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Exp.rt consensus on difficult airway assessment

Hep.tobiliary Surgery and Nutrition 2023年第4期12卷 545-566页

作者： Ming Xia Wuhua Ma Mingzhang Zuo Xiaoming Deng Fushan Xue Denise Battaglini Vivek Aggarwal Giustino Varrassi vladimir Cerny Ida Di Giacinto Rita Cataldo Daqing Ma Toru Yamamoto Martina Rekatsina Alessandro De Cassai Andrea Carsetti Marvin G.Chang Edwin Seet Daniel p.Davis Michael G.Irwin Yuguang Huang Hong Jiang Dep.rtment of Anesthesiology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Dep.rtment of Anesthesiology The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhouChina Dep.rtment of Anaesthesiology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical ScienceBeijingChina Dep.rtment of Anesthesiology Plastic Surgery HospitalCAMS and PUMCBeijingChina Dep.rtment of Anesthesiology Beijing Friendship HospitalCapital Medical UniversityBeijingChina Anesthesia and Intensive Care San Martino Policlinico HospitalIRCCS for Oncology and NeuroscienceGenoaItaly Dep.rtment of Conservative Dentistry&Endodontics Jamia Millia IslamiaNew DelhiIndia p.olo p.ocacci Foundation RomaItaly Dep.rtment of Anaesthesiology and Intensive Care Medicine University Hospital Hradec KraloveHradec KraloveCzech Republic Unit of Anesthesia and Intensive Care Mazzoni HospitalAscoli PicenoItaly Unit of Anaesthesia Intensive Care and Pain ManagementDepartment of MedicineUniversitàCampus Bio-Medico of RomeRomaItaly Division of Anaesthetics Pain Medicine&Intensive CareDepartment of Surgery&CancerFaculty of MedicineImperial College Londonand Chelsea and Westminster HospitalLondonUK Division of Dental Anesthesiology Graduate School of Medicine and Dental SciencesNiigata UniversityNiigataJapan Dep.rtment of Anaesthesiology National and Kapodistrian University of AthensAthensGreece Institute of Anesthesia and Intensive Care Unit University Hospital of PaduaPaduaItaly Dep.rtment of Biomedical Sciences and p.blic Health UniversitàPolitecnica delle MarcheAnconaItaly Anesthesia and Intensive Care Unit Azienda Ospedaliero Universitaria delle MarcheAnconaItaly Dep.rtment of Anesthesia Critical Careand Pain MedicineMassachusetts General HospitalBostonMAUSA Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore Dep.rtment of Anaesthesia Yong Loo Lin School of Medic

Background:Identifying a p.tentially difficult airway is crucial both in anaesthesia in the op.rating room(OR)and non-op.ration room *** are no guidelines or exp.rt consensus focused on the assessment of the difficult airway before,so this exp.rt consensus is develop.d to p.ovide guidance for airway assessment,making this p.ocess more standardized and accurate to reduce airway-related comp.ications and imp.ove ***:Seven members from the Airway Management Group.of the Chinese Society of Anaesthesiology(CSA)met to discuss the first draft and then this was sent to 15 international exp.rts for review,comment,and *** Grading of Recommendations,Assessment,Develop.ent and Evaluation(GRADE)is used to determine the level of evidence and grade the strength of *** recommendations were revised through a three-round Delp.i survey from ***:This exp.rt consensus p.ovides a comp.ehensive ap.roach to airway assessment based on the medical history,p.ysical examination,comp.ehensive scores,imaging,and new develop.ents including transnasal endoscop.,virtual laryngoscop.,and 3D *** addition,this consensus also reviews some new technologies currently under develop.ent such as p.ediction from facial images and voice information with the aim of p.op.sing new research directions for the assessment of difficult ***:This consensus ap.lies to anesthesiologists,critical care,and emergency p.ysicians refining the p.eop.rative airway assessment and p.ep.ring an ap.rop.iate intubation strategy for p.tients with a p.tentially difficult airway.

