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Lactate:a prospective target for therapeutic intervention in psychiatric disease

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Neural Regeneration Research 2024年第7期19卷 1473-1479页

作者： Yanhui Cai haiyun Guo Tianle Han Huaning wang Department of Psychiatry Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Anesthesiology and Perioperative Medicine Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina

Although antipsychotics that act via monoaminergic neurotransmitter modulation have considera ble therapeutic effect,they cannot completely relieve clinical symptoms in patients suffering from psychiatric disorde *** may be attributed to the limited range of neurotransmitters that are regulated by psychotropic *** findings indicate the need for investigation of psychotropic medications that target less-studied neurotransmitte *** these candidate neurotransmitters,lactate is developing from being a waste metabolite to a glial-neuronal signaling molecule in recent *** studies have suggested that cerebral lactate levels change considerably in numerous psychiatric illnesses;animal experiments have also shown that the supply of exogenous la ctate exerts an antidepressant *** this review,we have described how medications targeting newer neurotransmitte rs offer promise in psychiatric diseases;we have also summarized the advances in the use of lactate(and its corresponding signaling pathways)as a signaling *** addition,we have described the alterations in brain lactate levels in depression,anxiety,bipolar disorder,and schizophrenia and have indicated the challenges that need to be overcome before brain lactate can be used as a therapeutic target in psychopharmacology.

关键词： antidepressant anxiety bipolar disorder depression lactate psychiatric disease psychopharmacology schizophrenia signal molecular therapeutics

Growth of Czochralski silicon under magnetic field

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Science China(Technological Sciences) 2004年第3期47卷 281-292页

作者： XU Yuesheng LIU Caichi wang haiyun ZHANG Weilian YANG Qingxin LI Yangxian REN Binyan LIU Fugui Institute of Information Function Materials Hebei University of Technology Tianjin 300130 China

Growth of Czochralski (CZ) silicon crystals under the magnetic field induced by a cusp-shaped permanent magnet of NdFeB has been investigated. It is found that the mass transport in silicon melt was controlled by its diffusion while the magnetic intensity at the edge of a crucible was over 0.15 T. In comparison with the growth of conventional CZ silicon without magnetic field, the resistivity homogeneity of the CZ silicon under the magnetic field was improved. Furthermore, the Marangoni convection which has a significant influence on the control of oxygen concentration was observed on the surface of silicon melt. It is suggested that the crystal growth mechanism in magnetic field was similar to that in micro-gravity if a critical value was reached, named the growth of equivalent micro-gravity. The relationship of the equivalent micro-gravity and the magnetic intensity was derived as g=(v0/veff)g0. Finally, the orders of the equivalent micro-gravity corresponding to two crucibles with characteristic sizes were calculated.

关键词： Magnetic field equivalent micro-gravity diffusion-controlled mechanism Marangoni convection.

Hunt for the tipping point during endocrine resistance process in breast cancer by dynamic network biomarkers

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Journal of Molecular Cell Biology 2019年第8期11卷 649-664页

作者： Rui Liu Jinzeng wang Masao Ukai Ki Sewon Pei Chen Yutaka Suzuki haiyun wang Kazuyuki Aihara Mariko Okada-Hatakeyama Luonan Chen School of Mathematics South China University of Science and Technology Guangzhou 510640 China Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Kunming 650223 China School of Life Science and Technology ShanghaiTech University Shanghai 200031 China Shanghai Research Center for Brain Science and Brain-Inspired Intelligence Shanghai 201210 China School of Life Sciences and Technology Tongji University Shanghai 200092 China National Research Center for Translational Medicine (Shanghai) Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Graduate School of Medical Life Science Yokohama City University Yokohama 230-0045 Japan Laboratory for Integrated Cellular Systems RIKEN Center for Integrative Medical Sciences (IMS) Yokohama 230-0045 Japan Key Laboratory of Systems Biology Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Shanghai 200031 China Department of Medical Genome Sciences Graduate School of Frontier Sciences The University of Tokyo Chiba 277-8562 Japan Institute of Industrial Science The University of Tokyo Tokyo 153-8505 Japan Laboratory of Cell Systems Osaka University Osaka 565-0871 Japan

Acquired drug resistance is the major reason why patients fail to respond to cancer *** is a challenging task to *** the tipping point of endocrine resistance and detect the associated *** from new systems biology theory, the dynamic network biomarker (DNB) method is designed to quantitatively identify the tipping point of a drastic system transition and can theoretically identify DNB genes that play key roles in acquiring drug *** analyzed time-course mRNA sequence data generated from the tamoxifen-treated estrogen receptor (ER)-positive MCF-7 cell line, and identified the tipping point of endocrine resistance with its leading *** results show that there is interplay between gene mutations and DNB genes, in which the accumulated mutations eventually affect the DNB genes that subsequently cause the change of transcriptional landscape, enabling full-blown drug resistance. Survival analyses based on clinical datasets validated that the DNB genes were associated with the poor survival of breast cancer *** results provided the detection for the pre-resistance state or early signs of endocrine *** predictive method may greatly benefit the scheduling of treatments for complex diseases in which patients are exposed to considerably different drugs and may become drug resistant.

