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Multiple Antibiotic Resistance and Heavy Metal Resistance Profile of Bacteria Isolated from Giant Freshwater Prawn (Macrobrachium rosenbergii) Hatchery

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Agricultural Sciences in China 2009年第6期8卷 740-745页

作者： S w Lee M Najiah w wendy A Zahrol M Nadirah Department of Fishery and Aquaculture Faculty of Agrotechnology and Food Science Universiti Malaysia Terengganu

In this article, antibiogram and heavy metal resistance profile of bacteria isolated from giant freshwater prawn （Macrobrachium rosenbergii） hatchery in Malaysia are described. Although giant freshwater prawn was introduced into Malaysia since the 1980s, there was no database information on antibiogram and heavy metal resistance profile of bacteria from giant freshwater prawn （34. rosenbergii） hatchery in Malaysia. Therefore, this study was carried out to determine the effectiveness of antibiotic and heavy metal resistance profile to control bacterial diseases in M. rosenbergii hatchery. The results can provide valuable information for local M. rosenbergii post-larval producer. Antibiotic sensitivity test was carried out by disk-diffusion method against 15 types of antibiotics as follows： oxolinic acid （2 μg）, ampicillin （10μg）, erythromycin （15μg）, furazolidone （15 μg）, lincomycin （15μg）, amoxicillin （25 μg）, colistin sulphate （25 μg）, doxycycline （30μg）, florfenicol （30 μg）, flumequine （30 lag）, nalidixic acid （30μg）, tetracycline （30μg）, oleandomycin （15μg）, fosfomycin （50μg）, and spiramycin （100 μg）, whereas heavy metal resistance profile of the present bacterial isolates was determined by 2-fold agar dilution technique. In this study, 5 types of bacteria were successfully isolated; they were Aeromonas spp. （n = 77）, Escherichia coli （n = 73）, Edwardsiella spp. （n = 62）, Salmonella spp. （n = 75）, and Vibrio spp. （n = 43）. The result showed that furazolidone was the most effective antibiotic to control the bacteria isolated in this study, approximately 89.7% of the bacterial isolates were sensitive to this antibiotic. Multiple antibiotic resistance （MAR） index indicated that the hatchery water source and M. rosenbergii post-larval and sediment tanks were at high-risk exposure to the tested antibiotic. Furthermore, all the tested heavy metals （Cd2＋, Cr6＋, Hg2＋, and Cu2＋） failed to inhibit the growth of the bacterial isolates. Therefore, it indicated that the water

关键词： Macrobrachium rosenbergii hatchery antibiotic heavy metal MAR index

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Antibiotic Resistance and Heavy Metals Tolerance in Gram-Negative Bacteria from Diseased American Bullfrog (Rana catesbeiana) Cultured in Malaysia

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Agricultural Sciences in China 2009年第10期8卷 1270-1275页

作者： M Najiah S w Lee w wendy L w Tee M Nadirah S H Faizah Department of Fisheries Science and Aquaculture Faculty of Agrotechnology and Food Science Universiti Malaysia Terengganu Institute of Tropical Aquaculture Universiti Malaysia Terengganu Faculty of Agro Industry and Natural Resources Universiti Malaysia Kelantan

A total of 140 bacterial isolates have been successfully isolated from various organs of diseased American bullfrog （Rana catesbeiana） cultured in Malaysia. The most frequently isolated bacteria was Edwardsiella spp. （46 isolates） followed by Aeromonas spp. （33 isolates）, Flavobacterium spp. （31 isolates）, and Vibrio spp. （30 isolates）. Majority of the bacterial isolates were found sensitive to furazolidone （85.0%）, chloramphenicol （85.0%）, oxolinic acid （90.0%）, florfenicol （95.0%）, and flumequine （97.5%）. On the other hand, most of the bacterial isolates were resistant to oleandomycin （77.5%） and lincomycin （87.5%）. Nitrofurantoin and flumequine can be inhibited the growth of all of Vibrio spp. whereas all isolates of Edwardsiella spp. were found sensitive to florfenicol and flumequine. Multiple antibiotic resistance （MAR） index were in range of 0.30-0.40, indicating that bacterial isolates from cultured bullfrogs may have received high risk exposure to the tested antibiotics. In addition, 90-100% of the isolates were resistant to copper, cadmium, and chromium. These results provided insight information on tolerance level of bacterial isolates from cultured bullfrogs to 21 antibiotics as well as heavy metals.