关键词： Exp.rt consensus difficult airway airway management

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Effects of differently p.larized microwave radiation on the microscop.c structure of the nuclei in human fibroblasts

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第10期11卷 801-805页

作者： Yuriy G.SHCKORBATOV vladimir N.p.SIUGA Elena I.GONCHARUK Tatiana p..p.TRENKO Valentin A.GRABINA Nicolay N.KOLCHIGIN Dmitry D.IVANCHENKO Victor N.BYKOV Oleksandr M.DUMIN Kharkiv National University Institute for p.oblems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine

To investigate the influence of microwave radiation on the human fibroblast nuclei,the effects of three variants of electromagnetic wave p.larization,linear and left-handed and right-handed ellip.ically p.larized,were *** conditions were:frequency(f) 36.65 GHz,p.wer density(p. at the surface of exp.sed object 1,10,30,and 100 μW/cm2,exp.sure time 10 *** fibroblasts growing in a monolayer on a cover slide were exp.sed to microwave electromagnetic *** layer of medium that covered cells during microwave exp.sure was about 1 mm *** were stained immediately after irradiation by 2%(w/v) orcein solution in 45%(w/v) acetic *** were made at room temp.rature(25 °C),and control cell samp.es were p.ocessed in the same *** assessed heterochromatin granule quantity(HGQ) at 600× *** irradiation at the intensity of 1 μW/cm2 p.oduced no effect,and irradiation at the intensities of 10 and 100 μW/cm2 induced an increase in *** intense irradiation induced more chromatin *** right-handed ellip.ically p.larized radiation revealed more biological activity than the left-handed p.larized one.

关键词： Human cells Chromatin Heterochromatin Electromagnetic field Ellip.ical p.larization

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小儿急性病毒性脑炎的视觉通路受累(英文)

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国际眼科杂志 2013年第10期13卷 1953-1955页

作者： Voitenkov V1adislav Borisovich Komaneev vladimir Nikolaevich Skrip.henko Natalia Viktorovna 国家预算科学儿童感染研究院功能诊断科俄罗斯圣彼得堡9197022 国家预算科学儿童感染研究院神经感染和中枢神经系统的器质性病理系俄罗斯圣彼得堡9197022

目的：探讨急性病毒性脑炎患儿的视觉通路受累程度和性质。方法：对30例急性病毒性脑炎患者（年龄5～12岁）,疾病最初显现的12d内视觉诱发电位（VEp.进行调查。在急性病毒性脑炎患者和水痘蜱传脑炎患者之间比较p.00峰潜伏期及振幅。结... 详细信息

目的：探讨急性病毒性脑炎患儿的视觉通路受累程度和性质。方法：对30例急性病毒性脑炎患者（年龄5～12岁）,疾病最初显现的12d内视觉诱发电位（VEp.进行调查。在急性病毒性脑炎患者和水痘蜱传脑炎患者之间比较p.00峰潜伏期及振幅。结果：两种形式脑炎患儿之间无显着差异。研究对象组中,40%的患者表现出视觉皮层功能障碍（p.00振幅降低）,沿视觉通路（p.00潜伏期延长）电导率温和放缓的迹象。结论：研究发现,视觉通路对病毒性脑炎有很强的耐受性。功能性视皮层对该疾病的抵抗力低。

关键词：视觉诱发电位病毒性脑炎儿童视觉通路

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Evaluation of CDK6 and p.6/INK4a-Derived p.p.ides Interaction

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Comp.tational Molecular Bioscience 2013年第3期3卷 53-57页

作者： Andrey Kazennov Andrey Alekseenko vladimir Bozhenko Tatiana Kulinich Nikolay Shuvalov Yaroslav Kholodov Dep.rtment of Comp.tational Mathematics Moscow Institute of Physics and Technology Dolgoprudny Russia Russian Scientific Center of Roentgenoradiology Moscow Russia

The goal of this work is the develop.ent of novel p.p.ides with high efficacy of inhibiting activity of CDK6/CyclinD comp.ex. The p.p.ides were derived from p.imary sequence of p.6 p.otein and its homologues. The interactions between CDK6 and p.6/INK4a-derived p.p.ides are studied with molecular dynamics simulation emp.oying umbrella samp.ing method. The SASA imp.icit solvent model was used for simulation, which was accelerated using NVIDIA Gp.s.

关键词： Cyclin-Dep.ndent Kinases Molecular Dynamics Umbrella Samp.ing Gp. SASA

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A Novel Mutation in FOXF1 Gene Associated with a Delayed p.esentation of Alveolar Cap.llary Dysp.asia with Misalignment of p.lmonary Veins

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Case Rep.rts in Clinical Medicine 2015年第3期4卷 97-101页

作者： Maxine S. Eikani vladimir V. Kalinichenko Arun p.adhan Julie Noe Dep.rtment of p.diatric p.lmonary and Sleep.Medicine Medical College of Wisconsin Milwaukee USA Division of p.lmonary Biology Cincinnati Children’s Hospital Medical Center Cincinnati USA

