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Antifibrotic Effect of Total Flavonoids of Astmgali Radix on Dimethylnitrosamine-lnduced Liver Cirrhosis in Rats

Chinese Journal of Integrative Medicine 2017年第1期23卷 48-54页

作者： CHENG Yang MAI Jing-yin wang mei-feng CHEN Gao-feng PING Jian Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 201203China Shanghai Pudong New Area Hospital of Traditional Chinese Medicine Shanghai 201299China

Objective：To study the effect of total flavonoids of Astmgali Radix（TFA）on liver cirrhosis induced with dimethylnitrosamine（DMN）in rats,and the effect on peroxisome proliferator-activated receptorγ（PPARγ）,uncoupling protein 2（UCP2）and farnesoid X receptor（FXR）.Methods：Fifty-three Sprague-Dawley rats were randomly divided into a control group（10 rats）and a DMN group（43 rats）.Rats in the DMN group were given DMN for 4 weeks and divided randomly into a model group（14 rats）,a low-dosage TFA group（14 rats）and a high-dosage TFA group（15 rats）in the 3rd *** were given TFA for 4 weeks at the dosage of 15 and 30 mg/kg in the low-and high-TFA groups,*** the end of the experiment blood and liver samples were *** liver function and liver tissue hydroxyproline content were ***-eosin（HE）,Sirus red and immunohistochemical stainings of collagenⅠ,smooth muscle actin（α-SMA）was conducted in paraffinembedded liver tissue *** time polymerase chain reaction（PCR）was adopted to determine PPARγ,UCP2 and FXR m RNA *** blot was adopted to determine protein levels of collagenⅠ,α-SMA,PPARγ,UCP2 and ***：Compared with the model group,TFA increased the ratio of liver/body weight（low-TFA group P〈0.05,high-TFA group P〈0.01）,improved liver biochemical indices（P〈0.01 for ALT,AST,GGT in both groups,P〈0.05 for albumin and TBil in the high-TFA group）and reduced liver tissue hydroxproline content（P〈0.01 in both groups）in treatment groups *** staining showed that TFA alleviated liver pathological changes markedly and Sirus red staining showed that TFA reduced collagen deposition,alleviated formation and extent of liver ***Ⅰandα-SMA immunohistochemical staining showed that staining area and extent markedly decreased in TFA groups compared with the model *** could increase PPARγ,it regulated target UCP2,and FXR levels significantly compared with the model group（in the low-TFA group all P〈0.05,in t

关键词： total flavonoids of Astmgali Radix dimethylnitrosamine liver cirrhosis peroxisome proliferator-activated receptor γ uncoupling protein 2 farnesoid X receptor rat

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Growth and Phosphorus Uptake of Oat (Avena nuda L.) as Affected by Mineral Nitrogen Forms Supplied in Hydroponics and Soil Culture

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Pedosphere 2009年第3期19卷 323-330页

作者： FAN Ming-Shou LI Zhen wang feng-mei ZHANG Jian-Hua College of Agronomy Inner Mongolia Agricultural University Hohhot Inner Mongolia 010019 （China） Department of Biology Hong Kong Baptist University Hong Kong （China）

Plants show different growth responses to N sources supplied with either NH4^＋ or NO3^-. The uptake of different N sources also affects the rhizosphere pH and therefore the bioavallability of soil phosphorus, particularly in alkaline soils. The plant growth, P uptake, and P availability in the rhizosphere of oat （Arena nuda L.） grown in hydroponics and in soil culture were investigated under supply with sole NH4^＋-N, sole NO3-N, or a combination. Sole NO^- -fed oat plants accumulated more biomass than sole NH4^＋ -fed ones. The highest biomass accumulation was observed when N was supplied with both NH^＋ -N and NO3^- -N. Growth of the plant root increased with the proportion of NO3^- in the cultural medium. Better root growth and higher root/shoot ratio were consistently observed in NO3^- fed plants. However, root vigor was the highest when N was supplied with NO3^- ＋NH4^＋. NH4^＋ supply reduced the rhizosphere pH but did not affect P uptake by plants grown in soils with CaHPO4 added as P source. No P deficiency was observed, and plant P concentrations were generally above 2 g kg^-1. P uptake was increased when N was supplied partly or solely as NO3^--N, similarly as biomass accumulation. The results suggested that oat was an NO3-preferring plant, and NO3^- -N was essential for plant growth and the maintenance of root absorption capacity. N supply with NH4^＋ -N did not improve P nutrition, which was most likely due to the absence of P deficiency.

