Antitumor activity and low gastrointestinal toxicity of a novel selective inhibitor of nuclear export,SZJK-0421,in multiple myeloma

作     者：Jing Wang Hang Miao Xuxing Shen Lin Yang Yongqiang Zhu Lijuan Chen Jing Wang;Hang Miao;Xuxing Shen;Lin Yang;Yongqiang Zhu;Lijuan Chen

作者机构：Department of HematologyJiangsu Province Hospitalthe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China College of Life ScienceNanjing Normal UniversityNanjing 210037China Multi-component of Traditional Chinese Medicine and Microecology Researh CenterJiangsu Probince Academy of Traditional Chinese MedicineNanjing 210028China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2024年第14卷第7期

页      面：3281-3285页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(Nos.82070223 and 82370205) the Social Development Project of Jiangsu Science and Technology Plan(No.BE2022810,China) 

主　　题：Multiple myeloma Selective inhibitor Nuclear export Cytotoxicity Gastrointestinal toxicity 

摘      要：To the Editor:Multiple myeloma(MM)is a plasma cell disease that remains *** anti-MMtherapies are currently in clinical research,including CAR-T therapy,bispecific antibodies,and XPO1 ***1 is a nuclear export protein that helps leucine-rich proteins transport from the nucleus to the ***1 is highly expressed in patients with MM and XPO1 overexpression is associated with short PFS and OS^(2).These observations suggest that XPO1 has considerable value as a therapeutic target for patients with MM.