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PIF4 interacts with ABI4 to serve as a transcriptional activator complex to promote seed dormancy by enhancing ABA biosynthesis and signaling

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Journal of Integrative Plant Biology 2024年第5期66卷 909-927页

作者： Xiaofeng Luo Yujia Dai Baoshan Xian Jiahui Xu Ranran Zhang muhammad Saad Rehmani Chuan Zheng Xiaoting Zhao Kaitao mao Xiaotong Ren Shaowei wei Lei wang Juan He weiming Tan Junbo Du weiguo Liu Shu Yuan Kai Shu Shaanxi Key Laboratory of Qinling Ecological Intelligent monitoring and Protection School of Ecology and EnvironmentNorthwestern Polytechnical UniversityXi'an 710129China Research&Development Institute of Northwestern Polytechnical University in ShenzhenShenzhen 518057China College of Agronomy and Biotechnology China Agricultural UniversityBeijing 100193China Institute of Ecological Agriculture Sichuan Agricultural UniversityChengdu 611130China College of Resources Sichuan Agricultural UniversityChengdu 611130China

Transcriptional regulation plays a key role in the control of seed dormancy,and many transcription factors(TFs)have been ***,the mechanisms underlying the interactions between different TFs within a transcriptional complex regulating seed dormancy remain largely ***,we showed that TF PHYTOCHROmE-INTERACTING FACTOR4(PIF4)physically interacted with the abscisic acid(ABA)signaling responsive TF ABSCISIC ACID INSENSITIVE4(ABI4)to act as a transcriptional complex to promote ABA biosynthesis and signaling,finally deepening primary seed *** pif4 and abi4 single mutants exhibited a decreased primary seed dormancy phenotype,with a synergistic effect in the pif4/abi4 double ***4 binds to ABI4 to form a heterodimer,and ABI4 stabilizes PIF4 at the protein level,whereas PIF4 does not affect the protein stabilization of ***,both TFs independently and synergistically promoted the expression of ABI4 and NCED6,a key gene for ABA *** genetic evidence is also consistent with the phenotypic,physiological and biochemical analysis ***,this study revealed a transcriptional regulatory cascade in which the PIF4–ABI4 transcriptional activator complex synergistically enhanced seed dormancy by facilitating ABA biosynthesis and signaling.

关键词： ABA ABI4 PIF4 seed dormancy and germination transcriptional complex

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论邓小平现代化话语体系的内在逻辑

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中州学刊 2024年第8期 14-21页

作者：刘吕红毛磊郑州大学马克思主义学院河南郑州450001

邓小平现代化话语体系作为用“中国理论”阐释“中国实践”的原创理论成果,内嵌于中国现代化话语体系与叙事体系,成为建构体现中国特色性、中国主体性的现代化自主知识体系的重要标识。探讨与揭示邓小平现代化话语体系的内在逻辑需聚焦... 详细信息

邓小平现代化话语体系作为用“中国理论”阐释“中国实践”的原创理论成果,内嵌于中国现代化话语体系与叙事体系,成为建构体现中国特色性、中国主体性的现代化自主知识体系的重要标识。探讨与揭示邓小平现代化话语体系的内在逻辑需聚焦四大方面:从内容逻辑看,沿循“立足点—突破点—着眼点—关键点”基本思路,呈现在推进中国特色社会主义实践场域、创新社会主义经济范式、立足人民中心立场、发展生产力根本遵循中展开“三步走”“社会主义市场经济”“小康之家”“共同富裕”“一个中心,两个基本点”的现代化叙事。从价值逻辑看,依循“人民—国家—民族—人类”基本立场,围绕“人民美好生活”“社会主义现代化国家”“实现民族复兴”“人类文明发展”展开现代化叙事。从方法逻辑看,按照“历史—比较—哲学—整合”方法思路,基于“历史—任务”主题遵循、“共性—个性”范式特征、“唯物辩证法”运思逻辑、“官方—民间”上下结合展开现代化叙事。从实践逻辑看,依据“本体—主体—载体”的建构思路,坚持马克思主义现代化思想的根本指导,以夯实中国现代化的话语导向;推进党的领导和人民参与的协同发力,以深化中国现代化的话语阐释;创新现代化话语叙事理路,以拓展中国现代化的话语价值。