关键词： alkaline soils nitrogen nutrition oat (Arena nuda L.) P uptake rhizosphere pH

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Numerical Simulation Analysis of Influence Factors to Shearing Force of Rolling Shear

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Journal of Iron and Steel Research International 2011年第8期18卷 30-36页

作者： MA Li-feng wang Jian-mei HUANG Qing-xue SHUANG Yuan-hua College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024 Shanxi China

The calculation results show that relative cut-in depth at the moment of maximum shearing force decreases with the increase of steel plate thickness; along with blade clearance increasing, shearing force would increase slightly compared with the slide pressure of blade carrier; shearing force increases significantly with the increasing blunt end radius; shearing force displays a bit decrement with the decreasing platen force, while the pressure on slide plate of blade carrier increases substantially; shearing force increases a bit with the increasing shear velocity and decreases when nip angle increases while the horizontal component force of shearing force along the direction of plate width increases rapidly. The above results have important reference and actual using value for studying calculation of mechanical parameters of rolling shear and its structural design.

关键词： rolling shear shearing force numerical simulation impact analysis

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A new method for identifying flow pattern of spouted fluidized bed by coupling Hilbert-Huang transform characteristics of differential pressure signals in different zones

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Particuology 2024年第6期89卷 67-78页

作者： Yongzhi mei Yang wang Lihui Zhang feng Duan School of Energy and Environment Anhui University of TechnologyMaanshan243002China Wuhu Technology and Innovation Research Institute Wuhu241000China Wuhu Cigarette Factory of China Tobacco Anhui Industrial Co. Ldt.Wuhu241002China

On a cold spouted fluidized bed,this study compares the characteristic differences in intrinsic mode function(IMF)energy and Hilbert–Huang spectrum between the spout zone and annulus zone under different combinations of spouted gas and fluidized gas flow rates for five typical flow *** energy distribution characteristics under different flow patterns are also *** Hilbert–Huang spectrum and IMF energy of pressure difference signals exhibit distinct variations in different zones as the flow pattern ***,there exists a correlation between the energy in the middle-frequency range and the flow *** the K-means algorithm,the middle-frequency range energy of IMFs in the spout zone and annulus zone is subjected to clustering analysis,leading to the identification of partition boundaries for each flow *** on this,a flow pattern identification method of spouted fluidized bed coupled with middle-frequency range energy in spout zone and annulus zone is proposed,which has very high identification accuracy.

关键词： Spouted fluidized bed Flow pattern Zoning signal Flow pattern transition Hilbert-Huang transform

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Genetic Structure and Eco-Geographical Differentiation of Cultivated Keng Rice(Oryza sativa ***) in China Revealed by Microsatellites

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Journal of Integrative Agriculture 2012年第11期11卷 1755-1766页

作者： ZHANG Dong-ling wang mei-xing QIYong-wen SUN Jun-li wang feng-mei LI Jin-jie ZHANG Hong-liang ELI Zi-chao Key Laboratory of Crop Heterosis and Utilization Ministry of Education/Beijing Key Laboratory of Crop Genetic Improvement China Agricultural University Beijing 100193 P.R. China Zhejiang Academy of Agricultural Sciences Hangzhou 310021 P.R.China Guangzhou Sugarcane Industry Research Institute Guangzhou 510316 P.R. China Ministry of Agriculture Beijing 100026 P.R. China

China is one of the largest centers of genetic diversity of Oryza sativa L. and is the original centers of Oryza sativa L. subspecies japonica. Using a genetically representative core collection of 1 442 rice landraces of japonica in China, the genetic structure, differentiation, and geographic diversity were analyzed. The model-based structure analysis on varieties within three ecotypes revealed 16 eco-geographical types, which are partially accorded with some of the ecological zones in China. The differentiation of eco-geographical types contributed to the local ecological adaption and physical isolation, and maybe could be used to develop the heterotic groups of japonica. To facilitate the identification of different ecotypes and eco-geographical types, we provided the SSR character alleles of each ecotype or geographical eco-group and a rapid discriminated method based on these character alleles. Lastly, investigation on genetic diversity, genetic differentiation indicated that southwest region of China, including south of Yunnan Province, northwest of Guangxi Zhuang Autonomous Region, and southwest of Guizhou Province, possessed the highest genetic diversity and all the necessary conditions as a center of genetic diversity and should be the center of genetic diversity of rice landraces of japonica in China.

关键词： japonica rice population structure eco-geographical differentiation China microsateltites

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Glucose,cellobiose,lactose and raffinose used as chiral stationary phases in HPLC

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Chinese Chemical Letters 2008年第10期19卷 1248-1251页

作者： Jian Yu wang feng Zhao mei Zhang Ya Peng Li Ming Yuan Department of Chemistry Yunnan Normal University Kunming 650092 China

This paper presents the enantioseparation using glucose, cellobiose, lactose and raffinose as chiral selector bonded to silica gel via an arm in HPLC. Surprisingly, they also possess high enantioseparation selectivity, may be used in normal-phase and reversed- phase mode, and there is a big chiral discriminating complementary. This work indicates that oligosaccharides could soon become very attractive as a new class of chiral stationary phase for HPLC.

