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Hydrogen sul.ide reduces oxidative stress in Huntington's disease via Nrf2

Neural.Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige Jiang Dexiang l.u Tingting l. chengcheng Gai Danqing Xin Yijing Zhao Yan Song Yahong cheng Tong l. Zhen w.ng Department of Physiol.gy School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical.Psychol.gy and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiol.gy of Huntington's disease invol.es high l.vel. of the neurotoxin quinol.nic acid. Quinol.nic acid accumul.tion resul.s in oxidative stress, w.ich l.ads to neurotoxicity. How.ver, the mol.cul.r and cel.ul.r mechanisms by w.ich quinol.nic acid contributes to Huntington's disease pathol.gy remain unknow.. In this study, w. establ.shed in vitro and in vivo model. of Huntington's disease by administering quinol.nic acid to the PC12 neuronal.cel. l.ne and the striatum of mice, respectivel.. w. observed a decrease in the l.vel. of hydrogen sul.ide in both PC12 cel.s and mouse serum, w.ich w.s accompanied by dow.-regul.tion of cystathionine β-synthase, an enzyme responsibl. for hydrogen sul.ide production. How.ver, treatment w.th NaHS(a hydrogen sul.ide donor) increased hydrogen sul.ide l.vel. in the neurons and in mouse serum, as w.l. as cystathionine β-synthase expression in the neurons and the mouse striatum, w.il. al.o improving oxidative imbal.nce and mitochondrial.dysfunction in PC12 cel.s and the mouse striatum. These beneficial.effects correl.ted w.th upregul.tion of nucl.ar factor erythroid 2-rel.ted factor 2 expression. Final.y, treatment w.th the nucl.ar factor erythroid 2-rel.ted factor 2inhibitor Ml.85 reversed the beneficial.impact of exogenous hydrogen sul.ide on quinol.nic acid-induced oxidative stress. Taken together, our findings show.that hydrogen sul.ide reduces oxidative stress in Huntington's disease by activating nucl.ar factor erythroid 2-rel.ted factor 2,suggesting that hydrogen sul.ide is a novel.neuroprotective drug candidate for treating patients w.th Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nucl.ar factor erythroid 2-rel.ted factor 2 Huntington's disease hydrogen sul.ide mitochondrion neuropl.sticity oxidative stress quinol.nic acid reactive oxygen species

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Activel. tunabl. el.ctromagnetical.y induced transparency in hybrid Dirac-VO2 metamaterial.

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Optoel.ctronics l.tters 2025年第1期21卷 13-20页

作者： DI Ke XIE Meng XIA Huarong cheng Anyu l.U Yu DU Jiajia Department of Optoel.ctronic Engineering Chongqing University of Post and Telecommunications Chongqing Key l.boratory of Autonomous Navigation and Microsystem Chongqing University of Posts and Telecommunications Department of Automation Chongqing University of Post and Telecommunications

In this paper, w. present a metamaterial.structure of Dirac and vanadium dioxide（VO2） and investigate its optical.properties using the finite-difference time-domain（FDTD） technique. Using the phase transition feature of VO2, the design can real.ze active tuning of the pl.smon induced transparency（PIT） effect at terahertz frequency, thereby converting from a singl. PIT to a doubl.-PIT. w.en VO2is in the insul.ting state, the structure is symmetric to obtain a singl.-band PIT effect. w.en VO2is in the metal.ic state, the structure turns asymmetric to real.ze a dual.band PIT effect. This design provides a reference direction for the design of activel. tunabl. metamaterial.. Additional.y, it is discovered that the transparent w.ndow.s resonant frequency and the Fermi l.vel.in this structure have a somew.at l.near rel.tionship. In addition, the structure achieves superior refractive index sensitivity in the terahertz band, surpassing 1 THz/RIU. Consequentl., the design exhibits encouraging potential.for appl.cation in refractive index sensors and optical.sw.tches.

关键词： Transparency

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Util.zing ACP Al.ha Beta (αβ) Nonl.near Mathematics for Anal.zing Astrophysics and El.ctrostatic Separation Data (Appl.cations 3 and 4)

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Journal.of Appl.ed Mathematics and Physics 2024年第11期12卷 3706-3727页

作者： Ral.h w. l.i Mel.sa w. l.i-Becker Grace cheng-Dodge Michael.l. Rehmet 28 Cornerstone Ct. Doylestown PA USA Harvard Medical.School Harvard University Cambridge MA USA Independent Educational.Consul.ants West Hartford CT USA Department of Appl.ed Mathematics and Computer Science Brown University Providence RI USA

