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Serum mac-2 binding protein glycosylation isomer level predicts hepatocellular carcinoma development in E-negative chronic hepatitis B patients

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world Journal of Gastroenterology 2019年第11期25卷 1398-1408页

作者： Lung-Yi mak wai-Pan To Danny Ka-Ho wong James Fung Fen Liu wai-Kay Seto Ching-Lung Lai man-Fung Yuen Department of medicine Queen Mary Hospital Department of medicine The University of Hong Kong State Key Laboratory for Liver Research The University of Hong Kong

BACKGROUND Liver cirrhosis is a major risk factor for hepatocellular carcinoma(HCC)development in chronic hepatitis B(CHB). Serum mac-2 binding protein glycosylation isomer(m2 BPGi) is a novel serological marker for fibrosis. The role of m2 BPGi in prediction of HCC is *** To examine the role of serum m2 BPGi in predicting HCC development in hepatitis B e antigen(HBeAg)-negative *** Treatment-naive CHB patients with documented spontaneous HBeAg seroconversion were recruited. Serum m2 BPGi was measured at baseline(within3 years from HBeAg seroconversion), at 5 years and 10 years after HBeAg seroconversion and expressed as cut-off index(COI). multivariate cox regression was performed to identify predictors for HCC development. ROC analysis was used to determine the cut-off value of m2 *** Among 207 patients(57% male, median age at HBeAg seroconversion 40 years old) with median follow-up of 13.1(11.8-15.5) years, the cumulative incidence of HCC at 15 years was 7%. median m2 BPGi levels were significantly higher in patients with HCC compared to those without HCC(baseline: 1.39 COI vs 0.38 COI, P multivariate analysis revealed age at HBeAg seroconversion[odds ratio(OR) = 1.196, 95% confidence interval(CI): 1.034-1.382, P = 0.016] and baseline m2 BPGi(OR = 4.666, 95%CI: 1.296-16.802, P = 0.018) were significant factors predictive of HCC. Using a cut-off value of 0.68 COI, baseline m2 BPGi yielded AUROC of 0.883 with 91.7% sensitivity and 80.8% *** High serum m2 BPGi within 3 years after HBeAg seroconversion was a strong predictor for subsequent HCC development in treatment-naive HBeAg-negative CHB patients.

关键词： Hepatocellular carcinoma Hepatitis B Liver fibrosis mac-2 binding protein glycosylation isomer Biomarker

对预测教堂内早期声能量衰变的延时耦合空间模型的改进(英文)

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华南理工大学学报（自然科学版） 2007年第B10期35卷 25-27页

作者：褚轶景麦卓明香港理工大学屋宇设备工程系

采用脉冲激励响应的方法对两种不同类型的教堂早期声能量衰变过程进行了研究.结果表明,在Barron模型中耦合效应比声源与接收点的距离影响更大.文中还提出了延时耦合空间模型.将几何声学引入统计声学来检测扩散场条件,同时通过对声音从... 详细信息

采用脉冲激励响应的方法对两种不同类型的教堂早期声能量衰变过程进行了研究.结果表明,在Barron模型中耦合效应比声源与接收点的距离影响更大.文中还提出了延时耦合空间模型.将几何声学引入统计声学来检测扩散场条件,同时通过对声音从声源传播到每个扩散场子空间的延时,修正了关于脉冲宽度的初始条件.基于耦合空间的理论预测与实际测量结果较为一致.

关键词：早期声能量衰变延时耦合空间模型脉冲激励响应

A Stochastic model for the Control of Intelligent Assembly Robots

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A Stochastic Model for the Control of Intelligent Assembly R...

肝细胞肝癌的外科治疗及与乙醇注射的比较研究

第十九届中国控制会议

作者： K．L．mak H．Y．K．Lau m．C．C．Ngan Department of Industrial and manufacturing Systems Engineering The University of Hong Kong Pokfulam RoadHong Kong Department of Industrial and manufacturing Systems Engineering The University of Hong Kong Pokfulam RoadHong Kong Department of Industrial and manufacturing Systems Engineering The University of Hong Kong Pokfulam RoadHong Kong

