检索结果-南通市图书馆

Protein regulation mechanism of cold tolerance in Haemaphysalis longicornis

在线全文

学校读者我要写书评

暂无评论

Insect Science 2023年第3期30卷 725-740页

作者： Ningmei wang Aimeng Ji Abolfazl Masoudi Shuang Li Yuhong Hu Yefei zhang zhijun Yu han wang Hui wang Jingze liu Ministry of Education Key Laboratory of Molecular and Cellular Biology Hebei Key Laboratory of Animal PhysiologyBiochemistry and Molecular BiologyCollege of Life SciencesHebei Normal UniversityShijiazhuangChina Instrumental Analysis Center Hebei Normal UniversityShjiazhuangChina Hebei Xiaowutai Mountain National Nature Reserve Management Center ZhangjiakouHebei ProvinceChina

Ticks are external parasitic arthropods that can transmit a variety of pathogens by sucking ***-temperature tolerance is essential for ticks to survive during the cold *** the protein regulation mechanism of low-temperature tolerance of Haemaphysalis longicornis could help to explain how ticks survive in *** this study,the quantitative proteomics of several tissues of *** exposed to low temperature were studied by data independent acquisition *** of 3699,3422,and 1958 proteins were identified in the salivary gland,midgut,and ovary,*** proteins involved in energy metabolism,cell signal transduction,protein synthesis and repair,and cytoskeleton synthesis changed under low-temperature *** comprehensive analysis of the protein regulation of multiple tissues of female ticks exposed to low temperature showed that maintaining cell homeostasis,maintaining cell viability,and enhancing cell tolerance were the most important means for ticks to maintain vital signs under low *** expression of proteins involved in and regulating the above cell activities was the key to the survival of ticks under low *** the analysis of a large amount of data,we found that the expression levels of arylamine N-acetyltransferase,inositol polyphosphate multikinase,and dual-specificity phosphatase were up-regulated under low *** speculated that they might have important significance in low-temperature ***,we performed RNA interference on the mRNA of these 3 proteins,and the results showed that the ability of female ticks to tolerate low temperatures decreased significantly.

关键词： low-temperature tolerance protein regulation tick survival strategy

Impaired Parahippocampal Gyrus-Orbitofrontal Cortex Circuit Associated with Visuospatial Memory Deficit as a Potential Biomarker and Interventional Approach for Alzheimer Disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2020年第8期36卷 831-844页

作者： Lin Zhu Zan wang Zhanhong Du Xinyang Qi Hao Shu Duan liu Fan Su Qing Ye Xuemei liu Zheng Zhou Yongqiang Tang Ru Song Xiaobin wang Li Lin Shijiang Li Ying han Liping wang zhijun zhang Department of Neurology Affiliated ZhongDa HospitalSchool of MedicineSoutheast UniversityNanjing 210009China Shenzhen Key Laboratory of Neuropsychiatric Modulation Guangdong Provincial Key Laboratory of Brain Connectome and BehaviorChinese Academy of Science(CAS)Key Laboratory of Brain Connectome and Manipulationthe Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsShenzhen 518055China Laboratory Animal Center Southeast UniversityNanjing 210009China Department of Neurology Xuan Wu Hospital of Capital Medical UniversityBeijing 100053China Department of Biophysics Medical College of WisconsinMilwaukeeWI 53226USA University of the Chinese Academy of Sciences Beijing 100049China Beijing Institute of Geriatrics BeijingChina National Clinical Research Center for Geriatric Disorders BeijingChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina

The parahippocampal gyrus-orbitofrontal cortex(PHG-OFC)circuit in humans is homologous to the postrhinal cortex(POR)-ventral lateral orbitofrontal cortex(vlOFC)circuit in *** are associated with visuospatial malfunctions in Alzheimer’s disease(AD).However,the underlying mechanisms remain to be *** this study,we explored the relationship between an impaired POR-vlOFC circuit and visuospatial memory deficits through retrograde tracing and in vivo local field potential recordings in 5XFAD mice,and investigated alterations of the PHG-OFC circuit by multi-domain magnetic resonance imaging(MRI)in patients on the AD *** demonstrated that an impaired glutamatergic POR-vlOFC circuit resulted in deficient visuospatial memory in 5XFAD ***,MRI measurements of the PHG-OFC circuit had an accuracy of 77.33%for the classification of amnestic mild cognitive impairment converters versus ***,the PHG-OFC circuit explains the neuroanatomical basis of visuospatial memory deficits in AD,thereby providing a potential predictor for AD progression and a promising interventional approach for AD.

关键词： Alzheimer’s disease Amnestic mild cognitive impairment Postrhinal cortex Visuospatial memory Ventral lateral orbitofrontal cortex Uncinate fasciculus

Brocaeloid D,a novel compound isolated from a wheat pathogenic fungus, Microdochium majus 99049

在线全文

学校读者我要写书评

暂无评论

Synthetic and Systems Biotechnology 2019年第4期4卷 173-179页

作者： Jingyu zhang Zhenzhen wang zhijun Song Loganathan Karthik Chengjian Hou Guoliang Zhu Lan Jiang Jianying han Rong Ma Li Li Lixin zhang Xueting liu Tom Hsiang State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai200237China Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing100101China Department of Medicinal Chemistry Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100050China School of Environmental Sciences University of Guelph50 Stone Road EastGuelphOntarioN1G 2W1Canada University of Chinese Academy of Sciences Beijing100049China

Microbes serve as the most important resource for drug *** our screening for bioactive compounds from our natural products library,a pathogenic fungus,Microdochium majus strain 99049,from wheat was selected for further investigation.A new alkaloid named brocaeloid D(1),together with six previously characterized compounds(2–7)were *** 1 belongs to 4-oxoquinoline with C-2 reversed prenylation and a succinimide *** the structures of these newly isolated compounds were determined by different means in spectroscopic *** absolute configurations of 1 was further deduced from comparison of its CD spectrum with that of known compound *** bioactivities of these identified compounds were evaluated against several pathogenic microorganisms and cancer cell *** 1–5 showed activity against HUH-7 human hepatoma cells with IC50 values of 80μg/*** 6 showed mild activity against HeLa cells(IC50=51.9μg/mL),weak anti-MTB activity(MIC=80μg/mL),and moderate anti-MRSA activity(MIC=25μg/mL),and compound 7 showed weak anti-MRSA activity(MIC=100μg/mL).

关键词： Wheat pathogenic fungus Anticancer Antibacterial Natural product

The Main Progress of Perovskite Solar Cells in 2020-2021

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2021年第10期13卷 113-130页

作者： Tianhao Wu Zhenzhen Qin Yanbo wang Yongzhen Wu Wei Chen Shufang zhang Molang Cai Songyuan Dai Jing zhang Jian liu Zhongmin Zhou Xiao liu Hiroshi Segawa Hairen Tan Qunwei Tang Junfeng Fang Yaowen Li Liming Ding zhijun Ning Yabing Qi Yiqiang zhang Liyuan han State Key Laboratory of Metal Matrix Composites School of Material Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Centre Shanghai Key Laboratory of Functional Materials ChemistryJoint International Research Laboratory of Precision Chemistry and Molecular EngineeringSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyMeilong Road 130Shanghai 200237People’s Republic of China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyLuoyu Road 1037Wuhan 430074People’s Republic of China College of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094People’s Republic of China Beijing Key Laboratory of Novel Thin-Film Solar Cells and State Key Laboratory of Alternate Electrical Power System With Renewable Energy Sources North China Electric Power UniversityBeijing 102206People’s Republic of China Department of Microelectronic Science and Engineering Ningbo UniversityZhejiang 315211People’s Republic of China College of Chemical Engineering Jiangsu Key Lab of Biomass-Based Green Fuels and ChemicalsNanjing Forestry UniversityNanjing 210037People’s Republic of China College of Chemistry and Molecular Engineering Qingdao University of Science and TechnologyQingdao 266042People’s Republic of China Special Division of Environmental and Energy Science Komaba Organization for Educational Excellence(KOMEX)College of Arts and SciencesUniversity of TokyoTokyo 153-8902Japan National Laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artificial Functional MaterialsCollege of Engineering and Applied SciencesNanjing UniversityNanjing 210093People’s Republic of China College of Information Science and Technology Jinan UniversityGuangzhou 510632People’s Republic of China School of Physics and Electronic Science Engineering Research Center of Nan