关键词： drug resistance breast cancer tipping point dynamic network biomarker (DNB) molecular network mRNA-seq

A new clinical entity: multi-etiological heart failure in the elderly and its therapeutic implication

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Journal of Geriatric Cardiology 2005年第2期2卷 109-113页

作者： Shiwen wang haiyun WU Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China

Heart failure (HF) is a major health problem for the geriatric population. In the United States, most of the 5 millions patients with HF are elderly.1 Seventy-five percent of HF hospitalizations occurred in patients older than 65 years and 50% in patients 75 years and older.1 In the Framingham population, the prevalence of HF increased eightfold among men from the fifth decade of life to the seventh decade.2 However, despite of considerable improvement in the treatment, the mortality of HF patients remained relatively constant between 1948 and 1997.

关键词： CHF multi-etiological heart failure in the elderly and its therapeutic implication A new clinical entity

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如何快速高效分离李斯特菌属

工业微生物 2024年第1期54卷 122-124页

作者：贺炎娜李丹张云鲜王丹王海芸崔永静蒙牛乳业(焦作)有限公司河南焦作454000

为了有效区分鉴别李斯特菌属,选择几种李斯特菌属的标准菌株,包括英诺克李斯特氏菌、斯氏李斯特氏菌、伊氏李斯特氏菌、单核细胞增生李斯特氏菌,按照相同的方法进行检测。过程中对其菌落形态、生理生化特性、溶血现象进行分析,区分不同... 详细信息

为了有效区分鉴别李斯特菌属,选择几种李斯特菌属的标准菌株,包括英诺克李斯特氏菌、斯氏李斯特氏菌、伊氏李斯特氏菌、单核细胞增生李斯特氏菌,按照相同的方法进行检测。过程中对其菌落形态、生理生化特性、溶血现象进行分析,区分不同菌株的特性,从而有效、快速地鉴别目标菌。染色镜检、动力试验、过氧化氢酶试验不能有效地区分李斯特菌属,生化鉴定及溶血试验可以有效区分。不同标准菌株之间的对比试验可有效鉴别目标菌。

关键词：李斯特菌溶血鉴别 VITEK 2 Compact

特高压换流站交流滤波电容器组不平衡保护故障研究

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电力电容器与无功补偿 2024年第2期45卷 6-13页

作者：彭寅章王海云张维宁牛征南东亮新疆大学电气工程学院乌鲁木齐830047 国网新疆电力有限公司电力科学研究院乌鲁木齐830013 国网新疆电力有限公司乌鲁木齐830000

交流滤波器作为特高压直流输电工程关键组成部分,扮演着调节电压、提供无功补偿的角色,其安全稳定运行至关重要。针对某换流站交流滤波器组发生不平衡保护动作,通过介绍该站交流滤波器配置情况,结合故障电流的分布特点,对交流滤波器C1... 详细信息

交流滤波器作为特高压直流输电工程关键组成部分,扮演着调节电压、提供无功补偿的角色,其安全稳定运行至关重要。针对某换流站交流滤波器组发生不平衡保护动作,通过介绍该站交流滤波器配置情况,结合故障电流的分布特点,对交流滤波器C1电容器不平衡异常进行了分析。为了提高现场运维人员处理故障效率,提出了一种故障电容器组定位方法,该方法可精确定位双H桥的1/6区域,解决了电容器组不平衡保护的故障定位难题,对特高压换流站可靠运行具有实际参考价值。

关键词：交流滤波器无功补偿不平衡保护故障定位

Myc诱导的核抗原通过调控蛋白激酶B/哺乳动物雷帕霉素靶蛋白/信号通路促进急性髓细胞性白血病细胞增殖

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安徽医药 2024年第7期28卷 1339-1343页

作者：杭海芳路伟俞夜花庞淯阳王海云上海交通大学医学院附属第九人民医院血液内科上海200011 上海交通大学医学院附属第九人民医院急诊科上海200011

目的探讨Myc诱导的核抗原(Myc induced nuclear antigen,MINA)在急性髓细胞性白血病(AML)中的表达及其对HL-60细胞的增殖影响及其分子机制。方法研究时间为2021年5月至2023年1月。AML数据集来自癌症基因组图谱(TCGA)。通过TCGA数据库下... 详细信息

