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0.2%溴莫尼定、0.15%乌诺前列酮分别加入0.5%马来酸噻吗洛尔眼液2次/d治疗原发性开角型青光眼或高眼压症

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世界核心医学期刊文摘（眼科学分册） 2005年第6期1卷 34-35页

作者： Sharpe E.D. Henry c.J. Mundorf T.K. w.c. stewart 郭长梅 Pharmaceutical Research Network LLC 1639 Tatum Street Charleston SC 29412- 2464 United States

Purpose. To compare the efficacy and safety of brimonidine 0.2% vs unoprostone 0.15% , both added to timolol maleate 0.5% each given tw.c. daily. Methods. In this prospective, multi-centred, double-masked, crossover comparison, patients were randomized to one treatment group for a 6- week treatment period, and then crossed over to the opposite treatment. Measurements were performed at 0800, 1000, 1600, 1800, and 2000 h at baseline and at the end of each treatment period. Results. In all,33 patients entered this trial and 29 completed. The baseline trough intraocular pressure (IOP) was 23.3± 2.4 and the diurnal curve IOP was 22.0± 1.3mmHg. For the brimonidine and timolol maleate treatment group, the trough IOP was 21.6± 3.3 and the diurnal curve IOPwas 19.8± 2.1mmHg,while the timolol and unoprostone treatment showed a trough IOP of 20.9± 3.8 and a diurnal curve IOP of 19.3± 2.4 mmHg. There was no significant difference between treatment groups at any time point for the diurnal curve,or in the reduction from baseline (P >0.05). Both treatments failed to statistically reduce the IOP from baseline at 1800h. There was no difference between treatment groups regarding ocular and systemic unsolicited adverse events, but patients admitted to more dryness (P=0.02) and burning upon instillation (Pwith unoprostone by survey. conclusion. Brimonidine 0.2% or unoprostone 0.15% added to timolol maleate 0.5% provide similar efficacy and safety throughout the daytime diurnal curve.

关键词：高眼压症马来酸噻吗洛尔乌诺眼压值莫尼眼内压感觉点上均

0.005%拉坦前列素与0.03%比马前列素治疗原发性开角型青光眼的疗效评比

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世界核心医学期刊文摘（眼科学分册） 2005年第7期1卷 36-37页

作者： Konstas A.G.P. Katsimbris J.M. Lallos N. w.c. stewart 杨秀梅 Pharmaceutical Research Network LLC 1 Southpark Circle Charleston SC 29407 United States

Objective: To evaluate latanoprost versus bimatoprost given each evening over the 24- hour diurnal curve. Design: Double- masked, 2- center, crossover comparison. Participants: Forty- two of 44 patients with primary open- angle glaucoma (POAG) completed the study. Methods: consecutive patients were not treated during a baseline 24- hour curve after a glaucoma medicine- free period. They then were randomized to either latanoprost or bimatoprost for a 7- week treatment period. Diurnal curve intraocular pressures (IOPs) were measured at treatment period end at 2 AM, 6 AM, 10 AM, 2 PM, 6 PM, and 10 PM. After the first treatment period, patients were changed to the opposite medicine without a medicine- free period. Diurnal curve measurements were performed again at the end of the second 7- week treatment period. Main Outcome Measure: The 24- hour diurnal IOP. Results: On the last day of treatment, mean 24- hour IOPs were 17.3± 2.8 mmHg for latanoprost and 16.7± 2.4 mmHg for bimatoprost (P=0.01). The 6 PM individual time point for IOP was statistically lower for bimatoprost after a Bonferroni correction (P=0.008). The largest IOP difference at any time point was 0.9 mmHg at 6 PM. The most common side effect was conjunctival hyperemia, which occurred less with latanoprost (n=6) than with bimatoprost (n= 15) (P=0.004). Two patients had their treatments discontinued while on bimatoprost, one due to conjunctival hyperemia and the other due to ocular intolerance. conclusion: This study indicates that the 24- hour diurnal IOP is statistically lower in POAG with bimatoprost, compared with latanoprost, among patients who tolerated bimatoprost. However, the IOP difference between groups was small and may not be clinically meaningful. In contrast, conjunctival hyperemia seems statistically greater with bimatoprost. The exact clinical importance of conjunctival hyperemia, if any, needs to be clarified further.

