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多种代用资料和模型模拟得到的亚洲季风在8.2ka显著气候影响的证据（英文）

地球环境学报 2011年第3期2卷 426-441页

作者： MORRILL Carrie wagner amy j OTTO-BLIESNER Bette L ROSENBLOOM Nan Cooperative Institute for Research in Environmental Sciences University of Colorado NOAA's National Climatic Data Center Paleoclimatology Branch Climate and Global Dynamics Division National Center for Atmospheric Research

Given the likelihood of future reductions in the strength of the Atlantic Meridional Overturning Circulation(AMOC),it is important to document how changes in the AMOC have altered climate patterns in the past and to assess the skill of coupled climate models in reproducing these *** past abrupt changes in the AMOC,the 8.2 ka event provides a particularly useful case study because its duration,magnitude of AMOC reduction and background climate state are closest to conditions expected in the *** this research,we present an expanded proxy synthesis of the 8.2 ka event in monsoonal Asia,including new high-resolution lake and bog records,more sites from the East Asia monsoon region and proxies of winter monsoon *** compare proxy evidence with a new simulation of the 8.2 ka event using the Community Climate System Model version 3(CCSM3) and prescribing North Atlantic freshwater forcing according to the latest *** find clear and objectively-determined evidence for 8.2 ka climate anomalies at nearly all of the fourteen proxy sites,emphasizing the strong and widespread impacts of the event in monsoonal Asia during both summer and winter *** model simulation corroborates that these anomalies,described generally as a weakening of the summer monsoon and strengthening of the winter monsoon,were likely caused by a reduction of the *** of regional anomalies in East Asia reveals some spatial heterogeneity,however,that in the model simulation is caused by contraction of the seasonal migration of the subtropical monsoon *** duration of climate anomalies at 8.2 ka in monsoonal Asia,both in proxy records and the model simulation,generally matches the duration of the event in Greenland ice core δ^(18)O,further supporting a tight connection to the North Atlantic.

关键词： abrupt climate change coupled climate model Atlantic Meridional Overturning Circulation freshwater forcing Holocene

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Stochastic SIS metapopulation models for the spread of disease among species in a fragmented landscape

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International journal of Biomathematics 2016年第4期9卷 97-119页

作者： amy j. Ekanayake Department of Mathematics Western Illinois University 1 University Circle Maeomb Illinois 61455 USA

Two stochastic models are derived for a susceptible-infectious-susceptible epidemic spreading through a metapopulation： a continuous time Markov chain （CTMC） model and an It6 stochastic differential equation （SDE） model. The stochastic models are numerically compared. Close agreement suggests that computationally intense CTMC simulations can be approximated by simpler SDE simulations. Differential equations for the moments of the SDE probability distribution are also derived, the steady states are solved numerically using a moment closure technique, and these results are compared to simulations. The moment closure technique only coarsely approximates simulation results. The effect of model parameters on stability of the disease-free equilibrium is also numerically investigated.

关键词： Epidemic metapopulation Ito stochastic differential equation Markov chain moment closure.

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A sting in the tail： the N-terminal domain of the androgen receptor as a drug target

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Asian journal of Andrology 2016年第5期18卷 687-694页

作者： amy E Monaghan Iain j McEwan School of Medicine Medical Sciences and Nutrition Institute of Medical Sciences University of Aberdeen Foresterhill Aberdeen AB25 2ZD United Kingdom.

