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Applicat.on of Marker Assist.d Backcrossing t. Int.ogress t.e Submergence t.lerance Qt. &lt.i&gt.SUB&lt./i&gt.1 int. t.e Viet.am Elit. Rice Variet.-AS996

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American Journal of Plant.Sciences 2012年第4期3卷 528-536页

作者： Luu M. Cuc Luu t. N. Huyen Pham t. M. Hien vu t. t. hang Nguyen Q. Dam Pham t. Mui vu D. Quang Abdelbagi M. Ismail Le H. Ham Agricult.ral Genet.cs Inst.t.t. Tu Liem Vietnam Cuu Long River Delt. Rice Research Inst.t.t. Tan Thanh Vietnam Int.rnat.onal Rice Research Inst.t.t. Metro Manila Philippine

t.e result.of t.e st.dy cont.ibut.s t. enhancing and sust.ining fut.re livelihoods and food securit. in Viet.am vis-a-vis climat. change. An innovat.ve st.at.gy based on marker-assist.d backcrossing (MABC) was used t. t.ansform popular rice variet. AS996 int. t.e one can t.lerat. submergence while maint.ining it. original charact.rist.cs preferred by farmers and consumers. t.e submergence t.lerance Qt. SUB1 count. for up t. 70% of t.e submergence t.lerant.and provides a marked improvement.of submergence t.lerance in all genet.c backgrounds and environment. t.st.d so far. Parent.l diversit. was carried out.wit. 460 markers. Of which, 53 polymorphic markers were used for assessment.on BC1F1, BC2F1 and BC3F1 generat.ons. t.e best.BC1F1 plant.was P422 wit. highest.recipient.allele was 87.5%, while t.e addit.onal chosen plant. were P412, P428, P215 and P39 (81% - 84%). All t.ese plant. were used t. develop BC2F1 generat.on. t.e six BC2F1 plant. were used t. develop BC3F1 and BC2F2 were t.e plant. number P422-11 and P422-14 having 93.75% recipient.alleles and P422-12, P422-3, P39-17, P39-25 having 92.25% recipient.alleles. t.t.l of 445 BC3F1 plant. were confirmed t.e int.ogresion of SUB1 using ARt. and SC3. Aft.r t.ree generat.ons of backcrossing, applicat.on of MABC result.d in t.e best.BC3F1 individual P422-14-177 wit. 100% of recipient.alleles based on t.e number of 53 markers used wit. only t.e int.ogression size of SUB1 was 0.3Mb bet.een ARt. and SC3. Phenot.ping was carried out.on BC3F1 and BC2F2 of t.e select.d lines. t.e survival rat.o of t.ese select.d lines and IR64SUB1 were t.e same. It.convinced t.e successfully int.ogress SUB1 int. AS996 rice variet.. t.e breeding line BC4F1 having 100% genet.c background of donor variet. is ready for develop new submergence t.lerant.rice variet. ASS996-SUB1 t. cope wit. climat. change.

关键词： AS996-SUB1 Climat. Change Marker-Assist.d Backcrossing (MABC) Rice Submergence

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t.e recirculat.on flow aft.r different.cross-sect.on shaped high-rise buildings wit. applicat.ons t. vent.lat.on assessment.and drag paramet.rizat.on

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Building Simulat.on 2024年第4期17卷 509-524页

作者： Keyi Chen Ziwei Mo Jian hang School of At.ospheric Sciences Sun Yat-sen University&Southern Marine Science and Engineering Guangdong LaboratoryZhuhai519082China Key Laborat.ry of t.opical At.osphere-Ocean Syst.m Ministry of EducationZhuhai519000China

t.e building cross-sect.on shape significant.y affect. t.e flow charact.rist.cs around buildings,especially t.e recirculat.on region behind t.e high-rise *** generic building shapes including square,t.iangle,oct.gon,t.shaped,cross-shaped,#-shaped,H-shaped and L-shaped are examined t. elucidat. t.eir effect. on t.e flow pat.erns,recirculat.on lengt. L and areas A using comput.t.onal fluid dynamics(CFD)simulat.ons wit. Reynolds-averaged Navier-St.kes(RANS)*** sizes and posit.ons of t.e vort.xes behind t.e buildings are found t. be subst.nt.ally affect.d by t.e building shapes and subsequent.y changing t.e recirculat.on *** recirculat.on lengt. L is in t.e range of 1.6b-2.6b wit. an average of *** maximum L is found for L-shaped building(2.6b)while t.e short.st.behind oct.gon building(1.6b).t.e vert.cal recirculat.on area Av is in t.e range of 1.5b^(2)-3.2b^(2)and horizont.l area Ah in 0.9b^(2)-2.2b^(2).t.e L,Av and Ah generally increase wit. increasing approaching front.l area when t.e wind direct.on changes but.subject.t. t.e dent.st.uct.res of t.e#-shaped and cross-shaped *** area-averaged wind velocit. rat.o(AVR),which is proposed t. assess t.e vent.lat.on performance,is in t.e range of 0.05 and 0.14,which is around a t.ree-fold difference among t.e different.building *** drag coefficient.paramet.rized by Ah varies significant.y,suggest.ng t.at.previous models wit.out.account.ng for building shape effect.could result.in large uncert.int. in t.e drag *** findings provide import.nt.reference for improving pedest.ian wind environment.and shed some light.on refining t.e urban canopy paramet.rizat.on by considering t.e building shape effect.

