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Expression of ghrelin and insulin-like growth factor-1 in immature piglet model of chronic cyanotic congenital heart defects with decreased pulmonary blood flow

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Chinese Medical Journal 2011年第15期124卷 2354-2360页

作者： wang dong liu ying-long lu xiao-dong zhu yao-bin ling feng liu ai-jun li gang xu yu-lin Department of Pediatric Cardiac Surgery Center Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background Cyanotic patients have potential growth retardation and malnutrition due to hypoxemia and other reasons. Ghrelin is a novel endogenous growth hormone secretagogue that has effects on growth and cardiovascular activities. The aim of this study was to evaluate the plasma level and myocardial expression of ghrelin and insulin-like growth factor-1 （IGF-1） using an immature piglet model of chronic cyanotic congenital heart defects with decreased pulmonary blood flow. Methods Twelve weanling Chinese piglets underwent procedures of main pulmonary artery-left atrium shunt with pulmonary artery banding or sham operation as control. Four weeks later, hemodynamic parameters were measured. Enzyme-linked immunosorbent assay for plasma ghrelin and IGF-1 level measurement were performed. Ventricular ghrelin and IGF-1 mRNA expressions were measured by quantitative real-time polymerase chain reaction. Results Four weeks after surgical procedure, the cyanotic model produced lower arterial oxygen tension （（68.73±15.09） mmHg）, arterial oxygen saturation （（82.35±8.63）%）, and higher arterial carbon dioxide tension （（51.83±6.12） mmHg）, hematocrit （（42.67±3.83）%） and hemoglobin concentration （（138.17±16.73） g/L） than the control piglets （（194.08±98.79） mmHg, （96.43±7.91）%, （36.9±4.73） mmHg, （31.17±3.71）%, （109.83±13.75） g/L）（all P 〈0.05）. Plasma ghrelin level was significantly higher in the cyanotic model group in comparison to the control （P=0.004）, and the plasma IGF-1 level was significantly lower than control （P=0.030）. Compared with control animals, the expression of ghrelin mRNAs in the ventricular myocardium was significantly decreased in the cyanotic model group （P=0.000）, and the expression of IGF-1 mRNAs was elevated （P=0.001）. Conclusions Chronic cyanotic congenital heart defects model was successfully established. Plasma ghrelin level and myocardial IGF-1 mRNA expression were significantly up-regulated, while plasma iGF-1 level and myocardial ghrelin mRNA expression

关键词： congenital heart defects cyanosis piglet ghrelin insulin-like growth factor-1

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Effect of partial liquid ventilation on oleic acid-induced inflammatory responses in piglets

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Chinese Medical Journal 2010年第15期123卷 2088-2093页

作者： zhu yao-bin wang Qiang liu ying-long li xiao-feng li Jian-an lu xiao-dong ling feng liu ai-jun FAN Xiang-ming Department of Pediatric Cardiac Surgery Center Fu Wai HospitalChinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background Pediatric patients are susceptible to lung *** lung injury （Ali） in children often results in a high *** liquid ventilation （PLV） has been shown to markedly improve oxygenation and reduce histologic evidence of injury in a number of lung injury *** study aimed to examine the hypothesis that PLV would attenuate the production of local and systemic cytokines in an immature piglet model of Ali induced by oleic acid （OA）.Methods Twelve Chinese immature piglets were induced to develop Ali by oleic *** animals were randomly assigned to two groups （n=6）：（1） conventional mechanical ventilation （MV） group and （2） PLV with FC-77 （10 ml/kg） *** Compared with MV group, PLV group got better cardiopulmonary variables （P 〈0.05）.These variables included heart rate, mean blood pressure, blood pH, partial pressure of arterial oxygen （PaO2）, PaO2/FiO2 and partial pressure of arterial carbon dioxide （PaCO2）.Partial liquid ventilation reduced IL-1β, IL-6, IL-10 and TN F-α both in plasma and tissue concentrations compared with MV group （P 〈0.05）.Conclusions Partial liquid ventilation provides protective effects against inflammatory responses in the lungs of oleic acid-induced immature piglets.

