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Optimization of a fermented pumpkin-based beverage to improve Lactobacillus mali survival and-glucosidase inhibitory activity:A response surface methodology approach

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Food Science and Human wellness 2018年第1期7卷 57-70页

作者： w.y.koh U.Uthumporn A.Rosma A.R.Irfan y.H.Park Food Technology Division School of Industrial TechnologyUniversiti Sains MalaysiaMinden 11800PenangMalaysia Bioprocess Division School of Industrial TechnologyUniversiti Sains MalaysiaMinden 11800PenangMalaysia Department of Applied Microbiology and Biotechnology Yeungnam UniversityGyeongsanSouth Korea

The aim of this research was to develop an optimum fermentation and composition model for a new fermented pumpkin-based beverage with high probiotic survival and-glucosidase inhibitory *** between fermentation temperature,inoculum and ingredient concentration with response variables(fermentation time at the fermentation endpoint pH 4.5,survival rate of Lactobacillus mali K8 in pumpkin-based beverage treated with simulated gastrointestinal tract enzyme fluids,-glucosidase inhibitory activity and sensory overall acceptability after 4 weeks of refrigerated storage)was investigated using response surface *** formulation was obtained at an approximation of 40%pumpkin puree concentration,8 Log CFU/mL inoculum and at 35℃.The product derived from this optimum formula reached the fermentation endpoint after 28.34±0.10 h and the quality change during 4 weeks storage was *** product achieved 88.56±0.67%of *** survival after treatment with simulated gastric and intestinal juices;demonstrated 95.89±0.30% α-glucosidase inhibitory activity,as well as scored 6.99±0.40 on sensory overall acceptability after 4 weeks of *** findings illustrated that the model is effective in improving probiotic survival and α-glucosidase inhibitory activity with excellent sensory acceptability,thus may offer a dietary means for the management of hyperglycaemia.

关键词： Probiotics Response surface methodology Box-Behnken Hyperglycaemia Functional food

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Effect of Eu3+,Bi3+,and Li+ doping on luminescent property of GdNbO4

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Journal of Rare Earths 2024年第1期42卷 66-75页

作者： S.w.wi y.S.Lee Department of Physics and Integrative Institute of Basic Sciences Soongsil University

we investigated the emission properties of Eu3+-doped GdNbO4-based oxide phosphors,aiming at improving the Eu3+emission by codoping of Bi3+and Li+.Eu3+singly doped,Eu3+and Bi3+doubly doped,and Eu3+,Bi3+,and Li+triply doped GdNbO4were prepared using a high-temperature solid-state reaction *** red-orange emissions from Eu3+in the singly doped samples are significantly improved by the codoping of Bi3+,mainly due to the energy transfer from Bi3+to Eu3+.The additional codoping of Li+is found to increase the Eu3+emission *** improvement might be attributed to the increase in the photoluminescent quantum yield originating from larger grain sizes and better crystallinity.A detailed analysis of the X-ray diffraction pattern and the asymmetric ratio estimated from the photoluminescence spectra show that the local lattice environment around Eu3+in GdNbO4does not change significantly with the codoping of Bi3+and Li+.Our results indicate that Li+doping is a promising way to improve the emission properties of rare-earth ion-doped GdNbO4phosphors.

关键词： Eu 3+ GdNbO 4 Codoping of Li + Photoluminescence Sensitizer Rare earths

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Cavity-agnostic acoustofluidic manipulations enabled by guided flexural waves on a membrane acoustic waveguide actuator

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Microsystems & Nanoengineering 2024年第2期10卷 153-171页

作者： Philippe Vachon Srinivas Merugu Jaibir Sharma Amit Lal Eldwin J.Ng yul koh Joshua E.-y.Lee Chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingaporeSingapore Institute of Microelectronics Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore SonicMEMS Laboratory School of Electrical and Computer EngineeringCornell UniversityIthacaNYUSA School of Electrical and Data Engineering University of Technology SydneyUltimoNSWAustralia

