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A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： Diek w.wheeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering Department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify when to stop subdividing clusters based on the fundamental principle that cells must differ more between than within *** we present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering with statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as two-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia MouseLight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification Levene's one-tailed statistical test unsupervised hierarchical clustering

Genistein:a possible solution for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynowska Bartosz Karaszewski Grzegorz węgrzyn Department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and owing to their prevalence,severity.

关键词： organs Alzheimer death

Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack w.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关键词： programming passing proof

Dynamic modeling of a three-dimensional braided composite thin plate considering braiding directions

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 123-138页

作者： Chentong GAO Huiyu SUN Jianping GU w.M.HUANG College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics School of Mechanical and Aerospace Engineering Nanyang Technological University Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology School of Materials Science and EngineeringNanjing Institute of Technology

Currently, there are a limited number of dynamic models available for braided composite plates with large overall motions, despite the incorporation of three-dimensional(3D) braided composites into rotating blade components. In this paper, a dynamic model of 3D 4-directional braided composite thin plates considering braiding directions is established. Based on Kirchhoff's plate assumptions, the displacement variables of the plate are expressed. By incorporating the braiding directions into the constitutive equation of the braided composites, the dynamic model of the plate considering braiding directions is obtained. The effects of the speeds, braiding directions, and braided angles on the responses of the plate with fixed-axis rotation and translational motion, respectively, are investigated. This paper presents a dynamic theory for calculating the deformation of 3D braided composite structures undergoing both translational and rotational motions. It also provides a simulation method for investigating the dynamic behavior of non-isotropic material plates in various applications.

关键词： three-dimensional (3D) braided composite braiding direction composite thin plate large overall motion dynamic model O313.7

Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

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Neural Regeneration Research 2025年第11期20卷 3063-3075页

作者： Stephen Vidman Yee Hang Ethan Ma Nolan Fullenkamp Giles w.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy

Potential use of lactate for the treatment of neonatal hypoxic-ischemic encephalopathy

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Neural Regeneration Research 2022年第4期17卷 788-790页

作者： Isadora D’Ávila Tassinari Luciano Stürmer de fraga Laboratory of Neurobiology and Metabolism(NeuroMet) Department of PhysiologyInstituto de Ciências Básicas da Saúde(ICBS)Federal University of Rio Grande do Sul(UFRGS) Post-Graduate Program in Physiology Instituto de Ciências Básicas da Saúde(ICBS)Federal University of Rio Grande do Sul(UFRGS) Unidade de Experimentação Animal Centro de Pesquisa ExperimentalHospital de Clínicas de Porto Alegre(HCPA)Porto AlegreBrazil

Function of lactate:Lactate is a three-carbon molecule produced by glycolytic metabolism that is a metabolic waste product with no known use in clinical ***,it is a metabolite that the body should quickly guarantee the ***,lactate is now recognized as a potential energy substrate,as well as an anti-inflammatory signaling *** actions were first reported in adult animal models with a brain injury,including a traumatic brain injury and cerebral ischemia,and have also been observed in human patients(Magistretti and Allaman,2018).Recently,however,two studies by independent research groups described promising n euro p rotective results from the use of lactate in animal models with neonatal hypoxia-ischemia(Roumes et al.,2021;Tassinari et al.,2020).

关键词： neonatal metabolism ischemia

Charged scalar fields in a Kerr-Sen black hole:exact solutions, Hawkingradiation, and resonant frequencies

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Chinese Physics C 2019年第3期43卷 91-98页

作者： H.S.Vieira V.B.bezerra Departamento de Física Universidade Federal da Paraíba

In this study, we consider charged massive scalar fields around a Kerr-Sen spacetime. The radial and angular parts of the covariant Klein-Gordon equation are solved in terms of the confluent Heun function. From the exact radial solution, we obtain the Hawking radiation spectrum and discuss its resonant frequencies. The massless case of the resonant frequencies is also examined.

关键词： Klein-Gordon equation charged and rotating black hole heterotic string field theory confluent Heun function black hole physics

On the fractional doubly parabolic Keller-Segel system modelling chemotaxis

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Science China Mathematics 2022年第9期65卷 1827-1874页

作者： Mario bezerra Claudio Cuevas Clessius Silva Herme Soto Department of Mathematics Federal University of PernambucoRecife 50540-740Brazil Department of Mathematics Rural Federal University of PernambucoRecife 52171-900Brazil Department of Mathematics and Statistics University of La FronteraTemucoCasilla 54-DChile

This work is concerned with the time-fractional doubly parabolic Keller-Segel system in R^(N)(N≥1),and we derive some refined results on the large time behavior of solutions which are presupposed to enjoy some uniform boundedness ***,the well-posedness and the asymptotic stability of solutions in Marcinkiewicz spaces are *** results are achieved by means of an appropriate estimation of the system nonlinearity in the course of an analysis based on Duhamel-type representation formulae and the Kato-Fujita framework which consists in constructing a fixed-point argument by using a suitable time-dependent space.

关键词： chemotaxis aggregation Keller-Segel model decay properties asymptotic profiles global solutions

Can the host phylogeny(Chiroptera)influence the com m unity of ectoparasite flies(Diptera)?

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Current Zoology 2020年第3期66卷 331-332页

作者： Rayanna H.S.bezerra Adriana BOCCHIGLIERI Universidade Federal de Sergipe Programa de Pos-graduaqao em Ecologia e ConservaqaoLaboratorio de MastozoologiaCidade Universitaria Prof.Jose Aloisio de CamposSao CristovaoSEBrazil

Among the factors thar may influence parasitism are ecological and phylogenetic aspects(Krasnov et al.2005),where a host species may acquire a parasite by contact with other hosts co-occurring in a given environment or because of its ancestor(Hoberg and Brooks 2008).Thus,the parasite community can be considered a reflection of the ecological characteristics and the phylogeny of the host(Krasnov et al.2005).

关键词： phylogeny Diptera