Corrosion and in vitro cytocompatibility investigation on the designed Mg-Zn-Ag metallic glasses for biomedical application

作     者：Jian Wang Lingzhong Meng Weixin Xie Chen Ji Ronghua Wang Pinghu Zhang Liling Jin Liyuan Sheng Yufeng Zheng 

作者机构：School of Mechanical EngineeringYangzhou UniversityYangzhou225127China Department of Materials Science and EngineeringSeoul National UniversitySeoulSouth Korea Huizhou Port CustomsHuizhou516081China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile DiseasesInstitute of Translational MedicineMedical CollegeYangzhou UniversityYangzhou225009China Center for Research in Computational Thermochemistry(CRCT)Department of Chemical EngineeringEcole polytechnique de MontréalMontréalQuébecH3C 3A7Canada Shenzhen InstitutePeking UniversityShenzhen 518057China PKU-HKUST ShenZhen-HongKong InstitutionShenzhen518057China 

出 版 物：《Journal of Magnesium and Alloys》 (镁合金学报（英文）)

年 卷 期：2024年第12卷第4期

页      面：1566-1580页

核心收录：

学科分类：0806[工学-冶金工程] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：National Key Research and Development Program of China(2018YFC1106702) Guangdong Basic and Applied Basic Research Foundation(2020A1515011301,2019A1515110067 and 2020A1515110055) Shenzhen Basic Research Project(JCYJ20210324120001003,JCYJ20200109144608205 and JCYJ20200109144604020) IER Foundation(HT-JDCXY-201902 and HT-JD-CXY-201907)for financial support 

主　　题：Metallic glasses Mg-Zn-Ag Corrosion behavior In vitro cytocompatibility 

摘      要：In the present work,seven Mg-Zn-Ag alloys with the nominal composition of Mg_(96-x)Zn_(x)Ag_(4)(x=17,20,23,26,29,32,35 in at.%)were prepared by induction melting and single-roller *** X-ray diffraction(XRD)analyses indicate the metallic glasses with three composition of Mg_(73)Zn_(23)Ag_(4),Mg_(70)Zn_(26)Ag_(4),and Mg_(67)Zn_(29)Ag_(4)were obtained *** differential scanning calorimetry(DSC)measurement was used to obtain the characteristic temperature of Mg-Zn-Ag metallic glasses for the glass-forming ability *** maximum glass transition temperature(Trg)was found to be 0.525 with a composition close to Mg_(67)Zn_(29)Ag_(4),which results in the best glass-forming ***,the immersion test in simulated body fluid(SBF)demonstrate the relative homogeneous corrosion behavior of the Mg-Zn-Ag metallic *** corrosion rate of Mg-Zn-Ag metallic glasses in SBF solution decreases with the increase of Zn *** sample Mg_(67)Zn_(29)Ag_(4)has the lowest corrosion rate of 0.19mm/yr,which could meet the clinical application requirement *** in vitro cell experiments show that the Madin-Darby canine kidney(MDCK)cells cultured in sample Mg_(67)Zn_(29)Ag_(4)and its extraction medium have higher ***,the Mg-Zn-Ag metallic glasses exhibit obvious inhibitory effect on human rhabdomyosarcoma(RD)tumor *** present investigations on the glass-forming ability,corrosion behavior,cytocompatibility and tumor inhibition function of the Mg-Zn-Ag based metallic glass could reveal their biomedical application possibility.