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Survival and prognostic factors of non-small cell lung cancer patients with postoperative locoregional recurrence treated with radical radiotherapy

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chinese Journal of Cancer 2017年第11期36卷 657-664页

作者： Li Ma Bo Qiu Jun zhang Qi-Wen Li Bin wang Xu-Hui zhang Meng-yun Qiang Zhao-{3. chen Su-Ping Guo Hui liu Department of Radiation Oncology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine 651 Dongfeng Road EastGuangzhou Guangdong 510060 P. R. China

Background: Locoregional recurrence remains the challenge for long-term survival of non-small cell lung cancer(NSCLC) patients after radical surgery, and curative-intent radiotherapy could be a treatment choice. This study aimed to assess the survival and prognostic factors of patients with postoperative locoregionally recurrent NSCLC treated with radical ***: We reviewed medical records of 74 NSCLC patients with postoperative locoregional recurrence who received radical radiotherapy between April 2.12.and February 2.16 at Sun Yat-sen University Cancer Center(Guangzhou, china). The efficacy and safety of radical radiotherapy were analyzed. The probability of survival was estimated using the Kaplan-Meier method and compared using the log-rank test. The Cox proportional hazards model was used to identify prognostic ***: Grade {2.4 adverse events included neutropenia(8 cases, 10.8%), esophagitis(7 cases, 9.5%), pneumonitis(1 case, 1.4%), and vomiting(1 case, 1.4%).The 2.year overall survival, progression-free survival, local recurrencefree survival(LRFS), and distant metastasis-free survival(DMFS) rates of all patients were 84.2.42.5,70.0, and 50.9%,respectively. Univariate and multivariate analyses showed that a higher biological effective dose(BED) of radiation was associated with longer LRFS [hazard ratios(HR)=0.{2.7,95% confidence interval(CI) = 0.112.0.899, P = 0.016] and that wild-type epidermal growth factor receptor(EGFR) was associated with longer DMFS compared with EGFR mutation(HR = 0.{2.{2.95% CI=0.171-0.855, P = 0.019).Conclusions: Radical radiotherapy is effective and well-tolerated in NSCLC patients with postoperative locoregional recurrence. High BED is a predictor for long LRFS, and the presence of wild-type EGFR is a predictor for long DMFS.

关键词： Non-small cell lung cancer Locoregional recurrence Radical radiotherapy Biological effective dose Epidermal growth factor receptor

乌美溴铵/维兰特罗在中国治疗慢性阻塞性肺疾病患者的上市后安全性监测研究

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中华结核和呼吸杂志 2024年第7期47卷 632-637页

作者：牟向东李小明何小鹏贾立华关英慧安福成陈丽萍贾琦肖爱莲张黎川肖志华王玉梅关巍刘田田苏麟清华大学附属北京清华长庚医院呼吸与危重症医学科北京102218 北京燕化医院呼吸科北京102599 咸阳市中心医院呼吸与危重症医学科咸阳712000 北京大学国际医院药剂科北京102206 吉林大学第一医院呼吸与危重症医学科吉林130031 北京市门头沟区医院呼吸与危重症医学科北京102399 沈阳医学院附属第二医院呼吸与危重症医学科沈阳110000 北京市隆福医院呼吸内科北京100010 太原钢铁(集团)有限公司总医院呼吸与危重症医学科太原030008 大连大学附属中山医院呼吸与危重症医学科大连116000 大同市第三人民医院呼吸与危重症医学科大同037046 南方科技大学医院呼吸内科深圳518000 深圳市宝安区中心医院呼吸与危重症医学科深圳518000 葛兰素史克(上海)医药研发有限公司上海201203

目的评估乌美溴铵/维兰特罗在真实世界临床实践中应用于中国患者的安全性。方法采用前瞻性、多中心、单臂、观察性研究,在2.2.年12.14日至2.2.年1月3.日,从中国的14家研究中心纳入在真实世界临床实践中接受乌美溴铵/维兰特罗治疗的患者... 详细信息

