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photocatalytic activity of metal nanoparticle-decorated titanium dioxide for simultaneous H_(2) production and biodiesel wastewater remediation

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Chinese Journal of Chemical Engineering 2021年第8期34卷 86-100页

作者： patsakol prayoonpunratn Trin Jedsukontorn mali Hunsom Fuels Research Center Department of Chemical TechnologyFaculty of ScienceChulalongkorn UniversityBangkok 10330Thailand Current address:Department of Chemical Engineering Faculty of EngineeringMahidol UniversityNakorn Pathom 73170Thailand Associate Fellow of Royal Society of thailand(AFRST) Bangkok 10300Thailand

A set of metal nanoparticle-decorated titanium dioxide(mx/TiO_(2);where x is the percent by mass,%)photocatalysts was prepared via the sol-immobilization in order to enhance the simultaneous hydrogen(H_(2))production and pollutant reduction from real biodiesel *** of the metal nanoparticle(Np)type(m=Ni,Au,pt or pd)and,for pd,the amount(1%–4%)decorated on the surface of thermal treated commercial TiO_(2)(T_(400))was *** obtained results demonstrated that both the type and amount of decorated metal Nps did not significantly affect the pollutant reduction,measured in terms of the reduction of chemical oxygen demand(COD),biological oxygen demand(BOD)and oil&grease levels,but they affected the H_(2) production rate from both deionized water and biodiesel wastewater,which can be ranked in the order of pt_(1)/T_(400)>pd_(1)/T_(400)>Au_(1)/T_(400)>Ni_(1)/T_(400).this was attributed to the high difference in work function between pt and the parent ***,the difference between pt1/T400 and pd1/T400 was not great and so from an economic consideration,pd/TiO_(2) was selected as appropriate for further *** the four different pdx/TiO_(2) photocatalysts,the pd3/TiO_(2) demonstrated the highest activity and gave a high rate of H_(2) production(up to 135 mmol·h−1)with a COD,BOD and oil&grease reduction of 30.3%,73.7%and 58.0%,respectively.

关键词： Hydrogen production wastewater Remediation photochemistry metal nanoparticle-decorated titanium dioxide

CYp24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells

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world Journal of Gastroenterology 2013年第17期19卷 2621-2628页

作者： János p Kósa péter Horváth János wlfling Dóra Kovács Bernadett Balla péter mátyus Evelin Horváth Gábor Speer István Takács Zsolt Nagy Henrik Horváth péter Lakatos 1 st Department of Internal medicine Semmelweis University Department of Organic Chemistry University of Szeged Department of Organic Chemistry Semmelweis University

AIm:the effects of vitamin D3 have been investigated on various tumors, including colorectal cancer (CRC). 25-hydroxyvitamin-D3-24-hydroxylase (CYp24A1), the enzyme that inactivates the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 (1,25-D3), is considered to be the main enzyme determining the biological halflife of 1,25-D3. During colorectal carcinogenesis, the expression and concentration of CYp24A1 increases significantly, suggesting that this phenomenon could be responsible for the proposed efficacy of 1,25-D3 in the treatment of CRC. the aim of this study was to investigate the anti-tumor effects of vitamin D3 on the human CRC cell line Caco-2 after inhibition of the cytochrome p450 component of CYp24A1 activity. mEthODS:we examined the expression of CYp24A1 mRNA and the effects of 1,25-D3 on the cell line Caco-2 after inhibition of CYp24A1. Cell viability and proliferation were determined by means of sulforhodamine-B staining and bromodeoxyuridine incorporation, respectively, while cytotoxicity was estimated via the lactate dehydrogenase content of the cell culture supernatant. CYp24A1 expression was measured by realtime reverse transcription polymerase chain reaction. A number of tetralone compounds were synthesized to investigate their Cp24A1 inhibitory activity. RESULTS:In response to 1,25-D3, CYp24A1 mRNA expression was enhanced significantly, in a time- and dose-dependent manner. Caco-2 cell viability and proliferation were not influenced by the administration of 1,25-D3 alone, but were markedly reduced by coadministration of 1,25-D3 and KD-35, a CYp24A1-inhibiting tetralone. Our data suggest that the mechanism of action of co-administered KD-35 and 1,25-D3 does not involve a direct cytotoxic effect, but rather the inhibition of cell proliferation. CONCLUSION:these findings demonstrate that the selective inhibition of CYp24A1 by compounds such as KD-35 may be a new approach for enhancement of the anti-tumor effect of 1,25-D3 on CRC.

