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Tumor necrosis factor-alpha, transforming growth factor-beta, degree of lower urinary tract symptoms as predictors of erectile dysfunction in benign prostatic hyperplasia patients

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Asian Journal of Urology 2024年第2期11卷 280-285页

作者： Gede w.K.Duarsa Yeremia G.Kusumah Ronald Sugianto Pande M.w.Tirtayasa Tjokorda G.B.Mahadewa Department of Urology Faculty of MedicineUniversitas UdayanaProf.Dr.I.G.N.G Ngoerah General HospitalBaliIndonesia Department of General Surgery Faculty of MedicineUniversitas UdayanaProf.Dr.I.G.N.G Ngoerah General HospitalBaliIndonesia Medical Doctor Study Program Faculty of MedicineUniversitas UdayanaBaliIndonesia Department of Urology Faculty of MedicineUniversitas UdayanaUniversitas Udayana Teaching HospitalBaliIndonesia Department of Neurosurgery Faculty of MedicineUniversitas UdayanaProf.Dr.I.G.N.G Ngoerah General HospitalBaliIndonesia

Objective: Erectile dysfunction (ED) is a condition of insufficient penile erection, consistently or recurrently, for sexual activity. Tumor necrosis factor-alpha (TNF-α) induces transforming growth factor-beta (TGF-β), which causes the transition of epithelial cells into mesenchymal cells that affect ED. This study aimed to evaluate the roles of TNF-α, TGF-β, degree of lower urinary tract symptoms, and prostatic volume for the presence of ED in benign prostatic hyperplasia (BPH) ***: Our study performed an analytic observational retrospective cohort study using secondary data from four hospitals in Bali, Indonesia, including medical records and other administrative data. The sample was BPH patients with several history ***: Our sample was 83 respondents, ranging from 50 years to 80 years, 61 respondents with ED and 22 with non-ED. The International Prostate Symptom Score showed a significant result, which indicates that ED is more common in patients with higher International Prostate Symptom Score (p=0.002). Moreover, the TNF-α of ≥43.9 pg/mg and TGF-β of ≥175.8 pg/mL were significantly associated with the presence of ED in BPH patients (pcant with ED (p=0.947).conclusion: TNF-α, TGF-β, and lower urinary tract symptoms severity can predict the occurrence of ED in BPH, while prostatic volume was not significant.

关键词： Prostate enlargement Biomarker Erectiledysfunction Riskfactor

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coating powder beds with liquids and foams based on viscous formulations using a twin screw mixer:A continuous process study

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Particuology 2024年第10期93卷 364-376页

作者： Mohamed S.Manga Dimitrios Kontziampasis Mustafa Al-Maqdad Sean clifford Serafim Bakalis David w.York School of chemical and Process Engineering Faculty of Engineering and Physical SciencesUniversity of LeedsLeedsLS29JTUK School of Mechanical Engineering Faculty of Engineering and Physical SciencesUniversity of LeedsLeedsLS29JTUK School of Science and Engineering University of DundeeDD14HNDundeeScotlandUK Dundee International Institute of central South University Tongzipo RoadCentral South UniversityChangshaHunan410013China Department of chemical Engineering School of EngineeringUniversity of NewcastleNewcastleNE17RUUK School of chemical Engineering University of BirminghamBirminghamB152TTUK Department of chemical Engineering Faculty of EngineeringUniversity of NottinghamNG72RDUK