This article presents an in-depth exploration of the acoustofluidic capabilities of guided flexural waves(GFws)generated by a membrane acoustic waveguide actuator(MAwA).By harnessing the potential of GFws,cavity-agnostic advanced particle manipulation functions are achieved,unlocking new avenues for microfluidic systems and lab-on-a-chip *** localized acoustofluidic effects of GFws arising from the evanescent nature of the acoustic fields they induce inside a liquid medium are numerically investigated to highlight their unique and promising *** traditional acoustofluidic technologies,the GFws propagating on the MAwA’s membrane waveguide allow for cavity-agnostic particle manipulation,irrespective of the resonant properties of the fluidic ***,the acoustofluidic functions enabled by the device depend on the flexural mode populating the active region of the membrane *** demonstrations using two types of particles include in-sessile-droplet particle transport,mixing,and spatial separation based on particle diameter,along with streaming-induced counter-flow virtual channel generation in microfluidic PDMS *** experiments emphasize the versatility and potential applications of the MAwA as a microfluidic platform targeted at lab-on-a-chip development and showcase the MAwA’s compatibility with existing microfluidic systems.

关键词： waveguide fluid cavity

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A new strain-based pentagonal membrane finite element for solid mechanics problems

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Theoretical & Applied Mechanics Letters 2024年第3期14卷 211-216页

作者： wei Hao koh Logah Perumal CheeKuang Kok Faculty of Engineering and Technology Multimedia UniversityMelaka 75450Malaysia

Polygonal finite elements remain an attractive option in finite element analysis due to their flexibility in modelingarbitrary shapes compared to *** this study,a pentagonal membrane element was developed with thestrain approach for the first *** element possesses invariance,and the equilibrium constraint was appliedto the assumed strain field using corrective *** by the advancing front technique,a pentagonalmesh was generated,and the mesh quality was enhanced with Laplacian *** performance of thedeveloped pentagonal element was assessed in a few numerical tests,and the results revealed its suitability inmodeling the bending of ***,the numerical results are enhanced when pentagonal elements are usedin mesh transitions along boundaries to smoothen curved edges and capture distributed loads.

关键词： Strain-based pentagonal element Corrective coefficients EquilibriumLaplacian smoothing Pentagonal mesh Mesh transition

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Image enhancement with intensity transformation on embedding space

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CAAI Transactions on Intelligence Technology 2024年第1期9卷 101-115页

作者： Hanul Kim yeji Jeon yeong Jun koh Department of Applied Artificial Intelligence Seoul National University of Science and TechnologySeoulSouth Korea Department of Computer Science and Engineering Chungnam National UniversityDaejeonSouth Korea

In recent times,an image enhancement approach,which learns the global transformation function using deep neural networks,has gained ***,many existing methods based on this approach have a limitation:their transformation functions are too simple to imitate complex colour transformations between low-quality images and manually retouched high-quality *** order to address this limitation,a simple yet effective approach for image enhancement is *** proposed algorithm based on the channel-wise intensity transformation is ***,this transformation is applied to the learnt embedding space instead of specific colour spaces and then return enhanced features to *** this end,the authors define the continuous intensity transformation(CIT)to describe the mapping between input and output intensities on the embedding ***,the enhancement network is developed,which produces multi-scale feature maps from input images,derives the set of transformation functions,and performs the CIT to obtain enhanced *** experiments on the MIT-Adobe 5K dataset demonstrate that the authors’approach improves the performance of conventional intensity transforms on colour space ***,the authors achieved a 3.8%improvement in peak signal-to-noise ratio,a 1.8%improvement in structual similarity index measure,and a 27.5%improvement in learned perceptual image patch ***,the authors’algorithm outperforms state-of-the-art alternatives on three image enhancement datasets:MIT-Adobe 5K,Low-Light,and Google HDRþ.

