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2nd-order spline wavelet convolution method in resolving chemical overlapped peaks

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Science China Chemistry 2004年第1期47卷 50-58页

作者： wang ying MO Jinyuan chen Xiaoyan School of Chemistry and Chemical Engineering Zhongshan University Guangzhou 510275 China School of Chemistry and Chemical Engineering Zhongshan University Guangzhou 510275 China School of Chemistry and Chemical Engineering Zhongshan University Guangzhou 510275 China

A 2nd-order spline wavelet convolution method in resolving overlapped peaks is developed. It determines the number of peaks, peak positions and width through wavelet? convolution, then uses spline function to construct the resoluter, which is used to resolve overlapped peaks. Theoretical proof is given, and the selections of wavelets and parameters are discussed. It is proven that baseline separation can be achieved after processed, the relative errors of peak position and area are less than 0.2% and 4.0% respectively. It can be directly applied to seriously overlapped signals, noisy signals and multi-component signals, and the results are satisfactory. It is a novel effective method for resolution.

关键词： 2nd-order spline wavelet, convolution, resolve, chemical signal, overlapped peaks.

Crystal structure of β-cyclodextrin-4-chlorobenzoic acid complex:Unusual C-Cl…π interaction between 4-chlorobenzoic acids in β-cyclodextrin dimer

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Chinese Chemical Letters 2011年第7期22卷 847-850页

作者： En Ju wang Guang ying chen Hainan Provincial Key Laboratory of Tropical Pharmaceutical Herb Chemistry School of Chemistry & Chemical Engineering Hainan Normal University Haikou 571158 China

The inclusion complex of β-cyclodextrin （β-CD） with 4-chlorobenzoic acid was synthesized and its crystal structure was determined by single crystal X-ray diffraction under cryogenic condition. The complex contains two β-CDs, two 4-chlorobenzoic acids and twenty-nine water molecules in the asymmetric unit, and can be formulated as 2（C42H70O35）·2（CTH5O2Cl）·29（H2O）. In the crystal lattice, two β-CDs form a face-to-face dimer jointed together through hydrogen bonding between the secondary hydroxyl groups of β--CDs. Two 4-chlorobenzoic acid molecules which contact by C-Cl…π interactions are included in the β-CD dimer cavity. The β-CD dimers are arranged in brickwork-like pattern along the crystallographic a-axis. The effect of guest molecule length on the inclusion geometry was discussed by comparative study of some fl-CD complexes containing similar guests.

关键词： β-Cyclodextrin 4-Chlorobenzoic acid Inclusion complex Crystal structure C-Cl…π interaction

Research progress on the ultra hydrophobic surface topography effect

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Chinese Science Bulletin 2006年第19期51卷 2297-2300页

作者： wang Jiadao YU ying chen Darong State Key Laboratory of Tribology Tsinghua University Beijing 100084China

Ultra hydrophobic surfaces take on bet- ter hydrophobicity and exhibit a water contact angle larger than 150°. In this paper the ultra hydrophobic- ity is analyzed and common fabrication methods are summarized in detail. The applications of micro to- pography in both the fabrication of hydrophobic sur- face and the experiments of drag reduction are ad- dressed. Finally, the development trend and fore- ground of ultra hydrophobic surface are discussed.

关键词：疏水性接触角表面形貌学减阻

RESEARCH PROGRESS IN NONLINEAR ANALYSIS OF HEART ELECTRIC ACTIVITIES

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Chinese Science Bulletin 2006年第4期51卷 385-393页

作者： NING Xinbao BIAN Chunhua wang Jun chen ying State Key Laboratory of Modem Acoustics Institute for BiomedicalElectronic Engineering Department of Electronic Science & Engineering Nanjing University Nanjing 210093 China

Nonlinear science research is a hot point in the world. It has deepened our cognition of determinism and randomicity, simplicity and com-plexity, noise and order and it will profoundly influ-ence the progress of the study of natural science, including life science. Life is the most complex nonlinear system and heart is the core of lifecycle system. In the late more than 20 years, nonlinear research on heart electric activities has made much headway. The commonly used parameters are based on chaos and fractal theory, such as correlation dimension, Lyapunov ex-ponent, Kolmogorov entropy and multifractal singu-larity spectrum. This paper summarizes the commonly used methods in the nonlinear study of heart electric signal. Then, considering the shortages of the above tradi-tional nonlinear parameters, we mainly introduce the results on short-term heart rate variability (HRV) signal (500 R-R intervals) and HFECG signal (1-2s). Finally, we point out it is worthwhile to put emphasis on the study of the sensitive nonlinearity parameters of short-term heart electric signal and their dynamic character and clinical effectivity.