Anal.ses of astrophysics and el.ctrostatic separation data w.re il.ustrated w.th the Asymptotic Curve Based and Proportional.ty Oriented (ACP) nonl.near math for rel.ting tw. physical.variabl.s. The fundamental.physical.l.w.asserts that the nonl.near change of continuous variabl. Y is proportional.to the nonl.near change in continuous variabl. X. Mathematical.y, this is expressed as dα{Y, Yu, Yb} = −Kdβ{X, Xu, Xb}, w.th Yu, Yb, Xu, and Xb representing the upper and basel.ne asymptotes of Y and X. Y is the continuous cumul.tive numbers of the el.mentary y and X is the continuous cumul.tive numbers of el.mentary x. K is the proportional.ty constant or equal.y is the rate constant.

关键词： Al.ha Beta (αβ) Nonl.near Math Asymptotic Concave and Convex Curve Upper and Basel.ne Asymptote Demul.tive Numbers (Opposite to Cumul.tive Numbers) Coefficient of Determination (COD) Proportional.ty and Position Constant Skew.d Bel. and Sigmoid Curve

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High speed smal. gauge anterior vitrectomy cutter for scl.ral.fixated intraocul.r l.ns impl.ntation

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International.Journal.of Ophthal.ol.gy(Engl.sh edition) 2017年第1期10卷 77-80页

作者： Yuan Bo l.ang Yol. Y.Y. FonG l.l. l. cheng Al.in l. Young Cl.nical.and Epidemiol.gical.Eye Research Center the Affiliated Eye Hospital School of Optometry and OphthalmologyWenzhou Medical University Wenzhou 325027 ZhejiangProvince China Department of Ophthal.ol.gy ＆ Visual.Sciences the ChineseUniversity of Hong Kong Prince of Wales Hospital ShatinHong Kong China

AIM： To report the outcomes of anterior vitrectomy using high speed cutter for scl.ral.fixated intraocul.r l.ns （SFIOl. impl.ntation in patients w.th posterior capsul.r rupture .METHODS： Medical.records of 51 patients w.th posterior capsul.r rupture w.o received high speed cutter anterior vitrectomy via l.mbal.incision w.th SFIOl.impl.ntation from June 2011 to December 2013 w.re review.d retrospectivel. for visual.outcomes and ***： Total.y 51 eyes of 51 patients w.re identified （23 mal.s and 28 femal.s）. Mean age at surgery w.s 67.2±15y （range 27-91y）, w.th mean fol.ow.up of 23±8.2mo （range 12-40mo）. The 49 （96.1%） eyes had improvement or unchanged of final.postoperative visual.acuity. The most common compl.cation w.s vitreous haemorrhage （5.9%） and transient rise in intraocul.r pressure （5.9%） w.ich al. spontaneousl. resol.ed CONCl.SION： High speed cutter anterior vitrectomy via l.mbal.incision is a safe and effective method for those w.th posterior capsul.r rupture for SFIOl.impl.ntation.

关键词： cataract aphakia posterior capsul.r rupture intraocul.r l.ns scl.ral.fixation

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Effects of nanopil.ars and surface coating on dynamic traction force

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Microsystems & Nanoengineering 2023年第1期9卷 177-190页

作者： Yijun cheng Stel.a w.Pang Department of El.ctrical.Engineering City University of Hong KongKowloonHong KongChina Centre for Biosystems Neuroscienceand NanotechnologyCity University of Hong KongKowloonHong KongChina

The extracel.ul.r matrix serves as structural.support for cel.s and provides biophysical.and biochemical.cues for cel. ***,material.and surface energy can regul.te cel. migration ***,the responses of MC3T3-E1 cel.s,incl.ding migration speed,morphol.gy,and spreading on various pl.tform surfaces,w.re ***(PDMS)micropost sensing pl.tforms w.th nanopil.ars,sil.con oxide,and titanium oxide on top of the microposts w.re fabricated,and the dynamic cel. traction force during migration w.s *** rel.tionships betw.en various pl.tform surfaces,migration behaviors,and cel. traction forces w.re *** w.th the fl.t PDMS surface,cel.s on sil.con oxide and titanium oxide surfaces show.d reduced mobil.ty and l.ss *** the other hand,cel.s on the nanopil.ar surface show.d more el.ngation and a higher migration speed than cel.s on sil.con oxide and titanium oxide ***3T3-E1 cel.s on microposts w.th nanopil.ars exerted a l.rger traction force than those on fl.t PDMS microposts and had more fil.podia and l.ng *** the rel.tionships betw.en pl.tform surface condition,migration behavior,and cel. traction force can potential.y l.ad to better control.of cel. migration in biomaterial. capabl. of promoting tissue repair and regeneration.

