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Ketogenic diet therapy in children with epilepsy caused by SLC2A1 mutations:a single-center single-arm retrospective study

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World Journal of Pediatrics 2024年第5期20卷 517-524页

作者： Ying-Yan wang Yun-Qing Zhou Li-Juan Luo Cui-jin wang Nan Shen Hao Li ji-Wen wang Department of Neurology Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Clinical Research Ward Clinical Research CenterShanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background This retrospective study assessed the efficacy and safety of ketogenic diet therapies in children with epilepsy caused by SLC2A1 genetic mutations and glucose transporter type 1 deficiency *** Pediatric patients with epilepsy symptoms admitted to our medical center between January 2017 and October 2021 were included if they presented with an SLC2A1 genetic mutation on whole-exome *** analyzed the patients’convulsions and treatment with antiepileptic *** patients were followed up at different time periods after ketogenic diet *** Six patients with SLC2A1 mutations were included in this *** patients had seizures of different types and frequencies,and they took antiepileptic drugs to relieve their *** were then treated with a ketogenic diet for at least four *** analyzed epilepsy control rates at 1,2,3,6,and 12 months after ketogenic diet *** patients were seizure-free within a month of receiving the diet *** patients were followed up for six months,three were followed up for 12 months after the treatment,and there was no recurrence of epilepsy during this *** antiepileptic drug withdrawal,none of the patients experienced seizure relapse when receiving ketogenic diet treatment *** severe adverse events occurred during the *** Ketogenic diet therapy is very effective and safe for the treatment of epilepsy caused by SLC2A1 ***,patients with glucose transporter type 1 deficiency syndrome caused by SLC2A1 mutations should begin ketogenic diet treatment as soon as possible.

关键词： Epilepsy Glucose transporter type 1 Ketogenic diet SLC2A1

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Research progress toward the influence of mosquito salivary proteins on the transmission of mosquito-borne viruses

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Insect Science 2024年第3期31卷 663-673页

作者： Zhao-Yang wang Kai-Xiao Nie ji-Chen Niu Gong Cheng Tsinghua University-Peking University Joint Center for Life Sciences School of MedicineTsinghua UniversityBejingChina Institute of Infectious Diseases Shenzhen Bay LaboratoryShenzhenGuangdongChina Department of Pathogen Biology School of Basic MedicineShandong First Medical University&Shandong Academy of Medical SciencesJinanChina

Mosquito-borne viruses(MBVs)are a large class of viruses transmitted mainly through mosquito bites,including dengue virus,Zika virus,Japanese encephalitis virus,West Nile virus,and chikungunya virus,which pose a major threat to the health of people around the *** global warming and extended human activities,the incidence of many MBVs has increased *** saliva contains a variety of bioactive protein *** not only enable blood feeding but also play a crucial role in regulating local infection at the bite site and the remote dissemination of MBVs as well as in remodeling the innate and adaptive immune responses of host ***,we review the physiological functions of mosquito salivary proteins(MSPs)in detail,the influence and the underlying mechanism of MSPs on the transmission of MBVs,and the current progress and issues that urgently need to be addressed in the research and development of MSP-based MBV transmission blocking vaccines.

关键词： immune response mosquito-borne virus mosquito salivary protein saliva vaccine transmission

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Regulating the key performance parameters for Hg-based IR NLO chalcogenides via bandgap engineering strategy

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Chinese Chemical Letters 2024年第10期35卷 516-520页

作者： A-Yang wang Sheng-hua Zhou Mao-Yin Ran Xin-Tao Wu hua Lin Qi-Long Zhu State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences (CAS) Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China College of Chemistry Fuzhou University University of Chinese Academy of Sciences

Recently, non-centrosymmetric（NCS） Hg-based chalcogenides have garnered significant interest due to their strong second-harmonic-generation intensities(deff), making them attractive candidates for infrared nonlinear optical（IR-NLO） application. However, achieving both wide band gaps（Eg） and large phasematched deffsimultaneously in these materials remains a challenge due to their inherent constraints on each other. In this research, we have successfully obtained two quaternary NCS Hg-based chalcogenides, Rb2HgGe3S8and Cs2HgGe3S8, by implementing a bandgap engineering strategy that involves alkali metal introduction and Hg/Ge ratio regulation. Both compounds consist of 2D [Hg Ge3S8]2–anionic layers made of 1D [HgGeS6]6–chains and dimeric [Ge2S6]4–polyhedra arranged alternately, and the charge-balanced Rb+/Cs+cations located between these layers. Remarkably, Rb2HgGe3S8and Cs2HgGe3S8exhibit overall properties required for promising IR-NLO materials, including sufficient PM deff（0.55–0.70 × AgGaS2@2050 nm）, large Eg（3.27–3.41 e V）, giant laser-induced damage thresholds（17.4–19.7 ×AgGaS2@1064 nm）, broad optical transmission intervals（0.32–17.5 μm）, and suitable theoretical birefringence（0.069–0.086@2050 nm）. Furthermore, in-depth theoretical analysis reveals that the exceptional IRNLO performance is attributed to the synergy effects of distorted [HgS4] and [GeS4] tetrahedra. Our study provides a useful strategy for enhancing the Egand advancing Hg-based IR-NLO materials, which is expected to extended and implemented in other chalcogenide systems.