The role of androgen receptor （AR） in the initiation and progression of prostate cancer （PCa） is well established. Competitive inhibition of the AR ligand-binding domain （LBD） has been the staple of antiandrogen therapies employed to combat the disease in recent years. However, their efficacy has often been limited by the emergence of resistance, mediated through point mutations, and receptor truncations. As a result, the prognosis for patients with malignant castrate resistant disease remains poor. The amino-terminal domain （NTD） of the AR has been shown to be critical for AR function. Its modular activation function （AF-1） is important for both gene regulation and participation in protein-protein interactions. However, due to the intrinsically disordered structure of the domain, its potential as a candidate for therapeutic intervention has been dismissed in the past. The recent emergence of the small molecule EPI-O01 has provided evidence that AR-NTD can be targeted therapeutically, independent of the LBD. Targeting of AR-NTD has the potential to disrupt multiple intermolecular interactions between AR and its coregulatory binding partners, in addition to intramolecular cross-talk between the domains of the AR. Therapeutics targeting these protein-protein interactions or NTD directly should also have efficacy against emerging AR splice variants which may play a role in PCa progression. This review will discuss the role of intrinsic disorder in AR function and illustrate how emerging therapies might target NTD in PCa.

关键词： androgen receptor inhibitor intrinsically disordered structure N-terminal domain prostate cancer small molecules

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CHO cell cytotoxicity and genotoxicity analyses of disinfection by-products： An updated review

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journal of Environmental Sciences 2017年第8期29卷 64-76页

作者： Elizabeth D.wagner Michael j.Plewa Safe Global Water Institute University of Illinois at Urbana-Champaign 1101 W Peabody Dr. Urbana IL 61801 United States Department of Crop Sciences University of Illinois at Urbana-Champaign 1101 W Peabody Dr. Urbana IL 61801 United States

The disinfection of drinking water is an important public health service that generates high quality, safe and palatable tap water. The disinfection of drinking water to reduce waterborne disease was an outstanding public health achievement of the 20 th *** unintended consequence is the reaction of disinfectants with natural organic matter,anthropogenic contaminants and bromide/iodide to form disinfection by-products（DBPs）.A large number of DBPs are cytotoxic, neurotoxic, mutagenic, genotoxic, carcinogenic and teratogenic. Epidemiological studies demonstrated low but significant associations between disinfected drinking water and adverse health effects. The distribution of DBPs in disinfected waters has been well defined by advances in high precision analytical chemistry. Progress in the analytical biology and toxicology of DBPs has been *** objective of this review was to provide a detailed presentation of the methodology for the quantitative, comparative analyses on the induction of cytotoxicity and genotoxicity of103 DBPs using an identical analytical biological platform and endpoints. A single Chinese hamster ovary cell line was employed in the assays. The data presented are derived from papers published in the literature as well as additional new data and represent the largest direct quantitative comparison on the toxic potency of both regulated and emerging *** data may form the foundation of novel research to define the major forcing agents of DBP-mediated toxicity in disinfected water and may play an important role in achieving the goal of making safe drinking water better.

关键词： DBPs Mammalian cell cytotoxicity Mammalian cell genotoxicity

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Enslaved Phase-Separation Fronts and Liesegang Pattern Formation

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Communications in Computational Physics 2011年第5期9卷 1081-1093页

作者： E.M.Foard A.j.wagner Department of Physics North Dakota State UniversityFargoND 58105USA

We show that an enslaved phase-separation front moving with diffusive speeds U=C/√T can leave alternating domains of increasing size in their *** find the size and spacing of these domains is identical to Liesegang *** equal composition of the components we are able to predict the exact form of the pattern *** our knowledge this is the first fully analytical derivation of the Liesegang *** also show that there is a critical value for C below which only two domains are *** analytical predictions are verified by numerical simulations using a lattice Boltzmann method.

关键词： Liesegang phase separation front reaction diffusion pattern formation lattice Boltzmann Matalon-Packter

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Organic petrographic and mineralogical composition of the No. 6 coal seam of the Soutpansberg Coalfield, South Africa: Insights into paleovegetation and depositional environment

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International journal of Coal Science & Technology 2024年第3期11卷 190-207页

作者： Sanki Biswas Nicola j.wagner Ofentse M.Moroeng DSI-NRF CIMERA/PPM Research Group Department of GeologyUniversity of JohannesburgJohannesburgSouth Africa