关键词：现代化话语体系现代化叙事中国自主知识体系

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Association between coronary artery stenosis and myocardial injury in patients with acute pulmonary embolism: A case-control study

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中华医学杂志(英文版) 2024年第16期137卷 1965-1972页

作者： Yang Yinjian Liu Chao ma Jieling Zhu Xijie ma Jingsi Lu Dan Yan Xinxin Gao Xuan wang Jia wang Liting Zhang Sijin Li Xianmei wu Bingxiang Sun Kai mao Yimin Xu Xiqi Lian Tianyu Cheng Chunyan Jing Zhicheng medical Science Research Center Institute of Clinical Medicine State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Cardiology Guangdong Cardiovascular Institute Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou Guangdong China Department of Cardiology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of School of Pharmacy Henan University Kaifeng Henan China Cardiac Department Aerospace Center Hospital Peking University Aerospace School of Clinical Medicine Beijing China Department of Cardiology State Key Laboratory of Cardiovascular Disease National Center for Cardiovascular Diseases Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Cardiovascular medicine The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang China Department of medical Laboratory Weifang Medical University Weifang Shandong China Department of Respiratory medicine The First Affiliated Hospital of Henan University of Science and Technology Luoyang Henan China Center of Basic medical Research Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou Guangdong China

Background: The potential impact of pre-existing coronary artery stenosis (CAS) on acute pulmonary embolism (PE) episodes remains underexplored. This study aimed to investigate the association between pre-existing CAS and the elevation of high-sensitivity cardiac troponin I (hs-cTnI) levels in patients with ***: In this multicenter, prospective case-control study, 88 cases and 163 controls matched for age, sex, and study center were enrolled. Cases were patients with PE with elevated hs-cTnI. Controls were patients with PE with normal hs-cTnI. Coronary artery assessment utilized coronary computed tomographic angiography or invasive coronary angiography. CAS was defined as ≥50% stenosis of the lumen diameter in any coronary vessel >2.0 mm in diameter. Conditional logistic regression was used to evaluate the association between CAS and hs-cTnI ***: The percentage of CAS was higher in the case group compared to the control group (44.3% [39/88]vs. 30.1% [49/163];P = 0.024). In multivariable conditional logistic regression model 1, CAS (adjusted odds ratio [OR], 2.680; 95% confidence interval [CI], 1.243–5.779), heart rate >75 beats/min (OR, 2.306; 95% CI, 1.056–5.036) and N-terminal pro-B type natriuretic peptide (NT-proBNP) >420 pg/mL (OR, 12.169; 95% CI, 4.792–30.900) were independently associated with elevated hs-cTnI. In model 2, right CAS (OR, 3.615; 95% CI, 1.467–8.909) and NT-proBNP >420 pg/mL (OR, 13.890; 95% CI, 5.288–36.484) were independently associated with elevated ***: CAS was independently associated with myocardial injury in patients with PE. Vigilance towards CAS is warranted in patients with PE with elevated cardiac troponin levels.

关键词： Pulmonary embolism Coronary artery stenosis myocardial injury Cardiac troponin I myocardial ischemia Right ventricular dysfunction Case-control study Coronary computed tomography angiography

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一种面向无源RFID系统的温度传感器设计

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传感技术学报 2024年第5期37卷 756-762页

作者：蔡明格叶茂天津市成像与感知微电子技术重点实验室天津300072 天津大学微电子学院天津300072

针对无源RFID系统的应用需求,设计了一款高精度片上集成温度传感器电路芯片。提出了一种由温度感应电路、PTAT偏置电流产生电路和Sigma-Delta ADC共同组成的温度传感器电路架构。采用基于双极晶体管的温度感应电路产生与温度成正比的电... 详细信息