＜正＞The topic of automated assembly is widely addressed by the robotics communities. However, so far there is no systematic framework to assist the construction of an intelligent robot control system. Even systems so called intelligent systems are not truly intelligent when they are compared to human. It is therefore essential to define and analyse the necessary intelligence criteria that an intelligent robot should posses. Such criteria are then implemented on an appropriate control platform so as to enhance the intelligence of the robot. As such, one of the principal aims of this paper is to discuss and identify the criteria of machine intelligence that are central to achieving an intelligent robot. with these criteria as basis, the paper then presents an intelligent framework that is based on the stochastic hidden markov model （Hmm）. This framework consists of a number of functional blocks for the design and implementation of an intelligent robot control system. Each functional block is responsible for a corresponding feature with specific intelligent capabilities. The paper starts with a review of the applications of Hmm in automated assembly, which is followed by the description of the main features and architecture of the proposed framework.

关键词： Hidden markov models intelligent robots control systems architecture force control

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国外学者来访报告 1996年第2期16卷 7-8页

作者： mak.,m 周俭日本东京大学第二外科

Photodynamic therapy-mediated modulation of inflammatory cytokine production by Epstein–Barr virus-infected nasopharyngeal carcinoma cells

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Cellular & molecular Immunology 2010年第4期7卷 323-326页

作者： Ho-Kee Koon Kwok-wai Lo Kwok-Nam Leung maria Li Lung Chris Chi-Kwong Chang Ricky Ngok-Shun wong wing-Nang Leung Nai-Ki mak Department of Biology Hong Kong Baptist UniversityKowloonHong Kong Department of Anatomical and Cellular Biology and State Key Laboratory in Oncology in South China Prince of Wales HospitalShatinHong Kong Department of Biochemistry and Food and nutritional Sciences Programme The Chinese University of Hong KongShatinHong Kong Department of Biology Hong Kong University of Science and TechnologyHong Kong Department of Chemistry Hong Kong University of Science and TechnologyKowloonHong Kong School of Chinese medicine The Chinese University of Hong KongShatinHong Kong

Nasopharyngeal carcinoma(NPC)is a malignant disease associated with Epstein–Barr virus(EBV)*** study aims to examine the effects of EBV infection on the production of proinflammatory cytokines in NPC cells after the Zn-BC-Am photodynamic therapy(PDT)*** were treated with the photosensitiser Zn-BC-Am for 24 h before light *** ELISA was used to evaluate the production of *** the same experimental condition,HK-1-EBV cells produced a higher basal level of IL-1a(1561 pg/ml),IL-1b(16.6 pg/ml)and IL-8(422.9 pg/ml)than the HK-1 *** the light dose of 0.25–0.5 J/cm2,Zn-BC-Am PDT-treated HK-1-EBV cells were found to produce a higher level of IL-1a and IL-1b than the HK-1 *** production of IL-1b appeared to be mediated via the IL-1b-converting enzyme(ICE)-independent *** contrast,the production of angiogenic IL-8 was downregulated in both HK-1 and HK-1-EBV cells after Zn-BC-Am *** results suggest that Zn-BC-Am PDT might indirectly reduce tumour growth through the modulation of cytokine production.

关键词： Photodynamic therapy nasopharyngeal carcinoma cytokines Epstein-Barr virus

multidisciplinary approaches in the study of aging - observations made by a morphologist

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Robotic surgery for rectal cancer: A systematic review of current practice

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： D.T.Yew L.Y.Yeung Y.T.mak m.S.m.wai School of Biomedical Sciences The Chinese University of Hong Kong

＜正＞The talk will review the study of human brain aging and animal brain aging（rodent and monkey）,utilizing different approaches including fmRI,immunocytochemistry（apoptotic markers,transmitters and peptides） as well as western blotting to analyse the events of *** development to adulthood,one could see a change from disorderly to orderly pattern as revealed by *** progressive aging,the activated area for a specific activity *** immunohistochemistry,silver staining and western blotting,the mechanisms and events of degeneration begin to unfold, cell death and cell death effectors（caspases） increase,contacts decrease,hypertau proteins appear and the decline of transmitters in the cortex and brainstem,affecting the latter in different nuclei which control the fundamental,visceral and sensory ***,some of these events may be akin to other kinds of degeneration,*** drug *** is hoped that this talk may illustrate the simple research effort over the years by anatomists employing different approaches.