Perovskite solar cells(PSCs)emerging as a promising photovoltaic technology with high efficiency and low manufacturing cost have attracted the attention from all over the *** the efficiency and stability of PSCs have increased steadily in recent years,and the research on reducing lead leakage and developing eco-friendly lead-free perovskites pushes forward the commercialization of PSCs step by *** review summarizes the main progress of PSCs in 2020 and 2021 from the aspects of efficiency,stability,perovskite-based tandem devices,and lead-free ***,a brief discussion on the development of PSC modules and its challenges toward practical application is provided.

关键词： Perovskite solar cells Stability Solar module Perovskite-based tandem devices Lead-free perovskite

Transcriptional activation and phosphorylation of OsCNGC9 confer enhanced chilling tolerance in rice

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2021年第2期14卷 315-329页

作者： Jiachang wang Yulong Ren Xi liu Sheng Luo Xiao zhang Xin liu Qibing Lin Shanshan Zhu Hua Wan Yang Yang Yu zhang Bin Lei Chunlei Zhou Tian Pan Yongfei wang Mingming Wu Ruonan jing Yang Xu Meng han Fuqing Wu Cailin Lei Xiuping Guo zhijun Cheng Xiaoming Zheng Yihua wang Zhigang Zhao Ling Jiang Xin zhang Yong-Fei wang Haiyang wang Jianmin Wan National Key Laboratory for Crop Genetics and Germplasm Enhancement Jiangsu Plant Gene Engineering Research CenterNanjing Agricultural UniversityNanjing 210095China National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China National Key Laboratory of Plant Molecular Genetics Institute of Plant Physiology and EcologyCAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 200032China MOE Key Laboratory of Bioinformatics School of Life SciencesTsinghua UniversityBeijing100084China

Low temperature is a major environmental factor that limits plant growth and *** transient elevation of cytoplasmic calcium has long been recognized as a critical signal for plant cold tolerance,the calcium channels responsible for this process have remained largely *** we report that OsCNGC9,a cyclic nucleotide-gated channel,positively regulates chilling tolerance by mediating cytoplasmic calcium elevation in rice(Oryza sativa).We showed that the loss-of-function mutant of OsCNGC9 is defective in cold-induced calcium influx and more sensitive to prolonged cold treatment,whereas OsCNGC9 overexpression confers enhanced cold ***,we demonstrated that in response to chilling stress,OsSAPK8,a homolog of Arabidopsis thaliana OST1,phosphorylates and activates OsCNGC9 to trigger Ca2+***,we found that the transcription of OsCNGC9 is activated by a rice dehydration-responsive element-binding transcription factor,*** together,our results suggest that OsCNGC9 enhances chilling tolerance in rice through regulating cold-induced calcium influx and cytoplasmic calcium elevation.