关键词： Rana catesbeiana MAR index Edwardsiella Aeromonas Flavobaeterium Vibrio antibiotic resistance,heavy metal tolerance

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The immune response to SARS-CoV-2 in people with HIV

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Cellular & Molecular Immunology 2024年第2期21卷 184-196页

作者： Maxine A.Höft wendy A.Burgers Catherine Riou Institute of Infectious Disease and Molecular Medicine University of Cape TownCape TownSouth Africa Division of Medical Virology Department of PathologyUniversity of Cape TownCape TownSouth Africa wellcome Centre for Infectious Diseases Research in Africa University of Cape TownCape TownSouth Africa

This review examines the intersection of the HIV and SARS-CoV-2 *** with HIV(PwH)are a heterogeneous group that differ in their degree of immune suppression,immune reconstitution,and viral *** COVID-19 in those with wellcontrolled HIV infection poses no greater risk than that for HIV-uninfected individuals,people with advanced HIV disease are more vulnerable to poor COVID-19 ***-19 vaccines are effective and well tolerated in the majority of PwH,though reduced vaccine efficacy,breakthrough infections and faster waning of vaccine effectiveness have been demonstrated in *** is likely a result of suboptimal humoral and cellular immune responses after *** with advanced HIV may also experience prolonged infection that may give rise to new epidemiologically significant variants,but initiation or resumption of antiretroviral therapy(ART)can effectively clear persistent ***-19 vaccine guidelines reflect these increased risks and recommend prioritization for vaccination and additional booster doses for PwH who are moderately to severely *** recommend continued research and monitoring of PwH with SARS-CoV-2 infection,especially in areas with a high HIV burden.

关键词： SARS-CoV-2 HIV Immune dysfunction Vaccine efficacy Prolonged infection Immunogenicity

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重叠的流线

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建筑实践 2010年第6期 36-43页

作者： wendy w Fok Zaha Hadid Architects

"流动、交叠、统一的元素在建筑内外空间同时发生。MAXXI是一个城市的概念,而非一座单独的建筑物。平行导向线的设计手法从室内穿插至室外空间,不断延续。MAXXI无尽流动的曲线空间给参观者带来时空交错的视觉体验,封闭的空间内

关键词：流线空间动线建筑师美术家博物馆博物院文化机构楼梯设计师展厅混凝土无机非金属材料建筑物

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Highly enhanced UV absorption and light emission of monolayer wS_(2)through hybridization with Ti_(2)N MXene quantum dots and g-C_(3)N_(4)quantum dots

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Opto-Electronic Advances 2024年第6期7卷 31-39页

作者： Anir S.Sharbirin Rebekah E.Kong wendy B.Mato Trang Thu Tran Eunji Lee Jolene w.P.Khor Afrizal L.Fadli Jeongyong Kim Department of Energy Science Sungkyunkwan UniversitySuwon 16419Republic of Korea

Two-dimensional(2D)transition metal dichalcogenides(TMD)are atomically thin semiconductors with promising optoelectronic applications across the visible ***,their intrinsically weak light absorption and the low photoluminescence quantum yield(PLQY)restrict their performance and potential use,especially in ultraviolet(UV)wavelength light *** dots(QD)derived from 2D materials(2D/QD)provide efficient light absorption and emission of which energy can be tuned for desirable light *** this study,we greatly enhanced the photon absorption and PLQY of monolayer(1L)tungsten disulfide(wS_(2))in the UV range via hybridization with 2D/QD,particularly titanium nitride MXene QD(Ti_(2)N MQD)and graphitic carbon nitride QD(GCNQD).with the hybridization of MQD or GCNQD,1LwS_(2)showed a maximum PL enhancement by 15 times with 300 nm wavelength excitation,while no noticeable enhancement was observed when the excitation photon energy was less than the bandgap of the QD,indicating that UV absorption by the QD played a crucial role in enhancing the light emission of 1L-wS_(2)in our 0D/2D hybrid *** findings present a convenient method for enhancing the photo-response of 1L-wS_(2)to UV light and offer exciting possibilities for harvesting UV energy using 1L-TMD.

