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Prolonged asystole following adenosine. Was it necessary?

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Journal of Geriatric Cardiology 2024年第6期21卷 686-688页

作者： Yuval Avidan Amir Aker vsevolod Tabachnikov Department of Cardiology Lady Davis Carmel Medical CenterHaifaIsrael

A77-year-old woman presented with interchangeable episodes of both fast and slow heart *** history was notable for paroxysmal atrial fibrillation treated with eliquis and tambocor and atrial septal defect closure 35 years *** for mild tachycardia,vitals and physical examination were *** 12-lead electrocardiogram(Figure 1)showed narrow complex tachycardia at 106 beats/min without obvious P-waves.

关键词： tachycardia septal atrial

Masquerading bundle branch block with intermittent right ventricular pacing in a patient with acute coronary syndrome

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老年心脏病学杂志:英文版 2023年第10期20卷 762-766页

作者： vsevolod Tabachnikov Yuval Avidan Department of Cardiovascular Medicine Lady Davis Carmel Medical CenterHaifaIsrael

The relatively uncommon masquerading bundle branch block(MBBB),a concept initially introduced in 1958 by UNGER,et al.[1]and colleagues,refers to a conduction abnormality that consists of the right bundle branch block(... 详细信息

关键词： bundle branch

Embedding of Pre-Lie Algebras into Preassociative Algebras

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Algebra Colloquium 2020年第2期27卷 299-310页

作者： vsevolod Gubarev University of Vienna Oskar-Morgenstern-Platz 11090ViennaAustria

With the help of Rota-Baxter operators and Grobner-Shirshov bases,we prove that every pre-Lie algebra can be injectively embedded into its universal enveloping preassociative algebra.

关键词： Rota-Baxter operator GrÖbner-Shirshov basis pre-Lie algebra preassociative algebra(dendriform algebra)

复合材料高强度粘合剂减少飞机紧固件使用的研究

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复合材料高强度粘合剂减少飞机紧固件使用的研究

作者： vsevolod Kostin 上海交通大学

学位级别：硕士

在本文中评估了薄壁复合结构构件胶接接头中粘接层厚度对整个接头强度影响,提供了对现有的用于预测粘合接头强度理论方法的批判性分析。通过一系列文献研究了胶接剂的厚度对强度影响,了解到复合板胶胶接接头强度的理论估计结果与实验结... 详细信息

在本文中评估了薄壁复合结构构件胶接接头中粘接层厚度对整个接头强度影响,提供了对现有的用于预测粘合接头强度理论方法的批判性分析。通过一系列文献研究了胶接剂的厚度对强度影响,了解到复合板胶胶接接头强度的理论估计结果与实验结果之间存在一定差距。之后,通过假设初始断裂区的大小和形状的变化与粘合剂层的厚度相关,发现预测胶接接头承载能力的最有效方法是通过断裂能释放强度和胶层预断裂区形成的断裂力学能量模型计算失效强度,最终将粘合剂接头强度的预测结果与实验数据进行比较得到了较为吻合的结果。

关键词：飞机粘接接头碳纤维粘接层厚度

An approach to net-centric control automation of technological processes within industrial IoT systems

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Advances in Manufacturing 2017年第4期5卷 388-393页

作者： Nikita Voinov Igor Chernorutsky Pavel Drobintsev vsevolod Kotlyarov Institute of Computer Science and Technology Peter the Great St. Petersburg Polytechnic UniversityPolytechnicheskaya 29 Saint Petersburg Russia 195251

The use of industrial internet networks with net- centric control is the driving trend behind the future material manufacturing of goods and services. The promising future of this approach is provided by these complex net-centric systems functioning with high relia- bility. The problem of intelligent net-centric control and reliable network functioning is fundamental, with the additional requirement that the system should preserve stakeholder security and privacy according to policies. The issue is that such systems are characterized by complex multi-parameter operability modes controlled by various criteria. This study considers an approach to providing reliable management of complicated Internet of things （IoT） systems. This is achieved by solving multi-criteria tasks over many processes of various physical natures. Corresponding methods of hierarchical decomposition of multi-criteria tasks, process levels of multi-criteria opti- mization, specifics of aggregation levels, and the master equation of the optimization process are described.

关键词： Net-centric control Technological process Internet of things (IoT) Reliability Multi-criteria optimization

Arrestins:structural disorder creates rich functionality

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Protein & Cell 2018年第12期9卷 986-1003页

作者： vsevolod V.Gurevich Eugenia V.Gurevich Vladimir N.Uversky Department of Pharmacology Vanderbilt UniversityNashvilleTN 37232USA Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute Morsani College of Medicine University of South FloridaTampaFL 33612USA Institute for Biological Instrumentation Russian Academy of SciencesPushchinoMoscow RegionRussia 142290

Arrestins are soluble relatively small 44-46 kDa proteins that specifically bind hundreds of active phosphorylated GPCRs and dozens of non-receptor partners. There are binding partners that demonstrate preference for each of the known arrestin conformations: free, receptor-bound, and microtubule-bound. Recent evidence suggests that conformational flexibility in every functional state is the defining characteristic of arrestins. Flexibility, or plasticity, of proteins is often described as structural disorder, in contrast to the fixed conformational order observed in high-resolution crystal structures. However, protein-protein interactions often involve highly flexible elements that can assume many distinct conformations upon binding to different partners. Existing evidence suggests that arrestins are no exception to this rule: their flexibility is necessary for functional versatility. The data on arrestins and many other multi-functional proteins indicate that in many cases, "order" might be artificially imposed by highly non-physiological crystallization conditions and/or crystal packing forces. In contrast, conformational flexibility (and its extreme case, intrinsic disorder) is a more natural state of proteins, representing true biological order that underlies their physiologically relevant functions.