关键词：心电图心率非线性分析混沌信号研究进展

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产出导向下教师职业技能训练教学实践探索

郑州师范教育 2024年第2期13卷 32-37页

作者：汪琛颖李林张玮叶桂阳郑州师范学院生命科学学院河南郑州450044

在调查分析中学生物学教师对于教学技能需求的基础之上,设置产出导向教育理念的教师职业技能训练课程教学目标。围绕中学生物学教师的教学技能的实际需求和生物科学专业人才培养方案的毕业要求,确定了教师职业技能训练课程的内容、教学... 详细信息

在调查分析中学生物学教师对于教学技能需求的基础之上,设置产出导向教育理念的教师职业技能训练课程教学目标。围绕中学生物学教师的教学技能的实际需求和生物科学专业人才培养方案的毕业要求,确定了教师职业技能训练课程的内容、教学方法以及评价方案。

关键词：产出导向教育教师职业技能训练课程师范生

Arg-gly-asp-mannose-6-phosphate inhibits activation and proliferation of hepatic stellate cells in vitro

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World Journal of Gastroenterology 2006年第8期12卷 1303-1307页

作者： Lian-Sheng wang ying-Wei chen Ding-Guo Li Han-Ming Lu Digestive Disease Laboratory Xinhua Hospital Shanghai Second Medical University Shanghai 200092 China

AIM： To investigate the effect of arg-gly-asp-mannose-6 phosphate （RGD-M6P） on the activation and proliferation of primary hepatic stellate cells in vitro. METHODS： Hepatic steUate cells （HSCs） were isolated from rats by in situ collagenase perfusion of liver and 18% Nycodenz gradient centrifugation and cultured on uncoated plastic plates for 24 h with DMEM containing 10% fetal bovine serum （FBS/DMEM） before the culture medium was substituted with 2% FBS/DMEM for another 24 h. Then, HSCs were cultured in 2% FBS/DMEM with transforming growth factor 131, M6P, RGD, or RGD- M6P, respectively. Cell morphology was observed under inverted microscope, smooth muscle α-actin （α-SMA） was detected by immunocytochemistry, type Ⅲ procollagen （PCⅢ） in supernatant was determined by radioimmunoassay, and the proliferation rate of HSCs was assessed by flow cytometry. RESULTS： RGD-M6P significantly inhibited the morphological transformation and the α-SMA and PC Ⅲ expressions of HSCs in vitro and also dramatically prevented the proliferation of HSCs in vitro. Such effects were remarkably different from those of RGD or M6R CONCLUSION： The new compound, RGD-M6P, which has a dramatic effect on primary cultured HSCs in vitro, can inhibit the transformation of HSCs in culture caused by TGFβ1, suppresses the expression of PCIII and decreases proliferation rate of HSC. RGD-M6P can be applied as a selective drug carrier targeting at HSCs, which may be a new approach to the prevention and treatment of liver fibrosis.

关键词： RGD Mannose-6-phosphate Hepatic stellate cell Liver fibrosis

Dicyclopentyl azodicarboxylate(DCpAD):A new alternative azo-reagent for the Mitsunobu reaction

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Chinese Chemical Letters 2011年第9期22卷 1047-1050页

作者： Jian Hai Yang Li Yan Dai Xiao Zhong wang ying Qi chen Department of Chemical and Biological Engineering Zhejiang University Hangzhou 310027 China

Dicyclopentyl azodicarboxylate is introduced as a new azo-reagent which can be conveniently prepared in two steps and be used in the Mitsunobu reaction. Though there are no distinct difference of reactivity between DC... 详细信息

