检索结果-南通市图书馆

Antitumor effects of a novel photosensitizer-mediated photodynamic therapy and its influence on the cell transcriptome

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2024年第5期32卷 911-923页

作者： JINGJING chen DAN {1. ZEQUN {1. MENGYUAN han HOUQING YIN WENTING ZHOU RIBAI YAN YAN PAN department of Pharmacology School of PharmacyChangzhi Medical CollegeChangzhiChina2 Department of PharmacologySchool of Basic Medical SciencesHealth Science CenterPeking UniversityBeijingChina3 Beijing Key Laboratory of Tumor Systems BiologyPeking UniversityBeijingChina4 Department of PharmacologyXinjiang Medical UniversityUrumqiChina5 School of Pharmaceutical SciencesPeking UniversityBeijingChina

Photodynamic therapy(PDT)is a promising cancer *** study investigated the antitumor effects and mechanisms of a novel photosensitizer meso-5-[ρ-diethylene triamine pentaacetic acid-aminophenyl]−1.,1.,20-triphenyl-porphyrin(DTP)mediated PDT(DTP-PDT).Cell viability,reactive oxygen species(ROS),and apoptosis were measured with a Cell Counting Kit-8 assay,DCFH-DA fluorescent probe,and Hoechst staining,*** apoptosis-and autophagy-related proteins were examined using western *** sequencing was used to screen differentially expressed mRNAs(DERs),and bioinformatic analysis was performed to identify the major biological events after *** results show that DTP-PDT inhibited cell growth and induced ROS generation in MCF-7 and SGC7901.*** ROS scavenger N-acetyl-L-cysteine(NAC)and the P38 MAPK inhibitor SB203580 alleviated DTP-PDT-induced ***-PDT induced cell apoptosis together with upregulated Bax and downregulated Bcl-2,which could also be inhibited by NAC or *** level of LC3B-Ⅱ,a marker of autophagy,was increased by DTP-PDT.A total of 3496 DERs were obtained after *** Ontology and Kyoto Encyclopedia of Genes and Genomes analyses indicated that DERs included those involved in cytosolic ribosomes,the nuclear lumen,protein binding,cell cycle,protein targeting to the endoplasmic reticulum,and ribosomal DNA *** Ontology and Reactome enrichment analyses indicated that DERs were associated with a variety of cancers and cell cycle ***-protein interaction results demonstrated that cdk1.and rps27a ranked in the top 1. interacting ***,DTP-PDT could inhibit cell growth and induce cell apoptosis and autophagy,partly through ROS and the P38 MAPK signaling *** associated with the cell cycle,ribosomes,DNA replication,and protein binding may be the key changes in DTP-PDT-mediated cytotoxicity.

关键词： Photodynamic therapy ROS Apoptosis Autophagy Bioinformatic analysis

High Density 3D Carbon Tube Nanoarray Electrode Boosting the Capacitance of Filter Capacitor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第11期16卷 242-254页

作者： Gan chen Fangming {1. Huachun Ma Pei Li Ziyan Zhou Pengxiang wang Xiaoyan Li Guowen Meng Bingqing Wei Key Laboratory of Materials Physics and Anhui Key Laboratory of Nanomaterials and NanotechnologyInstitute of Solid State PhysicsHFIPSChinese Academy of SciencesHefei 230031People’s Republic of China department of Materials Science and Engineering University of Science and Technology of ChinaHefei 230026People’s Republic of China department of Mec{1.ical Engineering University of DelawareNewarkDE 19716USA Mechano‑X Institute Applied Mechanics LaboratoryDepartment of Engineering MechanicsTsinghua UniversityBeijing 100084People’s Republic of China

Electric double-layer capacitors(EDLCs)with fast frequency response are regarded as small-scale alternatives to the commercial bulky aluminum electrolytic *** carbon-based nanoarray electrodes with precise alignment and smooth ion channels is crucial for enhancing EDLCs’***,controlling the density of macropore-dominated nanoarray electrodes poses challenges in boosting the capacitance of line-filtering ***,a simple technique to finely adjust the vertical-pore diameter and inter-spacing in three-dimensional nanoporous anodic aluminum oxide(3D-AAO)template is achieved,and 3D compactly arranged carbon tube(3D-CACT)nanoarrays are created as electrodes for symmetrical EDLCs using nanoporous 3D-AAO template-assisted chemical vapor deposition of *** 3D-CACT electrodes demonstrate a high surface area of 253.0 m^(2) g^(−1.,a D/G band intensity ratio of 0.94,and a C/O atomic ratio of *** a result,the high-density 3D-CT nanoarray-based sandwich-type EDLCs demonstrate a record high specific areal capacitance of 3.23 mF cm^(-2) at 1.0 Hz and exceptional fast frequency response due to the vertically aligned and highly ordered nanoarray of closely packed CT *** 3D-CT nanoarray electrode-based EDLCs could serve as line filters in integrated circuits,aiding power system miniaturization.