This study investigates the paleodepositional conditions of the No.6 Seam of the Madzaringwe Formation in Makhado and Voorburg south area of the Soutpansberg Coalfield(Limpopo Province,South Africa)utilizing organic petrography and inorganic geochemical *** coals are predominantly high-volatile bituminous B-A rank with high ash yields(avg.36.1 wt%),characterized by high-vitrinite(~41.5 vol%),moderate-to-high inertinite(9.8 vol%–33.7 vol%)and low liptinite(~2.3 vol%).The distribution of inertinite varies among different coal horizons(from bottom-lower to middle-upper),suggesting differential oxidation conditions and/or paleofire ***-to-inertinite(V/I)ratio,tissue preservation–gelification index(TPI–GI),and groundwater–vegetation index(GWI–VI)plots,indicate that the peat-forming forest-swamp vegetation accumulated under mesotrophic-to-rheotrophic hydrological *** presence of structured macerals(i.e.,telinite,collotelinite,fusinite,and semifusinite)suggests well-preserved plant tissues,whereas framboidal pyrite and sulphur content(0.24 wt%–2.16 wt%)point to brackish-water influence at the peat *** coals contain quartz,kaolinite,siderite,muscovite,dolomite,calcite,and pyrite minerals,most of which were likely sourced from felsic igneous *** Al/(Al+Fe+Mn)and(Fe+Mn)/Ti ratios for the studied samples range between 0.24–0.97 and 0.57–70.10,*** ratios,Al–Fe–Mn plot,and presence of massive botryoidal-type pyrite imply some influence of meteoric waters or fluids from hydrothermal activity ***,the chemical index of alteration(CIA:98.25–99.67),chemical index of weathering(CIW:92.04–97.66),and A–CN–K ternary diagram suggest inorganic matter suffered strong chemical weathering,indicating warm paleoclimatic conditions during the coal formation.

关键词： Macerals Coal facies Geochemical-indices Hydrothermal Madzaringwe formation Soutpansberg Coalfield

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Derivation of Hydrodynamics for Multi-Relaxation Time Lattice Boltzmann using the Moment Approach

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Communications in Computational Physics 2013年第3期13卷 614-628页

作者： Goetz Kaehler Alexander j.wagner Department of Physics North Dakota State UniversityFargoND 58105USA

A general analysis of the hydrodynamic limit of multi-relaxation time lattice Boltzmann models is *** examine multi-relaxation time BGK collision operators that are constructed similarly to those for the MRT case,however,without explicitly moving into a moment space *** corresponding’moments’are derived as left eigenvectors of said collision operator in velocity *** we can,in a representation independent of the chosen base velocity set,generate the conservation *** find a significant degree of freedom in the choice of the collision matrix and the associated basis which leaves the collision operator *** explain why MRT implementations in the literature reproduce identical hydrodynamics despite being based on different orthogonalization *** importantly,however,we outline a minimal set of requirements on the moment base necessary to maintain the validity of the hydrodynamic *** is particularly useful in the context of position and time-dependent moments such as those used in the context of peculiar velocities and some implementations of fluctuations in a lattice-Boltzmann simulation.

关键词： Lattice Boltzmann kinetic theory Navier-Stokes hydrodynamics

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juxtacrine interaction of macrophages and bone marrow stromal cells induce interleukin-6 signals and promote cell migration

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Bone Research 2015年第2期3卷 100-111页

作者： jia Chang amy j Koh Hernan Roca Laurie K McCauley Department of Periodontics and Oral Medicine University of Michigan School of Dentistry Department of Periodontology University of Florida College of Dentistry Department of Pathology University of Michigan Medical School

