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建筑技艺 2018年第8期24卷 28-29页

作者： Patrick janssen 龙瀛新加坡国立大学清华大学

地理空间信息无处不在并持续增加，我们接触到的一些地理空间信息数据可以通过API端口被抓取。借助开放的数据库，设计师可以学习使用程序进行3D地理信息模型的实时生成。

关键词：地理空间信息设备建模信息代码移动城市挤压空间信息数据地理信息模型

New therapeutic opportunities for Hepatitis C based on small RNA

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World Journal of Gastroenterology 2007年第33期13卷 4431-4436页

作者： Qiu-wei Pan Scot D Henry Bob J Scholte Hugo W Tilanus Harry LA janssen Luc JW van der Laan Departments of Gastroenterology & Hepatology and Surgery Erasmus MC-University Medical Centre Rotterdam The Netherlands Department of Surgery Erasmus MC-University Medical Centre Rotterdam The Netherlands Department of Cell Biology Erasmus MC- University Medical Centre Rotterdam The Netherlands Department of Gastroenterology & Hepatology Erasmus MC-University Medical Centre Rotterdam The Netherlands

Hepatitis C virus （HCV） infection is one of the major causes of chronic liver disease, including cirrhosis and liver cancer and is therefore, the most common indication for liver transplantation. Conventional antiviral drugs such as pegylated interferon-alpha, taken in combination with ribavirin, represent a milestone in the therapy of this disease. However, due to different viral and host factors, clinical success can be achieved only in approximately half of patients, making urgent the requirement of exploiting alternative approaches for HCV therapy. Fortunately, recent advances in the understanding of HCV viral replication and host cell interactions have opened new possibilities for therapeutic intervention. The most recent technologies, such as small interference RNA mediated gene-silencing, antisense oligonucleotides （ASO）, or viral vector based gene delivery systems, have paved the way to develop novel therapeutic modalities for HCV. In this review, we outline the application of these technologies in the context of HCV therapy. In particular, we will focus on the newly defined role of cellular microRNA （miR-222） in viral replication and discuss its potential for HCV molecular therapy.

关键词： Hepatitis C virus therapy miR-122 RNAi Antisense oligonucleotides Viral vectors

聚乙二醇干扰素α-2b单药或聚乙二醇干扰素α-2b联合拉米夫定治疗HBeAg阳性慢性乙型肝炎的多中心、随机、双盲、对照试验

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传染病信息 2005年第Z1期18卷 44-47页

作者： Harry LA janssen Erasmus MC-University Medical Centre Rotterdam

　　与干扰素非应答者相比,应答的慢性乙型肝炎(乙肝)患者发生肝硬化、肝衰竭及肝细胞癌的可能性明显下降[1,2].然而,大部分慢性乙肝患者不能获得应答.在已经获得批准治疗慢性乙肝的药物中,最常用的是干扰素和核苷类似物,如拉米夫定或... 详细信息

　　与干扰素非应答者相比,应答的慢性乙型肝炎(乙肝)患者发生肝硬化、肝衰竭及肝细胞癌的可能性明显下降[1,2].然而,大部分慢性乙肝患者不能获得应答.在已经获得批准治疗慢性乙肝的药物中,最常用的是干扰素和核苷类似物,如拉米夫定或阿德福韦.……

关键词：拉米夫定 HBeAg 慢性乙型肝炎聚乙二醇干扰素α 干扰素抗病毒药阳性单药对照试验双盲

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阿克苏诺贝尔让社会责任落地

品质 2006年第5期 20-21页

作者： Patricia janssen 清清（编译）

世界500强企业阿克苏诺贝尔公司近日发表了2005年度企业社会责任报告。报告详尽地报道了该公司在全球范围内提高持续性发展的业绩情况，并重点介绍了其在减少生产对环境的影响，特别是在节能方面所取得的成绩。

关键词：阿克苏诺贝尔公司社会责任可持续性发展环境保护产业链

Dual-functional porous and cisplatin-loaded polymethylmethacrylate cement for reconstruction of load-bearing bone defect kills bone tumor cells

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Bioactive Materials 2022年第9期7卷 120-130页

作者： Zhule Wang Liebert Parreiras Nogueira Håvard Jostein Haugen Ingrid CM.Van Der Geest Patricia Caetano de Almeida Rodrigues Dennis janssen Thom Bitter Jeroen J.J.P.van den Beucken Sander CG.Leeuwenburgh Radboud University Medical Center Department of Dentistry-Regenerative BiomaterialsRadboud Institute for Molecular Life SciencesNijmegenthe Netherlands University of Oslo Department of BiomaterialsInstitute of Clinical DentistryFaculty of DentistryOsloNorway Radboud University Medical Center Department of OrthopedicsRadboud Institute for Health SciencesNijmegenthe Netherlands

