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Changes in the Non-targeted Metabolomic Profile of Three-year-old Toddlers with Elevated Exposure to Polycyclic Aromatic Hydrocarbons

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Biomedical and Environmental Sciences 2024年第5期37卷 479-493页

作者： LI Yang LIN Dan ZHANG Xiu Qin JU Guang Xiu SU Ya ZHANG Qian DUAN Hai Ping YU Wei Sen wang bing ling PANG Shu Tao Department of Epidemiology and Health Statistics School of Public HealthQingdao UniversityQingdao 266021ShandongChina Department of Environmental Health Qingdao Municipal Center for Disease Control and PreventionQingdao Institute of Preventive MedicineQingdao 266033ShandongChina Physicochemical Laboratory Qingdao Municipal Center for Disease Control and PreventionQingdao Institute of Preventive MedicineQingdao 266033ShandongChina Section of Child Health Care Huangdao Maternity and Child Health Care Hospital of QingdaoQingdao 266499ShandongChina Qingdao Blood Center Qingdao 266071ShandongChina

Objective To investigate changes in the urinary metabolite profiles of children exposed to polycyclic aromatic hydrocarbons(PAHs)during critical brain development and explore their potential link with the intestinal *** Liquid chromatography-tandem mass spectrometry was used to determine ten hydroxyl metabolites of PAHs(OH-PAHs)in 36-month-old ***,37 children were categorized into low-and high-exposure groups based on the sum of the ten ***-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was used to identify non-targeted metabolites in the urine ***,fecal flora abundance was assessed by 16S rRNA gene sequencing using Illumina *** The concentrations of 21 metabolites were significantly higher in the high exposure group than in the low exposure group(variable importance for projection>1,P<0.05).Most of these metabolites were positively correlated with the hydroxyl metabolites of naphthalene,fluorine,and phenanthrene(r=0.336–0.531).The identified differential metabolites primarily belonged to pathways associated with inflammation or proinflammatory states,including amino acid,lipid,and nucleotide ***,these distinct metabolites were significantly associated with specific intestinal flora abundances(r=0.34–0.55),which were mainly involved in *** Higher PAH exposure in young children affected metabolic homeostasis,particularly that of certain gut microbiota-derived *** investigation is needed to explore the potential influence of PAHs on the gut microbiota and their possible association with neurodevelopmental outcomes.

关键词： Child Gut microbiota Non-targeted metabolomics Polycyclic aromatic hydrocarbons Urinary metabolite profile

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QRS波时限在射血分数保留性心力衰竭中的相关性研究

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医学信息 2024年第3期37卷 104-108页

作者：段玉彩魏亚君马凌袁迎娜王兵玲李忠联勤保障部队第九四〇医院心内科解放军火箭军第64基地医院感染科

目的研究QRS波时限在射血分数保留性心力衰竭（HFpEF）中的关系。方法选取2021年1月-2022年1月就诊于联勤保障部队第九四〇医院的HFpEF患者87例为心衰组，并根据纽约心脏病协会（NYHA）心脏功能分级将心衰组分为Ⅱ～Ⅳ组，另选取同期5... 详细信息

目的研究QRS波时限在射血分数保留性心力衰竭（HFpEF）中的关系。方法选取2021年1月-2022年1月就诊于联勤保障部队第九四〇医院的HFpEF患者87例为心衰组，并根据纽约心脏病协会（NYHA）心脏功能分级将心衰组分为Ⅱ～Ⅳ组，另选取同期53名健康体检者为对照组，比较各组临床资料，采用Spearman相关分析QRS波时限与临床各指标的关系，ROC曲线分析QRS波时限诊断HFpEF的效能。结果各组年龄、BMI、冠心病比例、糖尿病比例、FS比较，差异无统计学意义（P>0.05）。各组性别、高血压比例、房颤比例、肌酐、QRS、QTC、LVEF、LAD、LVEDV、LVESV、QRS波时限、NT-proBNP比较，差异有统计学意义（P<0.05）。Spearman相关性分析显示，QRS波时限与年龄、LAD、LVEDV、LVESV、NT-proBNP呈正相关，与LVEF呈负相关（P<0.05）。ROC曲线显示分析，QRS波时限诊断HFpEF的AUC为0.843(95%CI:0.772～0.915)，敏感度和特异度分别为88.50%和71.70%，截点值为98.5 ms;NT-proBNP诊断HFpEF的AUC为0.979(95%CI:0.961～0.998)，敏感度和特异度分别为93.10%和96.20%，截点值为619.5 pg/ml。QRS波时限与NT-proBNP联合对HFpEF的诊断价值更高，AUC达0.984(95%CI:0.967～0.100)，敏感度和特异度分别为92.00%和98.10%。结论 QRS波时限在HFpEF患者中随着NYHA分级增加而增宽，QRS波时限与NT-proBNP联合检测可有效提高HFpEF的诊断效率。