关键词： Compactly arranged Three-dimensional carbon tube nanoarray Dimensional carbon tube nanoarray Fast frequency response Electric double-layer capacitors Layer capacitors AC line-filtering Filtering

Moisture‑Electric–Moisture‑Sensitive Heterostructure Triggered Proton Hopping for Quality‑Enhancing Moist‑Electric Generator

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第3期16卷 351-366页

作者： Ya’nan Yang Jiaqi wang Zhe wang Changxiang Shao Yuyang han Ying wang Xiaoting Liu Xiaotong Sun Liru wang Yuanyuan Li Qiang Guo Wenpeng Wu Nan chen Liangti Qu Key Laboratory of Cluster Science Ministry of Education of ChinaKey Laboratory of Photoelectronic/Electrophotonic Conversion MaterialsSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081People’s Republic of China Yangtze Delta Region Academy of beijing Institute of Technology Jiaxing 314019People’s Republic of China department of Chemistry Key Laboratory of Organic Optoelectronics&Molecular EngineeringMinistry of EducationTsinghua UniversityBeijing 100084People’s Republic of China

Moisture-enabled electricity(ME)is a method of converting the potential energy of water in the external environment into electrical energy through the interaction of functional materials with water molecules and can be directly applied to energy harvesting and signal ***,ME can be unreliable in numerous applications due to its sluggish response to moisture,thus sacrificing the value of fast energy harvesting and highly accurate information ***,by constructing a moisture-electric-moisture-sensitive(ME-MS)heterostructure,we develop an efficient ME generator with ultra-fast electric response to moisture achieved by triggering Grotthuss protons hopping in the sensitized ZnO,which modulates the heterostructure built-in interfacial potential,enables quick response(0.435 s),an unprecedented ultra-fast response rate of 972.4 mV s^(−1.,and a durable electrical signal output for 8 h without any *** research provides an efficient way to generate electricity and important insight for a deeper understanding of the mechanisms of moisture-generated carrier migration in ME generator,which has a more comprehensive working scene and can serve as a typical model for human health monitoring and smart medical electronics design.

关键词： Moist-electric generators Grotthuss proton hopping Fast response Durable electrical output Personal health monitoring

Measuring-basis-encrypted six-state quantum key distribution scheme

在线全文

学校读者我要写书评

暂无评论

Progress in Natural Science:Materials International 2006年第1期16卷 84-89页

作者： chen Pan1. DENG Fuguo1. {1. Pingxiao1.and LONG Guilu1.2 (Key Laboratory for Quantum Information and Measurements and department of Physics, tsinghua university, beijing 1.0084, china 2. Key Laboratory for Atomic and Molecular NanoSciences, tsinghua university, beijing 1.0084, china) [a]department of Physics Tsinghua University Key Laboratory for Quantum Information and Measurements Beijing China [b]tsinghua {1. Key Laboratory for Atomic and Molecular NanoSciences Beijing China

A six-state quantum key distribution scheme with measuring-basis encryption technique, which is based on the six-state protocol and the MBE protocol, is proposed. In this modified six-state quantum key distribution protocol, Alice and Bob use a control key to synchronize the use of their measuring-basis so that they always use the same measuring-basis. This modified six-state quantum key distribution protocol retains the advantage of higher security and at the same time has a higher efficiency.

关键词： quantum key distribution measuring-basis encrypted six-state security.

Mechanism of Guangdong Shenqu in regulating intestinal flora in mice with food stagnation and internal heat based on 1.S rDNA sequencing Author links open overlay panel

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medical Sciences 2024年第2期11卷 232-244页

作者： Yani Jiang Zhenhong Zhang han chen Yanmin wang Yanrui Xu Zijie chen Yan Xu Jingjuan wang School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing102488China School of Chinese Traditional Medicine Beijing University of Chinese MedicineBeijing102488China department of Chemistry Cleveland State UniversityCleveland44115USA

