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Effects of childhood trauma on aggressive behaviors andhippocampal function:the modulation of COMT haplotypes

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Psychoradiology 2023年第1期3卷 232-241页

作者： Chao wang Linfei Zhu Wenyu Zheng Hanyuzhu Peng jiaojian wang Yue Cui Bing Liu Tianzi Jiang School of Psychology Shenzhen University Shenzhen 518060China State Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunming 650500China Brainnetome Center Chinese Acadery of SciencesBeijing 100190China National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China

Background:Aggression is a commonly hostile behavior linked to the hippocampal *** trauma(CT)exposure has been associated with altered sensitization of the hypothalamic-pituitary-adrenal(HPA)axis and hippocampal volumewhich could increase violent aggressive ***,Catechol-O-methyltransferase(COMT),the major dopamine metabolism enzyme,is impli-cated in stress responsivity,including ***,CT exposure may affect aggression through the effect on the hippocampal function,which might also be modulated by the COMT ***:This study examined whether both CT and haplotypes of COMT moderate hippocampal function and thus affect human aggressive ***:We obtained bilateral hippocampal functional connectivity maps using resting state functional magnetic resonance imag-ing(MRI)*** haplotype estimation was performed using Haploview 4.2 and PHASE *** we constructed a moderated mediation model to study the effect of the CTQ×COMT on aggressive ***:Three major haplotypes were generated from thirteen single nucleotide polymorphisms(SNPs)within the COMT gene and formed three haplotypes corresponding to high,medium,and low enzymatic activity of *** results showed interactive re-lationships between the Childhood Trauma Questionnaire(CTQ)and COMT with respect to the functional connectivity(FC)of the bilateral hippocampus(HIP)-orbital frontal cortex(OFC).Specifically,CT experience predicted lower negative HIP-OFC coupling in the APS and HPS haplotypes corresponding to the medium and high enzymatic activity of COMT,but greater FC in the LPS haplotypes corresponding to the low enzymatic *** also observed a conditional mediation effect of the right HIP-OFC coupling in the link between COMT and aggressive behavior that was moderated by CT ***:These results suggest that CT and COMT have a combined effect on aggressive behavior through hippocampal *** mediation an

关键词： childhood trauma COMT hippocampus aggression

Postpartum depression and major depressive disorder:the same or not?Evidence from resting-state functional MRI

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Psychoradiology 2022年第3期2卷 121-128页

作者： Bochao Cheng Yi Guo Xijian Chen Bin Lv Yi Liao Haibo Qu Xiao Hu Haoxiang Yang Yajing Meng Wei Deng jiaojian wang Department of Radiology West China Second University Hospital of Sichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University) Ministry of EducationChengdu 610041China Department of Gynecology and Obstetrics West China Second University HospitalSichuan UniversityChengdu 610041China Department of Rehabilitation Medicine West China Second University HospitalSichuan UniversityChengdu 610041China Department of Psychiatry West China Hospital of Sichuan UniversityChengdu 610041China Affiliated Mental Health Center&Hangzhou Seventh People’s Hospital Zhejiang University School of MedicineHangzhouZhejiang 310063China State Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunming 650500China Yunnan Key Laboratory of Primate Biomedical Research KunmingYunnan 650500China

Background Although postpartum depression(PPD)and non-peripartum major depressive disorder(MDD)occurring within and outside the postpartum period share many clinical characteristics,whether PPD and MDD are the same or not remains *** The current study was devoted to identify the shared and different neural circuits between PPD and MDD by resting-state functionalmagnetic resonance imaging data from 77 participants(22 first-episodic drug-naleMDD,26 drug-nale PPD,and 29 healthy controls(HC)).Results Both the PPD andMDD groups exhibited higher fractional amplitude of low-frequency fluctuation(fALFF)in left temporal pole relative to the HC group;the MDD group showed specifically increased degree centrality in the right cerebellum while PPD showed specifically decreased fALFF in the left supplementary motor area and posterior middle temporal gyrus(pMTG_L),and specifically decreased functional connectivities between pMTG and precuneus and between left subgeneual anterior cingulate cortex(sgACC_L)and right ***,sgACC and left thalamus showed abnormal regional homogeneity of functional activities between any pair of HC,MDD,and *** These results provide initial evidence that PPD and MDD have common and distinct neural circuits,which may facilitate understanding the neurophysiological basis and precision treatment for PPD.

