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Fatigue and Quality of Life of women Undergoing Chemotherapy or Radiotherapy for Breast Cancer

Clinical oncology and cancer researeh 2009年第3期6卷 179-185页

作者： winnie K.w.So Gene marsh w.m.ling F.Y.Leung Joe C.K.Lo maggie Yeung George K.H.Li Department of Nursing Studies The University of Hong Kong School of Nursing University of Colorado Health Science Center Nurse Specialist Department of Clinical OncologyPamela Youde Nethersole Eastern Hospital Infection Control Unit Princess Margaret Hospital Oncology Department Princess Margaret Hospital Clinical Oncology Department Tuen Mun Hospital Department of Surgery Queen Mary Hospital

OBJECTIVE To examine fatigue and quality of life (QOL) inbreast cancer patients undergoing chemotherapy or *** A self-report survey derived from the Chineseversion of Brief Fatigue Inventory, the Functional Assessmentof Chronic Illness Therapy for Breast Cancer, and the medicalOutcomes Study Social Support Survey. Descriptive statisticswas used to examine the intensity of fatigue and the prevalenceof severe fatigue. multivariate analysis of variance was used todetermine factors that affect the five domains of QOL among *** The majority of the participants (n = 261) perceiveda mild level of fatigue, but 35.6% of them suffered severe *** had a significantly negative association with all domainsof QOL except social/family wellbeing. The participants whowere receiving chemotherapy, undergoing curative treatment andhaving inadequate social support were more likely to have poorerQOL in all five domains (after adjustment for age).CONCLUSION Although the majority of the participantsexperienced a mild level of fatigue, there was a substantial groupof breast cancer patients who perceived their fatigue as severe. Thefindings of this study showed that fatigue had a detrimental effecton the various aspects of the participants' QOL. Demographic andclinical characteristics of breast cancer patients who were at riskof getting poorer QOL were identified. The results of the studydemonstrate that we should enhance healthcare professionals'awareness of the importance of symptom assessment, andprovide them with information for planning effective symptom-management strategies among this study population.

关键词： breast neoplasm fatigue quality of life drug therapy.

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Dynamic recrystallization mechanism, texture evolution development and mechanical characteristics of a mg–8.7Gd–4.18Y–0.42Zr magnesium alloy by ECAP

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Progress in Natural Science:materials International 2024年第02期34卷 376-388页

作者： ling Zhang Yinglong Li School of materials Science and Engineering Northeastern University School of mechanical and Engineering Ningxia Institute of Science and Technology

Equal channel angle pressing is recognized for its ability to refine alloy grains and alter grain orientation, thereby achieve better mechanical performance of the magnesium alloy. This study investigates the microstructures,dynamic recrystallization mechanism, texture development, and mechanical performance of Gw94K(mg–8.7Gd–4.18Y–0.42Zr wt. %) mg alloy following ECAP-4 passes at 400°C and 3 mm/min. Results show that when high-temperature deformation is undertaken, twin formation is suppressed while dislocation slip is facilitated, increasing dislocation density during deformation. Following ECAP deformation, the sample displayed higher fracture elongation, TYS, and UTS than the as-solutioned Gw94K alloy. In particular, the Gw94K alloy performed well mechanically after ECAP-4 passes, with an ultimate TYS of 231 mPa, an UTS of 290 mPa, and an elongation of 14.8 %. DDRX and shear bands induce CDRX, both of which are important in plastic deformation. as well as in modifying microstructure and grain orientation during ECAP deformation.

关键词： Dynamic recrystallization mechanism Equal channel angular pressing magnesium alloy mechanical performance mg-Gd-Y-Zr alloy Texture development

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Eigenvalues for the Clamped Plate Problem of L_(ν)^(2) Operator on Complete Riemannian manifolds

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Acta mathematica Sinica,English Series 2024年第9期40卷 2223-2243页

作者： ling Zhong ZENG Jiangxi Provincial Center for Applied mathematics&School of mathematics and Statistics Jiangxi Normal UniversityNanchang 330022P.R.China

L_(ν) operator is an important extrinsic differential operator of divergence type and has profound geometric *** this paper,we consider the clamped plate problem of L_(ν)^(2)operator on a bounded domain of the complete Riemannian manifolds.A general formula of eigenvalues of L_(ν)^(2) operator is *** this general formula,we obtain some estimates for the eigenvalues with higher order on the complete Riemannian *** several fascinating applications,we discuss this eigenvalue problem on the complete translating solitons,minimal submanifolds on the Euclidean space,submanifolds on the unit sphere and projective *** particular,we get a universal inequality with respect to the L_(II) operator on the translating ***,it is very difficult to get universal inequalities for weighted Laplacian and even Laplacian on the complete Riemannian ***,this work can be viewed as a new contribution to universal estimate.