Objective To investigate the effect of Guangdong Shenqu(GSQ)on intestinal flora structure in mice with food stagnation through 1.S rDNA *** Mice were randomly assigned to control,model,GSQ low-dose(GSQL),GSQ medium-dose(GSQM),GSQ high-dose(GSQH),and lacidophilin tablets(LAB)groups,with each group containing 1. mice.A food stagnation and internal heat mouse model was established through intragastric administration of a mixture of beeswax and olive oil(1.15).The control group was administered normal saline,and the model group was administered beeswax and olive oil to maintain a *** GSQL(2 g/kg),GSQM(4 g/kg),GSQH(8 g/kg),and LAB groups(0.625 g/kg)were administered corresponding drugs for 5 *** administration,1.S rDNA sequencing was performed to assess gut microbiota in mouse fecal *** The model group exhibited significant intestinal flora *** GSQ administration,the abundance and diversity index of the intestinal flora increased significantly,the number of bacterial species was regulated,andαandβdiversity were *** administration increased the abundance of probiotics,including Clostridia,Lachnospirales,and Lactobacillus,whereas the abundance of conditional pathogenic bacteria,such as Allobaculum,Erysipelotrichaceae,and Bacteroides *** prediction analysis indicated that the pathogenesis of food stagnation and GSQ intervention were primarily associated with carbohydrate,lipid,and amino acid metabolism,among other metabolic *** The digestive mec{1.ism of GSQ may be attributed to its role in restoring diversity and abundance within the intestinal flora,thereby improving the composition and structure of the intestinal flora in mice and subsequently influencing the regulation of metabolic pathways.

关键词： Guangdong Shenqu Food stagnation Gut microbiota High-throughput gene sequencing Species annotation Metabolic pathway

LiOH-mediated crystallization regulating strategy enhancing electrochemical performance and structural stability of SiO anodes for lithium-ion batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第9期17卷 8174-8183页

作者： Zhengqiu He Zewen Xu Yu Long Jiexin Zhu Hao Yang Kuo chen Qiang Zhou Ning Cao Xiaobo {1. Juan {1. Xiaojie Tan Litao {1. Luhai {1. Shengbao He Mengdi Zhang han Hu Mingbo Wu State Key Laboratory of Heavy Oil Processing College of Chemistry and Chemical EngineeringChina University of Petroleum(East China)Qingdao 266580China department of Chemistry National University of Singapore3 Science Drive 3Singapore 117543Singapore School of Chemical Sciences University of AucklandAuckland 1010New Zealand Petrochemical Research Institute Petro China Company Ltd.Beijing 102206China

Silicon monoxide(SiO)is widely recognized as a promising anode material for next-generation lithium-ion *** to its metastable amorphous structure,SiO exhibits a highly complex degree of crystallization at the microscopic level,which significantly influences its electrochemical *** a consequence,accurately regulating the crystallization of SiO,and further establishing the relationship between crystallinity and electrochemical performance are very critical for SiO *** this article,carbon-coated SiO materials with different crystallinity degrees were synthesized using lithium hydroxide monohydrate(LiOH·H_(2)O)as a structural modifier to reveal this ***,moderate amount of LiOH·H_(2)O addition results in the forming of an oxygen-rich shell,which effectively inhibits the inward migration of oxygen atoms on the SiO surface and suppresses volume ***,the crystallinity of SiO will gradually enhance and the crystalline phase appears with increasing the amount of LiOH·H_(2)O,which will generate a deteriorative Li+diffusion *** balancing the above two contradictions,a mass fraction of 1.LiOH·H_(2)O for the additive yielded SiO@C-1.characterized by optimal ***@C-1.demonstrates exceptional long-cycle stability with 74.8%capacity retention after 500 cycles at 1.A·g^(-1..Furthermore,it achieves a capacity retention of 52.2%even at a high density of 5 A·g^(-1..This study first reveals the relationship between SiO crystallinity and electrochemical performance,which efficiently guides the design of high-performance SiO anodes.

关键词： lithium-ion batteries SiO anodes crystallinity regulation high rate long life

Mitochondrial components transferred by MSC-derived exosomes promoted bone regeneration under high salt microenvironment via DRP1.Wnt signaling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第9期17卷 8301-8315页

作者： Yiming wang Shuai Lin Liujing {1. Mingzhao Li Zilu Zhu Zimeng Zhuang Meilian Cai han Zhang {1.yang Xing Weiran Li Ruili Yang department of Orthodontics School and Hospital of StomatologyPeking UniversityBeijing 100081China National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology School and Hospital of StomatologyPeking UniversityBeijing 100081China beijing Key Laboratory of Digital Stomatology School and Hospital of StomatologyPeking UniversityBeijing 100081China