关键词： postpartum depression major depressive disorder resting-state fMRI functional activity functional connectivity

Functional connectivity analyses of individual hippocampal subregions in major depressive disorder with electroconvulsive therapy

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Psychoradiology 2024年第1期4卷 210-217页

作者： Hui Sun Dundi Xu Qinyao Sun Tongjian Bai Kai wang jiaojian wang Jiang Zhang Yanghua Tian College of Electrical Engineering Sichuan UniversityChengdu 610065China School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu 625014China Department of Neurology the First Hospital of Anhui Medical UniversityHefei 230022China School of Mental Health and Psychological Sciences Anhui Medical UniversityHefei 230022China State Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunming 650500China Yunnan Key Laboratory of Primate Biomedical Research Kunming 650500China

Background The hippocampus has been widely reported to be involved in the neuropathology of major depressive disorder(MDD).All the previous researches adopted group-level hippocampus subregions atlas to investigate abnormal functional connectivities in MDD in absence of capturing individual *** addition,the molecular basis of functional impairments of hippocampal subregions in MDD remains *** We aimed to reveal functional disruptions and recovery of individual hippocampal subregions in MDD patients before and after ECT and linked these functional connectivity differences to transcriptomic profiles to reveal molecular *** we used group guided individual functional parcellation approach to define individual subregions of hippocampus for each ***-state functional connectivity(FC)analysis of individual hippocampal subregions was conducted to investigate functional disruptions and recovery in MDD patients before and after *** association between functional connectivity differences and transcriptomic profiles was employed to reveal molecular *** MDD patients showed increased FCs of the left tail part of hippocampus with dorsolateral prefrontal cortex and middle temporal gyrus while decreased FC with primary visual *** abnormal FCs in MDD patients were normalized after *** addition,we found that functional disruptions of the left tail part of hippocampus in MDD were mainly related to synaptic signaling and transmission,ion transport,cell-cell signaling and *** Our findings provide initial evidence for functional connectome disruption of individual hippocampal subregions and their molecular basis in MDD.

关键词： hippocampus major depressive disorder individual parcellation electroconvulsive therapy gene expression

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振动技术在金属铸造成形过程中的应用与研究

铸造技术 2018年第10期39卷 2240-2243页

作者：王成军崔骄建安徽理工大学机械工程学院安徽淮南232001

综述了振动技术在铸造成形中的研究现状。介绍了振动方式与设备的分类、金属铸造成形过程中金属液的振动处理应用、振动充型与振动凝固技术的应用,以及振动在铸件时效处理中的应用。讨论了金属铸造成形过程中机械振动与超声波振动对铸... 详细信息

综述了振动技术在铸造成形中的研究现状。介绍了振动方式与设备的分类、金属铸造成形过程中金属液的振动处理应用、振动充型与振动凝固技术的应用,以及振动在铸件时效处理中的应用。讨论了金属铸造成形过程中机械振动与超声波振动对铸件微观组织的改善、细化晶粒及力学性能优化等方面影响的机理,总结了不同振动工艺参数对铸件性能影响的规律。

关键词：铸造成形振动充型振动凝固振动时效细化晶粒

食用农产品检验检测的质量控制及细节问题分析

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食品安全导刊 2023年第1期 70-72页

作者：马敏娟李艳芬王焦健杨迪云南省红河州农产品质量安全检验检测中心云南红河661199

食用农产品检验检测是一项关乎国计民生的工作,控制食用农产品检验检测质量尤为重要,能够及时地发现、处理“问题”农产品,避免其流入市场和餐桌,保证公共卫生安全和消费者健康,杜绝食品卫生安全事故的发生。基于此,本文概述了食用农产... 详细信息

食用农产品检验检测是一项关乎国计民生的工作,控制食用农产品检验检测质量尤为重要,能够及时地发现、处理“问题”农产品,避免其流入市场和餐桌,保证公共卫生安全和消费者健康,杜绝食品卫生安全事故的发生。基于此,本文概述了食用农产品检验检测的必要性,分析了食用农产品检验检测质量控制及细节问题,并探讨提升食用农产品检验检测水平的对策。