针对无源RFID系统的应用需求,设计了一款高精度片上集成温度传感器电路芯片。提出了一种由温度感应电路、PTAT偏置电流产生电路和Sigma-Delta ADC共同组成的温度传感器电路架构。采用基于双极晶体管的温度感应电路产生与温度成正比的电压,并采用Sigma-Delta ADC对其进行量化,得到与温度对应的数字量。在偏置电路中采用了斩波稳定技术,减小了由晶体管的失配及运放的失调引起的误差。在电流镜中采用了动态匹配技术,消除了由于电流镜失配引起的误差。采用GSmC 0.13μm CmOS工艺完成了对温度传感器的电路设计及版图绘制,版图面积为420μm×350μm。后仿真结果表示,在-40℃~+85℃的温度范围内,温度传感器的精度为-1.6℃/0.8℃,分辨率为0.75℃。在电源电压为1.5 V下,温度传感器消耗的电流为0.253 mA。

关键词：温度传感器斩波稳定技术动态元件匹配技术 Sigma-Delta ADC 无源RFID

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Tet methylcytosine dioxygenase 2(TET2)deficiency elicits EGFR-TKI(tyrosine kinase inhibitors)resistance in non-small cell lung cancer

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1706-1720页

作者： Jian Zhang Kejia Zhao wenjing Zhou Ran Kang Shiyou wei Yueli Shu Cheng Yu Yin Ku Yonghong mao Hao Luo Juqin Yang Jiandong mei Qiang Pu Senyi Deng Zhengyu Zha Gang Yuan Shensi Shen Yaohui Chen Lunxu Liu Department of Thoracic Surgery and Institute of Thoracic Oncology West China Hospital of Sichuan UniversityChengdu 610097China western China Collaborative Innovation Center for Early Diagnosis and multidisciplinary Therapy of Lung Cancer Sichuan UniversityChengdu 610097China Biobank of west China Hospital Sichuan UniversityChengdu 610041China

Despite epidermal growth factor receptor(EGFR)tyrosine kinase inhibitors(TKl)have shown remarkable efficacy in patients with EGFR-mutant non-small cell lung cancer(NSCLC),acquired resistance inevitably develops,limiting clinical *** found that TET2 was poly-ubiquitinated by E3 ligase CUL7^(FBXw11) and degraded in EGFR-TKI resistant NSCLC *** perturbationof TET2 rendered parental cells more tolerant to TKI ***2 was stabilized by mEK1 phosphorylation at Ser 1107,while mEK1 inactivation promoted its proteasome degradation by enhancing the recruitment of CUL7^(FBXw11),Loss of TET2 resulted in the upregulation of TNF/NF-kB signaling that confers the EGFR-TKI *** or pharmacological inhibition of NF-kB attenuate the TKI resistance both in vitro and in *** findings exemplified how a cell growth controlling kinase mEK1 leveraged the epigenetic homeostasis by regulating TET2,and demonstrated an alternative path of non-mutational acquired EGFR-TKI resistance modulated by TET2 ***,combined strategy exploiting EGFR-TKI and inhibitors of TET2/NF-κB axis holds therapeutic potential for treating NSCLC patients who suffered from this resistance.

关键词： TET2 TKI resistance

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Novel photoresponsive dinuclear nickel catalysts for ethylene(co)polymerization

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Science China Chemistry 2024年

作者： Chenlong Nan Tong Pang Jiaxing Zhao Lijia Fan Chen Zou Xin-Qi Hao mao-Ping Song Jun-Fang Gong Changle Chen Hui Jiang College of Chemistry Pingyuan Laboratory Zhengzhou University CAS Key Laboratory of Soft matter Chemistry Department of Polymer Science and Engineering University of Science and Technology of China

Compared with the conventional strategies of electronic and/or steric perturbation, catalytic olefin polymerization modulated by light irradiation or metal-metal cooperativity effect is a fascinating challenge that attracts considerable attention in the academic community. In this context, we design a strategy that could employ both effects to influence the polymerization process. Some dinuclear salicylaldimine and α-imino-ketone nickel complexes bearing a stiff-stilbene bridge were prepared, which could transfer between(E)-isomers and(Z)-isomers under ultraviolet irradiation. This isomerization can tune the electronic, steric and metal-metal cooperativity effects of the nickel catalysts. In this way, the catalytic activity, as well as polymer microstructures including molecular weight and branching density can be modulated in ethylene polymerization and copolymerization *** strategy is generally applicable to other olefin polymerization catalytic systems and other types of transition metal mediated catalysis.

