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Nature’s marvels endowed in gaseous molecules Ⅰ:Carbon monoxide and its physiological and therapeutic roles

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Acta Pharmaceutica Sinica B 2021年第6期11卷 1434-1445页

作者： Xiaoxiao Yang Wen Lu Christopher P.Hopper Bowen Ke binghe wang Department of Chemistry and Center for Diagnostics and Therapeutics Georgia State UniversityAtlantaGA 30303USA Institut für Experimentelle Biomedizin Universit?tsklinikum WürzburgBavaria 97080Germany Department of Anesthesiology West China HospitalChengdu 610041China

Nature has endowed gaseous molecules such as O_(2),CO_(2),CO,NO,H2 S,and N2 with critical and diverse roles in sustaining life,from supplying energy needed to power life and building blocks for life ’s physical structure to mediating and coordinating cellular *** this article,we give a brief introduction of the complex functions of the various gaseous molecules in life and then focus on carbon monoxide as a specific example of an endogenously produced signaling molecule to highlight the importance of this class of *** past twenty years have seen much progress in understanding CO’s mechanism(s) of action and pharmacological effects as well as in developing delivery methods for easy *** remarkable trait of CO is its pleiotropic effects that have few parallels,except perhaps its sister gaseous signaling molecules such as nitric oxide and hydrogen *** review will delve into the sophistication of CO-mediated signaling as well as its validated pharmacological functions and possible therapeutic applications.

关键词： Carbon monoxide Gasotransmitter Gaseous signaling molecule CO releasing molecule Organic CO prodrug Homeostasis Pleiotropic effect Yin and Yang

Evaluation of the transfer function of human pulse system based on signal detection

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Chinese Science Bulletin 1999年第17期44卷 1566-1571页

作者： binghe wang Jinglin Xiang Yong Yang Liqin Zhi Wei Zheng Northwestern Polytech Univ Coll Marine Engn Xian 710072 Peoples R China Xian Tradit Chinese Med Hosp Cardiovasc Sect Xian 710005 Peoples R China

On the basis of the pulse source-system model, a convenient and effective method used to evaluate the transfer function of human pulse system has been proposed by using the principle of signal detection and system analysis. The experimental results show that the pulse system of the normal pulse has 3 formants; the smooth pulse, 2 formants; the wiry pulse, 4 formants; and the thready pulse, only 1 formant. Formant frequencies reflect the resonance behaviour of the arterial system.

关键词： human pulse system (HPS) signal detection transfer function frequency characteristics formants.

Preface The Sino-US chemistry professors conference:history and outlook

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Science China Chemistry 2010年第1期53卷 1-2页

作者： binghe wang Zhen Huang Lin Pu

On June 29–30, 2009, the Fifth Sino-US Chemistry Professors Conference, co-organized by Lanzhou University and the Chinese-American Chemistry & Chemical Biology Professors Association (CAPA, USA), was held in Lanzhou... 详细信息

关键词： US Zhang CAPA Preface The Sino-US chemistry professors conference wang

A new method for detecting line spectrum of ship-radiated noise using Duffing oscillator

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Chinese Science Bulletin 2007年第14期52卷 1906-1912页

作者： ZHENG SiYi GUO HongXia LI YaAn wang binghe ZHANG PengYi Department of Communication Engineering Engineering College of the Chinese People's Armed Police Force Xi'an 710086 China Department of Basic Science Engineering College of the Chinese People's Armed Police Force Xi'an 710086 China College of Marine Engineering Northwestern Polytechnic University Xi'an 710072 China

A detection scheme for line spectrum of ship-radiated noise is proposed using Duffing oscillator. The chaotic trajectory of Duffing oscillator is analyzed and the state equation of the system is improved to detect weak periodic signals in different frequencies. According to the simulation results, the phase transforms of Duffing oscillator are sensitive to periodic signals and immune to the random noise and the periodic interference signals which have larger angular frequency difference from the referential signal. By employing Lyapunov exponents in the field of detection as the criteria for chaos, the phase transforms of dynamic behaviors in quantity are successfully determined. Meanwhile, the threshold value in critical state has been evaluated more accurately. Based on the phase transforms of Duffing oscillator, a new method for detecting line spectrum of ship-radiated noise is given. Three types of ship-radiated noise signals are analyzed and the values of line spectrum are acquired successfully by this method. The experimental results show that this method has high sensitivity and high resolution.