关键词： acute respiratory distress syndrome partial liquid ventilations inflammatory response cytokine piglets

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lung microRNA profile in chronic cyanotic piglets with decreased pulmonary blood flow

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Chinese Medical Journal 2013年第12期126卷 2260-2264页

作者： wang dong liu ying-long lu xiao-dong ling feng liu ai-jun DU Jie HAN ling Department of Pediatric Cardiac Center Beijing Anzhen Hospital Capital Medical University Beijng 100029 China Institute of Heart lung and Blood Vessel Diseases Beijing Anzhen Hospital Capital Medical University Beijng 100029 China Beijing Anzhen Hospital Capital Medical University Beijng 100029 China Department of Pediatric Cardiac Surgery Center Fuwai Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing 100037 China Department of Cardiothoracic Surgery Second Affiliated Hospital of Kunming Medical University Kunming Yunnan 650101 China

Background Cyanotic congenital heart defects with decreased pulmonary blood flow due to lung ischemia,hypoxia,and others lead to infant morbidity and mortality more than acyanotic heart disease *** the great effort of medical research,their genetic link and underlying microRNAs molecular mechanisms remain *** this study,we aimed to investigate microRNAs regulation during cyanotic defects in lung of immature *** Cyanotic piglet model was induced by main pulmonary artery-left atrium shunt with distal pulmonary artery *** weeks later,hemodynamic parameters confirmed the development of cyanotic defects and pulmonary lobe RNA was extracted from all *** studied the repertoire of porcine lung microRNAs by Solexa deep sequencing technology and quantified highly expressed microRNAs by microarray ***,we quantitated selected microRNAs from cyanotic and control piglets by quantitative *** After surgical procedure 4 weeks later,the cyanotic model produced lower arterial oxygen tension,arterial oxygen saturation,and higher arterial carbon dioxide tension,hematocrit and hemoglobin concentration than controls （all P 〈0.05）.In 1273 miRNAs expressed in the immature piglets lungs,2 most abundant microRNAs （miR-370 and miR-320） demonstrated significant difference between cyanotic and control group （all P 〈0.05）.Conclusion Our results extended lung microRNA profile in immature piglets and suggested that miR-370 and miR-320 are significantly up-regulated in cyanotic lung tissues.

关键词： microRNAs sus scrofa lung cyanosis microarray analysis

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Comparative Transcriptional Profiling and Preliminary Study on Heterosis Mechanism of Super-Hybrid Rice

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Molecular Plant 2010年第6期3卷 1012-1025页

作者： Gui-Sheng Song Hong-li Zhai Yong-gang Peng Lei Zhang gang Wei xiao- ying Chen yu-Guo xiao lili wang yue-jun Chen bin Wu bin Chen yu Zhang Hua Chen Xiu-Jing feng Wan-Kui Gong yao liu Zhi-Jie Yin feng wang Guo-Zhen liu Hong-lin xu xiao-li Wei xiao-ling Zhao Pieter B.F. Ouwerkerk Thomas Hankemeier Theo Reijmers Rob van der Heijden Cong-Ming lu Mei wang Jan van der Greef Zhen zhu State Key Laboratory of Plant Genomics Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China National Plant Gene Research Center (Beijing) Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China State Key Laboratory of Genetic Engineering Institute of Genetics School of Life Sciences Fudan University Shanghai 200433 China Key Laboratory of Photosynthesis and Environmental Molecular Physiology Institute of Botany Chinese Academy of Sciences Beijing 100093 China Fujian Province Key Laboratory of Genetic Engineering for Agriculture Fujian Academy of Agricultural Sciences Fuzhou 350003 China Beijing Institute of Genomics Chinese Academy of Sciences Beijing 101300 China Institute of Biology Leiden University Sylvius Laboratory Wassenaarseweg 72 2333 BE Leiden The Netherlands Leiden/Amsterdam Center for Drug Research Center for Medical Systems Biology Leiden University Einsteinweg 5 2500 RA Leiden The Netherlands SU BioMedicine and TNO Quality of life Utrechtseweg 48 3700 AJ Zeist The Netherlands