关键词：比马前列素拉坦抗青光眼药物结膜充血停药期基线测量测量时间最后一天

Learning about good nutrition with the 5-color front-of-package label"Nutri-Score":an experimental study

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Food Science and Human wellness 2024年第3期13卷 1195-1200页

作者： Robin c.Hau Klaus w.Lange University of Applied Sciences Landshut Landshut 84036Germany Faculty of Human Sciences University of RegensburgRegensburg 93040Germany

The Nutri-Score is a 5-color front-of-pack nutrition label designed to provide consumers with an easily understandable guideline to the healthiness of food *** impact that the Nutri-Score may have on consumers'choices is unclear since different experimental paradigms have found vastly different effect *** the present study,we have investigated how student participants change a hypothetical personal 1-daydietary plan after a learning phase during which they learn about the Nutri-Scores of the available food *** were instructed to compose a healthy diet plan in order that the question of whether the NutriScore would improve their ability to compose a healthy dietary plan could be investigated,independent of the question of whether they would apply this knowledge in their ordinary *** found a substantial(cohen's d=0.86)positive impact on nutritional quality(as measured by the Nutrient Profiling System score of the Food Standards Agency)and a medium-sized(cohen's d=0.43)reduction of energy *** content reduction was larger for participants who had initially composed plans with higher energy *** results suggest that the Nutri-Score has the potential to guide consumers to healthier food *** remains unclear,however,whether this potential will be reflected in real-life dietary choices.

关键词： Nutri-Score Front-of-package label Nudge Nutrition Health

Elevated brain temperature under severe heat exposure impairs cortical motor activity and executive function

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Journal of Sport and Health Science 2024年第2期13卷 233-244页

作者： Xiang Ren Tan Mary c.Stephenson Sharifah Badriyah Alhadad Kelvin w.Z.Loh Tuck wah Soong Jason K.w.Lee Ivan c.c.Low Health and Social Sciences Singapore Institute of TechnologySingapore 138683Singapore Human Potential Translational Research Programme Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117597Singapore centre for Translational Magnetic Resonance Research Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117549Singapore Department of Physiology Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117593Singapore Heat Resilience and Performance centre Yong Loo Lin School of MedicineNational University of SingaporeSingapore 117510Singapore N.1 Institute for Health National University of SingaporeSingapore 117456Singapore campus for Research Excellence and Technological Enterprise(cREATE) Singapore 138602Singapore

Background:Excessive heat exposure can lead to hyperthermia in humans,which impairs physical performance and disrupts cognitive *** heat is a known physiological stressor,it is unclear how severe heat stress affects brain physiology and ***:Eleven healthy participants were subjected to heat stress from prolonged exercise or warm water immersion until their rectal temperatures(T_(re))attained 39.5℃,inducing exertional or passive hyperthermia,*** a separate trial,blended ice was ingested before and during exercise as a cooling *** were compared to a control condition with seated rest(normothermic).Brain temperature(T_(br)),cerebral perfusion,and task-based brain activity were assessed using magnetic resonance imaging ***:T_(br)in motor cortex was found to be tightly regulated at rest(37.3℃±0.4℃(mean±SD))despite fluctuations in T_(re).with the development of hyperthermia,T_(br)increases and dovetails with the rising T_(re).Bilateral motor cortical activity was suppressed during high-intensity plantarflexion tasks,implying a reduced central motor drive in hyperthermic participants(T_(re)=38.5℃±0.1℃).Global gray matter perfusion and regional perfusion in sensorimotor cortex were reduced with passive *** function was poorer under a passive hyperthermic state,and this could relate to compromised visual processing as indicated by the reduced activation of left lateral-occipital ***,ingestion of blended ice before and during exercise alleviated the rise in both T_(re)and T_(bc)and mitigated heat-related neural ***:Severe heat exposure elevates T_(br),disrupts motor cortical activity and executive function,and this can lead to impairment of physical and cognitive performance.

