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Effects of Terminalia catappa seeds on sexual behaviour and fertility of male rats

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Asian Journal of Andrology 2000年第3期2卷 213-219页

作者： w.d.ratnasooriya M.G.dharmasiri department of Zoology University of Colombo Colombo 3 Sri LankaDepartment of Zoology University of Colombo Colombo 3 Sri Lanka

Aim: To evaluate the aphrodisiac potential of Terminalia catappa Linn. seeds using a suspension of its kernel (SS)in 1% methyl cellulose in rats. Methods: Male rots were orally treated with 1500 mg/kg or 3000 mg/kg SS or ve-hicle, and their sexual behaviour was monitored 3 h later using a receptive female. Another group of rats was orallytreated with either 3000 mg/kg SS or vehicle for 7 consecutive days. Their sexual behaviour and fertility were evaluatedon days 1, 4 and 7 of treatment and day 7 post-treatment by pairing overnight with a pro-oestrous female. Results:The 1500 mg/kg dose, had a marked aphrodisiac action (prolongation of ejaculation latency) but no effect on libido(% mounting, % intromission and % ejaculation), sexual vigour (mounting-and-intromission frequency), or sexualperformance (intercopulatory interval). In contrast, the higher dose (3000 mg/kg) reversibly inhibited all the para?e-ten of sexual behaviour other than mounting-and-intromission frequency and copulatory efficiency. The effects of highdose SS were not due to general toxicity, liver toxicity, haemotoxicity, stress, muscle deficiency, muscle incoordina-fion, analgesia, hypoglycaemia or reduction in blood testosterone level. They were due to marked sedation. Conclu-sion: The kernel of T. catappa seeds has aphrodisiac activity and may be useful in the treatment of certain forms ofsexual inadequacies, such as premature ejaculation.

关键词： Terminalia catappa seeds aphrodisiac male sexual behaviour libido premature ejaculation fertility sedation

Long-term administration of large doses of paracetamol impairs the reproductive competence of male rats

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Asian Journal of Andrology 2000年第4期2卷 247-255页

作者： w.d.ratnasooriya J.R.A.C.Jayakody department of Zoology University of Colombo Colombo 3 Sri Lanka.Department of Zoology University of Colombo Colombo 3 Sri Lanka.

Aim: To evaluate the antireproductive effect of paracetamol in male rats. Methods: Male rats were orally adminis-tered daily with 500 mg/kg or 1000 mg/kg of paracetamol for 30 consecutive days. Their sexual behaviour and fertilitywere evaluated using receptive females. Results: At 2 h after treratment, sexual behaviour was not inhibited but onday 30 both doses of paracetamol caused marked impairment of libido (assessed by % mounting, % intromission and% ejaculation), sexual vigour (number of mounts and intromissions and copulatory efficiency) or sexual performance(intercopulatory interval). In mating experiments, the fertility (in terms of quantal pregnancy, fertility index, implan-tation index and number of implants) was significantly reduced. All these effects were reversible. The antireproductiveeffect was not due to a general toxicity but due to an increase in pre-implantation losses resulting from oligozoospermia,impairments of normal and hyper-activated sperm motility, and reduction in the fertilizing potential of ***: Long-term use of high doses of paracetamol may be detrimental to male reproductive competence.( Asian J Andro12000 dec; 2: 247-255 )

关键词： paracetamol fertility sexual behaviour oligozoospermia pre-implantation loss capacitation sperm motility

Human sperm motility stimulating activity of a sulfono glycolipid isolated from Sri Lankan marine red alga Gelidiella acerosa

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Asian Journal of Andrology 2001年第1期3卷 27-31页

作者： G.A.S.Premakumara w.d.ratnasooriya L.M.V.Tillekeratne A.S.Amarasekare Atta-Ur-Rahman Natural Products development Group Industrial Technology Institute(CISIR) Colombo 7 Sri LankaDepartment of Zoology Uuiversity of Colombo Colombo 03 Sri LankaChemistry University of Colombo Colombo 03 Sri LankaChemistry University of Colombo Colombo 03 Sri LankaHEJ Research Institute of Chemistry University of Karachi Karachi 32 Pakistan