关键词： QRS波时限射血分数保留性心力衰竭心力衰竭

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Flexible,efficient,and accurate tests for epidemics

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Science China Mathematics 2024年第8期67卷 1881-1898页

作者： Linjiajie Fang bing-Yi Jing Shen ling Qiyue wang Qing Yang Data Science and Analytics Thrust The Hong Kong University of Science and TechnologyHong KongChina Department of Statistics and Data Science Southern University of Science and TechnologyShenzhen 518055China Department of Mathematics and Statistics Dalhousie UniversityHalifaxNS B 3H 4R 2Canada Department of Mathematics The Hong Kong University of Science and TechnologyHong KongChina

Group testing involves discovering a small subset of distinguished subjects from a large population while efficiently reducing the total number of *** has been widely used for industrial testing,information technology,and biology,especially epidemic ***,in reality,are noisy for the presence of false *** tests are accurate but time-consuming,while others are cheaper but less *** which test to use is constrained by various considerations,such as availability,cost,accuracy,and *** this paper,we propose flexible,efficient,and accurate tests(FEATs).FEATs are based on group testing with simple but careful designs by incorporating ideas such as close contact cliques and repeated *** could dramatically improve the efficiency or accuracy of existing *** example,for accurate but slow tests,the FEAT can improve efficiency multiple times without compromising *** the other hand,for fast but inaccurate tests,the FEAT can sharply reduce the false-negative rate(FNR)and significantly increase *** justifications are *** point out some scenarios where the FEAT can be effectively employed.

关键词： epidemiology control blood testing testing efficiency testing accuracy

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The Ability of Baseline Triglycerides and Total Cholesterol Concentrations to Predict Incidence of Type 2 Diabetes Mellitus in Chinese Men and Women:A Longitudinal Study in Qingdao, China

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Biomedical and Environmental Sciences 2019年第12期32卷 905-913页

作者： CUI Jing MA Ping SUN Jian Ping Zulqamain Baloch YIN Fan XIN Hua Lei REN Jie TAN Ji Bin wang bing ling Qingdao Municipal Center for Disease Control and Prevention Qingdao Institute of Preventive MedicineQingdao 266033ShandongChina The Third People s Hospital of Qingdao Qingdao 266041Shandong China College of Veterinary Medicine South China Agricultural UniversityGuangzhou 510642GuangdongChina Department of Non-communicable Disease Prevention Shandong Province Center for Disease Control and PreventionJinan 250014ShandongChina Chinese Center for Disease control and Prevention Beijing 102206China

Objectives The purpose of this study was to assess the association between triglycerides(TG),total cholesterol(TC)at baseline,and type 2 diabetes mellitus(T2DM)incidence in a general Chinese ***,it aimed to evaluate the ability of TG and TC to predict T2DM *** Qingdao Diabetes Prevention Program participants recruited between 2006 and 2009 were followed up in 2012–***,TC,and T2DM status were *** proportional hazards models were used to estimate the association between TG,TC,and T2DM *** receiver operating characteristic(ROC)curve was used to evaluate the ability of TG and TC to identify T2DM *** The incidence of T2DM significantly increased with TG in women and TC in both men and women(Ptrend1.15 and>1.23 mmol/L in men and women,*** TC,they were>5.17 and>5.77 mmol/L in men and women,*** area under the ROCs of TG and TC were 0.54(0.51–0.57)and 0.55(0.52–0.58),respectively,in men,and 0.60(0.58–0.62)and 0.59(0.56–0.61),respectively,in *** Elevated TG and TC were risk factors for T2DM ***,no predictive capacity was found for both factors to identify T2DM incidence in Chinese men and ***,TG and TC levels in both Chinese men and women might be used for decreasing the incidence of T2DM but no clinical predictive capacity for T2DM.

