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Deletion of a 1,049 bp sequence from the 5′UTR upstream of the SiHEC3 gene induces a seed non-shattering mutation in sesame

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Journal of Integrative Agriculture 2024年第8期23卷 2589-2604页

作者： Ming Ju Guiting Li Qiuzhen Tian Hengchun Cao Qin Ma Yinghui Duan Hui Guo Zhanyou Zhang Yingying Huang huili wang Haiyang Zhang Hongmei Miao The Shennong Laboratory Zhengzhou 450002China Henan Sesame Research Center Henan Academy of Agricultural SciencesZhengzhou 450002China Key Laboratory of Specific Oilseed Crops Genomics of Henan Province Henan Sesame Research CenterHenan Academy of Agricultural SciencesZhengzhou 450002China

Sesame is a labor intensive crop with limited mechanized harvesting mainly due to the seed shattering(SS)*** this study,we performed a genetic analysis of the seed-shattering resistance(SR)trait with a SR sesame mutant *** the SS type,the parenchyma cells in the abscission zone of the 12M07 mutant are arranged loosely but adhere to the seed *** analysis of six generations derived from 12M07(SR)×Xiangcheng Dazibai(SS)showed that the SR trait is recessive and controlled by a single gene *** mapping of the F2population with 888,619 variants(single-nucleotide polymorphisms(SNPs)and insertion-deletion(InDels))and 31,884 structural variations(SVs)determined that only SV12002 in the 5′upstream region of gene Sindi0765000(named SiHEC3)in Chr.3 was significantly associated with the SR ***3 encodes the bHLH transcription factor.A 1,049 bp deletion occurred in the 5′UTR of Sihec3 in ***3 is mainly expressed in developing placental tissues,with the expression peaking in capsules at 45 days after pollination.A dual-luciferase reporter assay in tobacco confirmed that the promoter activity of Sihec3 was reduced because of the deletion of the 1,049 bp promoter ***–protein interaction network analysis showed that HEC3 is co-expressed with nine key proteins,such as SHATTERPROOF1(SHP1)and SEEDSTICK(STK)which participate in the secondary wall biosynthesis of the abscission layer in *** findings of this study show the important function of Sihec3corresponding with the SR trait and supply the genetic information for breeding new varieties that are amenable to mechanized harvesting in sesame and other crops.

关键词： sesame(Sesamum indicum L.) association mapping seed shattering structure variation bHLH transcription factor

Gene replacement therapy in Bietti crystalline corneoretinal dystrophy:an open-label,single-arm,exploratory trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2275-2284页

作者： Jinyuan wang Jinlu Zhang Shicheng Yu Hongyan Li Shaohong Chen Jingting Luo Haibo wang Yuxia Guan Haihan Zhang Shiyi Yin huili wang Heping Li Junle Liu Jingyuan Zhu Qiong Yang Ying Sha Chuan Zhang Yuhang Yang Xuan Yang Xifang Zhang Xiuli Zhao Likun wang Liping Yang Wenbin Wei Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical University100730 BeijingChina School of Clinical Medicine Tsinghua University100084 BeijingChina Chigenovo Co. Ltd.102206 BeijingChina Department of Ophthalmology Peking University Third HospitalBeijing Key Laboratory of Restoration of Damaged Ocular NervePeking University Third Hospital100191 BeijingChina Department of Ophthalmology The Third People’s Hospital of Dalian116091 DalianChina Department of Biomedical Informatics School of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina Institute of Systems Biomedicine Department of PathologySchool of Basic Medical SciencesPeking University Health Science Center100191 BeijingChina

Bietti crystalline corneoretinal dystrophy is an inherited retinal disease caused by mutations in CYP4V2,which results in blindness in the working-age population,and there is currently no available ***,we report the results of the first-in-human clinical trial(NCT04722107)of gene therapy for Bietti crystalline corneoretinal dystrophy,including 12 participants who were followed up for 180-365 *** open-label,single-arm exploratory trial aimed to assess the safety and efficacy of a recombinant adeno-associated-virus-serotype-2/8 vector encoding the human CYP4V2 protein(rAAV2/8-hCYP4V2).Participants received a single unilateral subretinal injection of 7.5×10^(10)vector genomes of rAAV2/***,73 treatment-emergent adverse events were reported,with the majority(98.6%)being of mild or moderate intensity and considered to be procedure-or corticosteroid-related;no treatment-related serious adverse events or local/systemic immune toxicities were *** with that measured at baseline,77.8%of the treated eyes showed improvement in best-corrected visual acuity(BCVA)on day 180,with a mean±standard deviation increase of 9.0±10.8 letters in the 9 eyes analyzed(p=0.021).By day 365,80%of the treated eyes showed an increase in BCVA,with a mean increase of 11.0±10.6 letters in the 5 eyes assessed(p=0.125).Importantly,the patients’improvement observed using multifocal electroretinogram,microperimetry,and Visual Function Questionnaire-25 further supported the beneficial effects of the *** conclude that the favorable safety profile and visual improvements identified in this trial encourage the continued development of rAAV2/8-hCYP4V2(named ZVS101e).