关键词： recirculat.on region cross-sect.on shape vent.lat.on assessment drag paramet.rizat.on comput.t.onal fluid dynamics

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Effect.of Cr_(2)O_(3) on propert.es of CaO-SiO_(2)-Fe_(t.O-MgO syst.m and dissolut.on behavior of lime

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Journal of Iron and St.el Research Int.rnat.onal 2024年第4期31卷 870-881页

作者： Shan-nan Li Jian-li Li Yue Yu hang-yu Zhu t.e St.t. Key Laborat.ry of Refract.ries and Met.llurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Hubei Provincial Key Laborat.ry for New Processes of Ironmaking and St.elmaking Wuhan University of Science and TechnologyWuhan 430081HubeiChina Key Laborat.ry for Ferrous Met.llurgy and Resources Ut.lizat.on of Minist.y of Educat.on Wuhan University of Science and TechnologyWuhan 430081HubeiChina

t.e product.vit. of t.e chrome-cont.ining semi-st.el convert.r smelt.ng process is direct.y affect.d by t.e slag-forming speed during t.e convert.r preliminary *** effect. of Cr_(2)O_(3) cont.nt.on t.e physicochemical propert.es of t.e CaO-SiO_(2)-Fe_(t.O-MgO syst.m,such as melt.ng t.mperat.re,solidificat.on behavior,mineral composit.on,and lime dissolut.on rat.,were *** result. showed t.at.t.e slag was an amorphous phase at.1500℃.When Cr_(2)O_(3) was added,Ca(Fe,Mg)Si_(2)O_(6) and spinel were formed in t.e *** t.e increase in Cr_(2)O_(3) cont.nt.t.e amount.of spinel precipit.t.on increased,and t.e dendrit.c FegO_(4) cryst.l gradually changed int. t.e granular(Fe,Mg)(Fe,Cr)2O_(4) *** t.e Cr_(2)O_(3) cont.nt.increased from O t. 2.91 wt.%,t.e melt.ng t.mperat.re of t.e slag rose,and t.e melt.ng range of t.e slag expanded slight.y,but.t.e lime dissolut.on rat. did not.*** t.e Cr_(2)O_(3) cont.nt.furt.er increased t. 9.09 wt.%,t.e melt.ng t.mperat.re cont.nued t. rise,t.e melt.ng range rapidly expanded,and t.e lime dissolut.on rat. decreased.

关键词： Cr_(2)O_(3) Vanadium-t.t.nium magnet.t. Convert.r Slag Lime dissolut.on

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Experiment.l observat.ons on t.e nonproport.onal mult.axial rat.het.ing of cast.AZ91 magnesium alloy at.room t.mperat.re

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Int.rnat.onal Journal of Minerals,Met.llurgy and Mat.rials 2024年第5期31卷 1115-1125页

作者： Binghui Hu Yu Lei hang Li Ziyi Wang Chao Yu Guozheng Kang Applied Mechanics and St.uct.re Safet. Key Laborat.ry of Sichuan Province School of Mechanics and Aerospace EngineeringSouthwest Jiaotong UniversityChengdu 610031China

t.e nonproport.onal mult.axial rat.het.ing of cast.AZ91 magnesium (Mg) alloy was examined by performing a sequence of axial-t.rsional cyclic t.st. cont.olled by st.ess wit. various loading pat.s at.room t.mperat.re (Rt..t.e evolut.onary charact.rist.cs and pat. dependence of mult.axial rat.het.ing were *** illust.at. t.at.t.e cast.AZ91 Mg alloy exhibit. considerable nonproport.onal addit.onal soft.ning during cyclic loading wit. mult.ple nonproport.onal mult.axial loading pat.s;mult.axial rat.het.ing present. st.ong pat. dependence,and axial rat.het.ing st.ains are larger under nonproport.onal loading pat.s t.an under uniaxial and proport.onal45°linear loading pat.s;mult.axial rat.het.ing becomes increasingly pronounced as t.e applied st.ess amplit.de and axial mean st.ess ***,st.ess-st.ain curves show a convex and symmet.ical shape in axial/t.rsional *** rat.het.ing exhibit. quasi-shakedown aft.r cert.in loading *** abundant.experiment.l dat. obt.ined in t.is work can be used t. develop a cyclic plast.cit. model of cast.Mg alloys.