关键词： Colorectal cancer CYp24A1 inhibition Vitamin D3 Tetralone derivatives Caco-2 cell culture

Neuroprotective potential of cannabidiol:molecular mechanisms and clinical implications

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Journal of Integrative medicine 2023年第3期21卷 236-244页

作者： Srushti m.Tambe Suraj mali purnima D.Amin mozaniel Oliveira Department of pharmaceutical Sciences and Technology Institute of Chemical TechnologyMatunga EastMumbai 400019India Department of pharmaceutical Sciences and Technology Birla Institute of TechnologyRanchi 835215India Adolpho Ducke Laboratory Emilio Goeldi MuseumPara 66077-830Brazil

Cannabidiol(CBD),a nonpsychotropic phytocannabinoid that was once largely disregarded,is currently the subject of significant medicinal *** is found in Cannabis sativa,and has a myriad of neuropharmacological impacts on the central nervous system,including the capacity to reduce neuroinflammation,protein misfolding and oxidative *** the other hand,it is well established that CBD generates its biological effects without exerting a large amount of intrinsic activity upon cannabinoid *** of this,CBD does not produce undesirable psychotropic effects that are typical of marijuana ***,CBD displays the exceptional potential to become a supplementary medicine in various neurological ***,many clinical trials are being conducted to investigate this *** review focuses on the therapeutic effects of CBD in managing neurological disorders like Alzheimer's disease,parkinson's disease and ***,this review aims to build a stronger understanding of CBD and provide guidance for future fundamental scientific and clinical investigations,opening a new therapeutic window for neuroprotection.

关键词： Cannabis sativa Cannabidiol Natural products Bioactive compounds Anti-neurodegenerative diseases

Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao weng Adam m.R.Groh moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.R.wayne moore Jack p.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

Review of fiber superluminescent pulse amplifications

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High power Laser Science and Engineering 2016年第3期4卷 106-112页

作者： Haitao Zhang Xinglai Shen He Hao Qinghua Li mali Gong Center for photonics and Electronics State Key Laboratory of Precision Measurement and Instruments Department of Precision Instruments Tsinghua University

High coherence of the laser is indispensable light sources in modern long or short-distance imaging systems, because the high coherence leads to coherent artifacts such as speckle that corrupt image formation. To deliver low coherence pulses in fiber amplifiers, we utilize the superluminescent pulsed light with broad bandwidth, nonlongitudinal mode structure and chaotic mode phase as the seed source of the cascaded fiber amplifiers. the influence of fiber superluminescent pulse amplification(SpA) on the limitations of the performance is analyzed. A review of our research results for SpA in the fibers are present, including the nonlinear theories of this low coherent light sources, i.e., self-focusing(SF), stimulated Raman scattering(SRS) and self-phase modulation(Spm) effects, and the experiment results of the nanosecond pulses with peak power as high as 4.8 mw and pulse energy as much as 55 mJ. To improve the brightness of SpA light in the future work, we introduce our novel evaluation term and a more reasonable criterion, which is denoted by a new parameter of brightness factor for active large mode area fiber designs. A core-doped active large pitch fiber with a core diameter of 190 μm and a mode-field diameter of 180 μm is designed by this method. the designed fiber allows near diffracted limited beam quality operation, and it can achieve 100 mJ pulse energy and 540 w average power by analyzing the mode coupling effects induced by heat.

关键词： superluminescent pulse amplification fiber amplification incoherent nonlinear effects very large mode field

Identification of Anxiolytic potential of Niranthin:In-vivo and Computational Investigations

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Natural products and Bioprospecting 2021年第2期11卷 223-233页

作者： Atul R.Chopade prakash m.Somade pratik p.Somade Suraj N.mali Department of pharmacology Rajarambapu College of PharmacyKasegaonSangliMaharashtra 415404India Dept.of physiology Krishna Institute of Medical SciencesKaradMaharashtraIndia Government College of pharmacy KaradMaharashtraIndia