coating with viscous formulations has been essential in numerous industries as it can be a means for providing functionalization, additional properties, as well as other benefits. However, there have been scarce studies that have investigated and proposed methodologies in literature. continuous coating of powders with viscous liquids poses as a promising technology, which has been mentioned in some studies, but has not yet been thoroughly investigated. This paper employs the use of image processing and analysis, in combination with statistical analysis of particles to evaluate the effectiveness of foams and liquids as a means of coating powder beds. Two different sizes of twin screw mixers that are working in continuous operation are employed, and a new continuous foaming device is fabricated and used for the experiments of coating. The effect of materials and process parameters (as for example rotational speed, and flowrate) on the quality of coating are investigated. Image analysis is used to assess the coating quality. The results clearly showcase the potential of using twin screw mixers for coating purposes and not only for mixing. The hypothesis that using large bubble foams to improve the coating of viscous liquids on particles is proven correct, as they provide higher quality coatings compared to their equivalent liquids, when used in the twin screw mixer. Surprisingly, using a larger scale twin screw mixer, does not show a substantial effect on the mixing, regarding quality, however there is still a requirement for mix optimization for achieving scale-up of this process. These results provide a new pathway for coating powders with viscous formulations in industrial applications, requiring less energy and effort in this process, and can pave the way towards introducing more sustainable industrial methodologies for coating.

关键词： Powder coating continuous processing Viscous liquid Foam Image analysis Positron emission particle traking(PEPT)

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coupled cu doping and Z-scheme heterojunction for synergistically enhanced tetracycline photodegradation

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Nano Research 2024年第7期17卷 5937-5948页

作者： Huidong Shen chunming Yang Song Hong Leiduan Hao Liang Xu Alex w.Robertson Zhenyu Sun country State Key Laboratory of Organic-Inorganic composites College of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029China Shaanxi Key Laboratory of chemical Reaction Engineering College of Chemistry and Chemical EngineeringYan’an UniversityYan’an 716000China Department of Physics University of WarwickCoventry CV 47ALUK

Semiconductor-based photocatalysis by utilizing solar energy for sustainable organic pollutant elimination has been a promising tactic to alleviate environmental ***,the development of robust and efficient photocatalysts to degrade organic pollutants still faces major challenges because of insufficient charge *** we design and fabricate a heterojunction consisting of copper,carbon-modified TiO_(2),and sulfur-doped g-c_(3)N_(4)nanosheets(i.e.,S-c_(3)N_(4)/cu/c-TiO_(2)).The heterostructure affords a remarkable synergistic photocatalysis for tetracycline hydrochloride degradation,achieving an 82.6%removal efficiency within 30 min under visible light irradiation,about 15.4 and 7.3 times higher than that of S-c_(3)N_(4)and c-TiO_(2),*** superior performance is attributed to the synergy between cu doping and the Z-scheme heterojunction,which not only enhances the interfacial electric field effect,facilitating charge separation,but also boosts the redox *** charge carrier transfer between cu/c-TiO_(2)and S-c_(3)N_(4)follows a Z-scheme,as verified by trapping experiments,electron spin-resonance spectroscopy,and density functional theory ***,the tetracycline hydrochloride degradation pathways are enunciated by liquid chromatograph mass spectrometry *** work provides an effective approach for constructing high-performance photocatalysts that have potential in environmental remediation.

关键词： photocatalysis cu doping Z-scheme heterojunction electrons and holes separation tetracycline degradation

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Responses of growth performance,antioxidant function,small intestinal morphology and mRNA expression of jejunal tight junction protein to dietary iron in yellow-feathered broilers

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Journal of Integrative Agriculture 2024年第4期23卷 1329-1337页

作者： Kaiwen Lei Hao wu Jerry w Spears Xi Lin Xi wang Xue Bai Yanling Huang Key Laboratory of Animal Science of State Ethnic Affairs commission Southwest Minzu UniversityChengdu 610041China Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization Southwest Minzu UniversityChengdu 610041China Department of Animal Science North Carolina State UniversityRaleighNC 27695-7621USA