Heterosis is a biological phenomenon whereby the offspring from two parents show improved and superior performance than either inbred parental lines. Hybrid rice is one of the most successful apotheoses in crops utilizing heterosis. Transcriptional profiling of F1 super-hybrid rice liangyou-2186 and its parents by serial analysis of gene expression （SAGE） revealed 1183 differentially expressed genes （DGs）, among which DGs were found significantly enriched in pathways such as photosynthesis and carbon-fixation, and most of the key genes involved in the carbon-fixation pathway exhibited up-regulated expression in F1 hybrid rice. Moreover, increased catabolic activity of corresponding enzymes and photosynthetic efficiency were also detected, which combined to indicate that carbon fixation is enhanced in F1 hybrid, and might probably be associated with the yield vigor and heterosis in super-hybrid rice. By correlating DGs with yield-related quantitative trait loci （QTL）, a potential relationship between differential gene expression and phenotypic changes was also found. In addition, a regulatory network involving circadian-rhythms and light signaling pathways was also found, as previously reported in Arabidopsis, which suggest that such a network might also be related with heterosis in hybrid rice. Altogether, the present study provides another view for understanding the molecular mechanism underlying heterosis in rice.

关键词： Heterosis super-hybrid rice transcriptional profiling photosynthesis carbon fixation regulatory network.

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Growth,Characterization and Fermi Surface of Heavy Fermion CeCoIn_(5) Superconductor

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Chinese Physics Letters 2011年第5期28卷 226-229页

作者： JIA xiao-Wen liu Yan yu li HE jun-feng ZHAO lin ZHANG Wen-Tao liu Hai-yun liu Guo-dong HE Shao-long ZHANG jun lu Wei WU yue dong-xiao-li SUN li-ling wang Gui-ling zhu Yong wang xiao-Yang PENG Qin-jun wang Zhi-Min ZHANG Sheh-Jin YANG feng xu Zu-Yan CHEN Chuang-Tian ZHOU Xing-Jiang National Lab for Superconductivity Beijing National Laboratory for Condensed Matter PhysicsInstitute of PhysicsChinese Academy of SciencesBeijing 100190 Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing 100190

High quality single crystals of heavy Fermion CeCoIn_(5) superconductor have been grown by flux method with a typical size of(1-2)×(1-2)×(~0.1)mm^(3).The single crystals are characterized by structural analysis from x-ray diffraction and Laue diffraction,as well as compositional *** and electrical measurements on the single crystals show a sharp superconducting transition with a transition temperature at T_(c,onset)~2.3 K and a transition width of~0.15 *** resistivity of the CeCoIn_(5) crystal exhibits a hump at~45 K,which is typical of a heavy Fermion *** resolution angle-resolved photoemission spectroscopy(ARPES)measurements of CeCoIn_(5) reveal clear Fermi surface sheets that are consistent with the band structure calculations when assuming itinerant Ce 4f electrons at low *** work provides important information on the electronic structure of heavy Fermion CeCoIn_(5) *** also lays a foundation for further studies on the physical properties and superconducting mechanism of the heavy Fermion superconductors.

关键词： temperature Fermi transition

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Significant loss of soil inorganic carbon at the continental scale

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National Science Review 2022年第2期9卷 13-20页