关键词： cor dystrophy crystalline

Enhanced multifunctional liquid metal-based hydrogels with vinyl silica nanoparticles for advanced strain sensing applications

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Science China Materials 2024年第10期67卷 3309-3320页

作者： Bingyan wang Wenxia Liu Zhaoping Song Guodong Li Dehai Yu Xiaona Liu huili wang Shaohua Ge State Key Laboratory of Biobased Materials and Green Papermaking Qilu University of TechnologyShandong Academy of ScienceJinan 250353China Department of Periodontology School and Hospital of StomatologyCheeloo College of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Laboratory for Dental Materials and Oral Tissue RegenerationJinan 250012China

Conductive hydrogels have garnered considerable interest for their applications in wearable electronic skins,owing to their superior ***,challenges persist,including low sensitivity,poor cyclic stability,and limited tolerance to extreme *** study develops a novel liquid metal-based conductive hydrogel with a dual cross-linked polyacrylic acid(PAA)matrix,employing both“soft”coordination and“hard”covalent cross-linking *** hybrid network is formulated using guar gum(GG)-stabilized gallium(Ga)droplets,which catalyze the copolymerization of vinyl-hybrid silica nanoparticles(VSNPs)and acrylic acid(AA).The resultant Ga3+ions interact with carboxyl groups in the PAA,forming soft coordination links that enhance the hydrogel’s rapid *** incorporation of VSNPs significantly enhances the hydrogel’s elasticity,toughness,and low-temperature resilience without ***,its intrinsic moldability,adhesion,and self-healing properties are *** as a strain sensor,this hydrogel demonstrates a high gauge factor(GF)of 17.4,responsive time of 250 ms for both activation and recovery,an ultra-low detection limit of 0.1%,and excellent durability over 800 cycles at 100%***-term immersion in a glycerol solution(20 min)further augments its stretchability to 2688%and GF to 28.1 across a strain range of 1325%–1450%,broadening its operational ranges to 0–1450%at−18°*** exposure(4 h)also improves water retention and high-temperature resistance,making this hydrogel a promising material for sustainable,high-performance wearable electronics.

关键词： vinyl silica nanoparticles liquid metals guar gum hydrogel strain sensor

单桩冲刷修复作业中流态固化土留存特性数值研究

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太阳能学报 2024年第10期45卷 440-445页

作者：王会丽毋晓妮李濡宇蒋海里汪潇上海公路桥梁(集团)有限公司上海交通大学船舶海洋与建筑工程学院上海交通大学海洋工程全国重点实验室江苏坤泽科技股份有限公司

固化土防冲刷技术是一种新型的冲刷修复及防护技术。为深入探究流态固化土的泵浆流失影响因素及规律，合理选择泵浆位置，该文采用计算流体力学方法对单桩基础周围流态固化土泵浆过程进行模拟，分析评估不同流态固化土和不同泵浆点对留... 详细信息

固化土防冲刷技术是一种新型的冲刷修复及防护技术。为深入探究流态固化土的泵浆流失影响因素及规律，合理选择泵浆位置，该文采用计算流体力学方法对单桩基础周围流态固化土泵浆过程进行模拟，分析评估不同流态固化土和不同泵浆点对留存率的影响。结果表明，对于单桩，固化土类型和泵浆点的选择主要考虑泵浆过程中流态固化土的终末时刻留存率；建议选用流动值小的流态固化土，以提高留存率；若固化土流动值小，则尽量选单桩上游近桩触底泵浆。

关键词：海上风电场桩基础计算流体力学冲刷修复流态固化土留存特性

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翻译中的“叙事建构”——莫楷《人面桃花》英译本的翻译策略剖析

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上海第二工业大学学报 2024年第3期41卷 341-346页

作者：王慧莉上海第二工业大学外语与文化传播学院上海201209

以格非小说《人面桃花》为例,借助Mona Baker的翻译建构理论,从时空建构、文本素材的选择性采用、标示式建构、参与者的再定位4个层面,分析了译者莫楷对原作的翻译建构策略。文章指出,为推动中国文化更好地走向世界,译者结合目标受众的... 详细信息

以格非小说《人面桃花》为例,借助Mona Baker的翻译建构理论,从时空建构、文本素材的选择性采用、标示式建构、参与者的再定位4个层面,分析了译者莫楷对原作的翻译建构策略。文章指出,为推动中国文化更好地走向世界,译者结合目标受众的阅读习惯及审美期待,创造性地重构原作叙事,兼顾了译作的“异质性”与“可读性”,在新的语境中有效传递了原作的文学及文化特征。

关键词：《人面桃花》小说叙事莫楷翻译建构策略中国文学外译

海域桥梁桩基冲刷固化土防护施工方案比选研究

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上海公路 2024年第3期 27-33,M0004页

作者：王会丽上海公路桥梁(集团)有限公司上海200433

现依托上海市科委科研项目《工程泥浆制备海域桥梁桩基防冲刷回填材料技术与装备》,首次将固化土技术引入跨海桥梁桩基防护工程中。该技术目前已在单桩形式的海上风电桩基冲刷防护工程中得到了成功应用,但针对海域桥梁群桩基础这一复杂... 详细信息