关键词：光谱噪声煤粉震荡器混沌学说

Click chemistry and drug delivery:A bird's-eye view

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Acta Pharmaceutica Sinica B 2023年第5期13卷 1990-2016页

作者： Shameer M.Kondengadan Shubham Bansal Ce Yang Dongning Liu Zach Fultz binghe wang Department of Chemistry and Center for Diagnostics and Therapeutics Georgia State UniversityAtlantaGA 30303USA

Click chemistry has been proven to be very useful in drug *** to the availability of a large number of click reactions with a various characteristics,selection of appropriate chemistry for a given application is often not a trivial *** review is written for pharmaceutical researchers who are interested in click chemistry applications and yet may not be click chemistry *** this,the review gives an overview of available click reactions organized by application ***,the general understanding of click reactions being fast and high yielding sometimes overshadows the need to analyze reaction kinetics in assessing suitability of a given reaction for certain *** this,we highlight the need to analyze the relationship among reaction kinetics,concentration effects,and reaction time scales,knowing that lack of such analysis could easily lead to ***,possible issues such as chemical stability with various click reagents are also discussed to aid experimental *** examples and extensive references are also provided to aid in-depth understanding of technical *** hope this review will help those interested in using click chemistry in drug delivery to select the appropriate reactions/reagents and minimize the number of pitfalls.

关键词： Bioorthogonal chemistry Bond-breaking reaction PROTAC Antibody—drug conjugates Gasotransmitters

CD45 MOLECULE AND GENERATION OF EPI-DERMAL γδ T CELLS FROM MICE

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免疫学杂志 1999年第2期15卷 11-14页

作者：蔡钦朝王秉鹤安徽中医学院安徽南京医科大学附属第一医院江苏南京

为探讨ＣＤ４５蛋白酪氨酸磷酸酶在γδＴ细胞发育过程中的作用，观察ＣＤ４５基因敲除变种鼠体内树突状表皮Ｔ细胞（ＤＥＴＣ）等γδＴ细胞。以原位免疫标记法检查小鼠表皮内ＤＥＴＣ的形状、数量及免疫表型；以ＲＴ－ＰＣＲ测定表皮... 详细信息

为探讨ＣＤ４５蛋白酪氨酸磷酸酶在γδＴ细胞发育过程中的作用，观察ＣＤ４５基因敲除变种鼠体内树突状表皮Ｔ细胞（ＤＥＴＣ）等γδＴ细胞。以原位免疫标记法检查小鼠表皮内ＤＥＴＣ的形状、数量及免疫表型；以ＲＴ－ＰＣＲ测定表皮细胞中Ｖγ３ＴＣＲｍＲＮＡ之表达水平；ＦＣＭ检测ＤＥＴＣ在表皮细胞中以及另一组γδＴ细胞、Ｖγ２Ｔ细胞在淋巴结细胞中所占比例。结果显示，ＣＤ４５缺失鼠与野生型鼠相比，上述各项指标仍无明显差异。提示ＣＤ４５分子虽在αβＴ细胞发育过程中起重要作用，但对包括ＤＥＴＣ及Ｖγ２Ｔ细胞在内的γδＴ细胞发育成熟可能并非必需。

关键词： CD45蛋白酪氨酸磷酸酶树突状表皮T细胞 γδT细胞 T细胞发育

A reservoir drying method for enhancing recovery of tight gas

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Petroleum Exploration and Development 2022年第1期49卷 144-155页

作者： ZHANG Liehui XIONG Yu ZHAO Yulong TANG Hongming GUO Jingjing JIA Chunsheng LEI Qiang wang binghe State Key Laboratory of Oil&Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500China Institute of Exploration&Exploitation PetroChina Yumen Oil CompanyYumen 735019China

Based on the study of damage mechanisms of generalized water blocking and related water-blocking removal methods, the drying agents for enhancing tight gas reservoir recovery were developed, and the basic properties, injection mode and drying effect of the drying agents were evaluated. The chemical effect, thermal effect, salt resistance, salt resistance formulas and delay mechanism of the drying agent systems for different types of tight reservoirs were investigated through lab experiment. The solubility and solubilization properties of supercritical carbon dioxide on drying agent systems were *** injection mode of dissolving drying agent in supercritical carbon dioxide was proposed. The mechanisms of supercritical carbon dioxide with water in micropores of formation matrix were analyzed. Micro-pore structures and seepage characteristics of reservoir before and after drying were compared. Based on the characterization in combination of NMR and laser etched pore structure model, drying effects of the drying agents on bound water of different occurrences were evaluated qualitatively and quantitatively. Lattice Boltzmann method was used to evaluate the influence of drying effect on gas micro-seepage *** influence of drying effect on productivity and production performance of gas well was analyzed by numerical *** drying effect can greatly reduce water saturation of tight reservoir and improve the gas seepage capacity in near wellbore and fractures. This work can provide guidance for developing new measures in enhancing recovery of tight gas reservoirs.