关键词： Triglycerides Total cholesterol Adult onset type 2 diabetes mellitus

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2018—2021年青岛市公共场所空气微生物监测结果分析

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环境与健康杂志 2024年第4期41卷 342-345页

作者：徐春生李丹丹王寅张秀芹王炳玲段海平青岛市疾病预防控制中心青岛市预防医学研究院环境卫生所山东266033

目的了解青岛市公共场所空气微生物污染状况,评估其健康风险,为加强公共场所卫生管理和传染病防控提供依据。方法根据国家公共场所健康危害因素监测工作方案,按照《公共场所卫生检验方法第3部分:空气微生物》(GB/T 18204.3—2013)于2018... 详细信息

目的了解青岛市公共场所空气微生物污染状况,评估其健康风险,为加强公共场所卫生管理和传染病防控提供依据。方法根据国家公共场所健康危害因素监测工作方案,按照《公共场所卫生检验方法第3部分:空气微生物》(GB/T 18204.3—2013)于2018—2021年对宾馆酒店、候车室、商场超市、健身房开展夏季和(或)冬季室内空气中细菌总数与真菌总数的监测。结果共监测173家次公共场所、451个监测点,真菌总数的合格率(77.6%)低于细菌总数的合格率(91.4%);不同类别公共场所微生物监测结果显示,宾馆酒店的合格率最低(68.7%);季度比较显示,夏季的合格率(69.7%)低于冬季(76.7%);年度比较显示,2019年合格率最低(54.5%),2021年最高(81.2%);上述差异均有统计学意义(P<0.05)。宾馆酒店结果显示,三星以下宾馆酒店微生物合格率最低(60.7%);夏季的合格率(61.7%)低于冬季(74.1%);2019年合格率最低(53.8%),2020年最高(76.6%);上述差异均有统计学意义(P<0.05)。结论青岛市公共场所细菌总数与真菌总数均有一定的超标现象,存在健康风险。需重点关注酒店、夏季、真菌的微生物超标问题,需采取措施降低公共场所空气微生物浓度。

关键词：公共场所空气微生物细菌总数真菌总数

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Toward Artificial Peptide Nanocapsules

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Nano-Micro Letters 2024年第10期16卷 240-243页

作者： Yuan wang bing Chen Laboratory for Biomaterials and Drug Delivery Department of AnesthesiologyDivision of Critical Care MedicineBoston Children's HospitalHarvard Medical SchoolBostonMA 02115USA College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023People's Republic of China

HIGHLIGHTS The formation of peptide nanocapsules is facilitated by a gradient interface,where the differential solvent concentration drives the peptides to preferentially localize and *** peptide nanocapsules,characterized by their hollow structures,demonstrated potential as carriers for targeted drug delivery.1 Introduction Peptide nanocapsules are a type of nanoscale delivery system that encapsulates active substances within a shell composed of peptides,leveraging the unique properties of peptides such as biocompatibility and biodegradability[1].Historically,the development of peptide nanocapsules was inspired primordially by the natural biological processes.

关键词： Peptide nanocapsules Self-assembly Drug delivery Nanomedicine

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A Strong,Tough,and Self-Healing Strengthening Thioctic Acid-based Elastomer for Highly Reliable Flexible Strain Sensor

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Chinese Journal of Polymer Science 2024年第10期42卷 1610-1618,I0016页

作者： Xin-Yu Chen Yu-bing Fu Xue-ling Yan Lan Liu School of Materials Science and Engineering Key Lab of Guangdong Province for High Property and Functional Polymer MaterialsSouth China University of TechnologyGuangzhou510641China

Elastomers with high strength and toughness,excellent self-healing properties,and biocompatibility have broad application prospects in wearable electronics and other fields,but preparing it remains a *** this work,we propose a highly adaptable strategy by introducing the small molecule crosslinking agent of triethanolamine(TEA)to the poly(thioctic acid)(PTA)chains and preparing the PAx Ey elastomers using a simple synthesis *** strategy stabilizes the PTA chains by constructing multiple non-covalent cross-linked dynamic networks,endowing materials with excellent strength and toughness(tensile strength of 288 kPa,toughness of 278.2 kJ/m3),admirable self-healing properties(self-healing efficiency of 121.6%within 7 h at 70℃),and good *** PAx Ey elastomers can also be combined with MWNTs to become flexible strain sensors,which can be used to monitor human joint movements with high sensitivity,repeatable responses,and stability.