This study aimed to investigate the dose-effect of iron on growth performance,antioxidant *** morphology,and mRNA expression of jejunal tight junction protein in 1-to21-d-old yellow-feathered broilers.A total of 7201-d-old yellow-feathered maleb roilers were allocated to 9 treatments with 8 replicate cages of 10 birds per *** dietary treatments were consisted of a basal diet(contained 79.6 mg Fe kg^(-1))supplemented with 0,20,40,60,80,160,320,640,and 1,280 mg Fe kg^(-1)in the form of FeSO_(4)·7H_(2)*** with the birds in the control group,birds supplemented with 20mg Fe kg^(-1)had higher average daily gain(ADG)(Pcantly decreased ADG(Pcompared with supplementation of 20mg Fe kg^(-1).Malondialdehyde(MDA)concentration in plasma and duodenum increased linearly(Pconcentration in liver and jejunum increased linearly(Pcally(Pwith increased dietary Fe *** villus height(VH)in duodenum and jejunum,and the ratio of villus height to crypt depth(V/c)in duodenum decreased linearly(P?0.05)as dietary *** dietary Fe increased,the jejunal relative mRNA abundance of claudin-1 decreased linearly(P=0.001),but the jejunal relative mRNA abundance of zona occludens-1(ZO-1)and occludin decreased linearly(P?0.05)or quadratically(P?0.05).compared with the supplementation of 20 mg Fe kg^(-1),the supplementation of640 mg Fe kg^(-1)or higher increased(P?0.05)MDA concentrations in plasma,duodenum,and jejunum,decreased VH in the duodenum and jejunum,and the addition of 1,280 mg Fe kg^(-1)reduced(P?0.05)the jejunal tight junction protein(claudin-1,ZO-1,occludin)mRNA *** summary,640 mg of supplemental Fe kg^(-1)or greater was associated with decreased growth performance,increased oxidative stress,disrupted intestinal morphology,and reduced mRNA expression of jejunal tight junction protein.

关键词： iron yellow-feathered broiler antioxidant function intestinal morphology tight junction protein

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weakly Supervised Object Localization with Background Suppression Erasing for Art Authentication and copyright Protection

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Machine Intelligence Research 2024年第1期21卷 89-103页

作者： chaojie wu Mingyang Li Ying Gao Xinyan Xie wing w.Y.Ng Ahmad Musyafa School of computer Science and Engineering South China University of TechnologyGuangzhou 511442China Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application Guangdong Provincial People's HospitalGuangzhou 510180China

The problem of art forgery and infringement is becoming increasingly prominent,since diverse self-media contents with all kinds of art pieces are released on the Internet every *** art paintings,object detection and localization provide an efficient and ef-fective means of art authentication and copyright ***,the acquisition of a precise detector requires large amounts of ex-pensive pixel-level *** alleviate this,we propose a novel weakly supervised object localization(wSOL)with background su-perposition erasing(BSE),which recognizes objects with inexpensive image-level ***,integrated adversarial erasing(IAE)for vanilla convolutional neural network(cNN)dropouts the most discriminative region by leveraging high-level semantic ***,a background suppression module(BSM)limits the activation area of the IAE to the object region through a self-guidance ***,in the inference phase,we utilize the refined importance map(RIM)of middle features to obtain class-agnostic loc-alization *** experiments are conducted on paintings,cUB-200-2011 and ILSVRc to validate the effectiveness of our BSE.

关键词： weakly supervised object localization erasing method deep learning computer vision art authentication and copyright protection

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Management of monogenic diabetes in pregnancy:A narrative review

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world Journal of Diabetes 2024年第1期15卷 15-23页

作者： Mohammad Sadiq Jeeyavudeen Sarah R Murray Mark w J Strachan Metabolic Unit Western General HospitalEdinburgh EH42XUUnited Kingdom MRc centre for Reproductive Health University of Edinburgh Queen’s Medical Research InstituteEdinburgh EH164TJUnited Kingdom

Pregnancy in women with monogenic diabetes is potentially complex,with significant implications for both maternal and fetal *** these,maturity-onset diabetes of the young(MODY)stands out as a prevalent monogenic diabetes subtype frequently encountered in clinical *** subtype of MODY requires a distinct approach tailored to the pregnancy,diverging from management strategies in non-pregnant *** MODY(GcK-MODY)typically does not require treatment outside of pregnancy,but special considerations arise when a woman with GcK-MODY becomes *** glycemic targets in GcK-MODY pregnancies are not exclusively dictated by the maternal/paternal MODY genotype but are also influenced by the genotype of the developing *** pregnancy,the choice between sulfonylurea or insulin for treating hepatocyte nuclear factor 1-alpha(HNF1A)-MODY and HNF4A-MODY depends on the mother’s specific circumstances and the available *** of other rarer MODY subtypes is individu-alized,with decisions made on a case-by-case ***,a collaborative approach involving expert diabetes and obstetric teams is crucial for the compre-hensive management of MODY pregnancies.