关键词：食用农产品检验检测质量控制细节问题

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基于沉浸式VR技术的下肢运动训练对脑卒中患者下肢功能的临床疗效

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温州医科大学学报 2024年第4期54卷 312-317页

作者：朱美丽徐华静温丽娜王娇健蒋松鹤温州医科大学附属第二医院育英儿童医院康复医学中心浙江温州325027 永康市第一人民医院康复医学科浙江金华321300

目的:探讨沉浸式虚拟现实技术(VR)结合下肢运动训练对脑卒中患者下肢功能的临床疗效及生活质量的影响。方法:选取2022年12月至2023年11月在永康市第一人民医院康复医学科接受住院康复治疗的初发脑卒中患者为研究对象,将符合纳入标准的6... 详细信息

目的:探讨沉浸式虚拟现实技术(VR)结合下肢运动训练对脑卒中患者下肢功能的临床疗效及生活质量的影响。方法:选取2022年12月至2023年11月在永康市第一人民医院康复医学科接受住院康复治疗的初发脑卒中患者为研究对象,将符合纳入标准的60例患者按照随机数字表法分为对照组和VR组,每组30例。两组患者均接受常规药物和康复治疗,对照组在此基础上增加下肢运动训练,VR组在下肢运动训练时结合VR康复训练。每天训练20 min,每周5次,共3周。通过下肢Fugl-Meyer运动功能量表(FMA-LE)、功能性步行分级(FAC)、Berg平衡量表(BBS)、Barthel指数(BI),来评估两组患者治疗前后的下肢功能和生活能力变化。结果:治疗前,两组患者基线值及量表评分比较差异无统计学意义(P>0.05),训练3周后,两组患者FMA-LE、FAC、BBS及BI评分较组内治疗前均显著改善,差异有统计学意义(P<0.05)。治疗结束后,VR组FMA-LE、FAC、BBS及BI评分均显著优于对照组,差异均有统计学意义(P<0.05)。结论:结合沉浸式VR技术的下肢运动训练能明显改善脑卒中偏瘫患者的下肢功能和生活质量。

关键词：沉浸式虚拟现实技术脑卒中下肢运动训练功能康复

基于参数随机分布的潜流带地下水数值模拟研究

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人民黄河 2025年第2期47卷 107-112,155页

作者：王辉刘军生王荆赵寿刚孙瑞东王田野张一博兰雁杨浩明侯佼建河南省引江济淮工程有限公司河南商丘476200 黄河水利委员会黄河水利科学研究院河南郑州450003 水利部堤防安全与病害防治工程技术研究中心河南郑州450003 郑州大学水利与交通学院河南郑州450001

含水层水文地质参数的合理性是决定地下水数值模型模拟精度的关键因素之一。以淮河流域清水河典型河段为研究区,通过含水层土体野外监测和室内试验,建立了渗透系数、给水度和贮水率的概率密度分布函数,并利用参数中值和置信度为95%的置... 详细信息

含水层水文地质参数的合理性是决定地下水数值模型模拟精度的关键因素之一。以淮河流域清水河典型河段为研究区,通过含水层土体野外监测和室内试验,建立了渗透系数、给水度和贮水率的概率密度分布函数,并利用参数中值和置信度为95%的置信区间,建立了基于多参数概率密度分布的地下水数值模型。结果表明:相较于采用地质勘探建议值的传统地下水数值模型,基于多参数概率密度分布的地下水数值模型的地下水位模拟结果的精确度得到了显著提升;河流水位、河床渗透系数等直接影响河流与地下水之间的水量交换强度,以及地下水的渗流和储存特征。

关键词：地下水数值模拟参数随机分布清水河

猕猴脑网络组图谱:包含分区、连接和组织学的多层面全新大脑地图

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Science Bulletin 2024年第14期69卷 2241-2259页