关键词： monolayer TMD wS_(2) 2D-derived quantum dots UV absorption energy transfer

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Role of lysosomal trafficking regulator in autophagic lysosome reformation in neurons:a disease perspective

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Neural Regeneration Research 2024年第5期19卷 957-958页

作者： Prashant Sharma Jenny Serra-Vinardell wendy J.Introne May Christine V.Malicdan NIH Undiagnosed Diseases Program Common FundOffice of the DirectorNational Institutes of HealthBethesdaMDUSA Human Biochemical Genetics Section Medical Genetics BranchNational Human Genome Research InstituteNational Institutes of HealthBethesdaMDUSA(Serra-Vinardell JIntrone)

Lysosomes are discrete organelles that act as recycling centers for extracellular and intracellular materials,playing a pivotal role in maintaining cellular *** acidic environment,maintained by numerous hydrolytic enzymes,facilitates substrate *** in lysosomal processes can lead to abnormal substrate degradation,significantly impacting cellular *** energy-demanding cells,such as post-mitotic neurons,are especially vulnerable to these changes,often resulting in neurological ***,a conserved catabolic process,requires extensive lysosomal *** plays a key role in removing unnecessary intracellular components,ensuring cellular homeostasis,and promoting cell survival during stress conditions such as starvation,infection,or cellular damage.

关键词： homeostasis lysosomal removing

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Anticancer Activities and the Drug Targets of Botanical Saponins from a Medicinal Herb,Gynostemma Pentaphyllum

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Journal of Acupuncture and Tuina Science 2008年第5期6卷 271-272页

作者： w.L.wendy HSIAO william Chi Shing TAI Ziyao MO Pui Kei wU School of Chinese Medicine Hong Kong Baptist UniversityHong KongP.R.China

Triterpenoid saponins are metabolites produced in most plant species through complex biosynthetic pathways. They play important roles to humans owing to their diverse medicinal effects, including antiinflammatory, antimicrobial, and anticancer activities. In our laboratory, the author have been investigating the anticancer activities of a mixture of triterpenoid saponins （designated GpMix） extracted from a medicinal plant, known as Jiao Gu Lan （Gynostemma pentaphyllum, 胶股蓝） or southern ginseng in China. The key findings are summed up as following.

关键词： Neoplasms, Second Primary Gynostemma Triterpenes

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Alter fecal microbiota composition and relieve symptom in depression-like rats after treatment by inulin-type fructo-oligosaccharides in Morinda Officinalis

Alter fecal microbiota composition and relieve symptom in de...

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2018年第十二届中国药物制剂大会

作者：池连娣 Zibei Lin Guoxing Huang w.L.wendy Hsiao Jiwen Zhang Ying Zheng State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau State Key Laboratory of Quality Research in Chinese Medicine Macau University of Science and Technology Center for Drug Delivery System Shanghai Institute of Materia Medica Chinese Academy of Sciences

Inulin-type fructooligosaccharides（FOS） purified from Morinda officinalis,with degrees of polymerization（DP） from 3 to 9, has been approved as the prescribed oral drug by CFDA in 2012 with the indications for mild and moderate depressive episode, while the bioprocess of this FOS mixtures are largely unknown. This work aimed to illustrate this bioprocess related to gut microbiota and intestine construction. The depression-like rat model was built by chronic unpredictable mild stress（CUMS） procedure for seven weeks, then verified by open field test（OFT） and sucrose preference test（SPT）. Under the three weeks’ treatment period, the fecal sample were collected at day 0, 15 and 22, and further analyzed the microbiota DNA composition using ERIC-PCR method. Hematoxylin and eosin（H＆E） staining was applied to investigate the gut epithelial morphology. Results showed that, rats with depression-like behaviors presented low SPT value（＜50%, p＜0.01） and low total travel distance in OFT test（p＜0.01）. Conversely, SPT value was increased（＞65%, p＜0.05） after treatments with FOS, indicating recovering the pleasant sensation. Meanwhile, in partial least square data analysis（PLS-DA） plot, differential modulations of normal and depressive rat model were observed at 0-day microbiota composition. Furthermore, while compared the 22-day plot, there were greatly changed the microbiota composition after treatments（fluoxetine, FOS-DP5 and FOS mixture）. In other side, the colon mucosa, intestinal villus（height and integrity） were severe damaged in intestine of depressive rat model. It was the intestinal inflammatory and severe damage happened in depression-like rats. However, intestinal micro-architecture abnormalities were restored and reversed by FOS treatment. Inferior to FOS, fluoxetine aroused intestinal irritation（cell necrosis, exfoliation and deep staining） on parts of treated rats. On balance, depression-like rat model has significant influence in behavior, intestine structure and micro

