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Genistein:a possible solution for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynowska Bartosz Karaszewski Grzegorz węgrzyn Department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and owing to their prevalence,severity.

关键词： organs Alzheimer death

Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack w.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关键词： programming passing proof

SIGNATURES OF UNIVERSAL CHARACTERISTICS OF FRACTAL FLUCTUATIONS IN GLOBAL MEAN MONTHLY TEMPERATURE ANOMALIES

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Journal of Systems Science & Complexity 2011年第1期24卷 14-38页

作者： A. M. selvam Indian Institute of Tropical Meteorology Pune 411008 India

This paper proposes a general systems theory for fractals visualising the emergence of successively larger scale fluctuations resulting from the space-time integration of enclosed smaller scale fluctuations. Global gridded time series data sets of monthly mean temperatures for the period 1880- 2007/2008 are analysed to show that data sets and corresponding power spectra exhibit distributions close to the model predicted inverse power law distribution. The model predicted and observed universal spectrum for interannual variability rules out linear secular trends in global monthly mean temperatures. Global warming results in intensification of fluctuations of all scales and manifested immediately in high frequency fluctuations.

关键词： Fractals and statistical normal distribution golden mean and fractal fluctuations long- range correlations and fat tail distributions power law distributions.

Bile salt induced solubilization of methylene blue: Study on methylene blue fluorescence properties and molecular mechanics calculation

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Journal of Pharmaceutical Analysis 2017年第1期7卷 71-75页

作者： Susithra selvam Ivy Sarkar Department of Chemistry Vel Tech University Avadi Chennai 600062 Tamilnadu India Department of Chemistry Indian Institute of Technology Madras Chennai 600036 Tamilnadu India

Methylene blue(MB) is a hydrophobic drug molecule, having importance both as a staining reagent and pharmaceutical agent. MB is strongly fluorescent, with an emission peak at 686 nm(λ_(ex)665 nm). In the study,the possibility of MB as an extrinsic fluorophore to study the micellization behavior of bile salts(BSs) was carried out. Since BSs are drug delivery systems, the solubilization of hydrophobic MB drug molecule by BSs was achieved and the nature of association of MB with BS media, namely sodium cholate(Na C) and sodium deoxycholate(Na DC) was evaluated. Change in the photophysical properties of MB is monitored through fluorescence intensity and fluorescence anisotropy at emission peak, 686 nm of MB. Molecular mechanics calculations were carried out to evaluate the MB–BS association. The estimated heat of formation, ΔH_f values are –625.19 kcal/mol for MB–Na C and –757.48 kcal/mol for MB–Na DC. The photophysical study also revealed that MB reports the step-wise aggregation pattern of BSs media, as an extrinsic fluorescence probe.

关键词： Methylene blue Sodium deoxycholate Sodium cholate Absorption Fluorescence spectroscopy Molecular mechanics

An Adaptive Scalable Data Pipeline for Multiclass Attack Classification in Large-Scale IoT Networks

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Big Data Mining and Analytics 2024年第2期7卷 500-511页

作者： selvam Saravanan Uma Maheswari Balasubramanian Department of Computer Science and Engineering Amrita School of ComputingAmrita Vishwa VidyapeethamBengaluru 560035India

The current large-scale Internet of Things(IoT)networks typically generate high-velocity network traffic *** use IoT devices to create botnets and launch attacks,such as DDoS,Spamming,Cryptocurrency mining,Phishing,*** service providers of large-scale IoT networks need to set up a data pipeline to collect the vast network traffic data from the IoT devices,store it,analyze it,and report the malicious IoT devices and types of ***,the attacks originating from IoT devices are dynamic,as attackers launch one kind of attack at one time and another kind of attack at another *** number of attacks and benign instances also vary from time to *** phenomenon of change in attack patterns is called concept ***,the attack detection system must learn continuously from the ever-changing real-time attack patterns in large-scale IoT network *** meet this requirement,in this work,we propose a data pipeline with Apache Kafka,Apache Spark structured streaming,and MongoDB that can adapt to the ever-changing attack patterns in real time and classify attacks in large-scale IoT *** concept drift is detected,the proposed system retrains the classifier with the instances that cause the drift and a representative subsample instances from the previous training of the *** proposed approach is evaluated with the latest dataset,IoT23,which consists of benign and several attack instances from various IoT *** classification accuracy is improved from 97.8%to 99.46%by the proposed *** training time of distributed random forest algorithm is also studied by varying the number of cores in Apache Spark environment.