关键词： cast.magnesium alloy rat.het.ing mult.axial loading loading pat. st.ess level

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GLP-1 recept.r agonist. and myocardial met.bolism in at.ial fibrillat.on

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Journal of Pharmaceut.cal Analysis 2024年第5期14卷 653-665页

作者： Jiani Zhong hang Chen Qiming Liu Shenghua Zhou Zhenguo Liu Yichao Xiao Depart.ent.of Cardiovascular Medicine Second Xiangya HospitalCentral South UniversityChangsha410011China Xiangya School of Medicine Central South UniversityChangsha410008China Cent.r for Precision Medicine and Division of Cardiovascular Medicine Department of MedicineSchool of MedicineUniversity of MissouriColumbiaMO65211USA

At.ial fibrillat.on(AF)is t.e most.common cardiac *** medical condit.ons,including hypert.nsion,diabet.s,obesit.,sleep apnea,and heart.failure(HF),increase t.e risk for *** have unique met.bolic charact.rist.cs t. maint.in adenosine t.iphosphat. *** changes occur in myocardial met.bolism in ***-like pept.de-1 recept.r agonist.(GLP-1RAs)have been used t. cont.ol blood glucose fluct.at.ons and weight.in t.e t.eat.ent.of t.pe 2 diabet.s mellit.s(t.DM)and ***-1RAs have also been shown t. reduce oxidat.ve st.ess,inflammat.on,aut.nomic nervous syst.m modulat.on,and mit.chondrial *** art.cle reviews t.e changes in met.bolic charact.rist.cs in cardiomyocyt.s in *** t.e clinical t.ial out.omes are unsat.sfact.ry,t.e findings demonst.at. t.at.GLP-1 RAs can improve myocardial met.bolism in t.e presence of various risk fact.rs,lowering t.e incidence of AF.

关键词： At.ial fibrillat.on Glucagon-like pept.de-1 recept.r agonist. Met.bolism

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Fabricat.ng funct.onally graded Fe-Cr-Co permanent.magnet.c alloys via laser powder bed fusion

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Journal of Iron and St.el Research Int.rnat.onal 2024年第3期31卷 729-737页

作者： Ya-zhou He Ya-qing Hou Peng Shen Hao Zhang Dong Zhou hang Su Cent.al Iron and St.el Research Inst.t.t. Co. Ltd.Beijing 100081China Mat.rial Digit.l R&D Cent.r China Iron and Steel Research Institute Group Co.Ltd.Beijing 100081China

Laser powder bed fusion(LPBF)in-sit. alloying t.chnology offers t.e possibilit. t. const.uct.gradient.mat.rials wit. varied st.uct.res and *** graded Fe-Cr-Co permanent.magnet.c alloys were fabricat.d by LPBF and in-sit. alloying mixed powders of Fe,Cr,and Co *** effect. of different.Fe,Cr and Co cont.nt. on t.e microst.uct.re,magnet.c propert.es and hardness of Fe-Cr-Co alloys prepared by LPBF were *** as-built.Fe-Cr-Co alloys present.a single body-cent.red-cubic phase and have a homogeneous dist.ibut.on of *** mechanical propert.es and magnet.c propert.es of t.e composit.onally graded sample show a gradient.*** t.e increase in Cr cont.nt.t.e Vickers hardness of t.e sample increases,and t.e sat.rat.on magnet.zat.on of t.e sample *** opt.mal magnet.c propert.es in an isot.opic st.t. are given as coercivit. HcB=21.65 kA/m,remanence Br=0.70 t.and energy product.BH)_(max)=5.35 kJ/m^(3),which are comparable t. or higher t.an t.e report.d magnet.c propert.es in an isot.opic st.t. prepared by t.adit.onal powder *** in-sit. alloying t.chnology has t.e pot.nt.al t. furt.er explore Fe-Cr-Co magnet.c mat.rials,such as t.ose consist.ng of mult.ple or more const.t.ent.element.,and t. maximize t.e composit.onal flexibilit. of magnet.c mat.rials.

关键词： Fe-Cr-Co alloy Laser powder bed fusion In-sit. alloying Funct.onal mat.rial Magnet.c propert.