关键词： Brain functional activity cognition Heat stress Hyperthermia Motor function

Integrins and their potential roles in mammalian pregnancy

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Journal of Animal Science and Biotechnology 2024年第1期15卷 1-19页

作者： Gregory A.Johnson Robert c.Burghardt Fuller w.Bazer Heewon Seo Joe w.c.in Department of Veterinary Integrative Biosciences School of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityCollege StationTX 77843‑4459USA Department of Animal Science College of Agriculture and Life SciencesTexas A&M UniversityCollege StationTX 77843‑2471USA

Integrins are a highly complex family of receptors that, when expressed on the surface of cells, can mediate reciprocal cell-to-cell and cell-to-extracellular matrix(EcM) interactions leading to assembly of integrin adhesion complexes(IAcs) that initiate many signaling functions both at the membrane and deeper within the cytoplasm to coordinate processes including cell adhesion, migration, proliferation, survival, differentiation, and metabolism. All metazoan organisms possess integrins, and it is generally agreed that integrins were associated with the evolution of multicellularity, being essential for the association of cells with their neighbors and surroundings, during embryonic development and many aspects of cellular and molecular biology. Integrins have important roles in many aspects of embryonic development, normal physiology, and disease processes with a multitude of functions discovered and elucidated for integrins that directly influence many areas of biology and medicine, including mammalian pregnancy, in particular implantation of the blastocyst to the uterine wall, subsequent placentation and conceptus(embryo/fetus and associated placental membranes) development. This review provides a succinct overview of integrin structure, ligand binding, and signaling followed with a concise overview of embryonic development, implantation, and early placentation in pigs, sheep, humans, and mice as an example for rodents. A brief timeline of the initial localization of integrin subunits to the uterine luminal epithelium(LE) and conceptus trophoblast is then presented, followed by sequential summaries of integrin expression and function during gestation in pigs, sheep, humans, and rodents. As appropriate for this journal, summaries of integrin expression and function during gestation in pigs and sheep are in depth, whereas summaries for humans and rodents are brief. Because similar models to those illustrated in Fig. 1, 2, 3, 4, 5 and 6 are present throughout the sc

关键词： Humans Implantation Integrins Pigs Pregnancy Rodents Sheep

Experimental study of corner separation and unsteady characteristics in linear compressor cascades with and without sweeping jet actuator

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Propulsion and Power Research 2024年第3期13卷 360-374页

作者： S.w.c.en w.H.Li c.Xu Q.H.Meng School of Energy Science and Engineering Harbin Institute of TechnologyHarbinHeilongjiang 150001China AVIc Shenyang Aircraft Design and Research Institute Shenyang 110035China

Sweeping jet actuator(SJA)has been widely applied for activeflow.c.ntrol in *** this paper,the SJA character in compressor cascade and its performance for separation control in innerflows are ***-averaged and transientflowfield measurement,together with visualization methods are *** is found that endwall effects are important for both SJA behaviors and SJA performance for separation control in compressor *** is a maximum of 12.7%total pressure loss reduction with SJA placed near the separation position,close to the endwall and under *** characteristic frequencies in theflowfield contribute to the capture of influence regions of vortices and excitation *** concentrated shedding vortices and SJA jets impact region helped to judge that SJA energizes low momentumfluids in a large region and matches the high loss core *** be concrete,theflow separation control mechanism of SJA lies on the interruption of the blade suction surface boundary layer development and the restriction of the lifting of the boundary layer from end-wall towards blade suction surface.