关键词： OsCNGC9 OsSAPK8 OsDREB1A cold signaling transduction chilling tolerance

The Tartary Buckwheat Genome Provides Insights into Rutin Biosynthesis and Abiotic Stress Tolerance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2017年第9期10卷 1224-1237页

作者： zhang, Lijun Li, Xiuxiu Ma, Bin Gao, Qiang Du, Huilong han, Yuanhuai Li, Yan Cao, Yinghao Qi, Ming Zhu, Yaxin Lu, Hongwei Ma, Mingchuan liu, Longlong Zhou, Jianping Nan, Chenghu Qin, Yongjun wang, Jun Cui, Lin liu, Huimin Liang, Chengzhi Qiao, zhijun Shanxi Acad Agr Sci Inst Crop Germplasm Resources Res Taiyuan 030031 Shanxi Peoples R China Minist Agr Key Lab Crop Gene Resources & Germplasm Enhanceme Taiyuan 030031 Shanxi Peoples R China Shanxi Key Lab Genet Resources & Genet Improvemen Taiyuan 030031 Shanxi Peoples R China Chinese Acad Sci Inst Genet & Dev Biol State Key Lab Plant Genom Beijing 100101 Peoples R China Univ Chinese Acad Sci Coll Life Sci Beijing 100049 Peoples R China Shanxi Agr Univ Coll Agron Taiyuan 030801 Shanxi Peoples R China Chinese Acad Sci Inst Microbiol State Key Lab Microbial Resources Beijing Peoples R China South China Agr Univ Coll Marine Sci Guangzhou 510642 Guangdong Peoples R China

Tartary buckwheat （Fagopyrum tataricum） is an important pseudocereal crop that is strongly adapted to growth in adverse environments. Its gluten-free grain contains complete proteins with a well-balanced composition of essential amino acids and is a rich source of beneficial phytochemicals that provide significant health benefits. Here, we report a high-quality, chromosome-scale Tartary buckwheat genome sequence of- 489.3 Mb that is assembled by combining whole-genome shotgun sequencing of both Illumina short reads and single-molecule real-time long reads, sequence tags of a large DNA insert fosmid library, Hi-C sequencing data, and BioNano genome maps. We annotated 33 366 high-confidence protein-coding genes based on expression evidence. Comparisons of the intra-genome with the sugar beet genome revealed an independent whole-genome duplication that occurred in the buckwheat lineage after they diverged from the common ancestor, which was not shared with rosids or asterids. The reference genome facilitated the identification of many new genes predicted to be involved in rutin biosynthesis and regulation, aluminum stress resistance, and in drought and cold stress responses. Our data suggest that Tartary buckwheat＇s ability to tolerate high levels of abiotic stress is attributed to the expansion of several gene families involved in signal transduction, gene regulation, and membrane transport. The availability of these genomic resources will facilitate the discovery of agronomically and nutritionally important genes and genetic improvement of Tartary buckwheat.

关键词： tartary buckwheat de novo genome assembly rutin biosynthesis aluminum resistance abiotic stress,whole genome duplication

Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2016年第4期59卷 1-7页

作者： WeiPing liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang han Chen QingHao Chen XiongJun Chen zhijun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou hanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo wang Peng wang YouBao wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu zhang Hui zhang LiYong zhang NingTao zhang QiWei zhang Tao zhang XiaoPeng zhang XueZhen zhang ZiMing zhang Wei Zhao Zuo Zhao Chao Zhou Department of Nuclear Physics China Institute of Atomic Energy Beijing 102413 China Institute of Modern Physics Lanzhou 730000 China College of Nuclear Science and Engineering Sichuan University Chengdu 610065 China Department of Engineering Physics Tsinghua University Beijing 100084 China Department of Physics and Astronomy Shanghai Jiaotong University Shanghai 200240 China School of Physics and Astronomy Monash University Melbourne Victoria 3800 Australia Center for Nuclear Study University of Tokyo Wako Saitama 351-0198 Japan Konkoly Observatory of the Hungarian Academy of Sciences 1121 Budapest Konkoly-Thege Miklos u. 13-17 Hungary Department of Physics University of South Dakota Vermillion SD 57069 United States School of Physics and Astronomy University of Minnesota Minneapolis MN 55455 United States Department of Physics University of Notre Dame Notre Dame IN 46556 Unites States Research Center for Nuclear Physics Osaka University Suita Osaka 565-0871 Japan School of Space Science and Physics Shandong University Weihai Campus Weihai 264209 China

Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given.