关键词： Bandgap engineering strategy Hg-based chalcogenides IR nonlinear material Structure-activity relationship Wide energy gap

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Three-dimensionally oriented organization of hexagonal MIL-96 microplates toward superior film microstructure

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Chinese Journal of Chemical Engineering 2024年第8期72卷 69-73页

作者： Sixing Chen Xinmiao jin Yuyang Wu Taotao ji Fei wang Yi Liu State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart MaterialsSchool of Chemical EngineeringDalian University of TechnologyDalian 116024China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Dalian Key Laboratory of Membrane Materials and Membrane Processes Dalian University of TechnologyDalian 116024China

Preferential orientation control of metal—organic framework(MOF)films is advantageous for maximizing pore uniformity and minimizing grain-boundary ***,the preparation of MOF films with both in-plane and out-of-plane orientations remains a grand *** this study,we reported the preparation of three-dimensionally oriented MIL-96 layers through combining morphology control of MIL-96 seeds with addition of polyvinylpyrrolidone surfactants and arachidonic *** three-dimensionally oriented MIL-96 film was readily obtained through in-plane epitaxial *** is anticipated that the aforementioned protocol can be effective for obtaining diverse MOF films with a three-dimensionally oriented organization.

关键词： Metaleorganic framework Film Orientation Epitaxial growth Morphological control

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Comparison of irradiation-induced void formations in tungsten with equiaxed and columnar structures

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Tungsten 2024年第4期6卷 794-805页

作者： Liu Xi jia-Jun Zhao ji-Jun Zhao Yuan-Yuan wang Key Laboratory of Materials Modification by Laser Ion and Electron Beams(Ministry of Education) Dalian University of Technology

Tungsten(W) has been received much attention,since it is regarded as one of the most promising plasma facing materials for fusion *** are two typical morphologies of unirradiated polycrystalline W,which have the equiaxed and columnar grains,***,the role of arrangement of grain boundary(GB) in absorbing irradiation-generated point defects is still waiting to be *** current investigation,irradiation-induced void formations in W with equiaxed and columnar microstructures are predicted,respectively,using the developed phase-field *** significant kinetic behavior,such as the generation and annihilation of point defects and the interaction between point defects and GB,is reasonably *** density,size and porosity of void formed in these two microstructures are examined and analyzed according to the effects of GB ratio,temperature and damage *** analytical results show that higher GB ratio can effectively reduce void porosity,and the columnar-grained structure has better irradiation resistance than that of the equiaxed one in the case of small grain *** importantly,the predicted void sizes changed with temperature and damage rate agree well with the experimentally measured *** work has a more beneficial contribution to the microstructural improvement of International Thermonuclear Experimental Reactor-grade W.

关键词： Grain morphology Irradiation-induced void Phase-field Tungsten

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Probing phase transition of band topology via radiation topology

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Photonics Research 2024年第6期12卷 1150-1157页

作者： CHANG-YIN ji WENZE LAN PENG FU GANG wang CHANGZHI GU YELIANG wang jiAFANG LI YUGUI YAO BAOLI LIU Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement(MOE) Beijing Key Laboratory of Nanophotonics&Ultrafine Optoelectronic Systemsand School of PhysicsBeijing Institute of TechnologyBeijing 100081China School of Integrated Circuits and Electronics MIIT Key Laboratory for Low-Dimensional Quantum Structure and DevicesBeijing Institute of TechnologyBeijing 100081China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences CAS Key Laboratory of Vacuum PhysicsUniversity of Chinese Academy of SciencesBeijing 100190China CAS Center for Excellence in Topological Quantum Computation CAS Key Laboratory of Vacuum PhysicsUniversity of Chinese Academy of SciencesBeijing 100190China