目的评估乌美溴铵/维兰特罗在真实世界临床实践中应用于中国患者的安全性。方法采用前瞻性、多中心、单臂、观察性研究,在2.2.年12.14日至2.2.年1月3.日,从中国的14家研究中心纳入在真实世界临床实践中接受乌美溴铵/维兰特罗治疗的患者,共随访2.周。研究主要结局为随访期内不良事件和严重不良事件的发生率。结果共纳入887例患者,年龄为(67.5±9.6)岁,其中男性689例(77.7%)。大多数患者(98.1%)有慢性阻塞性肺疾病史。468例患者(52.8%)报告了合并药物。在所有纳入的患者中,59例(6.7%)报告了不良事件,2.例(2.4%)报告了严重不良事件,其中9例报告了致死性严重不良事件,10例报告了非致死性严重不良事件,2.同时报告了非致死性和致死性严重不良事件。所有严重不良事件,包括致死性事件,经研究者判定均与乌美溴铵/维兰特罗无关。6例(0.7%)发生药物不良反应,其严重程度均为轻度。3.(0.3.)患者报告的不良事件属于重要已确定或潜在风险,经研究者判定均与乌美溴铵/维兰特罗无关。结论乌美溴铵/维兰特罗在真实世界临床实践中应用于中国患者具有良好的安全性,未观察到与该药相关的新的安全性信号。

关键词：肺疾病,慢性阻塞性安全性评价乌美溴铵维兰特罗真实世界数据

DataCon:面向安全研究的多领域大规模竞赛开放数据

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信息安全学报 2024年第1期9卷 123-136页

作者：郑晓峰段海新陈震宇应凌云何直泽汤舒俊郑恩南刘保君陆超逸沈凯文张甲陈卓林子翔清华大学网络科学与网络空间研究院北京100084 奇安信科技集团北京100088

网络安全数据是开展网络安全研究、教学的重要基础资源,尤其基于实战场景下的安全数据更是科研教学成果更符合安全实践的保障。然而,由于网络安全的技术变化快、细分领域多、数据敏感等原因,寻找合适的网络安全数据一直是研究者们进行... 详细信息

网络安全数据是开展网络安全研究、教学的重要基础资源,尤其基于实战场景下的安全数据更是科研教学成果更符合安全实践的保障。然而,由于网络安全的技术变化快、细分领域多、数据敏感等原因,寻找合适的网络安全数据一直是研究者们进行科研和老师开展实践教学时关注的重要问题。本文总结并分析了多个领域的经典公开安全数据集,发现其在研究应用时存在数据旧、规模小、危害大等不足;克服安全数据领域选择、大规模实战数据获取、安全隐私开放等困难,构造了更符合当前科研需求DataCon安全数据集。数据集大规模覆盖DNS、恶意软件、加密恶意流量、僵尸网络、网络黑产等多个领域,且均来自实战化场景,并基于DataCon竞赛平台将其开放给参赛者和科研人员。目前,DataCon数据集涵盖了已成功举办四届的“DataCon大数据安全分析大赛”的全部数据,大赛被国家教育部评为优秀案例,并进入多所高校研究生加分名单,数据内容也一直随着真实网络环境中攻防场景的变化而持续更新。目前,DataCon数据集涵盖了已成功举办四届的“DataCon大数据安全分析大赛”的全部数据,大赛被国家教育部评为优秀案例,并进入多所高校研究生加分名单,数据内容也一直随着真实网络环境中攻防场景的变化而持续更新。数据集持续收到科研人员、学术的数据使用申请,支撑了多篇学术论文的发表,充分说明了其有效性和可用性。我们希望DataCon数据及竞赛能够对网络安全领域产、学、研结合有所帮助和促进。

关键词： DataCon 安全研究开放数据竞赛

^(18)F-FDG uptake as a biologic factor predicting outcome in patients with resected non-small-cell lung cancer

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chinese Medical Journal 2007年第2期120卷 125-131页

作者： zhang Zhen-jiang chen Jing-han MENG Long DU Jia-jun zhang {3. liu Ying DAI Hong-hai Department of Thoracic Surgery Shandong Provincial Hospital Shandong University Jinan 250021 China Department of Pathology Shandong Provincial Hospital Jinan 250021 China Department of Radiology Shandong Tumor Hospital Jinan 250117 China