关键词： direct measurement underground laboratory (25)Mg(p γ)(26)Al (19)F(p α)(16)O (13)C(α n)(16)O and (12)C(α γ)(16)O reactions Gamow window JUNA

在线全文

学校读者我要写书评

暂无评论

全球钴供应市场结构及定价权分析

中国矿业 2017年第8期26卷 18-21页

作者：潘志君张恒刘宁王颖韩见中国地质大学(北京) 北京100083

钴是一种稀缺的战略金属。全球钴资源主要分布在刚果(金)、芬兰等国。刚果金的矿产钴产量占据全球的近一半,其政策变化极大的影响了钴的价格。从国家角度看,刚果金具有最大的定价权。从产业组织的角度来看,钴供应的市场结构属寡头垄断型... 详细信息

钴是一种稀缺的战略金属。全球钴资源主要分布在刚果(金)、芬兰等国。刚果金的矿产钴产量占据全球的近一半,其政策变化极大的影响了钴的价格。从国家角度看,刚果金具有最大的定价权。从产业组织的角度来看,钴供应的市场结构属寡头垄断型,四大钴巨头企业控制全球钴供应的40%以上,具有很强的市场定价权。同时,钴价格的快速飙升,也会带来矿产钴产量的提高,这个影响约有1~2年的滞后性。预计1~2年后当前紧张的钴供应和高企的钴价格将会得到缓解。

关键词：精炼钴市场结构资源供需定价权

microRNA-136基于Wnt信号通路在黑素瘤EMT中的作用

在线全文

学校读者我要写书评

暂无评论

中国皮肤性病学杂志 2020年第2期34卷 128-133页

作者：韩昭王久江张伶张建忠牛亮刘钊徐艳艳刘志军李小静河北工程大学附属医院皮肤科河北邯郸056000

目的探讨microRNA-136(miR-136)基于Wnt信号通路在黑素瘤上皮-间充质细胞转化(EMT)中的调控作用。方法常规培养正常小鼠A9细胞(阴性对照组)和小鼠黑素瘤B16细胞,采用脂质体转染法将B16细胞分为空白组(只转染试剂,无转染序列)、NC组(转染... 详细信息

目的探讨microRNA-136(miR-136)基于Wnt信号通路在黑素瘤上皮-间充质细胞转化(EMT)中的调控作用。方法常规培养正常小鼠A9细胞(阴性对照组)和小鼠黑素瘤B16细胞,采用脂质体转染法将B16细胞分为空白组(只转染试剂,无转染序列)、NC组(转染miR-136 nc)、miR-136模拟组(转染miR-136模拟物)、miR-136抑制组(转染miR-136抑制剂)。通过qRT-PCR法检测各组细胞中miR-136的表达,qRT-PCR及Western blot实验分别检测各组细胞Wnt3a、β-catenin、Ecadherin及N-cadherin mRNA及蛋白表达的差距。结果与阴性对照组相比,其他各组miR-136表达均显著降低,空白组与NC组比较差异无统计学意义(P>0.05)。相对于空白组与NC组,miR-136模拟组miR-136表达显著增加(P0.05)。与空白组和NC组相比,miR-136模拟组E-cadherin的mRNA及蛋白表达显著增加(P<0.05);β-catenin、Wnt3a和N-cadherin的mRNA及蛋白表达均显著降低(P均<0.05)。miR-136抑制组E-cadherin的mRNA及蛋白表达显著降低(P均<0.05),而β-catenin、wnt3a和N-cadherin的mRNA及蛋白表达显著升高(P均<0.05),组间差距均具有统计学意义。结论黑素瘤细胞中miR-136水平较正常细胞降低,过度表达的miR-136通过下调Wnt信号传导途径,抑制黑素瘤细胞的EMT。

关键词： microRNA-136 黑素瘤 Wnt信号通路 EMT