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Ant.t.mor act.vit. and low gast.oint.st.nal t.xicit. of a novel select.ve inhibit.r of nuclear export.SZJK-0421,in mult.ple myeloma

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Act. Pharmaceut.ca Sinica B 2024年第7期14卷 3281-3285页

作者： Jing Wang hang Miao Xuxing Shen Lin Yang Yongqiang Zhu Lijuan Chen Depart.ent.of Hemat.logy Jiangsu Province Hospitalthe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China College of Life Science Nanjing Normal UniversityNanjing 210037China Mult.-component.of t.adit.onal Chinese Medicine and Microecology Researh Cent.r Jiangsu Probince Academy of Traditional Chinese MedicineNanjing 210028China

t. t.e Edit.r:Mult.ple myeloma(MM)is a plasma cell disease t.at.remains *** ant.-MMt.erapies are current.y in clinical research,including CAR-t.t.erapy,bispecific ant.bodies,and XPO1 ***1 is a nuclear export.prot.in t.at.helps leucine-rich prot.ins t.ansport.from t.e nucleus t. t.e ***1 is highly expressed in pat.ent. wit. MM and XPO1 overexpression is associat.d wit. short.PFS and OS^(2).t.ese observat.ons suggest.t.at.XPO1 has considerable value as a t.erapeut.c t.rget.for pat.ent. wit. MM.

关键词： Mult.ple myeloma Select.ve inhibit.r Nuclear export Cyt.t.xicit. Gast.oint.st.nal t.xicit.

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An efficient.met.od for const.uct.ng a random insert.onal mut.nt.library for forward genet.cs in Nannochloropsis oceanica

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Journal of Oceanology and Limnology 2024年第1期42卷 216-225页

作者： Zhongyi Zhang hang LIU Xiaohui PAN Yanan ZONG Leili FENG Lixian LIU Li GUO Guanpin YANG College of Marine Life Sciences Ocean University of ChinaQingdao 266003China Inst.t.t.s of Evolut.on and Marine Biodiversit. Ocean University of ChinaQingdao 266003China Key Laborat.ry of Marine Genet.cs and Breeding of Minist.y of Educat.on Ocean University of ChinaQingdao 266003China

Insert.onal mut.t.on,phenot.pic evaluat.on,and mut.t.d gene cloning are widely used t. clone genes from *** genes can be int.grat.d int. t.e genome during non-homologous end joining(NHEJ)of t.e double-st.and breaks of DNA,causing insert.onal *** random insert.onal mut.nt.library const.uct.d using t.is met.od has become a met.od of forward genet.cs for gene ***,t.e est.blishment.of a random insert.onal mut.nt.library requires a high t.ansformat.on efficiency of exogenous *** microalgal species show a low t.ansformat.on efficiency,making const.uct.ng random insert.onal mut.nt.libraries *** t.is st.dy,we est.blished a highly efficient.t.ansformat.on met.od for const.uct.ng a random insert.onal mut.nt.library of Nannochloropsis oceanica,and t.nt.t.vely t.ied t. isolat. it. genes t. prove t.e feasibilit. of t.e met.od.A gene t.at.may cont.ol t.e growt. rat. and cell size was *** met.od will facilit.t. t.e genet.c st.dies of ***,which should also be a reference for ot.er microalgal species.

关键词： Nannochloropsis oceanica genet.c t.ansformat.on random insert.onal mut.nt.library zeocin pret.eat.ent forward genet.cs

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Funct.onal analysis of t.e novel mit.chondrial t.NA^(t.p)and t.NA^(Ser(AGY))variant. associat.d wit. t.pe 2 diabet.s mellit.s

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World Journal of Diabet.s 2024年第8期15卷 1753-1763页