Background The outcome of surgical treatment of non-small-cell lung cancer （NSCLC） remains poor. In many patients the biological behavior of NSCLC does not follow a definite pattern, and can not be accurately predicted before treatment. ^18F-fluoro-2.deoxy-glucose （^18F-FDG） uptake on positron-emission tomography （PET） is associated with the aggressiveness of NSCLC. The present study focused on the role of ^18F-FDG uptake in predicting the outcome of surgically treated patients with NSCLC. Methods A retrospective analysis was made of 82.patients who underwent complete resection and preoperative FDG PET. The maximum standardized uptake value （SUVmax）, in addition to five clinicopathological factors and three biomolecular factors, which could possibly influence survival, was compared for possible association with patients＇ recurrence and survival, by the Log-rank test in univariate analysis and the Cox proportional hazards model in multivariate analysis. The association between SUVmax and other factors was also analyzed. Results Patients with SUVmax more than 11 had a disease-free survival and overall survival shorter than patients with SUVmax less than 11 in univariate analyses （P〈0.001, P=0.002.. In the multivariate analysis, SUVmax （dichotomized by 11） was the only significant predictor for tumor recurrence. TNM stage and SUVmax （dichotomized by 11） were independent predictors for the overall survival. Associations of SUVmax with p5{2.overexpression, proliferating cell nuclear antigen （PCNA） labeling index and microvascular density of the tumor were significant in the entire group. Conclusions ^18F-FDG uptake on PET may be used to noninvasively assess biological aggressiveness of NSCLC in vivo, identifying the surgically-treated patients with poor prognosis who could benefit from additional therapy.

关键词： deoxyglucose positron-emission tomography carcinoma non-small-cell lung surgery prognosis

Design rules of pseudocapacitive electrode materials:ion adsorption,diffusion,and electron transmission over prototype TiO_(2.

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Science china Materials 2022年第2期65卷 391-399页

作者： Lijing wang Xiaolong Yao Da chen Jin wang Zhenzhou {3. Jieyu liu Tianquan lin Wei-Hua wang {3.lian Hong Fuqiang Huang Weichao wang Integrated Circuits and Smart System Lab(Shenzhen) Renewable Energy Conversion and Storage CenterTianjin Key Laboratory of Photo-Electronic Thin Film Device and TechnologyCollege of Electronic Information and Optical EngineeringNankai UniversityTianjin 300071China Key Laboratory of Civil Aviation Thermal hazards Prevention and Emergency Response Civil Aviation University of ChinaTianjin 300300China CAS Key Laboratory of Materials for Energy Conversion and State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China

The development of a high-performing pseudocapacitor requires a comprehensive understanding of electrode materials from the aspects of electron transfer and electrolyte ion adsorption and ***,these factors are considered over the prototype TiO_(2.,and a high pseudocapacitance is achieved via the introduction of various defects,i.e.,oxygen defect(V_(O))and co-doped defect(V_(O)+N_(O)).The study is based on joint explorations of first-principle calculations and the transfer matrix *** to pristine TiO_(2.(3.0 F g^(-1)),defective TiO_(2. produces pseudocapacitance as high as 1700 F g^(-1).Moreover,defects induce small barriers for electron transmission caused by surface band *** climbing image nudged elastic band diffusion of H ions displays a much higher barrier in TiO_(2.-V_(O) than in TiO_(2.-V_(O)+N_(O).Such a result indicates easy H diffusion in the co-doped *** work provides insights into the adsorption and diffusion of electrolyte ions and the influence of defects on electron *** results are also significant for the design and optimization of electrode materials for the next generation of supercapacitors.

关键词： pseudocapacitance charge storage ion diffusion electron transmission

江汉盆地新生代早期河流演化研究:来自地表河流和盆地钻孔碎屑锆石U-Pb年龄的约束

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地质科技通报 2023年第6期42卷 106-117页

作者：张洋陈孝康林旭李长安刘海金刘杰三峡大学土木与建筑学院湖北宜昌443002 三峡大学三峡地区地质灾害与生态环境湖北省协同创新中心湖北宜昌443002 中国地质大学(武汉)地理与信息工程学院武汉430078 东华理工大学地球科学学院南昌330013

大型河流的演化是构造-气候相互作用的结果,对其开展演化历史研究是揭示地球深部动力过程对地表过程影响的关键切入点。保存于江汉盆地的新生代地层详细记录了汉江、长江等大型河流的演化信息。通过对汉江流域进行系统的碎屑锆石U-Pb年... 详细信息