关键词： computer vision deep learning image enhancement image processing

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Developmental impacts and toxicological hallmarks of silver nanoparticles across diverse biological models

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Environmental Science and Ecotechnology 2024年第3期19卷 60-79页

作者： yán wāng yapeng Han De-Xiang Xu Department of Toxicology School of Public Health&Key Laboratory of Environmental Toxicology of Anhui Higher Education InstitutesAnhui Medical UniversityHefei230032China

Silver nanoparticles(AgNPs),revered for their antimicrobial prowess,have become ubiquitous in a range of products,from biomedical equipment to food ***,amidst their rising popularity,concerns loom over their possible detrimental effects on fetal development and subsequent adult *** review delves into the developmental toxicity of AgNPs across diverse models,from aquatic species like zebrafish and catfish to mammalian rodents and in vitro embryonic stem *** focus encompasses the fate of AgNPs in different contexts,elucidating associated hazardous results such as embryotoxicity and adverse pregnancy ***,we scrutinize the enduring adverse impacts on offspring,spanning impaired neurobehavior function,reproductive disorders,cardiopulmonary lesions,and *** hallmarks of developmental harm are identified,encompassing redox imbalances,inflammatory cascades,DNA damage,and mitochondrial ***,we explore potential explanations,linking immunoregulatory dysfunction and disrupted epigenetic modifications to AgNPsinduced developmental *** substantial progress,our understanding of the developmental risks posed by AgNPs remains incomplete,underscoring the urgency of further research in this critical area.

关键词： Silver nanoparticles(AgNPs) Developmental toxicity Maternal exposure Fetal development Redox imbalance Mitochondrial dysfunction

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Quantifying droplet–solid friction using an atomic force microscope

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Droplet 2024年第2期3卷 105-112页

作者： Xue Qi koh Calvin Thenarianto Ville Jokinen Dan Daniel Institute of Materials Research and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore Department of Chemistry and Materials Science School of Chemical EngineeringAalto UniversityEspooFinland Division of Physical Sciences and Engineering King Abdullah University of Science and Technology(KAUST)ThuwalSaudi Arabia

Controlling the wetting and spreading of microdroplets is key to technologies such as microfluidics,ink-jet printing,and surface *** angle goniometry is commonly used to characterize surface wetting by droplets,but the technique is ill-suited for high contact angles close to 180°.Here,we attach a micrometric-sized droplet to an atomic force microscope cantilever to directly quantify droplet–solid friction on different surfaces(superhydrophobic and underwater superoleophobic)with sub-nanonewton force *** demonstrate the versatility of our approach by performing friction measurements using different liquids(water and oil droplets)and under different ambient environments(in air and underwater).Finally,we show that underwater superoleophobic surfaces can be qualitatively different from superhydrophobic surfaces:droplet–solid friction is highly sensitive to droplet speeds for the former but not for the latter surface.

关键词： surface. underwater latter

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Critical appraisal of novel prediction models and risk calculators for post-hepatectomy liver failure and complications: practicability and generalisability in the real-world setting

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 696-698页

作者： Darren weiquan Chua yun Zhao ye Xin koh Department of Hepatopancreatobiliary and Transplant Surgery Singapore General Hospital and National Cancer Centre SingaporeSingaporeSingapore Duke-National University of Singapore Medical School SingaporeSingapore Liver Transplant Service SingHealth Duke-National University of Singapore Transplant CentreSingaporeSingapore

