Effect of Withania somnifera root extract on the sexual behaviour of male rats

作     者：I. Ilayperuma W.D. Ratnasooriya T.R. Weerasooriya I. ILAYPERUMA~;W.D. RATNASOORIYA~;T.R. WEERASOORIYA ~DEPARTMENT OF ANATOMY;FACULTY OF MEDICINE;UNIVERSITY OF RUHUNA;SRI LANKA ~DEPARTMENT OF ZOOLOGY;FACULTY OF SCIENCE;UNIVERSITY OF COLOMBO;SRI LANKA

作者机构：Department of Anatomy Faculty of Medicine University of Ruhuna Sri LankaDepartment of Zoology Faculty of Science University of Colombo Sri LankaDepartment of Anatomy Faculty of Medicine University of Ruhuna Sri Lanka 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2002年第4卷第4期

页      面：295-297页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Withania somnifera male sexual competence aphrodiasiac libido antimasculine male sexual behaviour 

摘      要：Aim: To determine the effect of a methanolic extract of Withania somnifera (L.) Dunal roots on sexual competence of male rats. Methods: Male rats were orally administered 3000 mg kg^***^1 of root extract for 7 days. Their sexual behaviour was evaluated 7 days prior to treatment, day 3 and 7 of treatment, and day 7, 14 and 30 posttreatment by pairing each male with a receptive female. Results: The root extract induced a marked impairment in libido, sexual performance, sexual vigour, and penile erectile dysfunction. These effects were partly reversible on cessation of treatment. These antimasculine effects are not due to changes in testosterone levels or toxicity but may be attributed to hyperprolactinemic, GABAergic, serotonergic or sedative activities of the extract. Conclusion: Use of W. somnifera roots may be detrimental to male sexual competence. (Asian J Androl 2002 Dec;4: 295-298)