Aim: To evaluate the sperm motility stimulating activity of a sulfono glycolipid (S-ACT-1) isolated from Gelidiellaacerosa, a Sfi Lankan marine red algae. Methods: S-ACT-I, a white amorphous powder was separated from morepolar fractions of the hexane soluble of 1:1 CH_2Cl_2/MeOH extract and subjected to ~1H, ^(13)C NMR and IR Spectroscopyafter reverse phase HPLC for identification. Effects of S-ACT-1 on human sperm motility was assessed in vitro at 10,100 and 1000μg/mL concentrations at 37℃ for 0, 5, 15, 30 and 60 min. Results: S-ACT-1 was identified as aglycolipid sulfate. The lower dose increased the sperm motility slightly, whilst the medium dose significantly increasedthe motility (P d the stimulant effect was sustainedthroughout the experimental period. Furthermore, the medium dose rendered 80% of the immotile viable sperm *** contrast, the highest dose impaired the sperm motility. The sperm stimulating activity of S-ACT-1 was dose-depen-dent and had a bell-shaped dose response curve for all the 5 incubation periods. Conclusion: S-ACT-1 of Gelidiellaacerosa is a Sulfono glycolipid. S-ACT-1 has a potent sperm motility stimulating activity in vitro and has the potentialto be developed into a sperm stimulant. (Asian J Androl 2001 Mar; 3: 27-31)

关键词： sperm motility stimulants reproduction sulfono glycolipids red alga Gelidiella acerosa

Effect of withania somnifera root extract on the sexual behaviour of male rats

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Asian Journal of Andrology 2002年第4期4卷 295-297页

作者： I. Ilayperuma w.d. ratnasooriya T.R. weerasooriya department of Anatomy Faculty of Medicine University of Ruhuna Sri LankaDepartment of Zoology Faculty of Science University of Colombo Sri LankaDepartment of Anatomy Faculty of Medicine University of Ruhuna Sri Lanka

Aim: To determine the effect of a methanolic extract of withania somnifera (L.) dunal roots on sexual competence of male rats. Methods: Male rats were orally administered 3000 mg'kg^***^1 of root extract for 7 days. Their sexual behaviour was evaluated 7 days prior to treatment, day 3 and 7 of treatment, and day 7, 14 and 30 posttreatment by pairing each male with a receptive female. Results: The root extract induced a marked impairment in libido, sexual performance, sexual vigour, and penile erectile dysfunction. These effects were partly reversible on cessation of treatment. These antimasculine effects are not due to changes in testosterone levels or toxicity but may be attributed to hyperprolactinemic, GABAergic, serotonergic or sedative activities of the extract. Conclusion: Use of w. somnifera roots may be detrimental to male sexual competence. (Asian J Androl 2002 dec;4: 295-298)

关键词： withania somnifera male sexual competence aphrodiasiac libido antimasculine male sexual behaviour

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse w.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： diek w.wheeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify when to stop subdividing clusters based on the fundamental principle that cells must differ more between than within *** we present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering with statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as two-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia MouseLight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification Levene's one-tailed statistical test unsupervised hierarchical clustering

In vitro anti-hyaluronidase activity of Sri Lankan low grown orthodox orange pekoe grade black tea(Camellia sinensis L.)

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Asian Pacific Journal of Tropical Biomedicine 2014年第12期4卷 959-963页

作者： wanigasekera daya ratnasooriya walimuni Prabhashini Kaushalya Mendis Abeysekera Chatura Tissa dayendra ratnasooriya Faculty of Allied Health Sciences General Sir John Kothalawala Defence University Herbal Technology Section Industrial Technology Institute363Bauddhaloka MawathaColombo 07Sri Lanka Faculty of Medicine University of Colombo

Objective:To access the anti-hyaluronidase activity of Sri Lankan low grown orthodox orange pekoe（OP） grade black tea with a view to develop an anti-aging skin ***:Five concentrations（0.125,0.250,0.500,1.000 and 2.000 mg/mL） of black tea brew（BTB） were made using a freeze dried sample of Sri Lankan low grown orthodox OP grade black tea which was prepared according to international organization for standardization *** gallate（EGCG） was used as the reference agent（concentrations tested:0.012,0.025,0.050,0.100 and 0.200 mg/mL）.Anti-hyaluronidase activity of BTB and EGCG in vitro were ascertained spectrometrically using hyaluronic acid（from rooster comb）and bovine testicular ***:The results revealed that BTB had moderate[IC50=（1.09±0.12） mg/mL]and dose dependent（r2=0.94） anti-hyaluronidase *** also exhibited dose dependent（r2=0.93,Pdase activity which was superior[IC50=（0.09±0.00） mg/mL]to ***:Sri Lankan low grown orthodox OP gradc black tca has promising antihyaluronidase activity in vitro and has the potential to be used as an anti-aging *** addition,it may prove useful as a beverage in the management of allergy,some joint diseases and cnvenomation.

关键词： Camellia sinensis Orange pekoe Black tea Sri Lankan tea Anti-aging Anti-hyaluronidase Hyaluronic acid

Genistein:a possible solution for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynowska Bartosz Karaszewski Grzegorz węgrzyn department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and owing to their prevalence,severity.

关键词： organs Alzheimer death

Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis