical UniversityNanningGuangxiChina department of Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina department of Clinical Nutrition West China Hospital of Sichuan UniversityChengduSichuanChina department of Gastrointestinal Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin Key Laboratory of Cancer Prevention and TherapyTianjinChina department of Nutrition and Metabolism of Oncology Affiliated Provincial Hospital of Anhui Medical UniversityHefeiAnhuiChina department of Clinical Nutrition The First Hospital of Hebei Medical UniversityShijiazhuangHebeiChina department of Gastrointestinal Surgery Institute of GastroenterologyThe First Affiliated Hospital of Kunming Medical UniversityKunmingYunnanChina Zhongshan Chenxinghai Hospital(Affiliated Zhongshan Chenxinghai Hospital of Guangdong Medical university) ZhongshanGuangdongChina department of Clinical Nutrition The First People's Hospital of KashiKashiXinjiangChina department of Clinical Nutrition Chongqing General HospitalChongqingChina department of Colorectal and Anal Surgery Huizhou Municipal Central HospitalHuizhouGuangdongChina department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhanHubeiChina department of Oncology Xingtai People’s HospitalHebei Medical UniversityXingtaiHebeiChina The First department of the Tumor Hospital of Harbin Medical university HarbinHeilongjiangChina department of Nutrition Guangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdongChina department of Oncology Affiliated

Background:The scored Patient-Generated Subjective Global Assessment(PG-SGA)has been widely used to assess the nutritional status of cancer *** purpose of this study is to compare the differences in PG-SGA scores and the 7 domain scores of the PG-SGA in male and female cancer ***:This study was conducted at 72 hospitals from July 2013 to December 2018,a part of the Investigation on Nutritional Status and its Clinical Outcomes of Common *** PG-SGA was recorded to evaluate the nutritional status of patients.A total of 19,528 patients with 13 common malignancies were included in this *** t test and the χ^(2) test were applied to analyze the sex diferences in the 7 domain *** Cancer Genome Atlas(TCGA)database was used to analyze the expression levels of symptom-related ***:There were significant sex dfferences in the PG-SGA(P=0.032),notably in patients with gastric cancer(male vs female:9.09±4.86 vs 9.58±5.07,P=0.005)and esophageal cancer(9.64±4.90 vs 10.46±4.96,P=0.011)and the average total PG-SGA of female patients was slightly higher than that of male patients(7.64±4.98 vs 7.77±5.14).The differences were mainly related to the weight,eating,symptom,as well as activity and physical function scores in the stratified *** causes of the sex differences were the rates of nausea,vomiting,dry mouth,and other symptoms,in both gastric and esophageal cancer *** of the TCGA database suggested that most of the related genes were sex neutral,except for genes related to dysphagia in gastric cancer(VEGFC was higher in female patients,VEGFA and VEGFB higher in male patients).Conclusions:There are sex differences in the PG-SGA scores in patients with various tumor types(female patients generally had higher scores than male patients),with differences mainly in the weight,eating,symptom,as well as activity and physical function *** sex differences in PG-SGA scores might be due to the differences i

关键词： PG-SGA Sex differences Malnutrition Cancer patients TCGA database

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妊娠合并脑血管病患者临床分析和麻醉处理

国际麻醉学与复苏杂志 2018年第4期39卷 346-350页

作者：曾敏闫婧董佳刘晓媛王联杰彭宇明韩如泉首都医科大学附属北京天坛医院麻醉科 100050

目的分析妊娠合并脑血管病患者的临床特点及麻醉管理经验。方法回顾性分析30例妊娠合并脑血管病患者的临床资料、麻醉管理和治疗转归等。结果妊娠期合并脑血管病患者共30例，其中缺血性脑血管病5例，包括脑梗死3例、静脉窦血栓2例；出... 详细信息

目的分析妊娠合并脑血管病患者的临床特点及麻醉管理经验。方法回顾性分析30例妊娠合并脑血管病患者的临床资料、麻醉管理和治疗转归等。结果妊娠期合并脑血管病患者共30例，其中缺血性脑血管病5例，包括脑梗死3例、静脉窦血栓2例；出血性脑血管病25例，病变类型包括烟雾病4例、子痫前期1例、动脉瘤4例、动静脉畸形13例、海绵状血管瘤3例。剖宫产前神经外科手术治疗5例，剖宫产同期紧急神经外科治疗4例，剖宫产后神经外科手术治疗6例，剖宫产后未进行神经外科处理15例。产科麻醉30例，其中孕中期3例，孕晚期27例（椎管内麻醉16例，全身麻醉11例）。产妇死亡2例，胎儿死亡l例。结论妊娠合并脑血管病的处理，需产科、麻醉科和神经外科密切协作、共同管理。手术时机及麻醉方法的选择需要综合考虑患者神经系统症状、颅内病变类型（血肿大小、部位）、孕龄、胎儿成熟度以及妊娠意愿，权衡利弊，适时终止妊娠并进行神经外科手术处理，改善母胎结局。

关键词：妊娠脑血管病麻醉