作者： xiao-dong Song Fei Yang Hua-Yong Wu Jing Zhang De-Cheng li feng liu yu-Guo Zhao Jin-ling Yang bing Ju Chong-Fa Cai Biao Huang Huai-yu long ying lu yue-yu Sui Qiu-bing wang Ke-Ning Wu feng-Rong Zhang Ming-Kui Zhang Zhou Shi Wan-zhu Ma gang Xin Zhi-Ping Qi Qing-Rui Chang En Ci Da-gang yuan Yang-zhu Zhang jun-Ping Bai Jia-ying Chen Jie Chen Yin-jun Chen yun-Zhong dong Chun-Lan Han ling li li-Ming liu Jian-jun Pan Fu-Peng Song Fu-jun Sun Deng-feng wang Tian-Wei wang Xiang-Hua Wei Hong-Qi Wu Xia Zhao Qing Zhou Gan-lin Zhang State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences College of Advanced Agricultural Sciences University of Chinese Academy of Sciences College of Resources and Environment Huazhong Agricultural University Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences College of Natural Resources and Environment South China Agricultural University Northeast Institute of Geography and Agroecology Chinese Academy of Sciences College of Land and Environment Shenyang Agricultural University School of Land Science and Technology China University of Geosciences College of Land Science and Technology China Agricultural University College of Environmental and Resource Sciences Zhejiang University Institute of Digital Agriculture Zhejiang Academy of Agricultural Sciences College of Agriculture Heilongjiang Bayi Agricultural University Tropical Crops Genetic Resources Institute Chinese Academy of Tropical Agricultural Sciences College of Natural Resources and Environment Northwest A & F University College of Resources and Environment Southwest University College of Resources Sichuan Agricultural University College of Resources and Environment Hunan Agricultural University Institute of Agricultural Product Quality Standard and Testing Research Tibet Academy of Agricultural and Animal Husbandry Sciences School of Agricultural Sciences Zhengzhou University Institute of Agriculture Environment and Resources Research Shanxi Academy of Agricultural Sciences College of Resources and Environment Henan Agricultural University College of Resources and Environment China Agricultural University College of Resources and Environmental Sciences Nanjing Agricultural University College of Resources and Environment Shandong Agricultural University Agricultural College Guangxi University College of Grassland and Environment Science Xinjiang Agricultural University College of Geographical Science Qinghai Normal University

Widespread soil acidification due to atmospheric acid deposition and agricultural fertilization may greatly accelerate soil carbonate dissolution and ***,to date,few studies have addressed these ***,we use meta-analysis and nationwide-survey datasets to investigate changes in soil inorganic carbon(SIC) stocks in *** observe an overall decrease in SIC stocks in topsoil(0-30 cm)(11.33 g C m-2yr-1) from the 1980 s to the 2010 *** SIC stocks have decreased by～8.99±2.24%(1.37±0.37 Pg C).The average SIC losses across China(0.046 Pg C yr-1) and in cropland(0.016 Pg C yr-1) account for～17.6%-24.0% of the terrestrial C sink and 57.1% of the soil organic carbon sink in cropland,*** deposition and climate change have profound influences on SIC *** estimate that～19.12%-19.47% of SIC stocks will be further lost by *** consumption of SIC may offset a large portion of global efforts aimed at ecosystem carbon sequestration,which emphasizes the importance of achieving a better understanding of the indirect coupling mechanisms of nitrogen and carbon cycling and of effective countermeasures to minimize SIC loss.

关键词： China soil inorganic carbon stocks global change carbonate soil acidification

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Diagnosis,treatment,and prevention of monkeypox in children:an experts'consensus statement

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World Journal of Pediatrics 2023年第3期19卷 231-242页