关键词： Dicyclopentyl azodicarboxylatc Mitsunobu reaction Azo-reagent

Phylogenetic and Structural Analysis of Major Surface Proteins Hemagglutinin and Neuraminidase of Novel Avian Influenza Virus A H7N9 from Chinese Patient

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Chemical Research in Chinese Universities 2013年第5期29卷 934-940页

作者： YUAN Xiao-hui wang ying-chen QU Zhang-yi REN Jia-yi WU Xiao-min wang Jing-fei Department of Microbiology Public Health College Harbin Medical University Harbin 150081 P. R. China Institute of Pathogen Biology Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100176 P R. China Key Laboratory of Resource and Plant Biology of Anhui Province College of Life Science Huaibei Normal University Huaibei 235000 P. R. China Harbin Veterinary Research Institute Chinese Academy of Agricultural Sciences Harbin 150081 P R. China

This research reveals the phylogenetic history and structural information of the hemagglutinin（HA） and neuraminidase（NA） from novel avian influenza virus A/Hangzhou/1/2013（HTN9_2013） strain from human infected in China. Strains closely related to the HTN9 2013 strain were obtained from Nation Center for Biotechnology Information（USA）-basic local alignment search tool（NCBI-BLAST） searching, and the phylogenetic trees were con- structed. The 3D structures of HA and NA from H7N9 2013 strain were built by homology modeling technology, and molecular dynamics（MD） simulations were performed on the high-performance computer cluster. Characteristic amino acid sites were then screened from multiple sequence alignment（MSA） via home-made Python script and mapped onto the 3D structures. The thermodynamic characteristic root-mean-square-fluctuation （RMSF） of these sites in the structure was also analyzed with MD trajectories. The HA of HTN9_2013 strain is closely related to the A/duck/Zhejiang/12/2011 strain isolated in China, while the NA of HTN9 2013 strain is mostly related to the A/mallard/Czech Republic/13438-29K/2010 strain isolated in Europe. The 3D structures of HA and NA from H7N9 2013 stain are mostly identical to the existing structure of H7 and N9. A total of 11 and 14 characteristic ami- no acid sites were identified in HA and NA, respectively, in HTN9_2013. Structural analysis indicates that certain sites in the top region of HA are important, at which the mutation of some amino acids can impact the receptor bin- ding that may be related to its infection of human beings.

关键词： Avian influenza virus Hemagglutinin Neuraminidase Homology modeling Phylogenetic

Numerical Investigation on Heat Transfer Characteristics of Microencapsulated Phase Change Material Slurry in a Rectangular Minichannel

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Journal of Thermal Science 2024年第2期33卷 564-577页

作者： wang Zhibin LI Zilong JIA Lisi DING Bin chen ying School of Materials and Energy Guangdong University of TechnologyGuangzhou510006China Guangdong Provincial Key Laboratory of Functional Soft Condensed Matter Guangzhou510006China College of New Energy China University of Petroleum(East China)Qingdao266580China

Microencapsulation phase change material slurry(MEPCMS) becomes a potential working fluid for cooling high energy density miniaturized components,thanks to the latent heat absorption of particles in the heat transfer *** this work,the Discrete Phase Model(DPM) based on the Euler-Lagrangian method is used to numerically investigate the convective heat transfer characteristics of MEPCMS flowing through a rectangular minichannel with constant heat *** results show that particles of MEPCMS are mainly subjected to drag force during the *** so,they can migrate from the high-temperature region to the low-temperature region driven by the thermophoretic force,affecting the particle distribution and phase change ***,the Nux of the MEPCMS fluctuates due to particle phase change with varying specific heat ***,the value increases first,then decreases,and eventually increases again until it approaches the fully developed value of the pure base fluid as the particles gradually ***,the heat transfer performance of the MEPCMS is influenced by the combination of fluid inlet temperature fluid inlet velocity(v),and mass concentration(c_(m)) of MEPCM *** result shows that the maximum reduction of the maximum bottom wall temperature difference(ΔT_(w)) is 23.98% at T_(in)=293.15 K,v=0.15 m·s^(-1),c_(m)=10%.

关键词： Microencapsulated Phase Change Material Slurry(MPCMS) Discrete Phase Model(DPM) particle-fluid interaction force minichannel heat sink thermophoresis