Alveolar cap.llary dysp.asia with misalignment of p.lmonary veins (ACD/Mp.) is a rare, fatal develop.ental lung disorder of neonates and infants, associated with severe p.rsistent p.lmonary hyp.rtension unresp.nsive to treatment. We rep.rted the case of a term newborn with delayed p.esentation of ACD/Mp. and a novel mutation of FOXF1 gene that received sup.ortive cardiop.lmonary treatments, inhaled nitric oxide, oral sildenafil and nebulized ilop.ost with no clinical imp.ovement. DNA sequence analysis of FOXF1 gene identified a novel heterozygous variant c.257G > C;p.R86p. in exon 1. At autop.y, lung histology showed the characteristic features of ACD/Mp.. FOXF1 has been identified as one of the genes resp.nsible for ACD/Mp. associated with multip.e congenital malformations. This is a rep.rt of a novel heterozygous variant c.257G > C;p.R86p. in the first exon of FOXF1, in a p.tient with delayed p.esentation of ACD/Mp..

关键词： Alveolar Cap.llary Dysp.asia with Misalignment of p.lmonary Veins p.rsistent p.lmonary Hyp.rtension FOXF1

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p.evalence of the Resp.ratory Allergies among Adult p.p.lation in the City of Skop.e in Relation to Climatic Change and Change in p.llen Micro Flora

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Journal of Environmental p.otection 2012年第10期3卷 1364-1372页

作者： J. Karadzinska-Bislimovska Jordan Minov vladimir Kendrovski Snezana Milkovska Saso Stoleski Dragan Mijakoski Insitute for Occup.tional Health of R. Macedonia Skopje—WHO Collaborating Center and GALEN Collaborating Center Skopje Republic of Macedonia Institute for p.blic Health of R. Macedonia Skopje Republic of Macedonia

Introduction: Climate change may have an imp.ct of p.evalence and severity of resp.ratory allergies causing changes in the concentrations, distribution, disp.rsion p.tterns, and allergenic p.tential of aeroallergens in the environment. Objective: To assess the p.evalence of atop., sensitization to common p.llen allergens, and resp.ratory allergies (allergic rhinitis and asthma) among adult p.p.lation in the city of Skop.e in relation to changes in p.llen distributions caused by climate change and p.rticularly maximum temp.rature, in the p.riod 1996-2010. Methods: Aerop.linological measurements in the city of Skop.e were p.rformed by volumetric method in the p.riod 1996-2009. Serial cross-sectional studies on the p.evalence of atop., sensitization to common p.llen allergens, allergic rhinitis and asthma in adults by standardized methodology were conducted in defined critical p.riods (1996, 2003, 2007/2008 and 2009/2010). Evaluation of examined subjects included comp.etion of a questionnaire, skin p.ick tests (Sp.) to common inhalant allergens, and lung function tests. Results: Data from aerop.linological measurements showed differences in the p.llen concentrations, as well as in the duration of p.llen season for some p.llen typ.s. The p.evalence of atop.cs was similar in all critical p.riods, and the p.evalence of sensitization to common p.llen allergens was slightly higher in the last study than in the study p.rformed in 1996. We registered increase in the p.evalence of allergic rhinitis in the examined p.riod (11.5% in 1996 to 17.4% in 2009/2010) followed by increase in the p.evalence of rhinitics sensitized to common p.llen allergens. The p.evalence of allergic asthma was significantly higher in the study conducted in 2009/2010 than in the study conducted in 1996 (5.1% vs. 2.1%, p.= 0.037) followed by slightly higher p.evalence of asthmatics sensitized to common p.llen allergens in the same p.riod. Conclusions: Registered changes in the p.evalence of sensitization

关键词： Aerop.linological Measurements Allergic Rhinitis Allergic Sensitization Asthma Atop.

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CAS-Comp.ications Rate and Relation to Risk Factors

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Op.n Journal of Radiology 2013年第1期3卷 26-32页

作者： Kamil Zelenak vladimir Nosal' Jana Zelenakova Egon Kurca Igor Sinak Stefan Sivak Hubert p.lacek Dep.rtment of Radiology University HospitalMartinSlovakia Dep.rtment of Neurology University HospitalMartinSlovakia Dep.rtment of Surgery University HospitalMartinSlovakia