作者： Rong-Meng Jiang yue-Jie Zheng Lei Zhou lu-Zhao feng lin Ma Bao-Ping xu Hong-Mei xu Wei liu Zheng-De Xie Ji-Kui Deng li-Juan Xiong Wan-jun luo Zhi-Sheng liu Sai-Nan Shu Jian-She wang Yi Jiang yun-xiao Shang Miao liu li-Wei Gao zhuang Wei Guang-Hua liu gang liu Wei Xiang yu-Xia Cui Gen lu Min lu xiao-Xia lu Run-Ming Jin Yan Bai Le-Ping Ye dong-Chi Zhao A-dong Shen Xiang Ma Qing-Hua lu feng-Xia xue Jian-Bo Shao Tian-You wang Zheng-Yan Zhao Xing-wang li Yong-Hong Yang Kun-ling Shen Diagnosis and Treatment Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Respiratory Shenzhen Children’s HospitalShenzhen 518038China Branch for Emerging Infectious Disease Public Health Emergency CenterChinese Center for Disease Control and PreventionBeijing 102206China School of Population Medicine&Public Health Chinese Academy of Medical Science/Peking Union Medical CollegeBeijing 100730China Department of Dermatology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s Health(Beijing)Beijing 100045China Department of Respiratory Beijing Children’s HospitalCapital Medical UniversityNational Clinical Research Center for Respiratory DiseasesNational Center for Children’s Health(Beijing)Beijing 100045China Department of Infectious Diseases Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Tianjin Children’s Hospital Children’s Hospital of Tianjin UniversityTianjin 300134China Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Laboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s Health(Beijing)Beijing 100045China Department of Infectious Diseases Shenzhen Children’s HospitalShenzhen 518038China Department of Infectious Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Ofce of Infection Management Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Neurology Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Pediatrics Tongji

Monkeypox is a zoonotic *** the first human monkeypox case was detected in 1970,it has been prevalent in some countries in central and western *** May 2022,monkeypox cases have been reported in more than 96 non-endemic countries and regions *** of September 14,2022,there have been more than 58,200 human monkeypox cases,and there is community *** cessation of smallpox vaccination in 1980,which had some cross-protection with monkeypox,resulted in a general lack of immunity to monkeypox,which caused global concern and *** of Sep-tember 14,2022,there are four monkeypox cases in China,including three in Taiwan province and one in Hong Kong *** foreign studies have shown that children are vulnerable to monkeypox and are also at high risk for severe disease or *** order to improve pediatricians'understanding of monkeypox and achieve early detection,early diagno-sis,early treatment,and early disposal,we have organized national authoritative experts in pediatric infection,respiratory,dermatology,critical care medicine,infectious diseases,and public health and others to formulate this expert consensus,on the basis of the latest"Clinical management and infection prevention and control for monkeypox"released by The World Health Organization,the"guidelines for diagnosis and treatment of monkeypox(version 2022)"issued by National Health Commission of the People's Republic of China and other relevant *** the development of this consensus,multidisciplinary experts have repeatedly demonstrated the etiology,epidemiology,transmission,clinical manifestations,laboratory examinations,diagnosis,differential diagnosis,treatment,discharge criteria,prevention,disposal process,and key points of prevention and control of suspected and confirmed cases.

关键词： Children Consensus Diagnosis Monkeypox Prevention Treatment

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Frontiers in high entropy alloys and high entropy functional materials

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Rare Metals 2024年第10期43卷 4639-4776页

作者： Wen-Tao Zhang xue-Qian wang feng-Qi Zhang xiao-Ya Cui bing-bing Fan Jia-Ming Guo Zhi-Min Guo Rui Huang Wen Huang xu-Bo li Meng-Ru li Yan Ma Zhi-Hua Shen Yong-gang Sun De-zhuang wang Fei-Yang wang li-Qiang wang Nan wang Tian-li wang Wei wang xiao-Yang wang Yi-Han wang Fu-Jie yu yu-Zhen Yin ling-Kun Zhang Yi Zhang Jian-Yang Zhang Qi Zhao yu-Ping Zhao Xin-dong zhu Yasir Sohail Ya-Nan Chen Tao feng Qi-long Gao Hai-Yan He Yong-Jiang Huang Zeng-Bao Jiao Hua Ji yao Jiang Qiang li xiao-Ming li Wei-bing liao Huai-jun lin Hui liu Qi liu Qing-feng liu Wei-Di liu Xiong-jun liu Yang lu Yi-Ping lu Wen Ma xue-Fei Miao Jie Pan Qing wang Hong-Hui Wu yuan Wu Tao Yang Wei-Ming Yang Qian yu Jin-yu Zhang Zhi-gang Chen liang Mao Yang Ren Bao-long Shen xun-li wang Zhe Jia He zhu Zhen-Duo Wu Si Lan School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China Jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and EngineeringSoutheast UniversityNanjing 211189China Department of Physics City University of Hong KongHongKong 999077China School of Materials Science and Engineering Tianjin UniversityTianjin 300072China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China Department of Mechanical Engineering Research Institute for Advanced ManufacturingThe Hong Kong Polytechnic UniversityHong Kong 100872China Center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou 310027China Key Laboratory of Solidification Control and Digital Preparation Technology(liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024China Institute of Advanced Wear&Corrosion Resistance and Functional Materials Jinan UniversityGuangzhou 510632China School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhou 221116China School of Physical Sciences Great Bay UniversityDongguan 523000China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China Beijing Advanced Innovation Center for Materials Genome Engineering Research Institute for Carbon NeutralityUniversity of Science and Technology BeijingBeijing 100083China Department of Mechanical Engineering The University of Hong KongHong Kong 999077China School of Computing Macquarie UniversitySydney 2113Australia Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China State Key Laborato