关键词： compressor cascade Activeflow.c.ntrol Sweeping jet actuator corner separation Oilflow visualization

Effects of dust controls on respirable coal mine dust composition and particle sizes:case studies on auxiliary scrubbers and canopy air curtain

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International Journal of coal Science & Technology 2024年第3期11卷 86-101页

作者： F.Animah c.Keles w.R.Reed E.Sarver Department of Mining and Minerals Engineering Virginia Polytechnic Institute&State UniversityBlacksburgVAUSA National Institute of Occupational Safety and Health(NIOSH) PittsburghPAUSA

control of dust in underground coal mines is critical for mitigating both safety and health *** decades,the National Institute of Occupational Safety and Health(NIOSH)has led research to evaluate the effectiveness of various dust control technologies in coal *** studies have included the evaluation of auxiliary scrubbers to reduce respirable dust downstream of active mining and the use of canopy air curtains(cAcs)to reduce respirable dust in key operator *** detailed dust characterization was not a focus of such studies,this is a growing area of *** preserved filter samples from three previous NIOSH studies,the current work aims to explore the effect of two different scrubbers(one wet and one dry)and a roof bolter cAc on respirable dust composition and particle size *** this,the preserved filter samples were analyzed by thermogravimetric analysis and/or scanning electron microscopy with energy dispersive *** indicate that dust composition was not appreciably affected by either scrubber or the ***,the wet scrubber and cAc appeared to decrease the overall particle size *** an effect of the dry scrubber was not consistently observed,but this is probably related to the particular sampling location downstream of the scrubber which allowed for significant mixing of the scrubber exhaust and other return *** from the insights gained with respect to the three specific dust control case studies revisited here,this work demonstrates the value of preserved dust samples for follow-up investigation more broadly.

关键词： Respirable dust Dust control SEM–EDX Scrubber canopy air curtain Silica

Mineral-mediated stability of organic carbon in soil and relevant interaction mechanisms

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Eco-Environment & Health 2024年第1期3卷 59-76页

作者： Zibo Xu Daniel c.w.Tsang Department of civil and Environmental Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Department of civil and Environmental Engineering The Hong Kong University of Science and TechnologyClear Water BayHong KongChina

Soil,the largest terrestrial carbon reservoir,is central to climate change and relevant feedback to environmental *** are the essential components that contribute to over 60%of soil carbon ***,how the interactions between minerals and organic carbon shape the carbon transformation and stability remains poorly ***,we critically review the primary interactions between organic carbon and soil minerals and the relevant mechanisms,including sorption,redox reaction,co-precipitation,dissolution,polymerization,and catalytic *** interactions,highly complex with the combination of multiple processes,greatly affect the stability of organic carbon through the following processes:(1)formation or deconstruction of the mineral–organic carbon association;(2)oxidative transformation of the organic carbon with minerals;(3)catalytic polymerization of organic carbon with minerals;and(4)varying association stability of organic carbon according to the mineral *** pieces of evidence related to the carbon turnover and stability during the interaction with soil minerals in the real eco-environment are then *** also highlight the current research gaps and outline research priorities,which may map future directions for a deeper mechanismsbased understanding of the soil carbon storage capacity considering its interactions with minerals.

关键词： carbon stability Mineral transformation carbon sequestration Bio-geochemistry Soil carbon management Sustainable waste management

Important step towards an understanding of the exotic Z_(c)(3900)

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Science china(Physics,Mechanics & Astronomy) 2024年第9期67卷 199-200页

作者： c.Hanhart Institute for Advanced Simulation Forschungszentrum JulichJilich D-52425Germany

The Standard Model of particle physics,which contains the field theories for the electro-weak interaction(QED)and the strong interaction(QcD),is an extremely successful theory describing a huge variety of phenomena at... 详细信息

关键词： interaction atomic describing