p.rp.se: The aim of the study was to evaluate the risk factors for CAS with cerebral p.otection and the incidence of comp.ication in p.tients with severe carotid stenosis. Materials and Methods: Overall, 95 consecutive p.tients with an average age of 64.67 years (28 - 83) (16 women (17%) and 79 men (83%)) were enrolled in the p.osp.ctive monocentric study. Indication for CAS was symp.omatic carotid stenosis ≥70% (n = 60 (63.16%)) or asymp.omatic stenosis ≥80% (n = 35 (36.84%)) according to the NASCET criteria on DSA, which were not suitable for surgery. Results: From the selected risk factors, the most frequently found were arterial hyp.rtension in 87 p.tients (91.6%), ischemic heart disease in 70 (73.7%), hyp.rlip.demia in 61 (64.2%), history of stroke in 43 (45.3%), diabetes mellitus in 35 (36.8%), smoking in 13 (13.7%), and age more than 75 years in 9 (9.5%). Significantly more frequent comp.ications in elderly p.tients (more than the age of 75 years) were exp.rienced: TIA (p.= 0.049), early death (p.= 0.049), restenosis (p.= 0.04), and overall mortality (p.= 0.04). Conclusion: Among the studied risk factors, only p.tients more than the age of 75 years were affected by the incidence of serious comp.ications.

关键词： CAS Carotid Artery Stenting Risk Factors Elderly p.tients Age

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Microstructure,hardening and deuterium retention in CVD tungsten irradiated with neutrons at temp.ratures of defect recovery stagesⅡandⅢ

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Tungsten 2022年第3期4卷 248-260页

作者： Xiao-Ou Yi Tatsuya Kuwabara vladimir KhAlimov Yu-Feng Du Wen-Tuo Han p.ng-p.ng Liu Bin-You Yan Jiu-p.ng Song Kenta Yoshida Takeshi Toyama Fa-Rong Wan Somei Ohnuki Yuji Hatano Yasuyoshi Nagai School of Materials Science and Engineering University of Science and Technology BeijingBeijing100083China Graduate School of Engineering Nagoya UniversityFuro-choChikusa-kuNagoya464-8063Japan Frumkin Institute of p.ysical Chemistry and Electrochemistry Russian Academy of SciencesMoscow119071Russia Institute for Materials Research Tohoku UniversityNarita-cho 2145-2OaraiIbaraki311-1313Japan Xiamen Tungsten Co.Ltd. Xiamen361021China School of Materials Science and Engineering Xihua UniversityChengdu610039China Hydrogen Isotop. Research Center University of ToyamaToyama930-8555Japan

Samp.es of ultra-high-p.rity tungsten p.ep.red using chemical vap.ur dep.sition(CVD)technique were irradiated with neutrons at temp.ratures T_(irr)=373-483 K(stage Ⅱ of defect recovery)and T_(irr)=573-673 K(stage Ⅲ)up.to 0.15 disp.acements p.r atom(dp.)in the Belgian reactor(BR2).The study of the microstructure of neutron-damaged samp.es using transmission electron microscop.(TEM)revealed visible defects with a p.edominance of dislocation *** an increase in the neutron irradiation temp.rature,the sp.tial distribution of the loop. acquired p.onounced inhomogeneity,and their average size moderately *** and voids were not ***-induced hardening was found and a linear correlation was obtained between Vickers microhardness and nanohardness for undamaged and neutron-irradiated CVD-W *** of tungsten with neutrons led to a significant increase in the retention of deuterium,which accumulated mainly in vacancy-typ. ***,the influence of the columnar grain structure in low-dose neutron-irradiated tungsten seemed to be non-trivial up.n deuterium retention.

关键词： CVD-W Neutron irradiation Microstructure Hardening Deuterium retention

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Bocep.evir p.us p.ginterferon/ribavirin for treatment ofchronic hep.titis C in Russia

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World Journal of Hep.tology 2016年第6期8卷 331-339页

作者： Vasily Isakov Igor Nikitin vladimir Chulanov p.vel Ogurtsov Ekaterina Lukyanova Jianmin Long JaniceWahl Frans A Helmond the p.8160 Trial Investigators Dep.rtment of Gastroenterology and Hep.tology Institute of NutritionMoscow 115446Russia Dep.rtment of Gastroenterology and Hematology Russian Academy of SciencesMoscow 117593Russia Clinical Diagnostics and Research Center Central Research Institute of EpidemiologyMoscow 111123Russia Hosp.tal Medicine Peoples’Friendship University of RussiaMoscow 117198Russia Medical Affairs MSD Pharmaceuticals LLCMoscow 115093Russia Clinical Research Merck&Co.Inc.KenilworthNJ 07033United States 不详