Anxiety is an unpleasant state,which can critically decrease the quality of life is often accompanied by nervous behaviour and *** is a lignan isolated from various phyllanthus *** literature survey on niranthin highlights wide ranges of the therapeutic *** a present study,based on our previous investigations,we evaluated pure,isolated and characterized niranthin as an anxiolytic *** niranthin[6-[(2R,3R)-3-[(3,4-dimethoxyphenyl)methyl]-4-methoxy-2-(methoxymethyl)butyl]-4-methoxy-1,3-benzodioxole]was purchased from commercial source and further subjected for assessment of its anxiolytic potentials using popular animal models including Elevated plus-maze model/test(Epm)and Light&Dark Exploration test(L&D).GABA-A receptor mediation was evaluated by pretreating the mice with the GABA-A receptor antagonist Flumazenil before the Epm *** docking simulation studies(pdb id:4COF)carried out by Vlife QSAR software showed that niranthin(docking score:−62.1714 kcal/mol)have shown comparatively best docking score compared to the standard drug Diazepam(docking score:−63.1568 kcal/mol).To conclude,Niranthin has probable potential in the management of anxiety *** in-silico and in-vivo analysis(indirectly)indicated the plausible role of GABA mediation for anxiolytic ***,these studies are preliminary,future in depth experimental explorations will be required to use Niranthin as anti-anxiety drug in near future.

关键词： pharmacology phytoconstituents Niranthin Lignan Anxiolytic activity Epm models

Determination of Surface precipitation Type Based on the Data Fusion Approach

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Advances in Atmospheric Sciences 2021年第3期38卷 387-399页

作者： marek pÓŁROLNICZAK Leszek KOLENDOwICZ Bartosz CZERNECKI mateusz TASZAREK Gabriella TÓth Department of meteorology and Climatology Institute of Physical Geography and Environmental PlanningAdam Mickiewicz University61-680 PoznańPoland Department of weather Forecasting and Climatology Hungarian Meteorological ServiceH-1024 BudapestHungary

Hazardous events related to atmospheric precipitation depend not only on the intensity of surface precipitation,but also on its *** related to determination of the precipitation type(pT)leads to financial losses in many areas of human activity,such as the power industry,agriculture,transportation,and many *** this study,we use machine learning(mL)algorithms with the data fusion approach to more accurately determine surface *** on surface synoptic observations,ERA5 reanalysis,and radar data,we distinguish between liquid,mixed,and solid precipitation *** study domain considers the entire area of poland and a period from 2015 to *** purpose of this work is to address the question:“How can mL techniques applied in observational and Nwp data help to improve the recognition of the surface pT?”Despite testing 33 parameters,it was found that a combination of the near-surface air temperature and the depth of the warm layer in the 0-1000 m above ground level(AGL)layer contains most of the signal needed to determine surface *** accrued probability of detection for liquid,solid,and mixed pTs according to the developed Random Forest model is 98.0%,98.8%,and 67.3%,*** application of the mL technique and data fusion approach allows to significantly improve the robustness of pT prediction compared to commonly used baseline models and provides promising results for operational forecasters.

关键词： precipitation type forecast data fusion Random Forest ERA5 poland

Developing an identities-based approach to support more robust resilience and recovery in heritage planning and management

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Built Heritage 2023年第2期7卷 3-14页

作者： Zachary m.Jones théodora pappas DASTU Politecnico di MilanoMilanItaly

Resilience has become an increasingly important concept in the cultural heritage feld,particularly in the aftermath of the unprecedented challenges the COVID-19 global pandemic ***,on a conceptual and practical level,resilience remains closely linked to the technical conservation of built heritage,and there remains a need to develop broader approaches inclusive of cultural and socioeconomic *** article investigates the potential applicability of theoretical concepts linked to identity and identities in heritage planning to help fll these gaps and develop approaches that consider resilience and are better able to address a range of unanticipated *** frst review the literature and policy documents to defne and identify the potential for identities-based *** then examine the case of matera,an extremely fragile world heritage site in southern Italy that has been continuously inhabited for more than 8000 years and provides a relevant example of *** explore the trends and efects of globalised tourism development before the pandemic and the post pandemic emergence of more local/regional and slow tourism patterns,largely based on cultural solutions to local development challenges and knowledge *** this comparison,we analyse the potential and limitations of introducing identities-based concepts into heritage planning as a more robust way to enhance resilience and prepare cities for unexpected future crises.

关键词： identity heritage management plans matera resilience locally based development mode