Topological photonics has received extensive attention from researchers because it provides brand new physical principles to manipulate *** topology is characterized using the Berry phase defined by Bloch *** now,the scheme for experimentally probing the topological phase transition of band topology has always been relatively lacking in topological ***,radiation topology can be aroused by the far-field polarization singularities of Bloch states,which is described by the Stokes *** such two types of topologies are both related to Bloch states on the band structures,it is rather surprising that their development is almost ***,in optical analogs of the quantum spin Hall effects(QSHEs)and Su-Schrieffer-Heeger model,we reveal the correlation between the phase transition of band topology and radiation topology and then demonstrate that the radiation topology can be employed to study the band topological *** experimentally demonstrate such an intriguing phenomenon in optical analogs of *** findings not only provide an insightful understanding of band topology and radiation topology,but also can serve as a route to manipulate light.

关键词： transition topology topological

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MAX-DOAS and in-situ measurements of aerosols and trace gases over Dongying,China:Insight into ozone formation sensitivity based on secondary HCHO

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Journal of Environmental Sciences 2024年第1期135卷 656-668页

作者： Xiaojun Zheng Zeeshan Javed Cheng Liu Aimon Tanvir Osama Sandhu Haoran Liu Xiangguang ji Chengzhi Xing hua Lin Daolin Du Institute of Environment and Ecology School of the Environment and Safety EngineeringJiangsu UniversityZhenjiang 212013China Department of Precision Machinery and Precision Instrumentation University of Science and Technology of ChinaHefei 230026China Key Laboratory of Environmental Optics&Technology Anhui Institute of Optics and Fine MechanicsHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education Institutes University of Science and Technology of ChinaHefei 230026China Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention(LAP3) Department of Environmental Science and EngineeringFudan UniversityShanghai 200433China National Agromet Center Pakistan Meteorological DepartmentIslamabad 44000Pakistan Institute of Physical Science and Information Technology Anhui UniversityHefei 230601China Information Materials and Intelligent Sensing Laboratory of Anhui Province Anhui UniversityHefei 230601China School of Environmental Science and Optoelectronic Technology University of Science and Technology of ChinaHefei 230026China

This study presents a comprehensive overview of the atmospheric pollutants including Sulfur dioxide(SO_(2)),Nitrogen dioxide(NO_(2)),Formaldehyde(HCHO),Particulate Matter PM;PM_(10):diameter≤10μm,and PM_(2.5):diameter≤2.5μm,and Ozone(O_(3)),over Dongying(Shandong Province)from March-April 2018 and September-October 2019 by employing ground-based Multiple Axis Differential Optical Absorption Spectroscopy(MAX-DOAS)observations along with the in-situ measurements attained by the national air quality monitoring *** concentrations of SO_(2)and NO_(2)were under the acceptable level,while both PM_(2.5),and PM_(10)were higher than the safe levels as prescribed by national and international air quality *** results depict that 21%of the total observation days were found to be complex polluted days(PM_(2.5)>35μg/m^(3) and O_(3)>160μg/m^(3)).The secondary HCHO was used for accurate analysis of O_(3)sensitivity.A difference of 11.40%and 10%during March-April 2018 and September-October 2019 respectively in O_(3)sensitivity was found between HCHO_(total)/NO_(2)and HCHO_(sec)/NO_(2).The results indicate that primary HCHO have significant contribution in HCHO.O_(3)formation predominantly remained to be in VOC-limited and transitional regime during March-April 2018 and September-October 2019 in *** results imply that concurrent control of both NO_(x) and VOCs would benefit in ozone ***,the criteria pollutants(PM,SO_(2),and NO_(2))depicted strong correlations with each other except for O_(3)for which weak correlation coefficient was obtained with all the *** study will prove to be baseline for designing of air pollution control strategies.

关键词： MAX-DOAS Trace gases Ozone sensitivity Secondary HCHO Complex Pollution

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Gastric cancer immunotherapy:A scientometric and clinical trial review

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World Journal of Gastroenterology 2024年第2期30卷 196-198页

作者： Qian-Cheng Du Xin-Yu wang hua Yu Thoracic Surgery Shanghai Xuhui Central HospitalShanghai 200031China Thyroid Breast and Vascular SurgeryShanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Department of General Surgery Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China

This letter is intended to arouse your interest in a recent review of comprehensive scientometrics and clinical trials on immunotherapy for gastric cancer(GC).Our study reviews recent advances in immunotherapy in the field of GC and highlights its new prospects as a treatment for *** research reveals China’s leadership in this field,as well as new therapeutic strategies such as immune checkpoint inhibitors,cellular immunotherapy,and *** combined findings highlight the potential of immunotherapy to improve survival and quality of life in patients with stomach *** believe that this study will provide important guidance for the future direction of the GC treatment field.