Bone homeostasis relies on the dynamic balance of osteoblast mediated bone construction and osteoclast-based bone resorption processes,which has been reported to be controlled by various mineral ***,there is no direct evidence of the effect and the underlying mechanism of high salt stimulation on bone *** this study,we demonstrated that high salt stimulation promoted excessive mitochondrial fission mediated by dynamin-related protein 1.in mesenchymal stem cells,which resulted in impaired mitochondrial morphology and ***,this impairment hindered the bone formation of mesenchymal stem cells,resulting in osteopenia in ***,the impaired property of mesenchymal stem cells which was caused by high salt was controlled by dynamin-related protein 1.mediated mitochondrial fission,which inhibited the classical Wnt signaling ***,the osteogenic property of mesenchymal stem cells decreased by high salt could be restored by exosomes to transfer the mitochondrial DNA into the impaired mesenchymal stem *** study provides not only new strategies for promoting bone regeneration but also new insights into the effect and mechanism of exosome-mediated delivery.

关键词： high salt dynamin-related protein 1 mitochondrial injury exosomes bone regeneration

Mid-infrared Period-Luminosity Relations of Gaia DR3 Long Period Variables

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2024年第7期24卷 56-70页

作者： Xiaohan {1. Xiaodian {1. Licai Deng Shu wang Tianlu {1. department of Physics College of ScienceTibet UniversityLhasa 850000China Key Laboratory of Cosmic Rays(Tibet university) Ministry of EducationLhasa 850000China CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of the Chinese Academy of SciencesBeijing 100049China department of Astronomy China West Normal UniversityNanchong 637009China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China

Long period variable(LPV)stars are very promising distance indicators in the infrared *** selected asymptotic giant branch(AGB)stars in the Large and Small Magellanic Cloud(LMC and SMC)from the Gaia Data Release 3 LPV catalog,and classified them into oxygen-rich(O-rich)and carbon-rich(C-rich)AGB *** the Wide-field Infrared Survey Explorer database,we determined the W1.and W2-band period-luminosity relations(PLRs)for each pulsation-mode sequence of AGB *** dispersion of the PLRs of O-rich AGB stars in sequences C'and C is relatively small,around 0.1. *** PLRs of LMC and SMC are consistent in each *** the W2 band,the PLR of large-amplitude C-rich AGB stars is steeper than that of small-amplitude C-rich AGB stars,due to their more circumstellar *** two methods,we find that some PLR sequences of O-rich AGB stars in the LMC are dependent on *** coefficients of the metallicity effect areβ=-0.533±0.21. mag dex~1.ndβ=-0.767±0.1.8 mag dex~1.or sequence C in W1.and W2 bands,*** significance of the metallicity effect in W1.band for the four sequences is 2.2-3.5σ.Both of these imply that distance measurements using O-rich Mira may need to take the metallicity effect into account.

关键词： stars variables general-stars distances-infrared stars

A quantification model for apoptosis in mouse embryos in the early stage of fetation

在线全文

学校读者我要写书评

暂无评论

Science china(Life Sciences) 2009年第10期52卷 922-927页

作者： wang PengFei1. FU JianHua1. MA WanYun1. {1. DieYan1. Lü DanYu2 & BAI WenJia3 1.Key Laboratory for Atomic and Molecular Nanosciences of Education Ministry, department of Physics, tsinghua university, beijing 1.0084, china 2 department of Anatomy & Histology and Embryology, School of Basic Medical Sciences Peking university Health Science Center, beijing 1.0083, china 3 department of Automation, tsinghua university, beijing 1.0084, china 1. Key Laboratory for Atomic and Molecular Nanosciences of Education Ministry Department of Physics Tsinghua University Beijing 100084 China 2. department of Anatomy & Histology and Embryology School of Basic Medical Sciences Peking University Health Science Center Beijing 100083 China 3. department of Automation Tsinghua University Beijing 100084 China

Apoptosis is the most important inducement and modulator for embryos in the early stage of fetation, i.e. after the 8-cell stage, mostly the morula and blastula stage, to proceed to the stage of nonlinear development. Using a two-photon laser scanning microscopy (TPLSM) system, we obtained 3-dimensional (3D) fluorescent images of preimplantation mouse embryos. A model for quantification was established. The statistical results for the spatial location of apoptosis bodies in embryos was obtained following image processing, as well as investigation of the kinetics of apoptosis. It was found that most (70%) apoptosis occurred in the trophectoderm, and the departure between the centroid and geometric center of embryos had a step transition when embryos developed into the 32-cell stage, which was consistent with the theoretical prediction that the blastocele would induce a symmetry break of the distribution of cells in embryos.

关键词： apoptosis preimplantation mouse embryo TPLSM quantification model