关键词： Thioctic acid Ion clusters Multiple dynamic networks Self-healing strengthening Flexible strain sensor

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HEAT KERNEL ON RICCI SHRINKERS(II)

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Acta Mathematica Scientia 2024年第5期44卷 1639-1695页

作者： Yu LI bing wang Institute of Geometry and Physics University of Science and Technology of ChinaHefei230026China Hefei National Laboratory Hefei230088China

This paper is the sequel to our study of heat kernel on Ricci shrinkers[29].In this paper,we improve many estimates in[29]and extend the recent progress of Bamler[2].In particular,we drop the compactness and curvature boundedness assumptions and show that the theory of F-convergence holds naturally on any Ricci flows induced by Ricci shrinkers.

关键词： Ricci flow Ricci shrinker heat kernel

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A Study on the Impact of Chemical Structure on the Evolution of Aggregate Structure in Fiber-shaped High Density Polyethylene Vitrimer

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Chinese Journal of Polymer Science 2024年第10期42卷 1557-1565,I0013页

作者： bing wang Yuan-Chu Gao Hai wang Hui Niu State Key Laboratory of Fine Chemicals School of Chemical EngineeringDalian University of TechnologyDalian116024China

Vitrimers have emerged as a prominent research area in the field of polymer *** of the studies have focused on synthesizing polymers with versatile dynamic crosslinking structures,while the impact of chemical structure on aggregate structure of vitrimers,particularly during polymer processing,remains insufficiently *** present study employed commercial maleic anhydride-grafted-high density polyethylene(M-g-HDPE)as the matrix and hexanediol as the crosslinker to facilely obtain fiber-shaped HDPE vitrimers through a reaction extrusion and post-drawing *** chemical structure characterization,morphology observation,thermal and mechanical properties investigation,as well as aggregate structure analysis,this work revealed the influence of dynamic bonds on the formation of aggregate structures during fiber-shaped vitrimers processing.A small amount of dynamic bonds in HDPE restricts the motion of PE chain during melt-extruding and post-drawing,resulting in a lower orientation of the PE ***,lamellar growth and fibril formation during post-drawing at high temperature are enhanced to some extent due to the competition between dynamic bond and chain *** uneven morphology of fibershaped HDPE vitrimers can be attributed to the stronger elastic effect brought by dynamic bonding,which plays a more dominant role in determining the mechanical properties of fiber-shaped vitrimers compared to aggregate *** Vitrimers have emerged as a prominent research area in the field of polymer *** of the studies have focused on synthesizing polymers with versatile dynamic crosslinking structures,while the impact of chemical structure on aggregate structure of vitrimers,particularly during polymer processing,remains insufficiently *** present study employed commercial maleic anhydride-grafted-high density polyethylene(M-g-HDPE)as the matrix and hexanediol as the crosslinker to facilely obtain fiber-shap

关键词： High density polyethylene vitrimer Fiber-shaped Aggregate structures Transesterification reaction

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Vitamin D binding protein in psychiatric and neurological disorders:Implications for diagnosis and treatment

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Genes & Diseases 2024年第5期11卷 324-334页

作者： ling Li bing Han Yan Kong Gaojia Zhang Zhijun Zhang Research Institution of Neuropsychiatry School of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Neurology Affiliated Zhongda HospitalNanjingJiangsu 210009China Department of Pharmacology Jiangsu Provincial Key Laboratory of Critical Care MedicineSchool of MedicineSoutheast UniversityNanjingJiangsu 210009China Department of Biochemistry and Molecular Biology School of MedicineSoutheast UniversityNanjingJiangsu 210009China Brain Cognition and Brain Disease Institute Department of Mental Health and Public HealthFaculty of Life and Health SciencesShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China

Vitamin D binding protein(VDBP)serves as a key transporter protein responsible for binding and delivering vitamin D and its metabolites to target *** plays a crucial part in the inflammatory reaction following tissue damage and is engaged in actin *** research has shed light on its potential role in various diseases,leading to a growing interest in understanding the implications of VDBP in psychiatric and neurological *** purpose of this review was to provide a summary of the existing understanding regarding the involvement of VDBP in neurological and psychiatric *** examining the intricate interplay between VDBP and these disorders,this review contributes to a deeper understanding of underlying mechanisms and potential therapeutic *** gained from the study of VDBP could pave the way for novel strategies in the diagnosis,prognosis,and treatment of psychiatric and neurological disorders.

关键词： Neurological disorder Polymorphism Psychiatric disorder Structure Vitamin D binding protein

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