作者：陆玉恒崔玥曹龙董振伟程禄祺吴雯王昌硕刘新异刘有通张宝贵李德莹赵舶凯王海艳李开心马亮时维阳李雯马亚伟杜宗昌张佳琪熊辉罗娜刘妍妍侯肖逍韩景路孙洪吉蔡涛彭强冯琳清王骄健 George Paxinos 杨正宜樊令仲蒋田仔 Brainnetome Center Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Henan Key Laboratory of Imaging and Intelligent Processing PLA Strategic Support Force Information Engineering UniversityZhengzhou 450001China Neuroscience Research Australia and The University of New South Wales Sydney NSW 2031Australia Key Laboratory for NeuroInformation of the Ministry of Education School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu 610054China State Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunming 650500China School of Mechanical and Power Engineering Harbin University of Science and TechnologyHarbin 150080China School of Life and Environmental Sciences Guilin University of Electronic TechnologyGuilin 541004China Sino-Danish College University of Chinese Academy of ScienceBeijing 100049China Research Center for Augmented Intelligence Zhejiang LabHangzhou 311100China Xiaoxiang Institute for Brain Health and Yongzhou Central Hospital Yongzhou 425000China

The rhesus macaque(Macaca mulatta)is a crucial experimental animal that shares many genetic,brain organizational,and behavioral characteristics with humans.A macaque brain atlas is fundamental to biomedical and evolutionary ***,even though connectivity is vital for understanding brain functions,a connectivity-based whole-brain atlas of the macaque has not previously been *** this study,we created a new whole-brain map,the Macaque Brainnetome Atlas(MacBNA),based on the anatomical connectivity profiles provided by high angular and spatial resolution ex vivo diffusion MRI *** new atlas consists of 248 cortical and 56 subcortical regions as well as their structural and functional *** parcellation and the diffusion-based tractography were evaluated with invasive neuronal-tracing and Nissl-stained *** a demonstrative application,the structural connectivity divergence between macaque and human brains was mapped using the Brainnetome atlases of those two species to uncover the genetic underpinnings of the evolutionary changes in brain *** resulting resource includes:(1)the thoroughly delineated Macaque Brainnetome Atlas(MacBNA),(2)regional connectivity profiles,(3)the postmortem high-resolution macaque diffusion and T2-weighted MRI dataset(Brainnetome-8),and(4)multi-contrast MRI,neuronal-tracing,and histological images collected from a single *** can serve as a common reference frame for mapping multifaceted features across modalities and spatial scales and for integrative investigation and characterization of brain organization and ***,it will enrich the collaborative resource platform for nonhuman primates and facilitate translational and comparative neuroscience research.

关键词： Macaca mulatta Brain atlas Connectivity-based parcellation Diffusion MRI Cytoarchitecture Cross-species comparison

线性堆载下软黏土一维电渗固结理论与试验分析

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岩石力学与工程学报 2014年第1期33卷 179-188页

作者：王军符洪涛蔡袁强曾芳金申矫健温州大学建筑与土木工程学院浙江温州325035 江西理工大学建筑与测绘学院江西赣州341000

考虑线性堆载下水流和电流的相互作用以及孔隙水压力的消散情况,通过将单向渗流固结过程的普遍方程推广到电渗领域,建立线性堆载下软黏土一维电渗固结方程,并给出阴极排水、阳极不排水和阴阳极都排水2种情况下孔隙水压力和平均固结度的... 详细信息

考虑线性堆载下水流和电流的相互作用以及孔隙水压力的消散情况,通过将单向渗流固结过程的普遍方程推广到电渗领域,建立线性堆载下软黏土一维电渗固结方程,并给出阴极排水、阳极不排水和阴阳极都排水2种情况下孔隙水压力和平均固结度的解析解。通过参数和试验分析,研究最大堆载和加载速率对孔隙水压力消散的影响,以及电压对理论固结度和试验固结度的影响,绘制不同最大堆载和加载速率时,单面排水和双面排水下孔隙水压力消散曲线、不同电压下理论固结度和试验固结度变化曲线。结果表明:最大堆载和加载速率越大,孔隙水压力消散得越快,同时最大堆载和加载速率对双面排水的影响要比对单面排水的更大;电源电压越大,理论固结度和试验固结度的增长速度都越快,在相同时间段内试验固结度的变化幅度小于理论固结度的变化幅度。

关键词：土力学线性堆载电渗解析解孔隙水压力消散理论固结度试验固结度