关键词： tight gas reservoir drying enhancing gas recovery water-blocking removal drying agent seepage ability

Organic carbon monoxide prodrug, BW-CO-111, in protection against chemically-induced gastric mucosal damage

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Acta Pharmaceutica Sinica B 2021年第2期11卷 456-475,604页

作者： Dominik Bakalarz Marcin Surmiak Xiaoxiao Yang Dagmara Wójcik Edyta Korbut ZbigniewSliwowski Grzegorz Ginter Grzegorz Buszewicz Tomasz Brzozowski Jakub Cieszkowski Urszula Głowacka Katarzyna Magierowska Zhixiang Pan binghe wang Marcin Magierowski Department of Physiology Jagiellonian University Medical CollegeCracow 31-531Poland Department of Forensic Toxicology Institute of Forensic ResearchCracow 31-033Poland Department of Internal Medicine Jagiellonian University Medical CollegeCracow 31-531Poland Department of Chemistry and Center for Diagnostics and Therapeutics Georgia State UniversityAtlantaGA30303USA Department of Forensic Medicine Medical University of LublinLublin 20-093Poland

Metal-based carbon monoxide(CO)-releasing molecules have been shown to exert antiinflammatory and anti-oxidative properties maintaining gastric mucosal *** are interested in further development of metal-free CO-based therapeutics for oral ***,we examine the protective effect of representative CO prodrug,*** rat models of gastric damage induced by necrotic ethanol or aspirin,a representative non-steroidal anti-inflammatory *** effectiveness was assessed by measuring the microscopic/macroscopic gastric damage area and gastric blood flow by laser *** mucosal mRNA and/or protein expressions of HMOX1,HMOX2,nuclear factor erythroid 2-related factor 2,COX1,COX2,iNos,Anxa1 and serum contents of TGFB1,TGFB2,IL1 B,IL2,IL4,IL5,IL6,IL10,IL12,tumor necrosis factorα,interferonγ,and GM-CSF were *** content in gastric mucosa was assessed by gas *** with BW-CO-111(0.1 mg/kg,i.g.)increased gastric mucosal content of CO and reduced gastric lesions area in both models followed by increased *** protective effects of the CO prodrug were supported by changes in expressions of molecular ***,because the pathomechanisms of gastric damage differ between topical administration of ethanol and aspirin,the possible protective and anti-inflammatory mechanisms of BW-CO-111 may be somewhat different in these models.

关键词： Gastroprotection Carbon monoxide Prodrug Anti-inflammation NSAID Ethanol Gastric mucosal damage

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东庞矿高产高效建设的实践

中国煤炭 2005年第9期31卷 89-90页

作者：王炳合河北金牛能源股份有限公司东庞矿

东庞矿设计生产能力180万t,矿井1983年底投产,1987达产后,产量逐年增加,1999年产量达到并稳定在240万t左右.矿井投产初期,回采采用高档普采技术,掘进以炮掘为主;井下运输系统采用3t底卸式矿车;洗煤工艺简单,不能达到用户群体要求;地面... 详细信息

东庞矿设计生产能力180万t,矿井1983年底投产,1987达产后,产量逐年增加,1999年产量达到并稳定在240万t左右.矿井投产初期,回采采用高档普采技术,掘进以炮掘为主;井下运输系统采用3t底卸式矿车;洗煤工艺简单,不能达到用户群体要求;地面储装运系统不完善且无原煤直装系统;矿井抗御自然灾害能力差,安全事故不断发生;管理水平落后.这些先天不足造成了用人多效率低、成本高效益差、事故频安全无保障,严重制约着矿井的发展.进入市场经济以来,东庞以实施科技兴矿战略为主线,积极探索复杂地质条件下'双高'矿井建设新途径,劳动生产效率和经济效益有了大幅度提高.

关键词：高产高效设计生产能力井下运输系统建设底卸式矿车储装运系统高档普采洗煤工艺自然灾害