Owing to their exceptional properties,high-entropy alloys(HEAs)and high-entropy materials have emerged as promising research areas and shown diverse ***,the recent advances in the field are comprehensively reviewed,organized into five *** first section introduces the background of HEAs,covering their definition,significance,application prospects,basic properties,design principles,and *** subsequent section focuses on cutting-edge high-entropy structural materials,highlighting developments such as nanostructured alloys,grain boundary engineering,eutectic systems,cryogenic alloys,thin films,micro-nano-lattice structures,additive manufacturing,high entropy metallic glasses,nano-precipitate strengthened alloys,composition modulation,alloy fibers,and refractory *** the following section,the emphasis shifts to functional materials,exploring HEAs as catalysts,magneto-caloric materials,corrosion-resistant alloys,radiation-resistant alloys,hydrogen storage systems,and materials for ***,the review encompasses functional high-entropy materials outside the realm of alloys,including thermoelectric,quantum dots,nanooxide catalysts,energy storage materials,negative thermal expansion ceramics,and high-entropy wave absorption *** paper concludes with an outlook,discussing future directions and potential growth areas in the *** this comprehensive review,researchers,engineers,and scientists may gain valuable insights into the recent progress and opportunities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： High entropy alloys Cutting-edge structural materials Cutting-edgefunctional materials

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Diagnosis,treatment and prevention of severe acute respiratory syndrome coronavirus 2 infection in children:experts'consensus statement updatedforthe Omicron variant

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World Journal of Pediatrics 2024年第3期20卷 272-286页

作者： Rong-Meng Jiang Zheng-De Xie Yi Jiang xiao-Xia lu Run-Ming Jin yue-Jie Zheng yun-xiao Shang Bao-Ping xu Zhi-Sheng liu Gen lu Ji-Kui Deng Guang-Hua liu xiao-Chuan wang Jian-She wang lu-Zhao feng Wei liu Yi Zheng Sai-Nan Shu Min lu Wan-jun luo Miao liu yu-Xia Cui Le-Ping Ye A-dong Shen gang liu li-Wei Gao li-Juan Xiong Yan Bai li-Kai lin zhuang Wei feng-Xia xue Tian-You wang dong-Chi Zhao Jian-Bo Shao Daniel Kwok-keung Ng Gary Wing-kin Wong Zheng-Yan Zhao Xing-wang li Yong-Hong Yang Kun-ling Shen Diagnosis and Treatment Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Laboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Pediatrics Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Respiratory Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Pediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Respiratory Shenzhen Children's HospitalShenzhen 518038China Department of Pediatric Respiratory Shengjing Hospital Affiliated to China Medical UniversityShenyang 110004China Department of Respiratory Beijing Children's HospitalCapital Medical UniversityNational Clinical Research Center for Respiratory DiseasesNational Center for Children's HealthBeijing 100045China Department of Neurology Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Respiratory Guangzhou Women and Children's Medical CenterGuangzhou 510623China Department of Infectious Diseases Shenzhen Children's HospitalShenzhen 518038China Department of Pediatrics Fujian Branch of Shanghai Children's Medical CenterFujian Children's HospitalFuzhou350005China Department of Clinical Immunology and Allergy Children's Hospital of Fudan UniversityNational Center for Children's HealthShanghai 201102China Department of Infectious Diseases Children's Hospital of Fudan UniversityNational Center for Children's Health.Shanghai