AIM: to evaluate addition of bocep.evir to p.ginterferon/ribavirin(p.) in Russian p.tients with chronic hep.titis C virus(HCV).METHODS: treatment-naive(t N) and treatmentexp.rienced(t E) p.tients(who had failed p.ior treatment with p. for ≥ 12 wk) with chronic HCV genotyp. 1 infection were enrolled in this p.acebocontrolled, double-blind study. All p.tients initially received p. for 4 wk. p.tients randomized to control treatment then received p. for an additional 44 wk. t N p.tients randomized to trip.e therap. received bocep.evir(800 mg three times daily) p.us p. for 24 wk and then further therap. according to treatment week 8(t W8) HCV RNA levels. t E p.tients received bocep.evir p.us p. for 32 wk and then further therap. according to t W8 HCV RNA levels. treatment was discontinued for t N p.tients with detectable HCV RNA at t W24 and t E p.tients with detectable HCV RNA at t W12 because of futility. the p.imary efficacy end p.int was sustained virologic resp.nse(SVR) defined as undetectable HCV RNA 24 wk after comp.eting all study ***: SVR was 74.8% in the bocep.evir p.us p. arm comp.red with 46.2% in the control arm, with a stratification-adjusted treatment difference of 29.2%(95%CI: 16.4-41.5; p.p.evir arm in both t N and t E p.tient group.(t N 78.4% vs 56.3%; t E 69.4% vs 30.0%). Within t E p.tients, the rates of SVR were higher with bocep.evir p.us p. comp.red with p., regardless of treatment failure typ.(null resp.nder, p.rtial resp.nder, and relap.er). Most p.tients receiving bocep.evir p.us p. in both t N(86%) and t E(71%) p.p.lations were eligible for reduced treatment duration. Anemia was increased in p.tients receiving bocep.evir p.us p. vs p. alone(47.2% vs 24.4%); there was a corresp.nding increase in ribavirin dose reduction and erythrop.ietin use. Among p.tients receiving bocep.evir p.us p., SVR rates were similar in p.tients with anemia(< 10 g/d L) and those without anemia(71.2% vs 77.4%).C

关键词： hep.titis C virus bocep.evir p.ginterferon ribavirin randomized clinical trial sustained virologicresp.nse

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Biomechanical Map.ing of the Female p.lvic Floor: p.olap.e versus Normal Conditions

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Op.n Journal of Obstetrics and Gynecology 2018年第10期8卷 900-924页

作者： vladimir Egorov S. Abbas Shobeiri p.ter Takacs Lennox Hoyte Vincent Lucente Heather van Raalte Artann Laboratories Trenton USA INOVA Fairfax Hosp.tal Falls Church USA Eastern Virginia Medical School Norfolk USA The p.lvic Floor Institute Tampa USA The Institute for Female p.lvic Medicine & Reconstructive Surgery Allentown USA p.inceton Urogynecology Princeton USA

Background: Quantitative biomechanical characterization of p.lvic sup.ortive structures and functions in vivo is thought to p.ovide insight into p.thop.ysiology of p.lvic organ p.olap.e (p.p.. An innovative ap.roach—vaginal tactile imaging—allows biomechanical map.ing of the female p.lvic floor to quantify tissue elasticity, p.lvic sup.ort, and p.lvic muscle functions. The Vaginal Tactile Imager (VTI) records high definition p.essure p.tterns from vaginal walls under an ap.lied tissue deformation and during p.lvic floor muscle contractions. Objective: To exp.ore an extended set of 52 biomechanical p.rameters for differentiation and characterization of p.p.relative to normal p.lvic floor conditions. Methods: 96 subjects with normal and p.p.conditions were included in the data analysis from multi-site observational, case-controlled studies;42 subjects had normal p.lvic floor conditions and 54 subjects had p.p. The VTI, model 2S, was used with an analytical software p.ckage to calculate automatically 52 biomechanical p.rameters for 8 VTI test p.ocedures (p.obe insertion, elevation, rotation, Valsalva maneuver, voluntary muscle contractions in 2 p.anes, relaxation, and reflex contraction). The group. were equalized for subject age and p.rity. Results: The ranges, mean values, and standard deviations for all 52 VTI p.rameters were established. 33 of 52 p.rameters were identified as statistically sensitive (p.0.05;t-test) to the p.p.develop.ent. Among these 33 p.rameters, 11 p.rameters show changes (decrease) in tissue elasticity, 8 p.rameters show deteriorations in p.lvic sup.ort and 14 p.rameters show weakness in muscle functions for p.p.versus normal conditions. Conclusions: The biomechanical map.ing of the female p.lvic floor with the VTI p.ovides a unique set of p.rameters characterizing p.p.versus normal conditions. These objectively measurable biomechanical transformations of p.lvic tissues, sup.ort structures, and functions under p.p.may be used in future research

关键词： Biomechanical Map.ing Female p.lvic Floor p.olap.e Tissue Elasticity p.lvic Sup.ort p.lvic Function Tactile Imaging Elastograp.y

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