关键词： mean curvature flows L_(ν)^(2)operator clamped plate problem eigenvalues Riemannian manifolds translating solitons

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mODIFIED STOCHASTIC EXTRAGRADIENT mETHODS FOR STOCHASTIC VARIATIONAL INEQUALITY

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Journal of Computational mathematics 2024年第2期42卷 390-414页

作者： ling Zhang lingling Xu School of management and Economic Beijing Institute of TechnologyBeijing 100081China School of mathematical Sciences Nanjing Normal UniversityNanjing 210023China School of mathematical Sciences and Jiangsu Key Laboratory for NSLSCS Nanjing Normal UniversityNanjing 210023China

In this paper,we consider two kinds of extragradient methods to solve the pseudo-monotone stochastic variational inequality ***,we present the modified stochastic extragradient method with constant step-size(mSEGmC)and prove the convergence of *** the strong pseudo-monotone operator and the exponentially growing sample sequences,we establish the R-linear convergence rate in terms of the mean natural residual and the oracle complexity O(1/ǫ).Second,we propose a modified stochastic extragradient method with adaptive step-size(mSEGmA).In addition,the step-size of mSEGmA does not depend on the Lipschitz constant and without any line-search ***,we use some numerical experiments to verify the effectiveness of the two algorithms.

关键词： Stochastic variational inequality Pseudo-monotone modified stochastic ex-tragradient methods Adaptive step-size

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Space telescope set to open a new chapter in China's solar research

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National Science Review 2024年第1期11卷 225-227页

作者： ling Xin 机构不祥

One year after China launched its first dedicated space telescope to study the Sun, the Advanced Space-based Solar Observatory(ASO-S) is now fine-tuned and ready for discoveries during the activity peak of this solar cycle. ‘ASO-S has completed its in-orbit tests, and all instruments are in stable operation. Some early results are already in the pipeline,’ said the mission’s chief scientist, Gan weiqun, as the telescope was officially delivered to his co-workers at the Purple mountain Observatories,

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Structural engineered living materials

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Nano Research 2024年第2期17卷 715-733页

作者： Yang Geng Zian Jia ling Li 635 Prices Fork Road Department of Mechanical EngineeringVirginia Polytechnic Institute and State UniversityBlacksburg VA24061USA

Biological structural materials not only exhibit remarkable mechanical properties but also often embody dynamic characteristics such as environmental responsiveness,autonomy,and self-healing,which are difficult to achieve in conventional engineering *** merging materials science,synthetic biology,and other disciplines,engineered living materials(ELms)provide a promising solution to combine living organisms with abiotic components,thus facilitating the construction of functional“living”*** natural materials,ELms possess vitality and hold immense application potential in areas such as medicine,electronics,and construction,captivating increasing research attention *** an emerging branch of ELms,structural ELms aim to mimic living biological structural materials by achieving desired mechanical performance while maintaining important“living”*** we summarize the recent progress and provide our perspectives for this emerging research *** first summarize the superiority of structural ELms by reviewing biological structural materials and biomimetic material design ***,we provide a systematic discussion on the definition and classifications of structural ELms,their mechanical performance,and physiological ***,we summarize some critical challenges faced by structural ELms and highlight directions of future *** hope this review article can provide a timely summary of the state of the art and relevant perspectives for future development of structural ELms.

关键词： structural materials engineered living materials(ELms) structural ELms composites mechanical properties

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A Graded Speed Control method for Cyborg Rats Based on Electrical Stimulation of the Cuneiform Nucleus

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Journal of Bionic Engineering 2024年第3期21卷 1334-1346页

作者： Hanyi ling Le Han Nenggan Zheng Qiushi Academy for Advanced Studies(QAAS) Zhejiang UniversityHangzhou310007China The State Key Lab of Brain-machine Intelligence Zhejiang UniversityHangzhou310007China College of Biomedical Engineering&Instrument Science Zhejiang UniversityHangzhou310007China College of Computer Science and Technology Zhejiang UniversityHangzhou310007China CCAI by mOE and Zhejiang Provincial Government(ZJU) Hangzhou310007China

The precise movement speed regulation is a key factor to improve the control effect and efficiency of the cyborg ***,the current stimulation techniques cannot realize the graded control of the *** this study,we achieved the multi-level speed regulation of cyborg rats in the large open field and treadmill by specifically targeting the Cuneiform Nucleus(CnF)of the mesencephalic Locomotor Region(mLR).Detailed,we measured the influence of each stimulation parameter on the speed control process which included the real-time speed,accelerated speed,response time,and acceleration *** concluded that the pulse period and the pulse width were the main determinants influencing the accelerated speed of cyborg *** the amplitude of stimulation was found to affect the response time exhibited by the cyborg *** study provides valuable insights into the regulation of rat locomotion speed and highlights the potential for utilizing this approach in various experimental settings.