现依托上海市科委科研项目《工程泥浆制备海域桥梁桩基防冲刷回填材料技术与装备》,首次将固化土技术引入跨海桥梁桩基防护工程中。该技术目前已在单桩形式的海上风电桩基冲刷防护工程中得到了成功应用,但针对海域桥梁群桩基础这一复杂情况下的应用尚需进一步研究。结合东海大桥桥墩桩基固化土防护典型施工试验工程,重点分析研究了工程泥浆固化土用于海域桥梁桩基冲刷防护的施工方案,并比选研究了海上施工与陆上施工方案的优缺点。结果表明,两种施工方案各有长短,可根据工程实际情况择优采用,为固化土防护技术的推广应用提供了参考。

关键词：固化土海域桥梁桩基冲刷防护施工

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三腹板预制U形节段梁吊装工况受力性能研究

隧道与轨道交通 2024年第1期 44-46,81,82页

作者：王会丽上海公路桥梁(集团)有限公司

预制U形节段梁为大开口薄壁构件,是一种梁、板组合的空间结构,但其空间受力效应明显,剪滞效应使得断面上的应力分布复杂。依托“轨道交通预制节段双线薄壁槽型梁设计施工关键技术研究”项目,运用有限元软件对三腹板预制U形梁不同方案下... 详细信息

预制U形节段梁为大开口薄壁构件,是一种梁、板组合的空间结构,但其空间受力效应明显,剪滞效应使得断面上的应力分布复杂。依托“轨道交通预制节段双线薄壁槽型梁设计施工关键技术研究”项目,运用有限元软件对三腹板预制U形梁不同方案下的吊装工况进行了模拟分析,研究了三腹板预制U形梁在吊装阶段的应力状态。通过吊腹板和吊底板等不同吊装方案的比选,最终确定了合理的吊点布设方案,并为后续施工提供了指导建议。

关键词：三腹板预制U形节段梁吊装受力性能

低频神经肌肉治疗仪联合盆底持续性强化训练对自然分娩初产妇康复情况的影响

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临床医学研究与实践 2024年第4期9卷 179-182页

作者：王慧丽商丘市中医院河南商丘476000

目的探讨低频神经肌肉治疗仪联合盆底持续性强化训练对自然分娩初产妇康复情况的影响。方法选取2019年1月至2022年6月于我院自然分娩的80例初产妇为研究对象,采用随机数字表法将其分为对照组与康复组,每组40例。对照组接受常规护理,康... 详细信息

目的探讨低频神经肌肉治疗仪联合盆底持续性强化训练对自然分娩初产妇康复情况的影响。方法选取2019年1月至2022年6月于我院自然分娩的80例初产妇为研究对象,采用随机数字表法将其分为对照组与康复组,每组40例。对照组接受常规护理,康复组在常规护理基础上接受低频神经肌肉治疗仪联合盆底持续性强化训练。比较两组的干预效果。结果干预后,康复组的Ⅰ类、Ⅱ类肌纤维肌力的持续收缩压大于对照组,收缩持续时间长于对照组(P<0.05)。干预后,康复组的膀胱颈移动度、膀胱尿道后角及肛提裂孔面积小于对照组(P<0.05)。干预后,康复组的女性性功能指数(FSFI)评分高于对照组,盆底功能障碍问卷-20(PFDI-20)评分低于对照组(P<0.05)。结论低频神经肌肉治疗仪联合盆底持续性强化训练可明显改善自然分娩初产妇的盆底结构,提高盆底肌力。

关键词：自然分娩初产妇低频神经肌肉治疗仪盆底持续性强化训练康复情况

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戏剧融入高校美育的应用路径研究

洛阳师范学院学报 2024年第1期43卷 80-83页

作者：王惠丽洛阳师范学院文学院河南洛阳471934

戏剧是促进高校美育发展的一个重要载体,戏剧融入高校美育不仅丰富了美育教学内容、教学方法和美学理论,还能促进学生正确价值观的建立,开阔其艺术知识视野,提高学生审美能力。部分高校过多重视智育教育,存在对美育重视不够、美育师资... 详细信息

戏剧是促进高校美育发展的一个重要载体,戏剧融入高校美育不仅丰富了美育教学内容、教学方法和美学理论,还能促进学生正确价值观的建立,开阔其艺术知识视野,提高学生审美能力。部分高校过多重视智育教育,存在对美育重视不够、美育师资力量薄弱以及美育课程设置不合理等问题。戏剧具有教育性、趣味性、艺术性等特征,是促进高校美育发展的一个重要途径。将戏剧融入高校美育应在课程设置上细分化和系统化,将戏剧作品进一步精品化、经典化,并借助多媒体、互联网开拓多样的教学方式,开展多元的戏剧实践活动,以构建智慧化美育设施,形成戏剧美育新生态。

关键词：高校美育戏剧路径