Click chemistry and drug delivery:A bird's-eye view
作者机构：Department of Chemistry and Center for Diagnostics and TherapeuticsGeorgia State UniversityAtlantaGA 30303USA
出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)
年 卷 期：2023年第13卷第5期
页 面：1990-2016页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学]
基 金：financial support from the National Institutes of Health(DK119202,CO and colitis DK128823,CO and acute kidney injury) the Georgia Research Alliance Eminent Scholar endowment fund internal resources at Georgia State University the support of the Center for Diagnostics and Therapeutics through a graduate CDT fellowship
主 题：Bioorthogonal chemistry Bond-breaking reaction PROTAC Antibody—drug conjugates Gasotransmitters
摘 要：Click chemistry has been proven to be very useful in drug *** to the availability of a large number of click reactions with a various characteristics,selection of appropriate chemistry for a given application is often not a trivial *** review is written for pharmaceutical researchers who are interested in click chemistry applications and yet may not be click chemistry *** this,the review gives an overview of available click reactions organized by application ***,the general understanding of click reactions being fast and high yielding sometimes overshadows the need to analyze reaction kinetics in assessing suitability of a given reaction for certain *** this,we highlight the need to analyze the relationship among reaction kinetics,concentration effects,and reaction time scales,knowing that lack of such analysis could easily lead to ***,possible issues such as chemical stability with various click reagents are also discussed to aid experimental *** examples and extensive references are also provided to aid in-depth understanding of technical *** hope this review will help those interested in using click chemistry in drug delivery to select the appropriate reactions/reagents and minimize the number of pitfalls.
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