关键词： Cyborg rats Cuneiform nucleus Graded control Speed regulation

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Lewis Base Catalyzed Selenofunctionalization of Alkynes with Acid-Controlled Divergent Chemoselectivity

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Chinese Journal of Chemistry 2024年第14期42卷 1623-1629页

作者： ling-ling Chen Ren-Fei Cao Hua Ke Zhi-min Chen School of Chemistry and Chemical Engineering Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong UniversityShanghai200240 China Engineering Technology Research Center for Environmental Protection materials Pingxiang UniversityPingxiangJiangxi337055 China

Lewis base catalyzed and Brønsted acid controlled chemodivergent electrophilic selenofunctionalizations of alkynes were developed for the first *** selenium-containing tetrasubstituted alkenes were readily obtained in moderate to excellent yields with complete E/Z *** the substrates were 1-ethynyl naphthol derivatives,linear selenium-containing tetrasubstituted alkenes were produced via intermolecular oxygen nucleophilic attack in the absence of acid additive;in contrast,cyclic selenium-containing tetrasubstituted alkenes were generated through intramolecular carbon nucleophilic capture with the addition of Brønsted acid.

关键词： Alkynes Electrophilic addition Chemoselectivity Lewis base catalysis Selenofunctionalization

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Evaluation of 3D crustal seismic velocity models in southwest China:model performance,limitation,and prospects

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Science China Earth Sciences 2024年第2期67卷 604-619页

作者： Xin wANG ling CHEN Qi-Fu CHEN Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing100049China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China

Southwest China is a tectonically and seismically active region,witnessing strong deformation due to the collision between the Indian and Eurasian *** the subsurface velocity structure of this region is thus important in understanding the tectonics and geodynamic processes of continental collision and in mitigating seismic *** studies have provided various 3D seismic velocity models in southwest ***,discrepancies exist among these models,and less effort has been made to quantify the reliability and accuracy of these existing velocity *** this study,we use regional 3D waveform simulation to evaluate the performance of various regional crustal 3D velocity models in reproducing observed *** particularly focus on two recent earthquake sequence in the region,the 2021 Yunnan Yangbi mS_(6.4) earthquake sequence and the 2022 Sichuan Luding mS_(6.8) earthquake *** tested 3D velocity models include the Southwest China Community Velocity model V1.0,the Unified Seismic Tomography models for Continental China Lithosphere V2.0,the adjoint full waveform tomography model of the crustal and upper mantle beneath Eastern Tibetan Plateau,and the shallow seismic structure model beneath continental *** results show that the tested 3D velocity models generally capture well long-period(waveforms,indicating that the 3D models adequately resolve overall large-scale subsurface ***,the 3D synthetics show discrepancies in higher frequencies(0.05–0.3 Hz)and the performance of the 3D velocity models varies from region to region,suggesting that smaller scale heterogeneities are not well *** shallow velocity structures(m)can improve the waveform fitting,emphasizing the importance of incorporating shallow structures in waveform *** full-waveform tomography model shows a slighter better performance than the other models,especially for the body-waves,highlighting the advantages

关键词： Southwest China Seismic tomography models Shallow Structures waveform simulation model evaluation

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multi-instance partial-label learning: towards exploiting dual inexact supervision

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Science China(Information Sciences) 2024年第3期67卷 48-61页

作者： wei TANG weijia ZHANG min-ling ZHANG School of Computer Science and Engineering Southeast University Key Laboratory of Computer Network and Information Integration (Southeast University) Ministry of Education School of Information and Physical Sciences The University of Newcastle

weakly supervised machine learning algorithms are able to learn from ambiguous samples or labels, e.g., multi-instance learning or partial-label learning. However, in some real-world tasks, each training sample is associated with not only multiple instances but also a candidate label set that contains one groundtruth label and some false positive labels. Specifically, at least one instance pertains to the ground-truth label while no instance belongs to the false positive labels. In this paper, we formalize such problems as multi-instance partial-label learning(mIPL). Existing multi-instance learning algorithms and partial-label learning algorithms are suboptimal for solving mIPL problems since the former fails to disambiguate a candidate label set, and the latter cannot handle a multi-instance bag. To address these issues, a tailored algorithm named mIPLGP, i.e., multi-instance partial-label learning with Gaussian processes, is *** first assigns each instance with a candidate label set in an augmented label space, then transforms the candidate label set into a logarithmic space to yield the disambiguated and continuous labels via an exclusive disambiguation strategy, and last induces a model based on the Gaussian processes. Experimental results on various datasets validate that mIPLGP is superior to well-established multi-instance learning and partial-label learning algorithms for solving mIPL problems.

关键词： machine learning multi-instance partial-label learning multi-instance learning partial-label learning Gaussian processes

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