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world Journal of Gastrointestinal Oncology 2014年第6期6卷 184-193页

作者： Tony wing Chung mak Janet Fung Yee Lee Kaori Futaba Sophie Sok Fei Hon Dennis Kwok Yu Ngo Simon Siu man Ng Division of Colorectal Surgery Department of Surgery The Chinese Uni-versity of Hong Kong Prince of Wales Hospital Department of Colorectal Surgery University Hospital Birmingham NHS Trust

AIm: To give a comprehensive review of current litera-ture on robotic rectal cancer ***: A systematic review of current literature via Pubmed and Embase search engines was per-formed to identify relevant articles from january 2007 to november 2013. The keywords used were: "robotic surgery", "surgical robotics", "laparoscopic computer-assisted surgery", "colectomy" and "rectal resection". RESULTS: After the initial screen of 380 articles, 20 pa-pers were selected for review. A total of 1062 patients(male 64.0%) with a mean age of 61.1 years and body mass index of 24.9 kg/m2 were included in the *** of 1062 robotic-assisted operations, 831(78.2%) anterior and low anterior resections, 132(12.4%) in-tersphincteric resection with coloanal anastomosis, 98(9.3%) abdominoperineal resections and 1(0.1%) Hart-mann's operation were included in the review. Robotic rectal surgery was associated with longer operative time but with comparable oncological results and anastomotic leak rate when compared with laparoscopic rectal surgery. CONCLUSION: Robotic colorectal surgery has con-tinued to evolve to its current state with promising re-sults; feasible surgical option with low conversion rate and comparable short-term oncological results. The challenges faced with robotic surgery are for more high quality studies to justify its cost.

关键词： Rectal cancer Robotics minimal invasive surgery Systematic review Rectal surgery

A Study on Uptake and Localization of merocyanine 540 (mC540) in murine myeloid Leukemia Cells by Confocal Laser Scanning microscopy (CLSm)

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Chinese Journal of Lasers 2000年第3期9卷 35-41页

作者： J. Y. Chen-1 N. H. Cheung-2 S. C. Chen-2, m. C. Fung-3 w. N. Leung-4 N. K. mak- 4+ ( -1Department of Physics, Fudan University, Shanghai 200433, China -2Department of Physics, Hong Kong Baptist University, Hong Kong, China -3Department of Bi 复旦大学上海香港浸会大学香港香港大学香港

The intracellular localization of merocyanine 540 (mC540), a photosensitizer commonly used in the photo-inactivation of leukemia cells, was studied using confocal laser scanning microscopy. It was found for the first time that mC540 not only localized in the plasma membrane but also in the cytoplasm and the nuclear membrane of the murine myeloid leukemia m1 and wEHI 3B (JCS) cells. Exposure of mC540 treated leukemia cells to light under conditions that could cause photobleaching did not cause the redistribution of cell-bound mC540. Rapid localization of mC540 in the cytoplasm was observed 5 minutes after exposure of leukemia cell to mC540, indicating that mC540 could promptly be internalized by these two leukemia cell lines. In contrast, localization of mC540 was limited only to the plasma membrane of erythrocytes. These results suggest that the binding pattern of mC540 is cell type dependent and may be related to the efficacy of photosenitization in photodynamic therapy.

关键词： merocyanine 540 Confocal Laser Scanning microscopy myeloid Leukemia cell

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赤红壤早稻田甲烷排放通量及其影响因素

生态学杂志 2005年第8期24卷 939-942页

作者：杜尧东刘锦銮杨宁王天龙 mak Khalil mJ Shearer 广东省气候与农业气象中心广州510080 广东省清远市气象局清远511500 波特兰州立大学物理系波特兰97207

用封闭箱法对广东省赤红壤早稻田CH4排放通量进行了观测。结果表明,CH4排放有明显的季节变化规律,3个排放高峰分别出现在水稻分蘖末期、孕穗抽穗期和乳熟期,平均通量为5.7mg.m-2.h-1。在测定期内,CH4排放与5和10cm土壤温度呈显著正相关... 详细信息

用封闭箱法对广东省赤红壤早稻田CH4排放通量进行了观测。结果表明,CH4排放有明显的季节变化规律,3个排放高峰分别出现在水稻分蘖末期、孕穗抽穗期和乳熟期,平均通量为5.7mg.m-2.h-1。在测定期内,CH4排放与5和10cm土壤温度呈显著正相关,与土壤Eh呈显著负相关,与土壤pH值、水层深浅相关不明显。

关键词：赤红壤早稻田 CH4排放影响因素