大型河流的演化是构造-气候相互作用的结果,对其开展演化历史研究是揭示地球深部动力过程对地表过程影响的关键切入点。保存于江汉盆地的新生代地层详细记录了汉江、长江等大型河流的演化信息。通过对汉江流域进行系统的碎屑锆石U-Pb年龄分析(n=690),结合前人在江汉盆地主要汇入河流发表的锆石U-Pb年龄数据,将其与江汉盆地内早始新世沉积钻孔的锆石U-Pb年龄数据进行了对比。结果表明,汉江下游的碎屑锆石U-Pb年龄物质组成混合了秦岭西部、大巴山和秦岭东部的河流碎屑物质信号,采用其下游干流样品的锆石U-Pb年龄组成进行物源对比更具有代表性;江汉盆地早始新世的碎屑物质主要来自秦岭和大别山,这主要归结为江汉盆地内部断陷与这些造山带的隆升形成显著的地势差异,为大型河流发育奠定基础;发源于武陵山和黄陵背斜的河流此时并不是江汉盆地中部、东部和南部凹陷的物质供给河流;黄陵背斜以西的长江在早始新世未进入江汉盆地。总体而言,江汉盆地在新生代早期的沉积物源以近源造山带为主,是对盆地周缘造山带隆升和类季风气候的沉积响应。

关键词：江汉盆地锆石 U-Pb年龄河流演化

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汽车铸造作业工人队列死因研究

中华劳动卫生职业病杂志 2008年第10期26卷 596-600页

作者：曾玉宇刘富英张敏卢锐姚惠琳杨秋玲陈卫红华中科技大学同济医学院公共卫生学院劳动与环境卫生学系环境与健康教育部重点实验室武汉430030 十堰市东风职业病防治所中国疾病预防控制中心职业卫生与中毒控制所

目的分析危害汽车铸造作业工人健康的主要疾病，探讨铸造作业有害因素对工人寿命的影响。方法采用流行病学队列研究方法，以某汽车铸造厂1980年在册的3.2.名职工为研究对象，从1980年随访至2.05年底，以全国城市居民年龄别死亡率均值为... 详细信息

目的分析危害汽车铸造作业工人健康的主要疾病，探讨铸造作业有害因素对工人寿命的影响。方法采用流行病学队列研究方法，以某汽车铸造厂1980年在册的3.2.名职工为研究对象，从1980年随访至2.05年底，以全国城市居民年龄别死亡率均值为参照，用标化死亡比（SMR）作为统计指标，并计算95％可信区间。结果随访至2.05年底，共计84999人年，共死亡2.5人，死亡率3.12.，累积死亡率为7．51％。铸工队列全死因SMR为0．96（95％CI：0．85～1．08）与全国平均水平持平，随着年龄增长，全死因SMR呈现升高趋势，50岁以上组工人的SMR均大于1。影响铸造工人寿命的主要疾病按累积死亡率从高到低排序分别是：恶性肿瘤（3.43.）、意外伤害（1．16％）、脑血管疾病（1．08％）、心血管疾病（0．79％）。恶性肿瘤占总死亡原因的45．7％。铸造工人中死亡率明显升高的疾病有恶性肿瘤（SMR=7．87）、意外伤害（SMR=2.70）、心血管疾病（SMR=2.68）、消化系统疾病（SMR=2.79）。一线作业工人恶性肿瘤死亡是辅助工人的1．95倍（RR=1．95，P〈0．05）。结论铸造作业中粉尘等职业危害因素明显影响工人的健康，恶性肿瘤死亡明显增加，应加强防护。

关键词：汽车健康工人效应队列研究肿瘤死亡原因

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碳纤维屏蔽纸屏蔽性能的研究

中国造纸学报 2008年第4期23卷 90-93页

作者：钟林新张美云陈均志刘叶陕西科技大学造纸工程学院陕西西安710021

对碳纤维屏蔽纸的屏蔽机理及其在电磁波频率为100 kHz^1.5 GHz范围内的屏蔽性能进行了探讨。结果表明,屏蔽纸对不同频率段电磁波产生不同的屏蔽效能;随着纸张电导率、厚度的增加,屏蔽效能提高。屏蔽纸在600 MHz^1.2.GHz频段具有更高的... 详细信息

对碳纤维屏蔽纸的屏蔽机理及其在电磁波频率为100 kHz^1.5 GHz范围内的屏蔽性能进行了探讨。结果表明,屏蔽纸对不同频率段电磁波产生不同的屏蔽效能;随着纸张电导率、厚度的增加,屏蔽效能提高。屏蔽纸在600 MHz^1.2.GHz频段具有更高的屏蔽效能。通过改变碳纤维含量和纸张厚度可以制备具有不同屏蔽效能的屏蔽纸,应用于不同场合,防止电磁辐射危害与干扰、防止电磁信息泄漏。