It has been more than 3 years since the novel coronavirus(SARS-CoV-2)pandemic raged *** coronavirus disease 2019(COVID-19)has greatly influenced human *** to data from the World Health Organization(WHO),there were ove... 详细信息

关键词： prevention infection statement

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Diagnosis and Treatment of Cholangiocarcinoma: A Consensus from Surgical Specialists of China

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2014年第4期34卷 469-475页

作者： Jian-qiang Cai Shou-wang Cai Wen-ming Cong Min-shan Chen Ping Chen xiao-ping Chen Yan-ling Chen Yi-fa Chen Chao-liu Dai Qiang Huang Zhi-yong Huang Bo Jiang bin Jiang Ke-wei Jiang Bo li Zong-fangli li-jian liang bin liu Hui-chun liu lian-xin liu Qing-guang liu Rong liu ying-bin liu Jian-guo lu Shi-chun lu Yi lu Yi-lei Mao bin Mei jun Niu Bao-gang Peng xiao Qin yu-dong Qiu Guang-yi wang yao-don wangg Zhi-ming wang Ren-hua Wan Ya-fu Wu Bao-cai Xing feng Xia Ge-liang xu Jia-mei Yang xiao-fang yu Yong Zeng Yong-yi Zeng Bi-xiang Zhang bin-hao Zhang Qi-yu Zhang Shui-jun Zhang Wan-guang Zhang Yong-jie Zhang Zhi-wei Zhang dong Zhou Wei-ping Zhou Cancer Institute and Hospital Chinese Academy of Medical Sciences Chinese PLA General Hospital Eastern Hepatobiliary Surgery Hospital of Second Military Medical University Sun Yat-sen University Cancer Center Daping Hospital of Third Military Medical University Tongji Hospital Tongji Medical CollegeHuazhong University of Science and Technology Fujian Medical University Union Hospital Shengjing Hospital of China Medical University Anhui Provincial Hospital Hunan Provincial People’s Hospital Taihe Hospital Affiliated to Hubei University of Medicine Peking University People’s Hospital West China Hospital Sichuan University The Second Affiliated Hospital of Xi’an Jiao Tong University The First Affiliated Hospital Sun Yat-sen University First Affiliated Hospital of Kunming Medical University The First Affiliated Hospital of Bengbu Medical College The First Affiliated Hospital of Harbin Medical University The First Affiliated Hospital of Xi’an Jiao Tong University Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Tangdu Hospital of Fourth Military Medical University Peking Union Medical College Hospital Qilu Hospital of Shandong University The First Affiliated Hospital of Guangxi Medical University Nanjing Drum Tower Hospital The First Affiliated Hospital of Jilin University Fujian Provincial Hospital Xiangya Hospital of Central South University The First Affiliated Hospital of Nanchang University Beijing Cancer Hospital Southwest Hospital of Third Military Medical University Shenzhen People’s Hospital The First Affiliated Hospital of Fujian Medical University The First Affiliated Hospital of Wenzhou Medical University The First Affiliated Hospital of Zhengzhou University Fujian Provincial Cancer Hospital

Cholangiocarcinoma refers to malignant tumors that develop in epithelial lining of biliary system, and it is divided into two categories according to tumor location, intrahepatic cholangiocarcinoma （ICC） and extrahepatic cholangiocarcinoma （ECC）. ICC occurs from the epithelial cells of the intrahepatic bile duct, its branches and interlobular biliary tree; and ECC is divided into hilar cholangiocarcinoma and distal cholangiocarcinoma by the circumscription at the confluence of cystic duct and the common hepatic duct.

关键词： A Consensus from Surgical Specialists of China Diagnosis and Treatment of Cholangiocarcinoma

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