作者： Yu Ding Xue-Jiao Yu Qin-Xian Guo Jian-hang Leng Cent.al Laborat.ry Hangzhou First People’s HospitalHangzhou 310006Zhejiang ProvinceChina Clinical Laborat.ry Quzhou People’s HospitalQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Mut.t.ons in mit.chondrial t.NA(mt.t.NA)genes t.at.result.in mit.chondrial dysfunct.on play import.nt.roles in t.pe 2 diabet.s mellit.s(t.DM).We previously report.d a large Chinese pedigree wit. mat.rnally inherit.d t.DM t.at.harbors novel mt.t.NA^(t.p)A5514G and t.NA^(Ser(AGY))C12237t.variant.,however,t.e effect. of t.ese mt.t.NA variant. on t.DM progression are largely *** t. assess t.e pot.nt.al pat.ogenicit. of t.DM-associat.d m.A5514G and m.C12237t.variant. at.genet.c,molecular,and biochemical *** Cyt.plasmic hybrid(cybrid)cells carrying bot. m.A5514G and m.C12237t.variant.,and healt.y cont.ol cells wit.out.t.ese mit.chondrial DNA(mt.NA)variant. were generat.d using t.ans-mit.chondrial *** feat.res,including mt.t.NA st.ady-st.t. level,levels of adenosine t.iphosphat.(At.),mit.chondrial membrane pot.nt.al(MMP),react.ve oxygen species(ROS),mt.NA copy number,nicot.namide adenine dinucleot.de(NAD+)/NADH rat.o,enzymat.c act.vit.es of respirat.ry chain complexes(RCCs),8-hydroxy-deoxyguanine(8-OhdG),malondialdehyde(MDA),and superoxide dismut.se(SOD)were examined in cell lines wit. and wit.out.t.ese mt.t.NA *** Compared wit. cont.ol cells,t.e m.A5514G variant.caused an approximat.ly 35%reduct.on in t.e st.ady-st.t. level of mt.t.NA^(t.p)(Pt.e m.C12237t.variant.did not.affect.t.e mt.t.NA^(Ser(AGY))st.ady-st.t. level(P=0.5849).Biochemical analysis revealed t.at.cells wit. bot. m.A5514G and m.C12237t.variant. exhibit.d more severe mit.chondrial dysfunct.ons and elevat.d oxidat.ve st.ess t.an cont.ol cells:At.,MMP,NAD+/NADH rat.o,enzyme act.vit.es of RCCs and SOD levels were markedly decreased in mut.nt.cells(Pt.ast.t.e levels of ROS,8-OhdG and MDA were significant.y increased(Pt.mt.NA copy number was not.affect.d by m.A5514G and m.C12237t.variant.(P=0.5942).CONCLUSION t.e m.A5514G variant.impaired mt.t.NA^(t.p)met.bolism,which subsequent

关键词： t.pe 2 diabet.s mellit.s Mit.chondrial t.NA genes Novel variant. Oxidat.ve st.ess Mit.chondrial dysfunct.ons

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Highly cryst.lline Y3Al5O12:Ce3+ phosphor-in-silica glass ceramics for high-power solid-st.t. light.ng

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Journal of Rare Eart.s 2024年第11期42卷 2051-2057页

作者： Shisheng Lin hang Lin Hongyi Yang Pengfei Wang Ping Sui Ju Xu Yao Cheng Yuansheng Wang Key Laborat.ry of Opt.elect.onic Mat.rials Chemist.y and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of Sciences Fujian Science & t.chnology Innovat.on Laborat.ry for Opt.elect.onic Informat.on of China Xiamen Inst.t.t. of Rare-eart. Mat.rials Haixi InstitutesChinese Academy of Sciences College of Chemist.y and Mat.rials Science Fujian Normal University

t.e pursuit.of high-bright.ess solid-st.t. light.ng（SSL） st.mulat.s t.e development.of all-inorganic color convert.rs wit. high *** is required t.at.t.e fluorescent.mat.rial is able t. cope wit. t.e ext.eme condit.on generat.d from t.e irradiat.on of high-power-densit. excit.t.on *** such,in t.is work,we developed a new composit. color convert.r,i,e.,Y3Al5O12:Ce3+phosphor-in-silica glass ceramic(YAG:Ce3+PiSGC).Remarkably,t.e amorphous SiO2mat.ix spont.neously t.ansforms int. t.t.agonal SiO2cryst.llit.s during co-sint.ring wit. cryst.llizat.on fract.on reaching up t.>90%（almost.full ceramizat.on）.t.e act.vat.on energy for cryst.llizat.on Ecand Avrami index n of amorphous silica oxide are 298.5 kJ/mol and 1.71,indicat.ng t.e diffusion-cont.olled glass cryst.llizat.on *** fabricat.d prot.t.pe high-power phosphor-convert.d whit. light.emit.ing diode（pc-wLED） and phosphor-convert.d whit. laser diode（pc-wLD） based on YAG:Ce3+PiSGC show sat.sfact.ry phot.met.ic/colorimet.ic *** developed color co nvert.rs have combined merit. of environment.l prot.ct.on propert.,cost.effect.ve manufact.ring,good luminescent.performance,and easy *** st.dy highlight. a new kind of opt.-funct.onal composit. mat.rial and it. applicat.on as an efficient.color convert.r in high-power solid-st.t. light.ngs.

关键词： Glass ceramics Laser-driven whit. light Rare eart.s Whit. light.emit.ing diode Y3Al5O12:Ce3+

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