Functional connectivity analyses of individual hippocampal subregions in major depressive disorder with electroconvulsive therapy
作者机构：College of Electrical EngineeringSichuan UniversityChengdu 610065China School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu 625014China Department of Neurologythe First Hospital of Anhui Medical UniversityHefei 230022China School of Mental Health and Psychological SciencesAnhui Medical UniversityHefei 230022China State Key Laboratory of Primate Biomedical ResearchInstitute of Primate Translational MedicineKunming University of Science and TechnologyKunming 650500China Yunnan Key Laboratory of Primate Biomedical ResearchKunming 650500China
出 版 物：《Psychoradiology》 (精神影像学(英文))
年 卷 期：2024年第4卷第1期
页 面：210-217页
基 金：supported by grants from the National Science Foundation of China(62176044) Natural Science Foundation of Yunnan Province(202102AA100053) Yunnan Fundamental Research Projects(202201BE070001-004)
主 题：hippocampus major depressive disorder individual parcellation electroconvulsive therapy gene expression
摘 要：Background The hippocampus has been widely reported to be involved in the neuropathology of major depressive disorder(MDD).All the previous researches adopted group-level hippocampus subregions atlas to investigate abnormal functional connectivities in MDD in absence of capturing individual *** addition,the molecular basis of functional impairments of hippocampal subregions in MDD remains *** We aimed to reveal functional disruptions and recovery of individual hippocampal subregions in MDD patients before and after ECT and linked these functional connectivity differences to transcriptomic profiles to reveal molecular *** we used group guided individual functional parcellation approach to define individual subregions of hippocampus for each ***-state functional connectivity(FC)analysis of individual hippocampal subregions was conducted to investigate functional disruptions and recovery in MDD patients before and after *** association between functional connectivity differences and transcriptomic profiles was employed to reveal molecular *** MDD patients showed increased FCs of the left tail part of hippocampus with dorsolateral prefrontal cortex and middle temporal gyrus while decreased FC with primary visual *** abnormal FCs in MDD patients were normalized after *** addition,we found that functional disruptions of the left tail part of hippocampus in MDD were mainly related to synaptic signaling and transmission,ion transport,cell-cell signaling and *** Our findings provide initial evidence for functional connectome disruption of individual hippocampal subregions and their molecular basis in MDD.
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