Malignant bone tumors are usually treated by resection of tumor tissue followed by filling of the bone defect with bone graft ***(PMMA)cement is the most commonly used bone substitute in clinical orthopedics in view of its ***,the dense nature of PMMA renders this biomaterial unsuitable for local delivery of chemotherapeutic drugs to limit the recurrence of bone ***,we introduce porosity into PMMA cement by adding carboxymethylcellulose(CMC)to facilitate such local delivery of chemotherapeutic drugs,while retaining sufficient mechanical properties for bone reconstruction in load-bearing *** results show that the mechanical strength of PMMA-based cements gradually decreases with increasing CMC *** incorporation of≥3%CMC,the PMMA-based cements released up to 18%of the loaded cisplatin,in contrast to cements containing lower amounts of CMC which only released less than 2%of the cisplatin over 28 *** release of cisplatin efficiently killed osteosarcoma cells in vitro and the fraction of dead cells increased to 91.3%at day 7,which confirms the retained chemotherapeutic activity of released cisplatin from these PMMA-based ***,tibias filled with PMMA-based cements containing up to 3%of CMC exhibit comparable compressive strengths as compared to intact *** conclusion,we demonstrate that PMMA cements can be rendered therapeutically active by introducing porosity using CMC to allow for release of cisplatin without compromising mechanical properties beyond critical *** such,these data suggest that our dual-functional PMMA-based cements represent a viable treatment option for filling bone defects after bone tumor resection in load-bearing sites.

关键词： Porous polymethylmethacrylate cement Bone tumor treatment Local drug delivery Chemotherapeutic drug Ex vivo biomechanical assessment

Triggering Investments in Sustainable Bio-Energy Projects Using Structural and Cohesion Funds- Results from the Projects Energy4Cohesion and Promoscene

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Triggering Investments in Sustainable Bio-Energy Projects Us...

The 18th European Biomass Conference and Exhibition

作者： Bi?mann M. janssen R. Abu Amara S.

Innovative bioenergy projects have proven positive environmental and social benefits for the marginalised and rural regions of Europe. Structural and Cohesion Funds（SCF） represent an increasing potential for financing bioenergy projects in less developed regions. Still, there are several barriers and difficulties for SCF bioenergy projects to be overcome. These barriers were identified and carefully analysed in the former EU projects Energy4 Cohesion and Promo Scene, both supported by the European Commission in the Intelligent Energy for Europe Programme. Most prominent barriers are the unsecure long-term supply of biomass and the difficulties to mobilise the required project funding. A clear set of recommendations derived from the projects Energy4 Cohesion and Promo Scene, based on the project results and the analysis of a top-ten list of successful rural bioenergy projects funded within SCF Programmes. It is now of highest importance to spread these results to the key actors involved in SCF Management and bioenergy project development in order to increase the share of bioenergy projects funded within SFC Programmes.

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低副瓣喇叭天线方向图的测量

雷达与对抗 1981年第4期 1-5页

作者： MIGHAEL A.janssen 何学良

设计为低副瓣的波纹喇叭天线的功率方向图在E平面和H平面测到低于主瓣最大值90分贝的电平。测量方向图与理论计算相当吻合。

关键词：喇叭天线发射机波纹定向天线电子设备低副瓣低旁瓣天线方向图天线波瓣图

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断路器的寿命管理

江苏电力译文 2001年第4期 18-25页

作者： A.L.J.janssen 龙禹

1996年CIGRE第13SC（开关设备）组成立了一个新的工作小组即13．08小组（断路器的寿命管理），来研究断路器寿命管理的情况并就如何延长运行中和改进中的开关设备的剩余预期寿命提出详细的建议。要研究的问题如下：过去和现在设计的高... 详细信息

1996年CIGRE第13SC（开关设备）组成立了一个新的工作小组即13．08小组（断路器的寿命管理），来研究断路器寿命管理的情况并就如何延长运行中和改进中的开关设备的剩余预期寿命提出详细的建议。要研究的问题如下：过去和现在设计的高、中压断路器的现有寿命经验；剩余预期寿命、可能性和步骤的确定和评估；风险评估；寿命延长的可能性，例如监控、维护方法、安全性、可维护性；试验；经济的影响，采取预防措施所带来的额外支出，可靠性降低等等；法律、环境和政策方面；电网状况的变化；本文介绍了CIGRE第13．08小组的研究摘要。

关键词：断路器寿命管理诊断监测

基于善意本性的公共品自愿供给与公平分配——中美行为经济实验研究

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