关键词： EPR GPCR NMR arrestin crystal structure disorder protein-protein interactions

How genetic errors in GPCRs affect their function:Possible therapeutic strategies

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Genes & Diseases 2015年第2期2卷 108-132页

作者： Henriette Stoy vsevolod V.Gurevich University of Tu¨bingen Tu¨bingen 72074Germany Department of Pharmacology Vanderbilt UniversityNashvilleTN 37232USA

Activating and inactivating mutations in numerous human G protein-coupled receptors(GPCRs)are associated with a wide range of disease *** we use several class A GPCRs with a particularly large set of identified disease-associated mutations,many of which were biochemically characterized,along with known GPCR structures and current models of GPCR activation,to understand the molecular mechanisms yielding pathological *** on this mechanistic understanding we also propose different therapeutic approaches,both conventional,using small molecule ligands,and novel,involving gene therapy.

关键词： Activation Agonist Mutation Gene therapy Genetic disorder GPCR

Gold mineralisation and orogenic metamorphism in the Lena province of Siberia as assessed from Chertovo Koryto and Sukhoi Log deposits

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Geoscience Frontiers 2016年第3期7卷 453-481页

作者： Marina A.Yudovskaya Vadim V.Distler vsevolod Yu.Prokofiev Nickolay N.Akinfiev Institute of Geology of Ore Deposits PetrographyMineralogy and Geochemistry RAS EGRI University of the Witwatersrand

The Chertovo Koryto gold deposit（80 t Au at 1.84 g/t） in the Lena world-class province,Siberia,is hosted in a metamorphosed sequence of the Paleoproterozoic Mikhailovsk Formation that comprises the oldest black shale strata of the Baikal-Patom *** mineralisation is confined to the thrust zone complicated with a conjugate anticline fold,zones of shearing and *** struaural position of the mineralisation is similar to that at the giant Sukhoi Log deposit in the neighbouring Mama-Bodaibo *** the latter,the isotope age data suggest that Khomolkho black shales,hosts to Sukhoi Log mineralisation,are of Ediacaran age and underwent prograde metamorphism during early *** geochemical composition of the terrigenous rocks that host Sukhoi Log,Chertovo Koryto,and a number of other deposits at the various stratigraphic levels throughout the Proterozoic sequence have much in *** do not show elevated metal contents above the common black shale abundances,except for Au and As,which is at variance with the accepted view on diagenetic enrichment of black shales in the Lena *** occurrence of sagenitic rutile in quartz and chlorite pseudomorphs after biotite and other petrographic observations provide evidence on a retrograde nature of the metamorphic mineral assemblages in the Mikhailovsk *** sulphides are pyrrhotite and arsenopyrite with very minor pyrite at Chertovo Koryto,whereas pyrite is the predominant sulphide in the Sukhoi Log *** inclusion data on both deposits emphasise a high-temperature nature of the mineralisation albeit revealing great contrast in the fluid *** Log mineralisation was formed at mixing between low-salinity aqueous solutions and dense gaseous carbonic fluids,which facilitated effective gold scavenging and precipitation,as demonstrated by thermodynamic *** precursory devolatilisation of the Mikhailovsk sediments at the prograde stage results in the paucity of gaseous carbon

关键词： Gold Black shales Orogenic metamorphism Orogenic fluid Sukhoi Log Chertovo Koryto

Tourmalinization at the Darasun goldfield,Eastern Transbaikalia:Compositional,fluid inclusion and isotopic constraints

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Geoscience Frontiers 2012年第1期3卷 59-71页

作者： vsevolod Prokofiev Ivan Baksheev Lidiya Zorina Boris Belyatsky Vladimir Ustinov Nadezhda Krivitskaya Institute of Geology of Ore Deposits Petrography Mineralogy & GeochemistryRussian Academy of SciencesMoscowRussia Lomonosov Moscow State University MoscowRussia Lomonosov Moscow State University Moscow Russia Vinogradov Institute of Geochemistry Irkutsk Russia Institute of Precambrian Geology and Geochronology RAS Saint-PetersburgRussia Vernadsky Institute of Geochemistry and Analytical Chemistry RAS MoscowRussia

Zoned tourmaline （schorl-dravite） in the matrix of hydrothermal explosive breccia and ore veins in gold deposits, Chita region, Eastern Transbaikalia, Russia, are associated with Na- and K-rich porphyry-type subvolcanic intrusives. 61So values of tourmaline from three gold deposits （Darasun, Talatui, Teremkinskoye） are ＋8.3%, ＋7.6%, and --6.0% and calculated 6180 values of fluids respon- sible for the tourmalinization are ＋7.3%, ＋7.7%, and ＋4.2%, respectively. These data imply an igneous fluid source, except at the Teremkin deposit where mixing with meteoric water is indicated. Wide ranges of Fe3＋/Fetot and the presence of vacancies characterize the Darasun deposit tourmaline indicating wide ranges off（O2） and pH of mineralizing fluids. Initial stage tourmalines from the gold deposits of the Darasun ore district are dravite or high mg schorl. Second stage tourmaline is characterized by oscillatory zoning but with Fe generally increasing towards crystal rims indicating decreasing temperature. Third stage tourmaline formed unzoned crystals with XMg （mole fraction of Mg） close to that of the first stage tourmaline, due to a close association with pyrite and arsenopyrite. From Fe^3＋/Fetot values, chemical composition and crystallization temperatures, logf（O2） of mineralizing fluids ranged from ca. -25 to 20, much higher than for the gold-bearing beresite-listvenite association, indicating that tourmalinization was not related to gold mineralization.

关键词： Tourmaline composition Fluid inclusions Oxygen isotopes Gold deposits Transbaikalia Russia