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Optimized new Shengmai powder(优化新生脉散方) inhibits myocardial fibrosis in heart failure by regulating the rat sarcoma/rapidly accelerated fibrosarcoma/mitogen-activated protein kinase kinase/extracellular regulated protein kinases signaling pathway

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Journal of Traditional Chinese medicine 2024年第3期44卷 448-457页

作者： ZHANG Zeyu JIA Zhuangzhuang SONG Yuwei ZHANG Xuan wANG Ci wANG Shuai ZHANG Peipei REN Qiuan wANG Xianliang mao Jingyuan Department of Cardiovascular the First Teaching Hospital of Tianjin University of Traditional Chinese MedicineNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion

OBJECTIVE: Exploring the effect of Optimized New Shengmai powder(优化新生脉散方, ONSmP) on myocardial fibrosis in heart failure(HF) based on rat sarcoma(RAS)/rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase kinase(mEK)/extracellular regulated protein kinases(ERK) signaling pathway. mETHODS: Randomized 70 Sprague-Dawley rats into sham(n = 10) and operation(n = 60) groups, then established the HF rat by ligating the left anterior descending branch of the coronary artery. we randomly divided the operation group rats into the model, ONSmP [including low(L), medium(m), and high(H) dose], and enalapril groups. After the 4-week drug intervention, echocardiography examines the cardiac function and calculates the ratios of the whole/left heart to the rat's body weight. Finally, we observed the degree of myocardial fibrosis by pathological sections, determined myocardium collagen(COL) Ⅰ and COL Ⅲ content by enzyme-linked immunosorbent assay, detected the m RNA levels of COL Ⅰ, COL Ⅲ, α-smooth muscle actin(α-SmA), and c-Fos proto-oncogene(c-Fos) by universal real-time, and detected the protein expression of p-RAS, p-RAF, p-mEK1/2, p-ERK1/2, p-ETS-like-1 transcription factor(p-ELK1), p-c-Fos, α-SmA, COL Ⅰ, and COL Ⅲ by western blot. RESULTS: ONSmP can effectively improve HF rat's cardiac function, decrease cardiac organ coefficient, COL volume fraction, and COL Ⅰ/Ⅲ content, down-regulate the m RNA of COL Ⅰ/Ⅲ, α-SmA and c-Fos, and the protein of p-RAS, p-RAF, p-mEK1/2, p-ERK1/2, p-ELK1, c-Fos, COL Ⅰ/Ⅲ, and α-SmA. CONCLUSIONS: ONSmP can effectively reduce myocardial fibrosis in HF rats, and the mechanism may be related to the inhibition of the RAS/RAF/mEK/ERK signaling pathway.

关键词： extracellular regulated protein kinases heart failure mitogen-activated protein kinases myocardial fibrosis optimized new Shengmai powder rapidly accelerated fibrosarcoma sarcoma

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光轴可移动圆形液晶透镜

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光学学报 2024年第11期44卷 205-214页

作者：冯文斌刘志强叶茂电子科技大学光电科学与工程学院四川成都611731

提出了一种光轴可移动的圆形液晶透镜。该透镜包含两个分别处于上下基板的电极:其中一个是离散同心圆电极,用于产生抛物面电压分布;另一个是梳状电极,用于产生线性的电压分布。每个电极施加两个驱动电压,通过控制4个驱动电压实现抛物面... 详细信息

提出了一种光轴可移动的圆形液晶透镜。该透镜包含两个分别处于上下基板的电极:其中一个是离散同心圆电极,用于产生抛物面电压分布;另一个是梳状电极,用于产生线性的电压分布。每个电极施加两个驱动电压,通过控制4个驱动电压实现抛物面电压分布中心位置的移动,从而实现透镜光轴的移动。文中详细地介绍了该透镜的工作原理以及驱动方式,给出了光轴位置坐标与4个驱动电压之间的解析表达式。实验上,通过光刻法加工了对应的电极结构,并制作了孔径为2 mm、液晶层厚度为50μm的液晶透镜。实验结果表明,当透镜的光轴可移动范围在-0.5~0.5 mm时,光焦度可调节的范围是-4.1~4.1 D。该透镜能在光轴移动过程中保持良好的透镜状态,而且光轴移动的误差小于0.01 mm。

关键词：光学器件液晶器件透镜光轴

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小胶质细胞在病毒性神经炎症中的作用

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武汉大学学报（医学版） 2024年第6期45卷 746-751,756页

作者：杨可璠毛善平武汉大学人民医院神经内科湖北武汉430060

小胶质细胞是中枢神经系统中固有的免疫细胞,它的存在为大脑提供了一个动态且高效的监控系统。越来越多的证据表明炎性小胶质细胞可能会引起组织损伤,破坏大脑正常的生理功能,诱使或加速大脑老化,导致神经退行性疾病的发生。很多病毒会... 详细信息

小胶质细胞是中枢神经系统中固有的免疫细胞,它的存在为大脑提供了一个动态且高效的监控系统。越来越多的证据表明炎性小胶质细胞可能会引起组织损伤,破坏大脑正常的生理功能,诱使或加速大脑老化,导致神经退行性疾病的发生。很多病毒会感染大脑并影响小胶质细胞的功能,特别是慢性、持续的病毒感染会导致低水平的神经炎症,这可能会引起大脑老化,发生神经退行性疾病。这篇综述解释了各类噬神经病毒在小胶质细胞所介导的免疫应答反应中出现的神经认知功能缺陷和加速大脑老化、引起神经退行性疾病中的潜在作用。

关键词：小胶质细胞 m1/m2亚型神经炎症神经退行性疾病嗜神经病毒

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Endothelial phosphodiesterase 4B inactivation ameliorates endothelial-to-mesenchymal transition and pulmonary hypertension

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1726-1741页

作者： Yanjiang Xing Yangfeng Hou Tianfei Fan Ran Gao Xiaohang Feng Bolun Li Junling Pang wenjun Guo Ting Shu Jinqiu Li Jie Yang Qilong mao Ya Luo Xianmei Qi Peiran Yang Chaoyang Liang Hongmei Zhao wenhui Chen Jing wang Chen wang State Key Laboratory of Respiratory Health and multimorbidity Institute of Basic Medical SciencesChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100005China Department of Lung Transplantation National Center for Respiratory MedicineNational Clinical Research Center for Respiratory DiseasesChina–Japan Friendship HospitalInstitute of Respiratory MedicineChinese Academy of Medical SciencesBeijing 100029China Haihe Laboratory of Cell Ecosystem Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300051China The State Key Laboratory of Complex Severeand Rare DiseasesInstitute of Basic Medical SciencesChinese Academy of Medical SciencesDepartment of PathophysiologyPeking Union Medical CollegeBeijing 100005China Department of Pharmacy West China HospitalSichuan UniversityChengdu 610044China

Pulmonary hypertension (PH) is a fatal disorder characterized by pulmonary vascular remodeling and obstruction. The phosphodiesterase 4 (PDE4) family hydrolyzes cyclic AmP (cAmP) and is comprised of four subtypes (PDE4A–D). Previous studies have shown the beneficial effects of pan-PDE4 inhibitors in rodent PH;however, this class of drugs is associated with side effects owing to the broad inhibition of all four PDE4 isozymes. Here, we demonstrate that PDE4B is the predominant PDE isozyme in lungs and that it was upregulated in rodent and human PH lung tissues. we also confirmed that PDE4B is mainly expressed in the lung endothelial cells (ECs). Evaluation of PH in Pde4b wild type and knockout mice confirmed that Pde4b is important for the vascular remodeling associated with PH. In vivo EC lineage tracing demonstrated that Pde4b induces PH development by driving endothelial-to-mesenchymal transition (EndmT), and mechanistic studies showed that Pde4b regulates EndmT by antagonizing the cAmP-dependent PKA–CREB–BmPRII axis. Finally, treating PH rats with a PDE4B-specific inhibitor validated that PDE4B inhibition has a significant pharmacological effect in the alleviation of PH. Collectively, our findings indicate a critical role for PDE4B in EndmT and PH, prompting further studies of PDE4B-specific inhibitors as a therapeutic strategy for PH.

关键词： Phosphodiesterase 4B Pulmonary hypertension Endothelial-to-mesenchymal transition

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