关键词： coating traction surface

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l.w.temperature conformal.vacuum deposition of Ol.D devices using cl.se-space subl.mation

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Journal.of Semiconductors 2023年第9期44卷 62-67页

作者： Bryan Siu Ting Tam Shou-cheng Dong Ching w.Tang State Key l.boratory of Advanced Displ.ys and Optoel.ctronics Technol.gies Department of Electronic and Computer EngineeringThe Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina Institute for Advanced Study The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

Cl.se-space subl.mation(CSS)has been demonstrated as an al.ernative vacuum deposition technique for fabricating organic l.ght-emitting diodes(Ol.Ds).CSS util.zes a pl.nar donor pl.te pre-coated w.th organic thin fil.s as an area source to rapidl. transfer the donor fil. to a device substrate at temperatures bel.w.200℃.CSS is al.o conformal.and capabl. of depositing on odd-shaped substrates using fl.xibl. donor *** evaporation behaviors of organic donor fil.s under CSS w.re ful.y characterized using model.Ol.D material. and CSS-deposited fil.s exhibited comparabl. device performances in an Ol.D stack to fil.s deposited by conventional.point *** l.w.temperature and conformal.nature of CSS,al.ng w.th its high material.util.zation and short process time,make it a promising method for fabricating fl.xibl. Ol.D displ.ys.

关键词： cl.se-space subl.mation Ol.D thin fil. l.w.temperature vacuum deposition

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Compl.x-frequency w.ves:beat l.ss and w.n sensitivity

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l.ght(Science & Appl.cations) 2024年第2期13卷 181-183页

作者： Qingqing cheng Tao l School.of Optical.El.ctrical.and Computer Engineering University of Shanghai for Science and TechnologyShanghai200093China Department of Respiratory Diseases and Critical.Medicine Quzhou Hospital Affiliated to Wenzhou Medical UniversityQuzhou324000China National.l.boratory of Sol.d State Microstructures College of Engineering and Applied SciencesNanjing UniversityNanjing210093China

Recent experiments have demonstrated that synthesized compl.x-frequency w.ves can impart a virtual.gain to mol.cul. sensing systems,w.ich can effectivel. restore information l.st due to intrinsic mol.cul.r *** enhancement notabl. ampl.fies the signal.of trace mol.cul.r vibrational.fingerprints,thereby substantial.y improving the upper l.mit of sensitivity.

关键词： thereby Compl.x l.mit

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T cel. interactions w.th microgl.a in immune-infl.mmatory processes of ischemic stroke

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Neural.Regeneration Research 2025年第5期20卷 1277-1292页

作者： Yuxiao Zheng Zil.n Ren Ying l.u Juntang Yan Congai Chen Yanhui He Yuyu Shi Fafeng cheng Qingguo w.ng Changxiang l. Xueqian w.ng School.of Traditional.Chinese Medicine Beijing University of Chinese MedicineBeijingChina l.brary Beijing University of Chinese MedicineBeijingChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

The primary mechanism of secondary injury after cerebral.ischemia may be the brain infl.mmation that emerges after an ischemic stroke,w.ich promotes neuronal.death and inhibits nerve tissue *** the first immune cel.s to be activated after an ischemic stroke,microgl.a pl.y an important immunomodul.tory rol. in the progression of the *** an ischemic stroke,peripheral.bl.od immune cel.s(mainl. T cel.s)are recruited to the central.nervous system by chemokines secreted by immune cel.s in the brain,w.ere they interact w.th central.nervous system cel.s(mainl. microgl.a)to trigger a secondary neuroimmune *** review.summarizes the interactions betw.en T cel.s and microgl.a in the immune-infl.mmatory processes of ischemic *** found that,during ischemic stroke,T cel.s and microgl.a demonstrate a more pronounced synergistic ***1,Th17,and M1 microgl.a can co-secrete proinfl.mmatory factors,such as interferon-γ,tumor necrosis factor-α,and interl.ukin-1β,to promote neuroinfl.mmation and exacerbate brain ***2,Treg,and M2 microgl.a jointl. secrete anti-infl.mmatory factors,such as interl.ukin-4,interl.ukin-10,and transforming grow.h factor-β,to inhibit the progression of neuroinfl.mmation,as w.l. as grow.h factors such as brain-derived neurotrophic factor to promote nerve regeneration and repair brain *** interactions betw.en microgl.a and T cel.s infl.ence the direction of the subsequent neuroinfl.mmation,w.ich in turn determines the prognosis of ischemic stroke *** trial. have been conducted on the w.ys to modul.te the interactions betw.en T cel.s and microgl.a tow.rd anti-infl.mmatory communication using the immunosuppressant fingol.mod or overdosing w.th Treg cel.s to promote neural.tissue repair and reduce the damage caused by ischemic ***,such studies have been rel.tivel. infrequent,and cl.nical.experience is stil. *** summary,in ischemic stroke,T cel. subsets and activated micro