The bone marrow contains a heterogeneous milieu of cells, including macrophages, which are key cellular mediators for resolving infection and inflammation. Macrophages are most well known for their ability to phagocytose foreign bodies or apoptotic cells to maintain homeostasis; however, little is known about their function in the bone microenvironment. In the current study, we investigated the in vitro interaction of murine macrophages and bone marrow stromal cells （BMSCs）, with focus on the juxtacrine induction of IL-6 signaling and the resultant effect on BMSC migration and growth. The juxtacrine interaction of primary mouse macrophages and BMSCs activated IL-6 signaling in the co-cultures, which subsequently enhanced BMSC migration and increased BMSC numbers. BMSCs and macrophages harvested from IL-6 knockout mice revealed that IL-6 signaling was essential for enhancement of BMSC migration and increased BMSC numbers via juxtacrine interactions. BMSCs were the main contributor of IL-6 signaling~ and hence activation of the IL-6/ gp130/STAT3 pathway. Meanwhile, macrophage derived IL-6 remained important for the overall production of IL-6 protein in the co-cultures. Taken together, these findings show the function of macmphages as co-inducers of migration and growth of BMSCs, which could directly influence bone formation and turnover.

关键词： BMSCs IL bone STAT cell

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CLUSTERING PATENTS USING NON-EXHAUSTIVE OVERLAPS

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journal of Systems Science and Systems Engineering 2010年第2期19卷 162-181页

作者： Charles V. TRAPPEY amy j.C. TRAPPEY Chun-Yi WU Department of Management Science National Chiao Tung University Taiwan China Department of Industrial Engineering & Management National Taipei University of Technology Taiwan China Department of lndustrial Engineering & Engineering Management National Tsing Hua University Taiwan China

Patent documents are unique external sources of information that reveal the core technology underlying new inventions. Patents also serve as a strategic data source that can be mined to discover state-of-the-art technical development and subsequently help guide R＆D investments. This research incorporates an ontology schema to extract and represent patent concepts. A clustering algorithm with non-exhaustive overlaps is proposed to overcome deficiencies with exhaustive clustering methods used in patent mining and technology discovery. The non-exhaustive clustering approach allows for the clustering of patent documents with overlapping technical findings and claims, a feature that enables the grouping of patents that define related key innovations. Legal advisors can use this approach to study potential cases of patent infringement or devise strategies to avoid litigation. The case study demonstrates the use of non-exhaustive overlaps algorithm by clustering US and japan radio frequency identification （RFID） patents and by analyzing the legal implications of automated discovery of patent infringement.

关键词： Data mining patent analysis patent infringement non-exhaustive overlap clustering ontology schema

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TIC-Tox: A preliminary discussion on identifying the forcing agents of DBP-mediated toxicity of disinfected water

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journal of Environmental Sciences 2017年第8期29卷 208-216页

作者： Michael j.Plewa Elizabeth D.wagner Susan D.Richardson Safe Global Water Institute and the Department of Crop Sciences University of Illinois at Urbana-Champaign Department of Chemistry and Biochemistry University of South Carolina

The disinfection of drinking water is a major public health achievement; however, an unintended consequence of disinfection is the generation of disinfection by-products（DBPs）. Many of the identified DBPs exhibit in vitro and in vivo toxicity, generate a diversity of adverse biological effects, and may be hazards to the public health and the *** a few DBPs are regulated by several national and international agencies and it is not clear if these regulated DBPs are the forcing agents that drive the observed toxicity and their associated health effects. In this study, we combine analytical chemical and biological data to resolve the forcing agents associated with mammalian cell cytotoxicity of drinking water samples from three cities. These data suggest that the trihalomethanes（THMs） and haloacetic acids may be a small component of the overall cytotoxicity of the organic material isolated from disinfected drinking water. Chemical classes of nitrogen-containing DBPs, such as the haloacetonitriles and haloacetamides, appear to be the major forcing agents of toxicity in these samples. These findings may have important implications for the design of epidemiological studies that primarily rely on the levels of THMs to define DBP exposure among populations. The TIC-Tox approach constitutes a beginning step in the process of identifying the forcing agents of toxicity in disinfected water.

关键词： DBPs CHO cell cytotoxicity Toxicity Additivity

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