关键词： Diabetes Pregnancy Maturity-onset diabetes of the young Insulin Sulphonylurea Glucokinase Hepatocyte nuclear factor 1-alpha,hepatocyte nuclear factor 1-beta,and hepatocyte nuclear factor 4-alpha

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Research on Defect Detection ofwind Turbine Blades Based onMorphology and Improved Otsu Algorithm Using Infrared Images

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computers, Materials and continua 2024年第1期81卷 933-949页

作者： Kang S. He Y. Li w. Liu S. School of Mechanical and control Engineering Baicheng Normal University Baicheng 137000 China School of Information and control Engineering Jilin Institute of Chemical Technology Jilin 132022 China

To address the issues of low accuracy and high false positive rate in traditional Otsu algorithm for defect detection on infrared images of wind turbine blades (wTB), this paper proposes a technique that combines morphological image enhancement with an improved Otsu algorithm. First, mathematical morphology's differential multi-scale white and black top-hat operations are applied to enhance the image. The algorithm employs entropy as the objective function to guide the iteration process of image enhancement, selecting appropriate structural element scales to execute differential multi-scale white and black top-hat transformations, effectively enhancing the detail features of defect regions and improving the contrast between defects and background. Afterwards, grayscale inversion is performed on the enhanced infrared defect image to better adapt to the improved Otsu algorithm. Finally, by introducing a parameter K to adjust the calculation of inter-class variance in theOtsumethod, theweight of the target pixels is increased. combined with the adaptive iterative threshold algorithm, the threshold selection process is further fine-tuned. Experimental results show that compared to traditional Otsu algorithms and other improvements, the proposed method has significant advantages in terms of defect detection accuracy and reducing false positive rates. The average defect detection rate approaches 1, and the average Hausdorff distance decreases to 0.825, indicating strong robustness and accuracy of the method. © 2024 The Authors.

关键词： adaptive iterative thresholding grayscale inversion improved Otsu algorithm infrared image Morphological enhancement

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Outcome prediction after resection of colorectal cancer liver metastases: out with the old, in with the new?

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 732-735页

作者： Iakovos Amygdalos Daniel Truhn Florian w.R.Vondran Department of General VisceralPediatric and Transplantation SurgeryUniversity Hospital RWTH AachenAachenGermany Department of Diagnostic and Interventional Radiology University Hospital RWTH AachenAachenGermany

colorectal cancer remains one of the commonest and most lethal malignancies worldwide(1).Up to 80%of patients with colorectal cancer develop liver metastases(cRLM),which are the main factor limiting survival(1,2).Despite advances in systemic therapy and the emergence of multimodal treatment concepts,curative surgical resection remains the best therapeutic option and provides the highest chance of long-term survival(1,2).However,liver resection is associated with perioperative morbidity and mortality,while multiple factors affect long-term prognosis(3,4).As a result,various predictive models have been developed over time,to improve preoperative patient selection and foresee unfavourable outcomes.