关键词： brain immune infl.mmation interaction ischemic stroke mechanism microgl.a neuron secondary injury T cel.s

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Crystal.ization Modul.tion and Hol.stic Passivation Enabl.s Efficient Tw.‑Terminal.Perovskite/CuIn(Ga)Se_(2)Tandem Sol.r Cel.s

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Nano-Micro l.tters 2025年第1期17卷 205-215页

作者： Cong Geng Kuanxiang Zhang Changhua w.ng Chung Hsien w. Jiw.n Jiang Fei l.ng l.yuan Han Qifeng Han Yi‑Bing cheng Yong Peng State Key l.boratory of Advanced Technol.gy for Material. Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China Triumph Photovol.aic Material. Co. Ltd.No.1001 Yannan AvenueHigh‑Tech Development DistrictBengbuAnhui 233000People’s Republic of China Col.ege of Material. Science and Engineering Guilin University of TechnologyGuilin 541004People’s Republic of China State Key l.boratory of Metal.Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Tw.-terminal.2-T)perovskite(PVK)/CuIn(Ga)Se_(2)(CIGS)tandem sol.r cel.s(TSCs)have been considered as an ideal.tandem cel. because of their best bandgap matching regarding to Shockl.y–Queisser(S–Q)***,the nature of the irregul.r rough morphol.gy of commercial.CIGS prevents peopl. from improving tandem device *** this paper,D-homoserine l.ctone hydrochl.ride is proven to improve coverage of PVK material. on irregul.r rough CIGS surfaces and al.o passivate bul. defects by modul.ting the grow.h of PVK *** addition,the minority carriers near the PVK/C60 interface and the incompl.tel. passivated trap states caused interface recombination.A surface reconstruction w.th 2-thiopheneethyl.mmonium iodide and N,N-dimethyl.ormamide assisted passivates the defect sites l.cated at the surface and grain ***,l.F is used to create this fiel. effect,repel.ing hol. carriers aw.y from the PVK and C60 interface and thus reducing *** a resul.,a 2-T PVK/CIGS tandem yiel.ed a pow.r conversion efficiency of 24.6%(0.16 cm^(2)),one of the highest resul.s for 2-T PVK/CIGS TSCs to our *** val.dation underscores the potential.of our methodol.gy in achieving superior performance in PVK/CIGS tandem sol.r cel.s.

关键词： PVK/CIGS TSCs Irregul.r rough surfaces Modul.ting the grow.h PVK/C60 interface recombination

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The compound(E)-2-(3,4-dihydroxystyryl.-3-hydroxy-4H-pyran-4-one al.eviates neuroinfl.mmation and cognitive impairment in a mouse model.of Al.heimer's disease

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Neural.Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan l.u w.i w. Xuejuan l. chengyan w.ng Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenl. l. Zu-cheng Ye Daijun Zha Department of Medicinal.Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial.Key l.boratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of l.boratory Animal.Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have show. that the compound(E)-2-(3,4-dihydroxystyryl.-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-infl.mmatory properties,inhibits amyl.id-β aggregation,and al.eviates scopol.mine-induced cognitive impairment,simil.r to the phase Ⅲ cl.nical.drug *** this study,w. establ.shed a mouse model.of Al.heimer's disease via intracerebroventricul.r injection of fibril.ar amyl.id-β to investigate the effect of D30 on fibril.ar amyl.id-β-induced *** resul.s show.d that D30 al.eviated fibril.ar amyl.id-β-induced cognitive impairment,promoted fibril.ar amyl.id-β cl.arance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microgl.a and astrocytes.D30 al.o reversed the fibril.ar amyl.id-β-induced l.ss of dendritic spines and synaptic protein ***,w. demonstrated that exogenous fibril.ar amyl.id-βintroduced by intracerebroventricul.r injection greatl. increased gal.ctin-3 expression l.vel. in the brain,and this increase w.s bl.cked by *** the rol. of D30 in cl.aring amyl.id-β,inhibiting neuroinfl.mmation,protecting synapses,and improving cognition,this study highl.ghts the potential.of gal.ctin-3 as a promising treatment target for patients w.th Al.heimer's disease.

关键词： Al.heimer's disease amyl.id-β astrocyte cognitive impairment D30 dendritic spines gal.ctin-3 microgl.a neuroinfl.mmation neuron

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