Over the last few decades,the evolution of liver resection has progressed through numerous milestones in peri-operative management,operative techniques and novel technologies that have dramatically improved patient safety and outcomes(1).Consequently,such developments have enabled surgeons to embark on liver resections of lesions in technically challenging locations,whereby extended resection or bilovascular reconstruction may be required to ensure oncologic *** the context of extended resections or resection of lesions from heavily diseased livers,concerns remain regarding the adequacy of the remnant future liver remnant(FLR)and liver function,placing patients at risk of the clinical phenomenon known as post-hepatectomy liver failure(PHLF).Although relatively uncommon,PHLF has a reported incidence of up to 32%in the literature and remains an important cause of post-hepatectomy morbidity and mortality(2).Presently,several definitions have been proposed to describe PHLF,the most recent of which was proposed by the International Study Group of Liver Surgery(ISGLS).In this definition,PHLF was defined as an increased international normalized ratio(INR)or hyperbilirubinemia on or after post-operative day 5,with further stratification of severity grades(A,B or C)based on the extent of clinical management(3).while definitions in PHLF assist in providing a common diagnostic framework among physicians,establishing predictors in PHLF is conceivably more helpful as it allows surgeons to have important decision-making details prior to planned liver resection.

关键词： Hepatectomy post-hepatectomy liver failure(PHLF) predictive model risk calculation

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Microstructural evolution in lithium plating process and its effect on the calendar storage life

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Nano Research 2024年第10期17卷 8834-8841页

作者： Ki Hwan koh Dong Ju Lee Anthony Mu Kangwoon Kim Taehee Kim Zheng Chen Department of Chemical and Nano Engineering University of California San DiegoLa JollaCA 92093USA Program of Materials Science and Engineering University of California San DiegoLa JollaCA 92093USA Sustainable Power and Energy Center University of California San DiegoLa JollaCA 92093USA

The growing demand for electric vehicles highlights the need for energy storage solutions with higher densities,spotlighting Li metal anodes as potential successors to traditional Li-ion batteries(LIBs).Achieving longer calendar aging life for Li metal anodes is crucial for their practical use,given their propensity for corrosion due to a low redox potential,which leads to compromised cycling stability and significant capacity loss during *** research investigated that this susceptibility is mainly dependent on the surface area of Li metal anode and the properties of the solid electrolyte interphase(SEI),particularly its stability and growth *** research adds to this understanding by demonstrating that the amount of Li plating is a key factor in its corrosion during open-circuit storage,as assessed across various *** discovered that increasing the Li plating amount effectively reduces Coulombic efficiency(C.E.)loss during aging,due to a lower surface area-to-Li *** implies that the choice of electrolyte for optimal storage life should consider the amount of Li plating,with higher capacities promoting better storage characteristics.

关键词： lithium metal batteries anode-free batteries calendar life of batteries lithium anode corrosion

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weakly Supervised Object Localization with Background Suppression Erasing for Art Authentication and Copyright Protection

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Machine Intelligence Research 2024年第1期21卷 89-103页

作者： Chaojie wu Mingyang Li ying Gao Xinyan Xie wing w.y.Ng Ahmad Musyafa School of Computer Science and Engineering South China University of TechnologyGuangzhou 511442China Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application Guangdong Provincial People's HospitalGuangzhou 510180China

The problem of art forgery and infringement is becoming increasingly prominent,since diverse self-media contents with all kinds of art pieces are released on the Internet every *** art paintings,object detection and localization provide an efficient and ef-fective means of art authentication and copyright ***,the acquisition of a precise detector requires large amounts of ex-pensive pixel-level *** alleviate this,we propose a novel weakly supervised object localization(wSOL)with background su-perposition erasing(BSE),which recognizes objects with inexpensive image-level ***,integrated adversarial erasing(IAE)for vanilla convolutional neural network(CNN)dropouts the most discriminative region by leveraging high-level semantic ***,a background suppression module(BSM)limits the activation area of the IAE to the object region through a self-guidance ***,in the inference phase,we utilize the refined importance map(RIM)of middle features to obtain class-agnostic loc-alization *** experiments are conducted on paintings,CUB-200-2011 and ILSVRC to validate the effectiveness of our BSE.

关键词： weakly supervised object localization erasing method deep learning computer vision art authentication and copyright protection

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