关键词： Oligosaccharides Chiral stationary phase HPLC

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Compensation temperatures and hysteresis behaviors of a graphene-like trilayer

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Communications in Theoretical Physics 2024年第5期76卷 166-179页

作者： Ying An Ji Liang Wei wang mei-mei Du feng-ge Zhang School of Science Shenyang University of TechnologyShenyang 110870China School of Electrical Engineering Shenyang University of TechnologyShenyang 110870China

This work focuses on the ground-state phase diagram,the compensation temperatures and the critical behaviors of a ferrimagnetic graphene-like trilayer induced by crystal fields and exchange *** simulation results show that a negative decrease in crystal field or an increase in exchange coupling can increase the critical *** importantly,an M curve with double compensation temperatures can be observed,which is not predicted by the Neel *** remarkable compensation phenomenon has potential application value in the field of magnetic recording.

关键词： graphene-like trilayer mixed-spin Ising model magnetization double compensation temperatures triple-loop hysteresis monte Carlo

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高效液相色谱串联质谱法检测水产品及其制品中沙丁胺醇残留

实验室检测

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实验室检测 2024年第2期2卷 23-27页

作者：王凤美韩静静张晓梅张鸿伟何京澄青岛海关技术中心青岛266109

目的建立水产品及其制品中沙丁胺醇残留检测的高效液相色谱-串联质谱法(high performance liquid chromatography-tandem mass spectrometry,HPLC-MS/MS)。方法样品加入乙酸铵缓冲液(pH=5.2),37℃条件下酶解过夜,乙酸乙酯-异丙醇(1:1,v/v)提取,QuEChERS净化,HPLC-MS/MS多反应监测模式检测,内标法定量。结果沙丁胺醇的测定低限为0.5μg/kg,在0.5、1.0、5.0μg/kg 3个浓度添加水平,总体平均回收率在87.8%~110.7%范围内,相对标准偏差为2.7%~9.6%。结论该方法操作简单,灵敏度、精密度、回收率均满足残留检测法规要求,精准解决了目前水产品制品中沙丁胺醇药物残留监控没有相关技术支撑的难题。

关键词：水产品及其制品沙丁胺醇高效液相色谱-串联质谱

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Self-Powered Flexible Multicolor Electrochromic Devices for Information Displays

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Research 2024年第2期2023卷 529-540页

作者： Wenzhao Xue Yun Zhang feng Liu Yao Dou mei Yan Wenshou wang School of Chemistry and Chemical Engineering University of JinanJinan 250022P.R.China

The development of self-powered flexible multicolor electrochromic(EC)systems that could switch different color without an external power supply has remained extremely ***,a new trilayer film structure for achieving self-powered flexible multicolor EC displays based on self-charging/discharging mechanism is proposed,which is simply assembled by sandwiching an ionic gel film between 2 cathodic nickel hexacyanoferrate(NiHCF)and Prussian blue(PB)nanoparticle films on indium tin oxide *** display exhibits independent self-powered color switching of NiHCF and PB films with fast responsive time and high reversibility by selectively connecting the Al wire as anodes with the 2 EC *** switching is thus achieved through a color overlay effect by superimposing the 2 EC films,including green,blue,yellow,and *** bleaching/coloration process of the displays is driven by the discharging/self-charging mechanism for NiHCF and PB films,respectively,ensuring the self-powered color switching of the displays reversibly without an external power *** is further demonstrated that patterns can be easily created in the self-powered EC displays by the spray-coating method,allowing multicolor changing to convey specific ***,a self-powered ionic writing board is demonstrated based on the self-powered EC displays that can be repeatedly written freehand without the need of an external power *** believe that the design concept may provide new insights into the development of self-powered flexible multicolor EC displays with self-recovered energy for widespread applications.

关键词： connecting repeatedly powered

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富马酸丙酚替诺福韦治疗初治失代偿期乙型肝炎肝硬化患者的临床研究

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肝脏 2024年第7期29卷 830-833页

作者：唐海涛王娴周佳琦王凤梅张文华甘肃省武威肿瘤医院肝胆中心 733000

目的探讨富马酸丙酚替诺福韦(TAF)治疗初治失代偿期乙型肝炎肝硬化患者的疗效和安全性。方法回顾性分析2021年10月—2023年10月在甘肃武威肿瘤医院初治失代偿期乙型肝炎肝硬化患者72例,接受TAF治疗患者34例,TDF治疗患者38例。比较两组治... 详细信息

目的探讨富马酸丙酚替诺福韦(TAF)治疗初治失代偿期乙型肝炎肝硬化患者的疗效和安全性。方法回顾性分析2021年10月—2023年10月在甘肃武威肿瘤医院初治失代偿期乙型肝炎肝硬化患者72例,接受TAF治疗患者34例,TDF治疗患者38例。比较两组治疗24周和48周时ALT、TBil、Alb、PT、CTP评分的变化,以及病毒学应答(HBV DNA0.05)。安全性方面,治疗48周时,TAF组的BUN、Scr水平显著低于TDF组(P<0.05),治疗期间两组未发现药物相关不良事件或严重不良事件。结论TAF对失代偿期乙型肝炎肝硬化患者具有良好的有效性和安全性。

关键词：富马酸丙酚替诺福韦乙型肝炎失代偿期肝硬化临床研究

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