关键词： Gastric cancer Immunotherapy Bibliometrics Comment Therapeutic strategies

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Decoding topological XYZ^(2) codes with reinforcement learning based on attention mechanisms

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Chinese Physics B 2024年第6期33卷 262-270页

作者：陈庆辉姬宇欣王柯涵马鸿洋纪乃华 School of Information and Control Engineering Qingdao University of TechnologyQingdao 266033China School of Sciences Qingdao University of TechnologyQingdao 266033China

Quantum error correction, a technique that relies on the principle of redundancy to encode logical information into additional qubits to better protect the system from noise, is necessary to design a viable quantum computer. For this new topological stabilizer code-XYZ^(2) code defined on the cellular lattice, it is implemented on a hexagonal lattice of qubits and it encodes the logical qubits with the help of stabilizer measurements of weight six and weight two. However topological stabilizer codes in cellular lattice quantum systems suffer from the detrimental effects of noise due to interaction with the environment. Several decoding approaches have been proposed to address this problem. Here, we propose the use of a state-attention based reinforcement learning decoder to decode XYZ^(2) codes, which enables the decoder to more accurately focus on the information related to the current decoding position, and the error correction accuracy of our reinforcement learning decoder model under the optimisation conditions can reach 83.27% under the depolarizing noise model, and we have measured thresholds of 0.18856 and 0.19043 for XYZ^(2) codes at code spacing of 3–7 and 7–11, respectively. our study provides directions and ideas for applications of decoding schemes combining reinforcement learning attention mechanisms to other topological quantum error-correcting codes.

关键词： quantum error correction topological quantum stabilizer code reinforcement learning attention mechanism

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Corrosion and in vitro cytocompatibility investigation on the designed Mg-Zn-Ag metallic glasses for biomedical application

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Journal of Magnesium and Alloys 2024年第4期12卷 1566-1580页

作者： jian wang Lingzhong Meng Weixin Xie Chen ji Ronghua wang Pinghu Zhang Liling jin Liyuan Sheng Yufeng Zheng School of Mechanical Engineering Yangzhou UniversityYangzhou225127China Department of Materials Science and Engineering Seoul National UniversitySeoulSouth Korea Huizhou Port Customs Huizhou516081China jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Institute of Translational MedicineMedical CollegeYangzhou UniversityYangzhou225009China Center for Research in Computational Thermochemistry(CRCT) Department of Chemical EngineeringEcole polytechnique de MontréalMontréalQuébecH3C 3A7Canada Shenzhen Institute Peking UniversityShenzhen 518057China PKU-HKUST ShenZhen-HongKong Institution Shenzhen518057China

In the present work,seven Mg-Zn-Ag alloys with the nominal composition of Mg_(96-x)Zn_(x)Ag_(4)(x=17,20,23,26,29,32,35 in at.%)were prepared by induction melting and single-roller *** X-ray diffraction(XRD)analyses indicate the metallic glasses with three composition of Mg_(73)Zn_(23)Ag_(4),Mg_(70)Zn_(26)Ag_(4),and Mg_(67)Zn_(29)Ag_(4)were obtained *** differential scanning calorimetry(DSC)measurement was used to obtain the characteristic temperature of Mg-Zn-Ag metallic glasses for the glass-forming ability *** maximum glass transition temperature(Trg)was found to be 0.525 with a composition close to Mg_(67)Zn_(29)Ag_(4),which results in the best glass-forming ***,the immersion test in simulated body fluid(SBF)demonstrate the relative homogeneous corrosion behavior of the Mg-Zn-Ag metallic *** corrosion rate of Mg-Zn-Ag metallic glasses in SBF solution decreases with the increase of Zn *** sample Mg_(67)Zn_(29)Ag_(4)has the lowest corrosion rate of 0.19mm/yr,which could meet the clinical application requirement *** in vitro cell experiments show that the Madin-Darby canine kidney(MDCK)cells cultured in sample Mg_(67)Zn_(29)Ag_(4)and its extraction medium have higher ***,the Mg-Zn-Ag metallic glasses exhibit obvious inhibitory effect on human rhabdomyosarcoma(RD)tumor *** present investigations on the glass-forming ability,corrosion behavior,cytocompatibility and tumor inhibition function of the Mg-Zn-Ag based metallic glass could reveal their biomedical application possibility.

关键词： Metallic glasses Mg-Zn-Ag Corrosion behavior In vitro cytocompatibility

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