关键词：屏蔽纸碳纤维屏蔽效能

Mapping essential urban land use categories in china(EULUC-china):preliminary results for 2.18

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Science Bulletin 2020年第3期65卷 182-187页

作者： Peng Gong Bin chen Xuecao Li Han liu Jie wang yuqi Bai Jingming chen Xi chen Lei Fang Shuailong Feng Yongjiu Feng Yali Gong Hao Gu Huabing Huang Xiaochun Huang Hongzan Jiao Yingdong Kang Guangbin Lei Ainong Li Xiaoting Li Xun Li yuechen Li Zhilin Li Zhongde Li Chong liu Chunxia liu Maochou liu Shuguang liu Wanliu Mao Changhong Miao Hao Ni Qisheng Pan Shuhua Qi Zhehao Ren Zhuoran Shan Shaoqing Shen Minjun Shi Yimeng Song Mo Su Hoi Ping Suen Bo Sun Fangdi Sun Jian Sun lin Sun Wenyao Sun Tian Tian Xiaohua Tong Yihsing Tseng Ying Tu Hong wang Lan wang Xi Wan Zongming wang Tinghai Wu Yaowen Xie Jian Yang Jun Yang Man yuan Wenze yue Hongda Zeng Kuo zhang Neng zhang Tao zhang yu zhang Feng Zhao Yichen Zheng Qiming Zhou Nicholas Clinton Zhiliang Zhu Bing Xu Ministry of Education Key Laboratory for Earth System Modeling Department of Earth System ScienceTsinghua UniversityBeijing 100084China Tsinghua Urban Institute Tsinghua UniversityBeijing 100084China Center for Healthy Cities Institute for China Sustainable UrbanizationTsinghua UniversityBeijing 100084China Department of Land Air and Water ResourcesUniversity of CaliforniaDavisCA 95616-8627USA Department of Geological and Atmospheric sciences Iowa State UniversityAmesIA 50011USA State Key Laboratory of Remote Sensing Science Institute of Remote Sensing and Digital EarthChinese Academy of SciencesBeijing 100101China AI for Earth Laboratory Cross-Strait InstituteTsinghua UniversityBeijing 100084China International Institute for Earth System sciences Nanjing UniversityNanjing 210093China Research Center for Ecology and environment of Central Asia Chinese Academy of SciencesUrumchi 830011China Key Laboratory of Forest Ecology and Management Institute of Applied EcologyChinese Academy of SciencesShenyang 110016China National Engineering Laboratory for Applied Technology in Forestry&Ecology in South china College of Life Science and TechnologyCentral South University of Forestry and TechnologyChangsha 410004China College of Surveying&Geo-Informatics Tongji UniversityShanghai 200092China Department of Urban Planning College of Architecture and Urban PlanningTongji UniversityShanghai 200092China Beijing Institute of Urban Planning Beijing 100045China Department of Urban Planning School of Urban DesignWuhan UniversityWuhan 430072China College of Earth sciences Jilin UniversityChangchun 130061China Research Center for Digital Mountain and Remote Sensing Application Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610041China Institute of Remote Sensing and Geographic Information System School of Earth and Space SciencesPeking UniversityBeijing 100871China Department of Urban and Regional Planning School of Geography and PlanningSun Yat-sen Univ

Land use reflects human activities on *** land use is the highest level human alteration on Earth,and it is rapidly changing due to population increase and *** areas have widespread effects on local hydrology,climate,biodiversity,and food production[1,2..However,maps,that contain knowledge on the distribution,pattern and composition of various land use types in urban areas,are limited to city *** mapping standard on data sources,methods,land use classification schemes varies from city to city,due to differences in financial input and skills of mapping *** address various national and global environmental challenges caused by urbanization,it is important to have urban land uses at the national and global scales that are derived from the same or consistent data sources with the same or compatible classification systems and mapping *** is because,only with urban land use maps produced with similar criteria,consistent environmental policies can be made,and action efforts can be compared and assessed for large scale environmental ***,despite of the fact that a number of urban-extent maps exist at global scales[3.4],more detailed urban land use maps do not exist at the same *** at big country or regional levels such as for the United States,{3. and European Union,consistent land use mapping efforts are rare[5,6](e.g.,https://***/open_land_use/).

关键词： EULUC-china 土地利用类型