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A review of public health guidelines for postpartum physical activity and sedentary behavior from around the world

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Journal of Sport and Health Science 2024年第4期13卷 472-483,F0003页

作者： Kelly R.Evenson wendy J.Brown Alison K.Brinson Emily Budzynski-Seymour Melanie Hayman Department of Epidemiology Gillings School of Global Public HealthUniversity of North Carolina at Chapel HillChapel HillNC 27599-8050USA Faculty of Health Sciences and Medicine Bond UniversityGold CoastQLD 4226Australia School of Human Movement and Nutrition Sciences The University of QueenslandBrisbaneQLD 4072Australia Department of Anthropology University of North Carolina at Chapel HillChapel HillNC 27599-3115USA Carolina Population Center University of North Carolina at Chapel HillChapel HillNC 27599-8120USA Faculty of Sport Health and Social SciencesSolent UniversitySouthamptonSO140YNUK Appleton Institute School of HealthMedical and Applied SciencesCentral Queensland UniversityRockhamptonQLD 4701Australia

Background:The period following pregnancy is a critical time window when future habits with respect to physical activity(PA) and sedentary behavior(SB) are established;therefore,it warrants *** purpose of this scoping review was to summarize public health-oriented country-specific postpartum PA and SB guidelines ***:To identity guidelines published since 2010,we performed a(a) systematic search of 4 databases(CINAHL,Global Health,PubMed,and SPORTDiscus),(b) structured repeatable web-based search separately for 194 countries,and(c) separate web-based *** the most recent guideline was included for each ***:we identified 22 countries with public health-oriented postpartum guidelines for PA and 11 countries with SB *** continents with guidelines included Europe(n=12),Asia(n=5),Oceania(n=2),Africa(n=1),North America(n=1),and South America(n=1).The most common benefits recorded for PA included weight control/management(n=10),reducing the risk of postpartum depression or depressive symptoms(n=9),and improving mood/well-being(n=8).Postpartum guidelines specified exercises to engage in,including pelvic floor exercises(n=17);muscle strengthening,weight training,or resistance exercises(n=13);aerobics/general aerobic activity(n=13);walking(n=11);cycling(n=9);and swimming(n=9).Eleven guidelines remarked on the interaction between PA and breastfeeding;several guidelines stated that PA did not impact breast milk quantity(n=7),breast milk quality(n=6),or infant growth(n=3).For SB,suggestions included limiting long-term sitting and interrupting sitting with ***:Country-specific postpartum guidelines for PA and SB can help promote healthy behaviors using a culturally appropriate context while providing specific guidance to public health practitioners.

关键词： Breastfeeding Caesarean section Guidelines Postnatal Recommendations

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物象的工艺文化+自我陶醉

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建筑实践 2013年第8期 82-85页

作者：张歆悦 wendy w Fok

wendy w Fok在建筑、数字媒体和设计领域进行的科研型项目归功于她对创造型设计与数学、逻辑学和材料研究的程序原则之间交错重叠关系的理解。她创造出一种革新的方法,将幻影交叠的空间装置艺术品与国际大都市景观中的新奇建筑和谐地融... 详细信息

wendy w Fok在建筑、数字媒体和设计领域进行的科研型项目归功于她对创造型设计与数学、逻辑学和材料研究的程序原则之间交错重叠关系的理解。她创造出一种革新的方法,将幻影交叠的空间装置艺术品与国际大都市景观中的新奇建筑和谐地融合起来,这一点成为她设计风格的实体化证明。在建造的自然内容关系方面,Fok将其与周边环境结合进行了深入的探究。同时,她的设计方法论对结构和绘图意义的动态性提出了挑战和创新。她认为理想的艺术、建筑和城市化是在设计、优化和建造方面的进程,为达成情境的建设,这些要素应该在可持续发展规划,交互设计、材料分析和建造的替代法方面提出更具先进性的要求。

关键词：参展作品几何形状自恋网格物象希腊神话立方体正方体设计师群组面体

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