关键词： Internet of Things(IoT) concept drift Apache Spark MongoDB Apache Kafka streaming

Platinum-supported mesoporous carbon(Pt/CMK-3) as anodic catalyst for direct methanol fuel cell applications:The effect of preparation and deposition methods

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Progress in Natural Science:Materials International 2012年第6期22卷 616-623页

作者： Balaiah Kuppan Parasuraman selvam National Centre for Catalysis Research and Department of Chemistry.Indian Institute of Technology-Madras

Platinum-supported ordered mesoporous carbon catalysts were prepared employing colloidal platinum reduced by four different reducing agents,viz.,paraformaldehyde,sodium *** glycol and hydrogen,and deposited over ordered mesoporous carbon (CMK-3) synthesized by silica hard template(SBA-15).The resulting platinum nanoparticles supported mesoporous carbon,designated as Pt/*** were tested for the electocatalytic oxidation of *** effect of the various reduction methods on the influence of particle size vis-a-vis on the electrocatalytic effect is *** the catalysts were systematically characterized by *** and *** results of the synthetic methods,characterization techniques and the electrocatalytic performance indicate that the Pt/CMK-3 catalysts are superior to that prepared with activated carbon(Pt/AC) as well as with that of the commercial platinum-supported carbon catalyst(Pt/E-TEK).In particular,the catalyst,Pt/CMK-3,prepared using paraformaldehyde reduced platinum showed much higher activity and long-term stability as compared to the other reducing methods.

关键词： Mesoporous carbon CMK-3 Nano-platinum Electrocatalyst Methanol oxidation Fuel cell

A Universal Spectrum for Interannual Variability of Monsoon Rainfall over India

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Advances in Atmospheric Sciences 1993年第2期10卷 221-226页

作者： A. Mary selvam Indian Institute of Tropical Meteorology Pune 411008 India

Continuous periodogram analyses of 115 years (1871-1985) summer monsoon rainfall over the Indian region show that the power spectra follow the universal and unique inverse power law form of the statistical normal distribution with the percentage contribution to total variance representing the eddy probability corresponding to the normalized standard deviation equal to [(log L / log T50)-1] where L is the period length in years and T50 the period up to which the cumulative percentage contribution to total variance is equal to 50. The above results are consistent with a recently developed non-deterministic cell dynamical model for atmospheric flows. The implications of the above result for prediction of interannual variability of rainfall is discussed.

关键词： A Universal Spectrum for Interannual Variability of Monsoon Rainfall over India over

Shape-Controlled Synthesis of Platinum-Based Nanocrystals and Their Electrocatalytic Applications in Fuel Cells

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Nano-Micro Letters 2023年第6期15卷 190-219页

作者： Can Li N.Clament Sagaya selvam Jiye Fang Department of Chemistry State University of New York at BinghamtonBinghamtonNYUSA

To achieve environmentally benign energy conversion with the carbon neutrality target via electrochemical reactions, the innovation of electrocatalysts plays a vital role in the enablement of renewable resources. Nowadays, Pt-based nanocrystals(NCs) have been identified as one class of the most promising candidates to efficiently catalyze both the half-reactions in hydrogen-and hydrocarbonbased fuel cells. Here, we thoroughly discuss the key achievement in developing shape-controlled Pt and Pt-based NCs, and their electrochemical applications in fuel cells. we begin with a mechanistic discussion on how the morphology can be precisely controlled in a colloidal system, followed by highlighting the advanced development of shape-controlled Pt, Pt-alloy, Pt-based core@shell NCs, Pt-based nanocages, and Pt-based intermetallic compounds. we then select some case studies on models of typical reactions(oxygen reduction reaction at the cathode and small molecular oxidation reaction at the anode) that are enhanced by the shape-controlled Pt-based nanocatalysts. Finally, we provide an outlook on the potential challenges of shape-controlled nanocatalysts and envision their perspective with suggestions.

关键词： Shape-control Colloidal synthesis Pt-based nanocrystals Electrochemical catalysis

Impregnation of carbonaceous nanofibers into glassy polymer-based composite membrane for CO_2 separation

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Chinese Journal of Chemical Engineering 2018年第11期26卷 2385-2390页

作者： Pannir selvam Murugiah Pei Ching Oh Kok Keong Lau CO_2 Research Centre Institute of Contaminant ManagementChemical Engineering DepartmentUniversiti Teknologi PETRONAS

The development of defect-free composite membrane(CM) is often challenging due to poor dispersion and distribution of filler particles in the polymer matrix. Despite the attractive physicochemical properties and gas separation performance of carbon nanotube(CNT) based CM, CNT displayed poor dispersion characteristics in most polymer matrix domain. Instead of incorporating CNT, a viable alternative, carbon nanofiber(CNF) which exhibits similar properties as CNT, but improved dispersion quality in the polymer matrix is found. In this work,CNF particles were incorporated in poly(2,6-dimethyl-1,4-phenylene oxide)(PPOdm) polymer continuous phase for CM development. The optimum gas separation performance of the PPOdm-CNF CM(11.25 at 197.02 barrer of CO_2 permeability) was obtained at 3 wt% of CNF loading. Compared to pristine PPOdmmembrane,CO_2 permeability and CO_2/CH_4 selectivity of PPOdm-3 wt% CNF CM were enhanced by 180% and 55%, *** 3 wt% CNF loading, the filler particles were dispersed and distributed more homogenously, in which no obvious CNF agglomeration was observed. In addition, the incorporation of CNF particles also enhanced the mechanical and thermal properties of the resultant CM.

关键词： Carbon nanofiber Composite membrane Carbon dioxide Gas separation