关键词： Machine learning(ML) artificial intelligence(AI) colorectal liver metastases hepatobiliary

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In situ apatite and carbonate Lu-Hf and molybdenite Re-Os geochronology for ore deposit research:Method validation and example application to cu-Au mineralisation

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Geoscience Frontiers 2024年第5期15卷 339-354页

作者： Alexander Simpson Stijn Glorie Martin Hand Sarah E.Gilbert carl Spandler Marija Dmitrijeva Greg Swain Angus nixon Jacob Mulder carsten Münker Department of Earth Sciences University of AdelaideSA 5005Australia Mineral Exploration cooperative Research centre University of AdelaideSA 5005Australia Adelaide Microscopy University of AdelaideSA 5005Australia Fortescue Level 287Adelaide TerraceEast PerthWA 6005Australia Institute of Geology und Mineralogy University of Köln50674 KölnGermany British Geological Survey NottinghamUK

The development of laser ablation inductively coupled plasma quadrupole tandem mass spectrometry(LA-IcP-Q-MS/MS)opens new opportunities to rapidly date a variety of hydrothermal *** we present in situ Lu-Hf and Re-Os dates for hydrothermal apatite and molybdenite,*** further report the first in situ Lu-Hf dates for bastnäsite,dolomite,and siderite,and assess their potential for constraining ore deposit *** method validation,we report isotope-dilution Lu-Hf dates for apatite reference material Bamble-1(1102±5 Ma)and calcite reference material ME-1(1531±7 Ma),enabling improved accuracy on matrix-matched calibration for LA-IcP-MS/MS Lu-Hf *** new methods are applied to the Vulcan Iron-Oxide copper-Gold(IOcG)prospect in the Olympic cu-Au Province of South *** deposits have been difficult to accurately date,given the general lack of reliable mineral geochronometers that are cogenetic with IOcG *** apatite Lu-Hf dates and molybdenite Re-Os dates demonstrate that mineralisation at Vulcan largely occurred at ca.1.6 Ga,contemporaneous with the world class Olympic Dam *** data also indicates that the Lu-Hf system in apatite is more robust than the U-Pb system for determining the timing of primary apatite formation in an IOcG *** further demonstrate that dolomite can retain Lu-Hf growth ages over an extended time period(>1.5 billion years),providing constraints on the timing of primary ore mineral crystallisation during brecciation and IOcG ***,late Neoproterozoic(ca.589–544 Ma)and carboniferous(ca.334±7 Ma)Lu-Hf dates were obtained for texturally late cubearing carbonate veins,illustrating that the carbonate Lu-Hf method allows direct dating of cu remobilisation *** has important implications for mineral exploration as the remobilised cu may have been transferred to younger deposits hosted in Neoproterozoic sedimentary basins overlaying the Olympic IOcG provi

关键词： Reaction-cell IcP-MS In-situ geochronology Lu-Hf Re-Os Iron Oxide copper Gold Metal fluids

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Exploring impacts of cOVID-19 on spatial and temporal patterns of visitors to canadian Rocky Mountain National Parks from social media big data

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Journal of Forestry Research 2024年第4期35卷 13-33页

作者： Dehui christina Geng Amy Li Jieyu Zhang Howie w.Harshaw christopher Gaston wanli wu Guangyu wang National Park Research centre Faculty of ForestryUniversity of British ColumbiaVancouver V6T 1Z4Canada Faculty of Applied Science University of British ColumbiaVancouver V6T 1Z3Canada Paul G.Allen School of computer Science&Engineering University of WashingtonSeattleWA 98195USA Faculty of Kinesiology Sportand RecreationUniversity of AlbertaEdmonton T6G 2J9Canada Department of wood Science Faculty of ForestryUniversity of British ColumbiaVancouver V6T 1Z4Canada

cOVID-19 posed challenges for global tourism *** in visitor temporal and spatial patterns and their associated determinants pre-and peri-pandemic in canadian Rocky Mountain National Parks are *** was collected through social media programming and analyzed using spatiotemporal analysis and a geographically weighted regression(GwR)*** highlight that cOVID-19 significantly changed park visitation *** tended to explore more remote areas *** GwR model also indicated distance to nearby trails was a significant influence on visitor *** results indicate that the pandemic influenced tourism temporal and spatial *** research presents a novel approach using combined social media big data which can be extended to the field of tourism management,and has important implications to manage visitor patterns and to allocate resources efficiently to satisfy multiple objectives of park management.

关键词： Tourism management Social media big data National parks cOVID-19 Geographical weighted regression

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