目的探讨Myc诱导的核抗原(Myc induced nuclear antigen,MINA)在急性髓细胞性白血病(AML)中的表达及其对HL-60细胞的增殖影响及其分子机制。方法研究时间为2021年5月至2023年1月。AML数据集来自癌症基因组图谱(TCGA)。通过TCGA数据库下载AML的临床信息和MINA的表达水平。构建MINA基因的过表达慢病毒载体,通过慢病毒感染,建立稳定MINA基因过表达的人原髓细胞白血病细胞(HL-60)细胞系,通过细胞计数法检测其对细胞增殖的影响;蛋白质印迹法检测MINA对HL-60细胞蛋白激酶B(Akt)、哺乳动物雷帕霉素靶蛋白(mTOR)磷酸化的影响。TCGA数据库分析MINA与mTOR在AML中表达的相关性。结果分析TCGA数据库,结果显示MINA mRNA在AML中表达16.25±0.58明显高于健康对照者10.20±0.29,MINA的表达水平与AML病人预后密切相关,相对于低表达者,高表达MINA的AML癌病人预后较差(HR=2.30,P=0.003)。成功构建稳定MINA高表达的HL-60细胞系,过表达MINA促进HL-60细胞增殖,第6天细胞数过表达组明显高于对照组(P<0.01);过表达MINA可明显增加Akt和mTOR的磷酸化水平,Akt抑制剂哌立福新(Perifosine)可逆转过表达MINA导致的HL-60细胞增殖。MINA与mTOR的表达水平在AML中具有明显的正相关性(r=0.36,P<0.01)。结论MINA在AML病人中高表达,高表达MINA的AML病人预后较差,MINA可能通过调控Akt/mTOR通路促进AML细胞增殖。

关键词：白血病,髓样,急性抗原,核 Myc诱导的核抗原预后增殖蛋白激酶B/哺乳动物雷帕霉素靶蛋白

Improving the value of molecular testing:current status and opportunities in colorectal cancer precision medicine

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Cancer Biology & Medicine 2024年第1期21卷 21-28页

作者： haiyun Li Linwei Guo Chenchen wang Xin Hu Ye Xu Department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Gastrointestinal Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Precision Cancer Medical Center Affiliated with Fudan University Shanghai Cancer Center Shanghai 201315China

Colorectal cancer(CRC)is the second leading cause of cancer-related deaths *** radical resection with adjuvant chemotherapy remains the primary treatment choice for CRC,but the 5-year postoperative survival rate is only approximately 60%,and approximately one-third of patients with CRC experience recurrence within 2 years of ***,the transformation of high-throughput sequencing has accelerated the development of precision *** example,KRAS mutations indicate resistance to anti-epidermal growth factor receptor(EGFR)-targeted therapies in ***,molecular-guided individualized therapy has brought new promise in major clinical areas and challenges,such as novel biomarkers predicting sensitivity and resistance to immunotherapy for microsatellite stable(MSS)CRC.

关键词： cancer chemotherapy colorectal

Amlodipine inhibits matrix metalloproteinases expression and secretion in mouse macrophage

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Journal of Geriatric Cardiology 2005年第4期2卷 240-242页

作者： Yamin CAO Shiwen wang haiyun WU Institute of Geriatric Cardiology General Hospital of Chinese PLA Beijing 100853 China Institute of Geriatric Cardiology General Hospital of Chinese PLA Beijing 100853 China Institute of Geriatric Cardiology General Hospital of Chinese PLA Beijing 100853 China

Objective To investigate whether the calcium channel blocker amlodipine could inhibit macrophage matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expression and secretion. Methods Peritoneal macrophages were isolated from BALB/C mice and incubated with low (5μg/L ), middle (15μg/L) and high (305μg/L) concentrations of amlodipine, or in the medium alone (controls) for 24 hours, and the expression and secretion of MMP-2 and MM-9 of the cells were analyzed by RT-PCR and gelatin zymography. Results Compared with controls, amlodipine at low concentration had no significant effects on the expression and secretion of either MMP-2 and MMP-9 (P>0.05) at middle concentrationit it could inhibited MMP-2 and MMP-9 expressions completely and significantly reduced the secretion of MMP-9 (P<0.05); but it had no effect on the secretion of MMP-2. At high concentration it also inhibited MMP-2 and MMP-9 expression completely. Conclusion Amlodipine at 15 ig/L inhibited the expression of MMP-2 and MMP-9 and reduced the secretion of MMP-9, suggesting that amlodipine may stabilize atherosclerotic plaque.

关键词： amlodipine macrophage matrix metalloproteinase reverse transcriptase polymerase chain reaction gelatin zymography.